GREMLIN Database
DUF1206 - Domain of Unknown Function (DUF1206)
PFAM: PF06724 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 70 (69)
Sequences: 34802 (22320)
Seq/√Len: 2686.9
META: 0.902

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_L22_L2.5081.00
65_V69_Y2.4251.00
55_G59_Y2.3051.00
15_V19_R2.2761.00
63_Q66_E2.2411.00
19_R23_G2.0951.00
38_T42_Q1.9721.00
47_W50_G1.9051.00
6_R10_Y1.7031.00
38_T41_G1.5871.00
40_A49_L1.5751.00
46_R50_G1.5461.00
62_W65_V1.5301.00
14_G18_L1.4851.00
61_L65_V1.4791.00
9_V12_L1.4441.00
36_L49_L1.4171.00
58_A62_W1.4011.00
19_R22_L1.3631.00
35_A38_T1.3041.00
3_Y6_R1.2781.00
1_A58_A1.2701.00
40_A46_R1.2641.00
30_G34_G1.2601.00
14_G21_A1.2011.00
37_A41_G1.1801.00
30_G38_T1.1731.00
62_W66_E1.1321.00
19_R24_S1.1261.00
64_L68_R1.1141.00
44_F47_W1.1021.00
59_Y63_Q1.0951.00
42_Q48_L1.0951.00
39_L42_Q1.0851.00
18_L21_A1.0841.00
53_A57_I1.0751.00
47_W51_L1.0741.00
11_A15_V1.0251.00
52_V55_G1.0151.00
42_Q46_R1.0131.00
34_G38_T1.0051.00
54_L58_A1.0021.00
5_A55_G1.0001.00
32_L36_L0.9831.00
66_E69_Y0.9761.00
4_A8_V0.9631.00
44_F48_L0.9381.00
33_D37_A0.9281.00
12_L15_V0.9231.00
62_W68_R0.9051.00
50_G54_L0.8981.00
8_V12_L0.8761.00
43_P46_R0.8551.00
33_D40_A0.8331.00
64_L67_A0.8231.00
27_S30_G0.8221.00
12_L16_L0.8071.00
37_A40_A0.7921.00
25_G28_S0.7921.00
6_R9_V0.7771.00
36_L40_A0.7751.00
45_G49_L0.7671.00
17_A20_A0.7661.00
23_G28_S0.7661.00
57_I61_L0.7521.00
40_A43_P0.7451.00
14_G17_A0.7341.00
50_G53_A0.7301.00
6_R14_G0.7291.00
6_R59_Y0.7131.00
20_A29_A0.7121.00
60_G64_L0.7071.00
4_A7_G0.7001.00
61_L64_L0.6941.00
49_L53_A0.6801.00
35_A39_L0.6771.00
10_Y17_A0.6721.00
5_A52_V0.6681.00
25_G29_A0.6591.00
1_A4_A0.6591.00
24_S28_S0.6221.00
52_V56_L0.6211.00
13_I17_A0.6201.00
39_L45_G0.6121.00
6_R66_E0.6081.00
63_Q69_Y0.6011.00
9_V59_Y0.5991.00
60_G67_A0.5991.00
48_L51_L0.5931.00
24_S27_S0.5841.00
12_L39_L0.5821.00
65_V68_R0.5791.00
59_Y62_W0.5671.00
16_L20_A0.5651.00
31_G35_A0.5581.00
13_I35_A0.5461.00
34_G37_A0.5341.00
9_V16_L0.5331.00
6_R56_L0.5191.00
9_V32_L0.5161.00
53_A56_L0.5111.00
10_Y13_I0.5081.00
30_G33_D0.5031.00
51_L55_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a01A 2 1 7.1 0.821 Contact Map
4wgvA 2 1 6.5 0.824 Contact Map
3j1zP 8 0.8143 6.2 0.826 Contact Map
3h90A 3 0.8143 5.6 0.83 Contact Map
4us3A 1 1 4.7 0.836 Contact Map
3l1lA 2 0.9571 4.3 0.84 Contact Map
2jafA 3 0.4714 3.3 0.848 Contact Map
4av3A 2 1 3.1 0.85 Contact Map
4djkA 2 1 2.4 0.858 Contact Map
3giaA 1 0.9714 2.3 0.861 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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