DUF1177 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF1177 - Protein of unknown function (DUF1177)

PFAM:	PF06675	Sequences: TVEGEKGSTDFVKIVIPGTNGKSSGGDAPTLGIIGRLGGIGARPERIGLVSDADGAIAALAAALKLADMQRKGDRLPGDVIITTHICPDAPTRPHEPVPFMGSPVDMATMNRHEVDPEMDAILSIDTTKGNRIINHRGFAISPTVKEGYILRVSEDLLDIMERVTGRLPVVFPITTQDITPYGNGLYHLNSILQPATATDAPVVGVAITAETAVPGCATGASHEVDIEEAARFCIEVAKAFGRGKCSFYDEEEFARLVKLYGSMKHLQTLG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	271 (270)
Sequences:	656 (423)
Seq/√Len:	25.7
META:	0.703

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
176_T	267_L	3.815	1.00
158_L	169_P	3.622	1.00
142_S	172_F	3.540	1.00
22_K	120_D	3.489	1.00
152_R	155_E	3.266	1.00
167_R	211_E	3.232	1.00
157_L	204_V	3.092	1.00
49_L	57_I	3.088	1.00
139_F	161_M	3.073	1.00
53_A	57_I	3.000	1.00
134_I	172_F	2.986	1.00
36_R	114_E	2.984	1.00
186_L	257_L	2.949	1.00
93_R	102_G	2.943	1.00
49_L	53_A	2.883	1.00
33_I	62_A	2.861	1.00
149_Y	176_T	2.858	1.00
163_R	215_P	2.633	0.99
129_K	208_I	2.580	0.99
58_A	227_I	2.462	0.99
125_I	234_C	2.441	0.99
147_E	268_Q	2.287	0.98
145_V	193_L	2.210	0.97
132_R	155_E	2.184	0.97
163_R	240_A	2.182	0.97
254_F	264_M	2.128	0.97
1_T	8_S	2.125	0.97
19_T	77_P	2.101	0.96
224_E	228_E	2.087	0.96
133_I	173_P	1.954	0.95
222_S	227_I	1.947	0.95
57_I	227_I	1.937	0.94
62_A	235_I	1.908	0.94
123_L	206_V	1.868	0.93
200_D	265_K	1.860	0.93
19_T	75_R	1.855	0.93
70_Q	75_R	1.840	0.93
15_V	23_S	1.832	0.93
152_R	175_T	1.828	0.92
106_D	109_T	1.815	0.92
111_N	198_A	1.786	0.92
13_K	116_D	1.778	0.91
223_H	226_D	1.758	0.91
60_L	231_A	1.755	0.91
132_R	162_E	1.729	0.90
162_E	169_P	1.715	0.90
81_I	119_M	1.712	0.90
176_T	264_M	1.704	0.89
256_R	260_L	1.683	0.89
129_K	210_A	1.668	0.88
228_E	232_R	1.633	0.87
64_L	67_A	1.631	0.87
136_H	170_V	1.621	0.87
134_I	142_S	1.618	0.87
68_D	72_K	1.608	0.87
152_R	187_Y	1.602	0.86
6_K	102_G	1.585	0.86
20_N	77_P	1.583	0.86
40_I	86_I	1.562	0.85
164_V	229_E	1.545	0.84
240_A	246_C	1.528	0.84
40_I	53_A	1.522	0.83
210_A	223_H	1.498	0.82
256_R	259_K	1.492	0.82
137_R	226_D	1.490	0.82
152_R	253_E	1.473	0.81
147_E	200_D	1.471	0.81
87_C	90_A	1.432	0.79
58_A	125_I	1.420	0.79
132_R	159_D	1.416	0.78
139_F	229_E	1.413	0.78
155_E	175_T	1.412	0.78
129_K	223_H	1.412	0.78
127_T	222_S	1.411	0.78
57_I	222_S	1.409	0.78
137_R	229_E	1.408	0.78
147_E	265_K	1.405	0.78
139_F	165_T	1.401	0.78
77_P	243_R	1.382	0.77
247_S	251_E	1.328	0.74
16_I	82_I	1.326	0.74
36_R	111_N	1.325	0.74
34_I	122_I	1.317	0.73
15_V	118_E	1.308	0.73
172_F	189_L	1.287	0.71
137_R	223_H	1.233	0.68
21_G	26_G	1.226	0.68
