GREMLIN Database
DUF1189 - Protein of unknown function (DUF1189)
PFAM: PF06691 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 244 (239)
Sequences: 1965 (1817)
Seq/√Len: 117.5
META: 0.74

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_Y209_T8.2831.00
72_K114_K6.1591.00
199_Q202_R4.0621.00
25_S206_Y3.6821.00
6_K10_S3.5341.00
112_L130_Y3.3441.00
80_P83_I3.2341.00
25_S202_R2.9541.00
181_A200_L2.9381.00
139_D142_D2.9001.00
29_L205_I2.6531.00
22_F26_I2.5611.00
73_L130_Y2.4301.00
72_K115_D2.3681.00
32_L209_T2.2771.00
184_G200_L2.2411.00
173_K212_I2.2381.00
13_F17_V2.2261.00
202_R206_Y2.2211.00
116_K127_T2.1511.00
201_F205_I2.1191.00
33_S37_S2.1161.00
66_F73_L2.0591.00
14_Y17_V2.0151.00
196_S199_Q1.9651.00
22_F202_R1.9621.00
3_Q20_Q1.9471.00
181_A197_Y1.7961.00
140_K144_L1.7871.00
112_L117_L1.7671.00
29_L177_A1.7421.00
177_A208_L1.7371.00
116_K129_P1.7191.00
189_K194_K1.6901.00
181_A201_F1.6901.00
96_G111_L1.6871.00
10_S13_F1.6691.00
20_Q24_K1.6471.00
4_L8_I1.6391.00
24_K27_L1.6101.00
75_T94_T1.6011.00
197_Y201_F1.6011.00
232_Y236_A1.5931.00
79_E95_T1.5831.00
65_D140_K1.5671.00
9_Y13_F1.5421.00
126_Q130_Y1.5231.00
18_R199_Q1.4971.00
142_D145_S1.4831.00
173_K176_Y1.4641.00
13_F16_D1.4571.00
58_A61_E1.4441.00
200_L204_A1.4401.00
155_K159_P1.4291.00
129_P132_D1.4281.00
51_F55_I1.4261.00
14_Y18_R1.4231.00
204_A208_L1.4171.00
75_T79_E1.4131.00
3_Q206_Y1.4001.00
6_K9_Y1.3971.00
65_D139_D1.3891.00
118_V127_T1.3831.00
66_F75_T1.3661.00
34_L162_F1.3611.00
8_I13_F1.3491.00
20_Q25_S1.3471.00
62_Q78_P1.3431.00
198_K202_R1.3291.00
178_L197_Y1.3281.00
66_F74_S1.3191.00
177_A201_F1.2650.99
233_F237_L1.2590.99
93_D96_G1.2570.99
28_Y32_L1.2530.99
42_I46_I1.2450.99
102_D105_D1.2330.99
133_L136_F1.2290.99
195_L199_Q1.2240.99
83_I90_I1.2210.99
212_I215_F1.2070.99
206_Y209_T1.1950.99
39_P43_S1.1950.99
75_T92_I1.1820.99
25_S205_I1.1690.99
27_L30_L1.1650.99
6_K13_F1.1530.99
113_T118_V1.1390.99
218_L225_I1.1330.99
111_L118_V1.1310.99
236_A239_Y1.1300.99
203_L207_A1.1260.99
24_K206_Y1.1150.99
142_D146_F1.1130.99
225_I228_F1.1050.99
202_R205_I1.0970.98
188_A200_L1.0960.98
124_E128_Y1.0940.98
185_L200_L1.0710.98
7_S28_Y1.0600.98
67_T137_T1.0480.98
215_F219_G1.0450.98
75_T78_P1.0410.98
73_L94_T1.0380.98
177_A204_A1.0370.98
181_A204_A1.0290.98
91_V96_G1.0290.98
52_I55_I1.0280.98
10_S14_Y1.0240.98
84_E87_G1.0220.98
66_F140_K1.0170.97
69_K72_K1.0170.97
22_F25_S1.0110.97
208_L236_A1.0070.97
230_L239_Y0.9940.97
32_L212_I0.9840.97
16_D20_Q0.9740.97
168_F171_I0.9730.97
21_K206_Y0.9690.97
33_S170_F0.9620.96
