GREMLIN Database
DUF1173 - Protein of unknown function (DUF1173)
PFAM: PF06666 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 385 (383)
Sequences: 660 (506)
Seq/√Len: 25.9
META: 0.611

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_Y42_I6.0011.00
322_R345_D5.3401.00
316_A320_E4.4241.00
353_L381_W4.0391.00
167_A181_L4.0071.00
160_R164_L3.7081.00
139_E330_Y3.6301.00
40_M67_S3.6091.00
143_L162_H3.5881.00
219_L237_L3.3961.00
139_E144_N3.2721.00
220_I277_I3.1851.00
146_W154_R3.1611.00
346_T351_V2.9221.00
255_L293_L2.7781.00
138_W275_V2.6840.99
341_A353_L2.6590.99
30_L39_E2.6460.99
185_E198_R2.6080.99
143_L159_V2.6040.99
191_D194_A2.5200.99
327_P339_A2.5170.99
317_L341_A2.3660.98
28_R54_M2.3600.98
150_M158_V2.3190.98
88_D91_D2.3170.98
317_L343_L2.3070.98
318_V324_F2.2620.98
150_M162_H2.2430.98
53_R69_E2.1950.97
43_A52_K2.1840.97
310_E326_K2.1180.97
301_N318_V2.0970.96
299_T318_V2.0690.96
147_T150_M2.0460.96
277_I294_A2.0260.96
276_A293_L2.0110.96
155_N344_T2.0070.95
315_D319_A1.9690.95
61_H65_C1.9640.95
133_L259_F1.9300.94
40_M43_A1.9250.94
235_L290_V1.9220.94
44_R49_Y1.9000.94
40_M52_K1.8800.94
324_F345_D1.8730.93
354_E357_P1.8620.93
245_L280_F1.8570.93
245_L290_V1.8540.93
110_A118_S1.8480.93
314_L341_A1.8310.93
70_P77_L1.8180.92
370_K374_Y1.7990.92
143_L150_M1.7950.92
189_E193_D1.7160.90
135_H330_Y1.7150.90
313_L353_L1.7110.90
41_Y53_R1.6770.89
310_E356_V1.6400.88
41_Y54_M1.6350.88
135_H328_L1.6220.87
160_R183_V1.6120.87
260_E263_L1.6010.86
128_L331_N1.5960.86
366_A374_Y1.5630.85
52_K67_S1.5630.85
142_G147_T1.5600.85
138_W296_M1.5570.85
235_L276_A1.5370.84
55_P58_G1.5340.84
10_E15_F1.4860.82
29_P40_M1.4790.82
303_I318_V1.4770.82
175_A179_D1.4740.81
20_A49_Y1.4690.81
28_R39_E1.4680.81
16_Q19_L1.4670.81
196_A242_D1.4390.80
182_Y240_L1.4220.79
364_Y367_A1.4130.78
372_I376_S1.4100.78
305_V314_L1.4070.78
206_L217_M1.3940.78
363_Y366_A1.3940.78
307_S310_E1.3890.77
55_P156_W1.3800.77
311_L315_D1.3640.76
33_C61_H1.3560.76
116_A142_G1.3560.76
58_G68_Y1.3540.75
95_T171_T1.3490.75
4_G8_F1.3480.75
156_W239_H1.3460.75
31_C61_H1.3400.75
249_E253_R1.3380.75
251_L293_L1.3350.74
131_R294_A1.3350.74
134_L138_W1.3250.74
172_V204_A1.3160.73
132_G258_R1.3090.73
360_A364_Y1.3000.72
155_N158_V1.2970.72
343_L353_L1.2950.72
327_P357_P1.2920.72
244_P301_N1.2870.72
144_N342_V1.2810.71
139_E161_K1.2770.71
322_R346_T1.2520.69
33_C65_C1.2520.69
31_C65_C1.2480.69
150_M153_K1.2470.69
175_A298_V1.2380.69
130_L309_Y1.2370.68
290_V293_L1.2280.68
310_E317_L1.2150.67
3_I8_F1.2130.67
353_L364_Y1.2130.67
305_V311_L1.2120.67
41_Y52_K1.2100.67
299_T305_V1.2030.66
94_T136_Y1.2020.66
188_S191_D1.1980.66
331_N352_A1.1970.66
138_W294_A1.1960.66
117_E120_S1.1930.66
360_A363_Y1.1900.65
157_G186_P1.1890.65