143_P	175_T	1.216	0.67
53_A	222_S	1.211	0.67
224_E	227_I	1.208	0.66
4_G	7_G	1.189	0.65
87_C	104_P	1.176	0.64
34_I	119_M	1.168	0.64
254_F	258_V	1.161	0.63
231_A	235_I	1.160	0.63
40_I	49_L	1.151	0.63
127_T	227_I	1.145	0.62
81_I	116_D	1.143	0.62
146_K	249_Y	1.141	0.62
152_R	186_L	1.138	0.62
152_R	174_I	1.133	0.61
264_M	267_L	1.131	0.61
176_T	266_H	1.128	0.61
139_F	206_V	1.124	0.61
217_C	246_C	1.124	0.61
122_I	145_V	1.123	0.61
155_E	187_Y	1.113	0.60
170_V	173_P	1.109	0.60
20_N	27_D	1.104	0.59
21_G	25_G	1.098	0.59
59_A	125_I	1.098	0.59
34_I	110_M	1.093	0.59
58_A	231_A	1.093	0.59
46_R	160_I	1.085	0.58
60_L	86_I	1.074	0.57
144_T	154_S	1.074	0.57
139_F	230_A	1.072	0.57
115_V	201_A	1.062	0.56
49_L	227_I	1.053	0.56
45_E	92_T	1.052	0.56
90_A	103_S	1.050	0.55
258_V	263_S	1.045	0.55
153_V	174_I	1.040	0.55
46_R	240_A	1.036	0.54
57_I	224_E	1.020	0.53
62_A	234_C	1.020	0.53
34_I	116_D	1.014	0.53
99_P	159_D	1.013	0.53
260_L	264_M	1.013	0.53
11_F	110_M	1.010	0.52
162_E	212_T	1.002	0.52
110_M	119_M	1.002	0.52
161_M	165_T	1.001	0.52
159_D	162_E	0.998	0.52
94_P	215_P	0.991	0.51
251_E	255_A	0.974	0.50
93_R	96_E	0.972	0.50
215_P	240_A	0.956	0.49
163_R	218_A	0.944	0.48
149_Y	172_F	0.940	0.47
2_V	110_M	0.939	0.47
150_I	174_I	0.939	0.47
88_P	128_T	0.937	0.47
46_R	219_T	0.932	0.47
161_M	172_F	0.930	0.47
111_N	114_E	0.924	0.46
34_I	67_A	0.919	0.46
145_V	150_I	0.918	0.46
142_S	156_D	0.918	0.46
155_E	158_L	0.918	0.46
36_R	198_A	0.916	0.46
142_S	193_L	0.913	0.45
106_D	114_E	0.907	0.45
29_P	247_S	0.906	0.45
96_E	99_P	0.905	0.45
160_I	240_A	0.904	0.45
215_P	218_A	0.896	0.44
175_T	186_L	0.894	0.44
95_H	100_F	0.891	0.44
160_I	246_C	0.890	0.44
164_V	223_H	0.886	0.43
123_L	139_F	0.886	0.43
165_T	169_P	0.872	0.42
33_I	234_C	0.869	0.42
127_T	130_G	0.867	0.42
156_D	204_V	0.864	0.42
21_G	79_D	0.861	0.42
59_A	82_I	0.858	0.41
46_R	99_P	0.852	0.41
208_I	222_S	0.852	0.41
154_S	157_L	0.847	0.41
175_T	187_Y	0.847	0.41
185_G	256_R	0.838	0.40
184_N	261_Y	0.833	0.40
32_G	119_M	0.831	0.39
171_V	228_E	0.822	0.39
96_E	152_R	0.820	0.39
240_A	245_K	0.816	0.38
170_V	231_A	0.814	0.38
144_T	153_V	0.811	0.38
22_K	118_E	0.811	0.38
94_P	97_P	0.810	0.38
46_R	224_E	0.808	0.38
47_I	77_P	0.808	0.38
236_E	239_K	0.808	0.38
36_R	106_D	0.808	0.38
182_Y	194_Q	0.807	0.38
26_G	30_T	0.805	0.38
57_I	215_P	0.802	0.37
142_S	161_M	0.801	0.37
265_K	268_Q	0.800	0.37
127_T	208_I	0.796	0.37
174_I	193_L	0.795	0.37
254_F	260_L	0.792	0.37
5_E	61_A	0.789	0.37
142_S	192_I	0.787	0.36
128_T	189_L	0.786	0.36
96_E	187_Y	0.785	0.36
141_I	171_V	0.777	0.36
11_F	105_V	0.775	0.36
