GREMLIN Database
DUF1177 - Protein of unknown function (DUF1177)
PFAM: PF06675 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 271 (270)
Sequences: 656 (423)
Seq/√Len: 25.7
META: 0.703

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
176_T267_L3.8151.00
158_L169_P3.6221.00
142_S172_F3.5401.00
22_K120_D3.4891.00
152_R155_E3.2661.00
167_R211_E3.2321.00
157_L204_V3.0921.00
49_L57_I3.0881.00
139_F161_M3.0731.00
53_A57_I3.0001.00
134_I172_F2.9861.00
36_R114_E2.9841.00
186_L257_L2.9491.00
93_R102_G2.9431.00
49_L53_A2.8831.00
33_I62_A2.8611.00
149_Y176_T2.8581.00
163_R215_P2.6330.99
129_K208_I2.5800.99
58_A227_I2.4620.99
125_I234_C2.4410.99
147_E268_Q2.2870.98
145_V193_L2.2100.97
132_R155_E2.1840.97
163_R240_A2.1820.97
254_F264_M2.1280.97
1_T8_S2.1250.97
19_T77_P2.1010.96
224_E228_E2.0870.96
133_I173_P1.9540.95
222_S227_I1.9470.95
57_I227_I1.9370.94
62_A235_I1.9080.94
123_L206_V1.8680.93
200_D265_K1.8600.93
19_T75_R1.8550.93
70_Q75_R1.8400.93
15_V23_S1.8320.93
152_R175_T1.8280.92
106_D109_T1.8150.92
111_N198_A1.7860.92
13_K116_D1.7780.91
223_H226_D1.7580.91
60_L231_A1.7550.91
132_R162_E1.7290.90
162_E169_P1.7150.90
81_I119_M1.7120.90
176_T264_M1.7040.89
256_R260_L1.6830.89
129_K210_A1.6680.88
228_E232_R1.6330.87
64_L67_A1.6310.87
136_H170_V1.6210.87
134_I142_S1.6180.87
68_D72_K1.6080.87
152_R187_Y1.6020.86
6_K102_G1.5850.86
20_N77_P1.5830.86
40_I86_I1.5620.85
164_V229_E1.5450.84
240_A246_C1.5280.84
40_I53_A1.5220.83
210_A223_H1.4980.82
256_R259_K1.4920.82
137_R226_D1.4900.82
152_R253_E1.4730.81
147_E200_D1.4710.81
87_C90_A1.4320.79
58_A125_I1.4200.79
132_R159_D1.4160.78
139_F229_E1.4130.78
155_E175_T1.4120.78
129_K223_H1.4120.78
127_T222_S1.4110.78
57_I222_S1.4090.78
137_R229_E1.4080.78
147_E265_K1.4050.78
139_F165_T1.4010.78
77_P243_R1.3820.77
247_S251_E1.3280.74
16_I82_I1.3260.74
36_R111_N1.3250.74
34_I122_I1.3170.73
15_V118_E1.3080.73
172_F189_L1.2870.71
137_R223_H1.2330.68
21_G26_G1.2260.68
143_P175_T1.2160.67
53_A222_S1.2110.67
224_E227_I1.2080.66
4_G7_G1.1890.65
87_C104_P1.1760.64
34_I119_M1.1680.64
254_F258_V1.1610.63
231_A235_I1.1600.63
40_I49_L1.1510.63
127_T227_I1.1450.62
81_I116_D1.1430.62
146_K249_Y1.1410.62
152_R186_L1.1380.62
152_R174_I1.1330.61
264_M267_L1.1310.61
176_T266_H1.1280.61
139_F206_V1.1240.61
217_C246_C1.1240.61
122_I145_V1.1230.61
155_E187_Y1.1130.60
170_V173_P1.1090.60
20_N27_D1.1040.59
21_G25_G1.0980.59
59_A125_I1.0980.59
34_I110_M1.0930.59
58_A231_A1.0930.59
46_R160_I1.0850.58
60_L86_I1.0740.57
144_T154_S1.0740.57
139_F230_A1.0720.57
115_V201_A1.0620.56
49_L227_I1.0530.56
45_E92_T1.0520.56
90_A103_S1.0500.55
258_V263_S1.0450.55
153_V174_I1.0400.55
46_R240_A1.0360.54
57_I224_E1.0200.53
62_A234_C1.0200.53
34_I116_D1.0140.53
99_P159_D1.0130.53
260_L264_M1.0130.53
11_F110_M1.0100.52
162_E212_T1.0020.52
110_M119_M1.0020.52
161_M165_T1.0010.52
159_D162_E0.9980.52
