GREMLIN Database
DUF1190 - Protein of unknown function (DUF1190)
PFAM: PF06693 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (155)
Sequences: 1056 (827)
Seq/√Len: 66.4
META: 0.597

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_E37_R4.3481.00
77_F81_R3.9231.00
28_Y32_L3.5801.00
73_L80_G3.4541.00
7_Y16_A3.3391.00
25_E29_A3.3031.00
8_T12_E3.2001.00
42_Y51_E3.1601.00
73_L77_F3.1501.00
10_V14_V2.9381.00
14_V25_E2.8871.00
69_F73_L2.5661.00
35_H95_Y2.3171.00
21_A25_E2.3111.00
9_S12_E2.2091.00
71_M78_M2.2001.00
20_S23_Q2.1431.00
112_T118_Y2.1181.00
29_A32_L1.8701.00
75_A79_M1.8591.00
14_V21_A1.7961.00
43_A46_A1.7521.00
11_D15_A1.7201.00
71_M82_M1.6730.99
33_A36_A1.6580.99
30_E34_E1.6520.99
139_P142_T1.6270.99
75_A78_M1.6060.99
144_T147_R1.5850.99
73_L82_M1.5360.99
44_S47_D1.5320.99
42_Y52_F1.5070.99
22_E25_E1.4940.99
46_A50_A1.4730.98
6_V94_L1.4570.98
72_P77_F1.4160.98
49_E55_G1.3980.98
49_E53_G1.3970.98
7_Y19_F1.3840.98
104_Y107_G1.3690.98
34_E38_T1.2930.97
126_R130_V1.2860.96
60_A63_T1.2720.96
7_Y17_G1.2640.96
47_D51_E1.2620.96
70_F73_L1.2600.96
147_R154_A1.2550.96
47_D50_A1.2530.96
49_E70_F1.2520.96
35_H39_A1.2030.95
70_F76_G1.1940.95
152_S156_A1.1890.94
41_R53_G1.1860.94
77_F83_L1.1830.94
95_Y98_R1.1770.94
143_S148_G1.1630.94
42_Y148_G1.1490.93
80_G154_A1.1460.93
43_A47_D1.1410.93
9_S113_A1.1100.92
53_G72_P1.1050.92
138_P141_R1.0780.91
42_Y152_S1.0670.90
119_G123_G1.0470.90
123_G126_R1.0460.90
77_F142_T1.0360.89
153_S157_R1.0020.87
36_A42_Y0.9950.87
152_S155_S0.9930.87
23_Q132_K0.9850.87
99_D102_S0.9760.86
111_V118_Y0.9570.85
7_Y81_R0.9450.84
45_R49_E0.9390.84
3_D32_L0.9320.83
141_R148_G0.9170.82
13_C24_C0.9160.82
69_F75_A0.9150.82
12_E16_A0.9110.82
124_G127_T0.9060.82
120_S123_G0.9030.81
119_G124_G0.9000.81
115_G121_A0.8980.81
53_G71_M0.8960.81
76_G83_L0.8940.81
67_G78_M0.8940.81
107_G110_Y0.8730.79
53_G56_Q0.8660.79
11_D14_V0.8660.79
73_L83_L0.8600.78
81_R86_G0.8570.78
5_A16_A0.8480.77
115_G118_Y0.8410.77
142_T157_R0.8390.76
52_F154_A0.8380.76
80_G84_S0.8350.76
113_A119_G0.8300.76
74_M91_S0.8160.74
120_S125_G0.8140.74
4_A10_V0.8130.74
47_D52_F0.8110.74
75_A91_S0.8040.73
80_G83_L0.8010.73
88_G152_S0.8000.73
17_G21_A0.7970.73
26_A29_A0.7940.72
7_Y92_Q0.7930.72
102_S105_P0.7920.72
22_E26_A0.7860.72
53_G78_M0.7810.71
140_T144_T0.7770.71
74_M82_M0.7680.70
23_Q42_Y0.7670.70
38_T94_L0.7590.69
42_Y53_G0.7590.69
147_R150_F0.7540.68
44_S50_A0.7520.68
40_P76_G0.7480.68
53_G70_F0.7450.67
127_T133_S0.7440.67
68_S73_L0.7290.66
36_A58_Q0.7220.65
145_V152_S0.7200.65
63_T66_G0.7160.64