91_V98_I0.9600.96
66_F112_L0.9500.96
116_K130_Y0.9440.96
77_E181_A0.9430.96
170_F174_L0.9420.96
39_P46_I0.9400.96
3_Q8_I0.9350.96
35_L50_S0.9340.96
48_L183_I0.9340.96
113_T116_K0.9260.96
17_V21_K0.9220.95
85_E89_I0.9190.95
73_L137_T0.9120.95
95_T98_I0.9120.95
216_T220_L0.8980.95
117_L130_Y0.8960.95
8_I210_L0.8940.95
166_F170_F0.8870.94
143_L146_F0.8810.94
184_G207_A0.8780.94
32_L38_L0.8760.94
3_Q25_S0.8750.94
197_Y208_L0.8670.94
67_T74_S0.8670.94
68_I138_L0.8650.94
3_Q16_D0.8470.93
99_T102_D0.8440.93
152_P160_L0.8380.93
25_S28_Y0.8320.92
217_I220_L0.8280.92
13_F206_Y0.8240.92
187_F208_L0.8220.92
113_T130_Y0.8140.91
152_P155_K0.8100.91
14_Y39_P0.8100.91
33_S39_P0.8080.91
182_L186_L0.8060.91
227_F231_I0.8030.91
21_K26_I0.8010.91
43_S48_L0.8000.91
232_Y239_Y0.7950.90
15_R19_K0.7880.90
234_I238_I0.7850.90
65_D76_D0.7800.90
7_S15_R0.7700.89
54_E57_E0.7690.89
96_G102_D0.7670.89
73_L77_E0.7650.89
6_K16_D0.7640.89
67_T92_I0.7610.88
37_S166_F0.7580.88
14_Y210_L0.7560.88
142_D147_L0.7560.88
5_K164_F0.7550.88
185_L189_K0.7520.88
226_P229_F0.7500.88
93_D99_T0.7500.88
59_I143_L0.7500.88
169_S173_K0.7450.87
36_L216_T0.7440.87
48_L55_I0.7440.87
70_N225_I0.7440.87
178_L181_A0.7400.87
103_L108_N0.7380.87
150_I153_F0.7360.87
4_L218_L0.7350.87
21_K202_R0.7330.87
224_S229_F0.7330.87
3_Q17_V0.7310.86
184_G204_A0.7310.86
68_I71_G0.7300.86
21_K25_S0.7270.86
15_R196_S0.7260.86
115_D118_V0.7230.86
208_L212_I0.7210.86
8_I206_Y0.7170.85
79_E94_T0.7160.85
23_G27_L0.7160.85
33_S177_A0.7120.85
225_I232_Y0.7110.85
228_F231_I0.7110.85
209_T213_L0.7080.85
41_T44_L0.7070.85
36_L215_F0.7040.84
80_P96_G0.6990.84
99_T111_L0.6990.84
181_A236_A0.6980.84
67_T75_T0.6940.83
71_G195_L0.6930.83
180_L236_A0.6910.83
68_I134_P0.6890.83
61_E125_T0.6890.83
143_L162_F0.6880.83
98_I165_L0.6870.83
223_F228_F0.6870.83
19_K227_F0.6830.82
130_Y180_L0.6800.82
103_L208_L0.6800.82
35_L207_A0.6800.82
92_I112_L0.6800.82
101_E105_D0.6800.82
24_K202_R0.6780.82
109_G113_T0.6770.82
170_F197_Y0.6750.82
6_K17_V0.6730.82
182_L185_L0.6690.81
40_L182_L0.6630.81
97_T141_E0.6630.81
183_I187_F0.6630.81
181_A211_P0.6620.80
211_P220_L0.6600.80
31_L39_P0.6580.80
237_L241_F0.6560.80
198_K201_F0.6560.80
204_A236_A0.6550.80
4_L7_S0.6530.80
3_Q21_K0.6530.80
223_F227_F0.6490.79
186_L237_L0.6490.79
92_I175_I0.6480.79
13_F25_S0.6460.79
43_S47_S0.6450.79
82_I118_V0.6440.79
178_L201_F0.6430.79
72_K75_T0.6430.79
229_F236_A0.6430.79
3_Q24_K0.6420.78
154_L162_F0.6390.78
96_G99_T0.6380.78
121_N235_I0.6360.78
220_L231_I0.6360.78
37_S169_S0.6330.77
