GREMLIN Database
Sm_multidrug_ex - Putative small multi-drug export protein
PFAM: PF06695 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 121 (121)
Sequences: 8591 (6263)
Seq/√Len: 569.4
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_A117_I3.3711.00
9_G19_A2.8631.00
28_I112_L2.7821.00
103_D106_K2.7661.00
8_L12_L2.7321.00
52_K56_D2.6901.00
78_A110_A2.5461.00
74_F110_A2.2761.00
65_K69_I2.2411.00
27_N115_V2.1421.00
74_F106_K2.0691.00
78_A113_L2.0601.00
20_F119_G2.0521.00
66_G69_I2.0461.00
81_V93_G1.8731.00
24_V116_L1.8261.00
20_F24_V1.7441.00
82_A117_I1.7381.00
7_P10_I1.7251.00
15_P18_L1.7041.00
2_L119_G1.6781.00
10_I16_P1.6711.00
28_I115_V1.6521.00
18_L22_I1.6451.00
90_A115_V1.5911.00
40_K43_K1.5181.00
46_R52_K1.5011.00
97_A107_A1.4921.00
30_P34_I1.4431.00
42_L98_F1.4291.00
39_R101_G1.3461.00
44_W48_I1.3421.00
105_K109_L1.3181.00
66_G70_E1.3111.00
42_L55_F1.2801.00
48_I51_F1.2661.00
58_L62_A1.2631.00
46_R56_D1.2431.00
63_R66_G1.2221.00
70_E73_G1.2041.00
20_F116_L1.1921.00
60_E63_R1.1811.00
90_A111_I1.1721.00
5_A23_A1.1681.00
44_W47_K1.1631.00
14_L18_L1.1541.00
81_V111_I1.1531.00
59_F63_R1.1111.00
46_R59_F1.0901.00
17_W21_L1.0761.00
56_D60_E1.0601.00
107_A111_I1.0601.00
39_R43_K1.0411.00
36_L104_F1.0401.00
42_L46_R1.0391.00
35_L94_A1.0341.00
14_L19_A1.0261.00
24_V112_L1.0191.00
74_F102_L1.0121.00
67_K70_E1.0051.00
53_K57_W0.9981.00
65_K68_K0.9721.00
37_F40_K0.9691.00
94_A111_I0.9641.00
39_R104_F0.9521.00
74_F78_A0.9421.00
31_V90_A0.9341.00
36_L40_K0.9271.00
78_A82_A0.9271.00
72_Y76_G0.9261.00
6_I19_A0.9211.00
54_F58_L0.9211.00
8_L11_A0.9101.00
23_A26_G0.9031.00
30_P33_F0.9001.00
10_I19_A0.8881.00
49_K52_K0.8871.00
69_I76_G0.8861.00
63_R101_G0.8841.00
18_L21_L0.8831.00
62_A96_A0.8801.00
60_E64_K0.8571.00
54_F57_W0.8491.00
68_K76_G0.8361.00
112_L116_L0.8271.00
57_W60_E0.8261.00
34_I94_A0.8241.00
31_V111_I0.8201.00
32_P108_F0.8161.00
57_W61_R0.8131.00
24_V119_G0.8121.00
80_F88_T0.7991.00
19_A23_A0.7991.00
106_K109_L0.7981.00
25_I29_L0.7941.00
31_V94_A0.7911.00
80_F96_A0.7891.00
35_L104_F0.7881.00
9_G14_L0.7841.00
27_N31_V0.7801.00
38_L98_F0.7781.00
75_L78_A0.7771.00
27_N90_A0.7671.00
22_I26_G0.7661.00
24_V115_V0.7631.00
42_L59_F0.7621.00
109_L112_L0.7601.00
104_F108_F0.7601.00
55_F59_F0.7591.00
31_V35_L0.7521.00
21_L25_I0.7471.00
4_G7_P0.7411.00
33_F37_F0.7401.00
48_I52_K0.7301.00
112_L115_V0.7221.00
108_F112_L0.7211.00
38_L42_L0.7171.00
39_R42_L0.7161.00
102_L107_A0.7061.00
34_I38_L0.7061.00
40_K44_W0.7051.00
46_R51_F0.7041.00
102_L110_A0.7011.00
81_V88_T0.6981.00
43_K46_R0.6951.00
65_K96_A0.6941.00
16_P20_F0.6861.00
74_F113_L0.6851.00
50_F53_K0.6831.00
51_F55_F0.6811.00
45_L48_I0.6691.00
59_F98_F0.6681.00
32_P104_F0.6651.00
24_V27_N0.6581.00
114_G118_A0.6361.00
2_L7_P0.6321.00
110_A113_L0.6281.00
28_I108_F0.6251.00
50_F54_F0.6241.00
66_G96_A0.6191.00
103_D109_L0.6181.00
19_A22_I0.6171.00
14_L22_I0.6081.00
38_L41_I0.5991.00
5_A9_G0.5981.00
61_R65_K0.5971.00
31_V108_F0.5931.00
34_I91_W0.5921.00
77_L97_A0.5911.00
73_G102_L0.5881.00
45_L55_F0.5871.00
73_G106_K0.5851.00
98_F101_G0.5811.00
84_P88_T0.5791.00
104_F109_L0.5771.00
58_L99_L0.5751.00
32_P36_L0.5721.00
96_A100_L0.5721.00
55_F58_L0.5680.99
6_I9_G0.5650.99
115_V118_A0.5650.99
80_F92_T0.5590.99
59_F95_L0.5590.99
38_L95_L0.5570.99
72_Y75_L0.5570.99
43_K47_K0.5480.99
45_L52_K0.5470.99
76_G96_A0.5450.99
26_G30_P0.5410.99
17_W20_F0.5400.99
3_R118_A0.5390.99
42_L51_F0.5370.99
22_I25_I0.5340.99
87_G92_T0.5300.99
52_K55_F0.5240.99
62_A95_L0.5220.99
45_L51_F0.5210.99
39_R98_F0.5200.99
6_I20_F0.5130.99
69_I72_Y0.5040.99
73_G76_G0.5020.99
6_I23_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jlnA 1 0.562 54.3 0.847 Contact Map
4k0jA 3 0.3388 8.6 0.898 Contact Map
4dx5A 3 0.438 8.3 0.898 Contact Map
2cfqA 1 0.9835 6 0.905 Contact Map
3giaA 1 0.438 5.5 0.907 Contact Map
4mt1A 3 0.3471 5 0.908 Contact Map
3ze3A 4 0.7025 4.3 0.911 Contact Map
2kluA 1 0.2645 3.8 0.914 Contact Map
4fc4A 3 0.6033 3.8 0.914 Contact Map
2kncA 1 0.4463 3.6 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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