94_P215_P0.9910.51
251_E255_A0.9740.50
93_R96_E0.9720.50
215_P240_A0.9560.49
163_R218_A0.9440.48
149_Y172_F0.9400.47
2_V110_M0.9390.47
150_I174_I0.9390.47
88_P128_T0.9370.47
46_R219_T0.9320.47
161_M172_F0.9300.47
111_N114_E0.9240.46
34_I67_A0.9190.46
145_V150_I0.9180.46
142_S156_D0.9180.46
155_E158_L0.9180.46
36_R198_A0.9160.46
142_S193_L0.9130.45
106_D114_E0.9070.45
29_P247_S0.9060.45
96_E99_P0.9050.45
160_I240_A0.9040.45
215_P218_A0.8960.44
175_T186_L0.8940.44
95_H100_F0.8910.44
160_I246_C0.8900.44
164_V223_H0.8860.43
123_L139_F0.8860.43
165_T169_P0.8720.42
33_I234_C0.8690.42
127_T130_G0.8670.42
156_D204_V0.8640.42
21_G79_D0.8610.42
59_A82_I0.8580.41
46_R99_P0.8520.41
208_I222_S0.8520.41
154_S157_L0.8470.41
175_T187_Y0.8470.41
185_G256_R0.8380.40
184_N261_Y0.8330.40
32_G119_M0.8310.39
171_V228_E0.8220.39
96_E152_R0.8200.39
240_A245_K0.8160.38
170_V231_A0.8140.38
144_T153_V0.8110.38
22_K118_E0.8110.38
94_P97_P0.8100.38
46_R224_E0.8080.38
47_I77_P0.8080.38
236_E239_K0.8080.38
36_R106_D0.8080.38
182_Y194_Q0.8070.38
26_G30_T0.8050.38
57_I215_P0.8020.37
142_S161_M0.8010.37
265_K268_Q0.8000.37
127_T208_I0.7960.37
174_I193_L0.7950.37
254_F260_L0.7920.37
5_E61_A0.7890.37
142_S192_I0.7870.36
128_T189_L0.7860.36
96_E187_Y0.7850.36
141_I171_V0.7770.36
11_F105_V0.7750.36
172_F193_L0.7690.35
222_S228_E0.7640.35
149_Y186_L0.7610.35
1_T10_D0.7560.34
46_R218_A0.7540.34
244_G255_A0.7540.34
132_R152_R0.7500.34
31_L119_M0.7500.34
46_R93_R0.7480.34
177_Q257_L0.7470.34
142_S189_L0.7470.34
144_T157_L0.7440.34
255_A259_K0.7410.33
103_S128_T0.7350.33
49_L224_E0.7330.33
145_V174_I0.7330.33
144_T156_D0.7260.32
108_A197_T0.7230.32
134_I161_M0.7210.32
15_V81_I0.7200.32
14_I67_A0.7190.32
252_E256_R0.7180.32
153_V175_T0.7160.32
110_M113_H0.7070.31
133_I247_S0.7070.31
130_G192_I0.7050.31
62_A231_A0.7010.31
224_E231_A0.7000.31
109_T113_H0.6980.31
87_C92_T0.6960.30
81_I118_E0.6960.30
53_A227_I0.6950.30
36_R191_S0.6950.30
164_V171_V0.6940.30
156_D247_S0.6930.30
13_K83_T0.6910.30
11_F109_T0.6890.30
135_N196_A0.6870.30
21_G30_T0.6840.30
145_V196_A0.6840.30
94_P267_L0.6820.30
99_P218_A0.6810.30
139_F234_C0.6800.29
2_V11_F0.6800.29
33_I217_C0.6770.29
155_E189_L0.6740.29
253_E257_L0.6740.29
28_A79_D0.6720.29
196_A203_V0.6710.29
60_L235_I0.6710.29
144_T204_V0.6650.29
64_L200_D0.6580.28
98_V227_I0.6570.28
67_A72_K0.6560.28
136_H167_R0.6550.28
117_P200_D0.6540.28
134_I170_V0.6520.28
252_E255_A0.6490.28
101_M194_Q0.6470.28
11_F142_S0.6460.27
6_K150_I0.6450.27
37_L220_G0.6450.27
71_R235_I0.6440.27
142_S149_Y0.6420.27
58_A127_T0.6400.27
160_I255_A0.6390.27
176_T186_L0.6380.27
28_A242_G0.6370.27
21_G28_A0.6350.27
40_I89_D0.6350.27
258_V265_K0.6350.27
156_D159_D0.6340.27
153_V187_Y0.6320.27
116_D119_M0.6310.27
60_L187_Y0.6290.26
49_L215_P0.6280.26
92_T103_S0.6280.26
154_S204_V0.6270.26
245_K249_Y0.6250.26
160_I163_R0.6230.26
161_M217_C0.6230.26
