GREMLIN Database
DUF1192 - Protein of unknown function (DUF1192)
PFAM: PF06698 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (58)
Sequences: 7417 (3895)
Seq/√Len: 511.4
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_E40_E4.4831.00
26_E43_I2.7671.00
42_A45_A2.3121.00
26_E47_Q2.2591.00
51_S54_D2.0031.00
15_Q28_R1.8301.00
33_E37_A1.6971.00
28_R39_L1.6951.00
22_V26_E1.6271.00
29_I36_I1.6201.00
49_H56_L1.5951.00
18_D42_A1.5541.00
41_A44_A1.4991.00
30_A33_E1.4741.00
37_A40_E1.4661.00
21_S24_E1.4581.00
50_R54_D1.4281.00
30_A34_A1.4041.00
23_E26_E1.3701.00
16_D19_L1.2671.00
22_V46_K1.2351.00
42_A46_K1.2261.00
29_I40_E1.1211.00
27_E30_A1.0891.00
12_E15_Q1.0651.00
22_V43_I1.0581.00
35_E38_R1.0441.00
47_Q51_S1.0231.00
25_L39_L1.0171.00
15_Q20_L0.9831.00
37_A41_A0.9751.00
46_K49_H0.9721.00
44_A47_Q0.9501.00
33_E36_I0.9451.00
43_I47_Q0.9391.00
11_H28_R0.9261.00
34_A37_A0.8871.00
26_E40_E0.8861.00
44_A48_A0.8731.00
29_I33_E0.8311.00
48_A52_A0.8101.00
11_H14_G0.7961.00
13_I31_L0.7951.00
47_Q50_R0.7891.00
6_R9_P0.7831.00
23_E27_E0.7731.00
25_L43_I0.7621.00
41_A45_A0.7621.00
29_I39_L0.7611.00
11_H39_L0.7471.00
1_D6_R0.7191.00
52_A55_A0.7161.00
39_L42_A0.7131.00
9_P12_E0.7131.00
40_E44_A0.7111.00
22_V47_Q0.6911.00
20_L31_L0.6911.00
17_L46_K0.6911.00
4_E9_P0.6871.00
3_D6_R0.6651.00
37_A44_A0.6621.00
4_E7_K0.6471.00
45_A49_H0.6441.00
34_A41_A0.6341.00
26_E30_A0.6321.00
49_H53_A0.6301.00
17_L38_R0.6231.00
55_A58_K0.6201.00
14_G39_L0.6041.00
13_I16_D0.5870.99
53_A56_L0.5820.99
22_V50_R0.5710.99
17_L32_L0.5590.99
10_A31_L0.5570.99
29_I43_I0.5570.99
3_D8_K0.5540.99
19_L49_H0.5450.99
27_E31_L0.5290.99
18_D45_A0.5240.99
30_A37_A0.5220.99
24_E49_H0.5210.99
47_Q52_A0.5190.98
45_A48_A0.5150.98
19_L24_E0.5140.98
1_D5_P0.5120.98
25_L28_R0.5060.98
32_L39_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tp9Y 1 0.7241 21 0.818 Contact Map
1vx73 1 0.7931 19.6 0.821 Contact Map
2idbA 3 0.6379 18.4 0.823 Contact Map
3wpaA 3 0 18.2 0.823 Contact Map
2wq1A 3 0.4655 17.1 0.826 Contact Map
1r73A 1 0.7069 16.9 0.826 Contact Map
3j60g 1 0.6897 16.6 0.826 Contact Map
2zjrV 1 0.6897 16.3 0.827 Contact Map
4cr2M 1 0.3966 16.1 0.828 Contact Map
4etpA 1 0.6379 16 0.828 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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