42_Y134_A0.7160.64
137_P153_S0.7150.64
7_Y12_E0.7150.64
141_R145_V0.7080.64
66_G70_F0.7080.64
119_G126_R0.7070.63
38_T51_E0.7050.63
122_S125_G0.7050.63
11_D25_E0.7050.63
139_P144_T0.6970.62
21_A56_Q0.6950.62
67_G77_F0.6920.62
22_E125_G0.6910.62
85_G88_G0.6880.61
104_Y110_Y0.6870.61
116_R134_A0.6800.60
129_R132_K0.6770.60
73_L81_R0.6760.60
74_M79_M0.6750.60
40_P52_F0.6720.59
35_H77_F0.6720.59
52_F145_V0.6720.59
41_R47_D0.6710.59
19_F23_Q0.6700.59
131_P134_A0.6630.58
97_S101_G0.6590.58
46_A49_E0.6560.58
48_C57_C0.6550.58
19_F49_E0.6530.57
126_R129_R0.6510.57
23_Q79_M0.6500.57
68_S75_A0.6450.56
41_R45_R0.6450.56
102_S107_G0.6440.56
55_G58_Q0.6410.56
127_T130_V0.6310.55
93_P112_T0.6270.54
78_M93_P0.6270.54
77_F143_S0.6260.54
122_S127_T0.6260.54
69_F79_M0.6250.54
55_G111_V0.6230.54
104_Y111_V0.6210.54
107_G152_S0.6190.53
91_S120_S0.6180.53
61_Q86_G0.6180.53
86_G131_P0.6170.53
101_G105_P0.6150.53
14_V27_A0.6150.53
71_M83_L0.6090.52
24_C48_C0.6050.52
100_G103_T0.6030.51
110_Y118_Y0.6020.51
142_T153_S0.5960.51
103_T106_G0.5950.51
96_R99_D0.5940.50
60_A66_G0.5920.50
119_G127_T0.5860.49
35_H52_F0.5850.49
87_G101_G0.5830.49
107_G117_S0.5780.49
99_D103_T0.5710.48
62_Q65_G0.5700.48
43_A82_M0.5700.48
4_A9_S0.5650.47
116_R124_G0.5620.47
139_P148_G0.5620.47
140_T148_G0.5590.46
92_Q97_S0.5580.46
8_T145_V0.5530.46
90_A137_P0.5520.45
16_A91_S0.5510.45
6_V16_A0.5490.45
64_S67_G0.5460.45
61_Q66_G0.5450.45
139_P143_S0.5450.45
46_A128_V0.5440.45
19_F35_H0.5440.45
45_R85_G0.5430.44
100_G104_Y0.5360.44
70_F141_R0.5320.43
60_A77_F0.5320.43
59_Q63_T0.5300.43
122_S126_R0.5300.43
32_L37_R0.5280.43
36_A137_P0.5280.43
82_M85_G0.5270.43
98_R101_G0.5260.42
123_G131_P0.5260.42
31_A94_L0.5230.42
6_V78_M0.5230.42
100_G105_P0.5180.41
111_V115_G0.5180.41
112_T116_R0.5160.41
83_L158_S0.5140.41
74_M81_R0.5120.41
19_F153_S0.5120.41
118_Y133_S0.5110.41
14_V17_G0.5110.41
121_A124_G0.5110.41
74_M78_M0.5100.41
115_G137_P0.5080.40
13_C48_C0.5070.40
112_T117_S0.5070.40
11_D22_E0.5050.40
78_M142_T0.5050.40
81_R95_Y0.5020.40
156_A159_S0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mi9A 1 0.1863 3.4 0.951 Contact Map
2kziA 1 0.2547 2.8 0.953 Contact Map
4lu2A 2 0.2857 2.7 0.953 Contact Map
1elwA 1 0.4969 2.6 0.954 Contact Map
3q8iA 2 0.2795 2.4 0.955 Contact Map
1na3A 1 0.5031 2.3 0.955 Contact Map
3r72A 1 0.2733 2.1 0.956 Contact Map
1oohA 1 0.2795 2 0.957 Contact Map
2lniA 1 0.5155 1.8 0.958 Contact Map
1r7lA 2 0.2236 1.7 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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