172_F	193_L	0.769	0.35
222_S	228_E	0.764	0.35
149_Y	186_L	0.761	0.35
1_T	10_D	0.756	0.34
46_R	218_A	0.754	0.34
244_G	255_A	0.754	0.34
132_R	152_R	0.750	0.34
31_L	119_M	0.750	0.34
46_R	93_R	0.748	0.34
177_Q	257_L	0.747	0.34
142_S	189_L	0.747	0.34
144_T	157_L	0.744	0.34
255_A	259_K	0.741	0.33
103_S	128_T	0.735	0.33
49_L	224_E	0.733	0.33
145_V	174_I	0.733	0.33
144_T	156_D	0.726	0.32
108_A	197_T	0.723	0.32
134_I	161_M	0.721	0.32
15_V	81_I	0.720	0.32
14_I	67_A	0.719	0.32
252_E	256_R	0.718	0.32
153_V	175_T	0.716	0.32
110_M	113_H	0.707	0.31
133_I	247_S	0.707	0.31
130_G	192_I	0.705	0.31
62_A	231_A	0.701	0.31
224_E	231_A	0.700	0.31
109_T	113_H	0.698	0.31
87_C	92_T	0.696	0.30
81_I	118_E	0.696	0.30
53_A	227_I	0.695	0.30
36_R	191_S	0.695	0.30
164_V	171_V	0.694	0.30
156_D	247_S	0.693	0.30
13_K	83_T	0.691	0.30
11_F	109_T	0.689	0.30
135_N	196_A	0.687	0.30
21_G	30_T	0.684	0.30
145_V	196_A	0.684	0.30
94_P	267_L	0.682	0.30
99_P	218_A	0.681	0.30
139_F	234_C	0.680	0.29
2_V	11_F	0.680	0.29
33_I	217_C	0.677	0.29
155_E	189_L	0.674	0.29
253_E	257_L	0.674	0.29
28_A	79_D	0.672	0.29
196_A	203_V	0.671	0.29
60_L	235_I	0.671	0.29
144_T	204_V	0.665	0.29
64_L	200_D	0.658	0.28
98_V	227_I	0.657	0.28
67_A	72_K	0.656	0.28
136_H	167_R	0.655	0.28
117_P	200_D	0.654	0.28
134_I	170_V	0.652	0.28
252_E	255_A	0.649	0.28
101_M	194_Q	0.647	0.28
11_F	142_S	0.646	0.27
6_K	150_I	0.645	0.27
37_L	220_G	0.645	0.27
71_R	235_I	0.644	0.27
142_S	149_Y	0.642	0.27
58_A	127_T	0.640	0.27
160_I	255_A	0.639	0.27
176_T	186_L	0.638	0.27
28_A	242_G	0.637	0.27
21_G	28_A	0.635	0.27
40_I	89_D	0.635	0.27
258_V	265_K	0.635	0.27
156_D	159_D	0.634	0.27
153_V	187_Y	0.632	0.27
116_D	119_M	0.631	0.27
60_L	187_Y	0.629	0.26
49_L	215_P	0.628	0.26
92_T	103_S	0.628	0.26
154_S	204_V	0.627	0.26
245_K	249_Y	0.625	0.26
160_I	163_R	0.623	0.26
161_M	217_C	0.623	0.26
31_L	248_F	0.622	0.26
156_D	211_E	0.622	0.26
186_L	246_C	0.621	0.26
174_I	177_Q	0.620	0.26
13_K	19_T	0.618	0.26
214_V	226_D	0.618	0.26
130_G	182_Y	0.615	0.26
45_E	93_R	0.615	0.26
107_M	257_L	0.615	0.26
72_K	210_A	0.614	0.26
105_V	111_N	0.613	0.26
39_G	87_C	0.612	0.26
87_C	147_E	0.612	0.26
80_V	251_E	0.609	0.25
114_E	191_S	0.608	0.25
128_T	239_K	0.608	0.25
174_I	186_L	0.606	0.25
184_N	194_Q	0.605	0.25
133_I	139_F	0.604	0.25
137_R	167_R	0.603	0.25
124_S	140_A	0.601	0.25
168_L	213_A	0.600	0.25
159_D	235_I	0.599	0.25
206_V	233_F	0.598	0.25
81_I	122_I	0.593	0.24
67_A	70_Q	0.593	0.24
263_S	267_L	0.587	0.24
71_R	255_A	0.586	0.24
141_I	157_L	0.582	0.24
58_A	139_F	0.580	0.24
120_D	210_A	0.577	0.24
46_R	215_P	0.577	0.24
