GREMLIN Database
DUF1203 - Protein of unknown function (DUF1203)
PFAM: PF06718 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (116)
Sequences: 7819 (4838)
Seq/√Len: 449.2
META: 0.921

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_E41_A3.3901.00
104_N111_A2.6931.00
102_V114_I2.6881.00
11_A17_V2.5241.00
73_M107_R2.2981.00
88_I100_L2.1411.00
66_A97_V2.1261.00
77_E90_R2.1171.00
77_E87_A1.8701.00
88_I114_I1.8381.00
64_L102_V1.8161.00
85_E89_E1.8131.00
83_E86_A1.7951.00
10_D60_R1.7831.00
101_H113_R1.7821.00
69_A98_A1.7771.00
61_L78_V1.7551.00
71_G99_Y1.7491.00
23_E32_R1.7131.00
35_G67_Y1.7071.00
87_A90_R1.7011.00
77_E106_R1.6291.00
58_R85_E1.5951.00
49_A52_E1.5241.00
74_V97_V1.4941.00
23_E26_P1.4891.00
21_N34_S1.4751.00
2_F17_V1.4561.00
68_D72_M1.4351.00
61_L106_R1.4051.00
2_F11_A1.4041.00
68_D74_V1.3781.00
15_E40_H1.3701.00
57_L62_L1.3701.00
7_C40_H1.3411.00
25_F99_Y1.2961.00
23_E34_S1.2701.00
26_P71_G1.2671.00
101_H115_E1.2611.00
7_C44_C1.2521.00
75_D94_D1.2461.00
56_V111_A1.2361.00
12_E15_E1.2301.00
27_A71_G1.2281.00
66_A91_L1.2221.00
87_A91_L1.2121.00
62_L102_V1.2081.00
80_E83_E1.2061.00
25_F71_G1.1881.00
57_L111_A1.1831.00
20_L37_I1.1551.00
61_L80_E1.1451.00
63_S105_A1.1401.00
4_C7_C1.1381.00
89_E93_A1.1341.00
40_H44_C1.1301.00
9_R56_V1.1241.00
35_G73_M1.1031.00
24_P33_E1.0961.00
64_L100_L1.0861.00
6_V46_A1.0811.00
100_L114_I1.0721.00
66_A75_D1.0571.00
55_E59_R1.0461.00
11_A40_H1.0021.00
16_E42_G0.9941.00
21_N36_P0.9921.00
101_H110_F0.9881.00
33_E103_H0.9771.00
64_L84_L0.9751.00
55_E58_R0.9571.00
75_D91_L0.9391.00
21_N35_G0.9301.00
40_H43_A0.9141.00
53_V84_L0.9121.00
9_R12_E0.8941.00
24_P67_Y0.8871.00
64_L88_I0.8861.00
31_Y107_R0.8791.00
29_S71_G0.8781.00
36_P67_Y0.8631.00
57_L112_A0.8511.00
6_V39_V0.8491.00
90_R93_A0.8391.00
56_V104_N0.8371.00
64_L87_A0.8361.00
84_L88_I0.8301.00
20_L39_V0.8281.00
8_L112_A0.8191.00
78_V106_R0.8181.00
65_R78_V0.8101.00
10_D56_V0.8021.00
12_E40_H0.7991.00
102_V112_A0.7991.00
86_A90_R0.7971.00
64_L91_L0.7941.00
47_Y52_E0.7891.00
48_D52_E0.7701.00
63_S108_G0.7701.00
79_V87_A0.7561.00
91_L97_V0.7541.00
71_G98_A0.7471.00
33_E67_Y0.7391.00
62_L111_A0.7361.00
88_I102_V0.7351.00
86_A89_E0.7331.00
75_D107_R0.7301.00
56_V59_R0.7281.00
74_V96_E0.7271.00
29_S72_M0.7171.00
9_R55_E0.7131.00
87_A106_R0.7021.00
80_E106_R0.6951.00
9_R45_E0.6921.00
4_C9_R0.6871.00
74_V94_D0.6831.00
9_R40_H0.6821.00
59_R62_L0.6801.00
63_S103_H0.6791.00
110_F113_R0.6741.00
53_V58_R0.6711.00
88_I92_F0.6631.00
57_L102_V0.6581.00
53_V85_E0.6541.00
69_A96_E0.6531.00
31_Y73_M0.6521.00
99_Y113_R0.6511.00
71_G74_V0.6440.99
22_Y37_I0.6410.99
29_S32_R0.6370.99
76_A107_R0.6320.99
23_E33_E0.6270.99
45_E48_D0.6140.99
33_E63_S0.6130.99
13_P17_V0.6100.99
78_V105_A0.6050.99
99_Y115_E0.6010.99
52_E85_E0.6000.99
62_L106_R0.5970.99
76_A106_R0.5920.99
63_S78_V0.5910.99
105_A112_A0.5850.99
83_E87_A0.5790.99
15_E42_G0.5760.99
91_L100_L0.5720.99
21_N25_F0.5700.99
65_R76_A0.5680.99
75_D90_R0.5680.99
67_Y73_M0.5670.99
2_F10_D0.5600.99
67_Y112_A0.5600.99
9_R44_C0.5510.98
10_D59_R0.5470.98
107_R111_A0.5450.98
35_G112_A0.5450.98
31_Y38_F0.5440.98
38_F76_A0.5390.98
98_A115_E0.5380.98
48_D51_D0.5370.98
25_F67_Y0.5340.98
106_R111_A0.5330.98
25_F73_M0.5320.98
42_G45_E0.5280.98
10_D13_P0.5260.98
75_D97_V0.5250.98
31_Y65_R0.5230.98
81_G84_L0.5220.98
110_F115_E0.5200.98
9_R15_E0.5180.98
31_Y104_N0.5150.98
65_R73_M0.5140.98
23_E28_D0.5040.97
91_L94_D0.5020.97
44_C48_D0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ougA 5 0.3448 15.3 0.933 Contact Map
2mr9A 1 0.3793 11.9 0.936 Contact Map
2ekkA 1 0.4052 11.6 0.936 Contact Map
1v5mA 1 0.7931 11.1 0.937 Contact Map
4bgbA 1 0.7759 9.7 0.938 Contact Map
2jy5A 1 0.4397 8.7 0.939 Contact Map
2gj7F 1 0 6.4 0.943 Contact Map
1yk1E 1 0.0776 6.2 0.943 Contact Map
1yk0E 1 0.0776 6 0.944 Contact Map
4ltyC 1 0.8103 5.9 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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