57_E141_E0.6320.77
11_P17_V0.6320.77
177_A205_I0.6300.77
3_Q6_K0.6280.77
68_I73_L0.6270.77
125_T128_Y0.6260.77
124_E139_D0.6260.77
73_L112_L0.6220.76
5_K9_Y0.6210.76
177_A184_G0.6190.76
29_L181_A0.6170.76
53_D57_E0.6150.75
3_Q13_F0.6150.75
34_L37_S0.6120.75
160_L231_I0.6120.75
27_L38_L0.6080.75
28_Y206_Y0.6050.74
176_Y208_L0.6020.74
203_L206_Y0.6010.74
226_P230_L0.5950.73
30_L166_F0.5950.73
204_A240_L0.5950.73
73_L133_L0.5930.73
176_Y180_L0.5910.73
217_I229_F0.5910.73
80_P95_T0.5910.73
47_S217_I0.5880.72
66_F130_Y0.5880.72
69_K117_L0.5880.72
207_A239_Y0.5840.72
154_L172_S0.5830.72
110_I138_L0.5780.71
90_I107_K0.5750.70
9_Y18_R0.5750.70
4_L46_I0.5750.70
48_L146_F0.5740.70
119_I127_T0.5720.70
18_R34_L0.5720.70
33_S216_T0.5710.70
73_L117_L0.5630.69
215_F218_L0.5630.69
68_I230_L0.5600.68
23_G202_R0.5590.68
96_G113_T0.5570.68
214_L235_I0.5560.68
36_L62_Q0.5560.68
119_I128_Y0.5530.68
185_L220_L0.5530.68
15_R18_R0.5530.68
156_I161_I0.5520.67
148_N151_K0.5520.67
206_Y210_L0.5520.67
121_N124_E0.5480.67
29_L173_K0.5480.67
26_I195_L0.5470.67
91_V106_Y0.5440.66
40_L153_F0.5440.66
60_E144_L0.5430.66
158_L163_L0.5420.66
37_S162_F0.5410.66
228_F232_Y0.5390.66
34_L125_T0.5390.66
51_F54_E0.5390.66
68_I102_D0.5360.65
121_N183_I0.5360.65
50_S165_L0.5350.65
20_Q197_Y0.5310.64
51_F90_I0.5290.64
20_Q184_G0.5290.64
99_T192_K0.5290.64
12_K18_R0.5280.64
18_R21_K0.5280.64
97_T103_L0.5270.64
139_D204_A0.5260.64
214_L220_L0.5220.63
219_G222_G0.5220.63
83_I178_L0.5210.63
229_F239_Y0.5210.63
130_Y135_D0.5200.63
162_F166_F0.5200.63
36_L70_N0.5190.63
175_I241_F0.5180.63
113_T212_I0.5170.62
237_L240_L0.5160.62
22_F206_Y0.5140.62
57_E61_E0.5130.62
29_L170_F0.5130.62
88_F128_Y0.5120.62
233_F240_L0.5110.61
76_D79_E0.5110.61
157_I163_L0.5090.61
85_E88_F0.5060.61
47_S116_K0.5050.61
38_L216_T0.5050.61
18_R22_F0.5040.60
172_S190_I0.5030.60
158_L162_F0.5030.60
87_G107_K0.5020.60
66_F94_T0.5020.60
82_I85_E0.5020.60
7_S10_S0.5020.60
26_I227_F0.5010.60
172_S212_I0.5010.60
128_Y177_A0.5010.60
114_K126_Q0.5010.60
63_L68_I0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gycB 2 0.1844 2.9 0.949 Contact Map
3wdoA 1 0.4508 2.3 0.951 Contact Map
2m8rA 1 0.168 2.2 0.952 Contact Map
2kogA 1 0.1639 2.1 0.953 Contact Map
4wmuA 1 0.3074 1.9 0.954 Contact Map
3qbrA 1 0.2992 1.9 0.954 Contact Map
3tx3A 2 0.2746 1.8 0.954 Contact Map
4gx0A 3 0.3238 1.6 0.955 Contact Map
3pk1A 1 0.3361 1.5 0.956 Contact Map
4hw4A 2 0.3238 1.5 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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