174_I	253_E	0.574	0.23
110_M	198_A	0.573	0.23
123_L	204_V	0.572	0.23
43_R	74_D	0.570	0.23
92_T	219_T	0.570	0.23
11_F	119_M	0.570	0.23
139_F	152_R	0.569	0.23
100_F	110_M	0.569	0.23
83_T	196_A	0.568	0.23
162_E	168_L	0.567	0.23
187_Y	253_E	0.567	0.23
162_E	224_E	0.565	0.23
12_V	159_D	0.565	0.23
93_R	107_M	0.564	0.23
193_L	196_A	0.564	0.23
16_I	129_K	0.562	0.23
12_V	82_I	0.560	0.23
53_A	193_L	0.557	0.23
254_F	257_L	0.557	0.23
82_I	201_A	0.556	0.23
20_N	23_S	0.555	0.22
158_L	168_L	0.555	0.22
191_S	194_Q	0.555	0.22
196_A	248_F	0.552	0.22
111_N	130_G	0.549	0.22
235_I	266_H	0.549	0.22
149_Y	201_A	0.548	0.22
136_H	152_R	0.546	0.22
180_T	184_N	0.546	0.22
24_S	255_A	0.545	0.22
49_L	64_L	0.544	0.22
72_K	119_M	0.544	0.22
5_E	8_S	0.544	0.22
17_P	132_R	0.543	0.22
36_R	107_M	0.541	0.22
159_D	163_R	0.540	0.22
58_A	211_E	0.539	0.22
53_A	67_A	0.538	0.22
111_N	183_G	0.536	0.21
2_V	147_E	0.535	0.21
130_G	198_A	0.535	0.21
64_L	180_T	0.535	0.21
67_A	237_V	0.534	0.21
94_P	102_G	0.534	0.21
134_I	209_T	0.533	0.21
60_L	122_I	0.532	0.21
164_V	234_C	0.531	0.21
201_A	259_K	0.530	0.21
64_L	72_K	0.528	0.21
90_A	93_R	0.527	0.21
41_G	74_D	0.527	0.21
114_E	198_A	0.527	0.21
6_K	247_S	0.526	0.21
214_V	221_A	0.525	0.21
228_E	240_A	0.524	0.21
120_D	241_F	0.522	0.21
42_A	182_Y	0.522	0.21
40_I	125_I	0.521	0.21
22_K	249_Y	0.520	0.21
225_V	230_A	0.520	0.21
56_A	91_P	0.518	0.21
52_D	55_G	0.517	0.21
94_P	99_P	0.517	0.21
13_K	119_M	0.516	0.21
249_Y	257_L	0.515	0.20
41_G	56_A	0.515	0.20
241_F	247_S	0.514	0.20
146_K	199_T	0.513	0.20
168_L	211_E	0.512	0.20
106_D	111_N	0.511	0.20
53_A	215_P	0.511	0.20
34_I	81_I	0.511	0.20
237_V	246_C	0.511	0.20
96_E	149_Y	0.511	0.20
65_K	128_T	0.509	0.20
97_P	100_F	0.509	0.20
111_N	193_L	0.508	0.20
258_V	270_L	0.508	0.20
86_I	90_A	0.507	0.20
72_K	189_L	0.507	0.20
133_I	189_L	0.506	0.20
96_E	141_I	0.506	0.20
49_L	222_S	0.506	0.20
125_I	245_K	0.505	0.20
11_F	36_R	0.504	0.20
164_V	212_T	0.504	0.20
136_H	142_S	0.503	0.20
60_L	176_T	0.503	0.20
134_I	193_L	0.503	0.20
152_R	257_L	0.501	0.20
153_V	228_E	0.501	0.20
72_K	265_K	0.500	0.20

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2w6rA	1	0.4391	20.3	0.98	Contact Map
3by5A	2	0.2214	19	0.98	Contact Map
2cujA	1	0.262	18	0.98	Contact Map
2w6kA	1	0.2583	13.7	0.981	Contact Map
4hjfA	1	0.0554	11.6	0.982	Contact Map
2bv2A	1	0.1033	10.1	0.982	Contact Map
2wqpA	2	0.2694	9.9	0.982	Contact Map
4urgA	1	0.4908	7.7	0.983	Contact Map
2zciA	2	0.1808	6.2	0.984	Contact Map
3g8rA	2	0.2177	6.1	0.984	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0088 seconds.