GREMLIN Database
SpoIIIAC - Stage III sporulation protein AC/AD protein family
PFAM: PF06686 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (56)
Sequences: 7095 (4600)
Seq/√Len: 614.7
META: 0.833

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_A34_G6.1771.00
19_K24_E4.1331.00
4_I38_I2.0681.00
22_G25_E1.9731.00
16_Q28_L1.6961.00
48_A51_E1.6631.00
45_I48_A1.6101.00
47_S51_E1.5641.00
14_L30_I1.5121.00
15_A31_E1.5081.00
8_G38_I1.4791.00
5_A9_I1.3671.00
44_P47_S1.3571.00
26_I29_L1.2961.00
11_A30_I1.2661.00
12_A16_Q1.2601.00
7_I34_G1.2351.00
33_A37_I1.2251.00
44_P48_A1.2231.00
18_L30_I1.2111.00
48_A52_T1.2101.00
42_A45_I1.1721.00
9_I13_F1.1651.00
7_I41_L1.1641.00
20_D25_E1.1581.00
15_A19_K1.1361.00
51_E54_K1.1051.00
36_I40_L1.0841.00
15_A27_A1.0791.00
16_Q24_E1.0741.00
18_L23_P1.0721.00
51_E55_S1.0291.00
5_A8_G1.0131.00
35_K38_I1.0051.00
37_I41_L0.9541.00
43_L47_S0.9291.00
52_T55_S0.9111.00
26_I30_I0.9081.00
24_E28_L0.8601.00
2_L6_G0.7981.00
29_L33_A0.7651.00
16_Q19_K0.7311.00
41_L44_P0.7201.00
19_K31_E0.7061.00
13_F32_L0.6881.00
28_L32_L0.6771.00
44_P52_T0.6751.00
27_A30_I0.6721.00
41_L45_I0.6661.00
12_A28_L0.6661.00
45_I52_T0.6521.00
33_A36_I0.6451.00
28_L31_E0.6321.00
46_I50_F0.6211.00
2_L50_F0.6191.00
12_A15_A0.6171.00
17_I21_A0.6091.00
15_A30_I0.6091.00
26_I52_T0.5991.00
37_I40_L0.5931.00
35_K49_L0.5921.00
11_A15_A0.5921.00
3_K41_L0.5871.00
47_S54_K0.5871.00
8_G31_E0.5861.00
32_L36_I0.5771.00
34_G38_I0.5751.00
50_F54_K0.5731.00
5_A14_L0.5711.00
45_I55_S0.5671.00
6_G9_I0.5561.00
4_I41_L0.5531.00
35_K39_L0.5490.99
12_A35_K0.5480.99
4_I49_L0.5350.99
20_D31_E0.5270.99
1_I21_A0.5250.99
16_Q23_P0.5210.99
2_L44_P0.5170.99
39_L46_I0.5160.99
26_I38_I0.5150.99
13_F29_L0.5150.99
12_A38_I0.5040.99
3_K33_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uisB 1 0.6071 3.8 0.802 Contact Map
4dx5A 3 0.9821 2.7 0.815 Contact Map
3w9iA 3 0.9821 2.5 0.819 Contact Map
3ne5A 3 0.9821 2.4 0.821 Contact Map
4mt1A 3 0.9821 2.3 0.822 Contact Map
5a63B 1 0.4643 2.2 0.824 Contact Map
4k0jA 3 0.9107 1.7 0.835 Contact Map
2ww8A 1 0 1.7 0.836 Contact Map
3aqpA 1 0.9643 1.6 0.837 Contact Map
4bwzA 2 0.9643 1.6 0.838 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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