31_L248_F0.6220.26
156_D211_E0.6220.26
186_L246_C0.6210.26
174_I177_Q0.6200.26
13_K19_T0.6180.26
214_V226_D0.6180.26
130_G182_Y0.6150.26
45_E93_R0.6150.26
107_M257_L0.6150.26
72_K210_A0.6140.26
105_V111_N0.6130.26
39_G87_C0.6120.26
87_C147_E0.6120.26
80_V251_E0.6090.25
114_E191_S0.6080.25
128_T239_K0.6080.25
174_I186_L0.6060.25
184_N194_Q0.6050.25
133_I139_F0.6040.25
137_R167_R0.6030.25
124_S140_A0.6010.25
168_L213_A0.6000.25
159_D235_I0.5990.25
206_V233_F0.5980.25
81_I122_I0.5930.24
67_A70_Q0.5930.24
263_S267_L0.5870.24
71_R255_A0.5860.24
141_I157_L0.5820.24
58_A139_F0.5800.24
120_D210_A0.5770.24
46_R215_P0.5770.24
174_I253_E0.5740.23
110_M198_A0.5730.23
123_L204_V0.5720.23
43_R74_D0.5700.23
92_T219_T0.5700.23
11_F119_M0.5700.23
139_F152_R0.5690.23
100_F110_M0.5690.23
83_T196_A0.5680.23
162_E168_L0.5670.23
187_Y253_E0.5670.23
162_E224_E0.5650.23
12_V159_D0.5650.23
93_R107_M0.5640.23
193_L196_A0.5640.23
16_I129_K0.5620.23
12_V82_I0.5600.23
53_A193_L0.5570.23
254_F257_L0.5570.23
82_I201_A0.5560.23
20_N23_S0.5550.22
158_L168_L0.5550.22
191_S194_Q0.5550.22
196_A248_F0.5520.22
111_N130_G0.5490.22
235_I266_H0.5490.22
149_Y201_A0.5480.22
136_H152_R0.5460.22
180_T184_N0.5460.22
24_S255_A0.5450.22
49_L64_L0.5440.22
72_K119_M0.5440.22
5_E8_S0.5440.22
17_P132_R0.5430.22
36_R107_M0.5410.22
159_D163_R0.5400.22
58_A211_E0.5390.22
53_A67_A0.5380.22
111_N183_G0.5360.21
2_V147_E0.5350.21
130_G198_A0.5350.21
64_L180_T0.5350.21
67_A237_V0.5340.21
94_P102_G0.5340.21
134_I209_T0.5330.21
60_L122_I0.5320.21
164_V234_C0.5310.21
201_A259_K0.5300.21
64_L72_K0.5280.21
90_A93_R0.5270.21
41_G74_D0.5270.21
114_E198_A0.5270.21
6_K247_S0.5260.21
214_V221_A0.5250.21
228_E240_A0.5240.21
120_D241_F0.5220.21
42_A182_Y0.5220.21
40_I125_I0.5210.21
22_K249_Y0.5200.21
225_V230_A0.5200.21
56_A91_P0.5180.21
52_D55_G0.5170.21
94_P99_P0.5170.21
13_K119_M0.5160.21
249_Y257_L0.5150.20
41_G56_A0.5150.20
241_F247_S0.5140.20
146_K199_T0.5130.20
168_L211_E0.5120.20
106_D111_N0.5110.20
53_A215_P0.5110.20
34_I81_I0.5110.20
237_V246_C0.5110.20
96_E149_Y0.5110.20
65_K128_T0.5090.20
97_P100_F0.5090.20
111_N193_L0.5080.20
258_V270_L0.5080.20
86_I90_A0.5070.20
72_K189_L0.5070.20
133_I189_L0.5060.20
96_E141_I0.5060.20
49_L222_S0.5060.20
125_I245_K0.5050.20
11_F36_R0.5040.20
164_V212_T0.5040.20
136_H142_S0.5030.20
60_L176_T0.5030.20
134_I193_L0.5030.20
152_R257_L0.5010.20
153_V228_E0.5010.20
72_K265_K0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w6rA 1 0.4391 20.3 0.98 Contact Map
3by5A 2 0.2214 19 0.98 Contact Map
2cujA 1 0.262 18 0.98 Contact Map
2w6kA 1 0.2583 13.7 0.981 Contact Map
4hjfA 1 0.0554 11.6 0.982 Contact Map
2bv2A 1 0.1033 10.1 0.982 Contact Map
2wqpA 2 0.2694 9.9 0.982 Contact Map
4urgA 1 0.4908 7.7 0.983 Contact Map
2zciA 2 0.1808 6.2 0.984 Contact Map
3g8rA 2 0.2177 6.1 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.