29_P54_M1.1880.65
202_A217_M1.1880.65
86_V97_K1.1870.65
29_P279_T1.1840.65
235_L238_K1.1800.65
340_D354_E1.1770.65
40_M199_R1.1700.64
189_E240_L1.1680.64
135_H296_M1.1640.64
135_H331_N1.1630.64
22_A25_T1.1590.63
120_S257_R1.1570.63
327_P336_A1.1560.63
54_M67_S1.1550.63
147_T162_H1.1500.63
8_F15_F1.1440.62
16_Q49_Y1.1420.62
355_V385_A1.1420.62
355_V358_A1.1410.62
307_S326_K1.1380.62
146_W152_G1.1380.62
34_R38_V1.1330.62
340_D357_P1.1300.61
80_L84_A1.1280.61
148_P324_F1.1280.61
197_A201_A1.1220.61
226_I252_W1.1220.61
5_G310_E1.1210.61
354_E376_S1.1160.60
362_E366_A1.1110.60
41_Y55_P1.1020.59
19_L31_C1.1000.59
168_E299_T1.0990.59
272_V298_V1.0870.58
40_M54_M1.0850.58
121_V133_L1.0800.58
282_V288_A1.0760.57
134_L294_A1.0690.57
57_T60_Q1.0590.56
142_G145_R1.0560.56
322_R343_L1.0510.56
307_S354_E1.0500.56
15_F18_A1.0440.55
306_E327_P1.0410.55
133_L343_L1.0400.55
8_F18_A1.0390.55
39_E54_M1.0360.55
306_E329_R1.0360.55
323_R344_T1.0340.54
161_K165_E1.0310.54
45_L303_I1.0310.54
124_D127_K1.0300.54
62_A79_E1.0260.54
18_A39_E1.0200.53
216_L295_L1.0130.53
307_S355_V1.0100.53
361_D366_A1.0030.52
98_L138_W1.0010.52
216_L262_E0.9970.52
306_E309_Y0.9950.52
262_E266_W0.9850.51
121_V221_G0.9830.51
53_R57_T0.9810.51
247_L290_V0.9800.50
357_P360_A0.9770.50
134_L296_M0.9750.50
87_E148_P0.9730.50
19_L33_C0.9660.49
182_Y244_P0.9620.49
255_L332_L0.9590.49
357_P364_Y0.9580.49
326_K329_R0.9570.49
6_Q14_G0.9560.49
119_D258_R0.9550.49
368_L371_L0.9510.48
184_P313_L0.9510.48
16_Q44_R0.9510.48
49_Y297_L0.9470.48
42_I293_L0.9460.48
41_Y57_T0.9450.48
299_T314_L0.9420.48
185_E199_R0.9390.47
203_L243_F0.9370.47
209_S316_A0.9360.47
151_A321_G0.9340.47
57_T167_A0.9270.47
364_Y371_L0.9240.46
365_E384_R0.9210.46
362_E365_E0.9170.46
88_D292_E0.9150.46
139_E361_D0.9110.45
300_E303_I0.9100.45
157_G161_K0.9040.45
370_K373_A0.9020.45
41_Y185_E0.9000.45
51_L260_E0.8990.44
159_V302_W0.8970.44
160_R239_H0.8950.44
30_L37_G0.8950.44
49_Y259_F0.8930.44
147_T323_R0.8920.44
375_R378_Y0.8910.44
28_R37_G0.8900.44
137_L302_W0.8880.44
157_G264_A0.8870.44
68_Y295_L0.8860.44
136_Y170_K0.8850.43
80_L128_L0.8840.43
155_N303_I0.8830.43
45_L50_V0.8820.43
155_N162_H0.8760.43
23_Y26_K0.8750.43
369_E372_I0.8740.43
337_P354_E0.8740.43
230_R266_W0.8740.43
156_W286_G0.8690.42
214_R281_G0.8670.42
67_S302_W0.8670.42
327_P338_L0.8660.42
276_A295_L0.8650.42
52_K279_T0.8650.42
224_K239_H0.8590.42
250_D257_R0.8570.41
15_F19_L0.8550.41
147_T206_L0.8520.41
55_P61_H0.8490.41
108_R183_V0.8480.41
356_V360_A0.8480.41
158_V162_H0.8470.41
221_G342_V0.8470.41
72_A79_E0.8450.41
258_R339_A0.8420.40
310_E357_P0.8420.40
66_P339_A0.8410.40
228_P233_H0.8400.40
8_F101_S0.8390.40
221_G232_G0.8380.40
35_P38_V0.8380.40
215_R227_E0.8360.40
317_L353_L0.8330.40
143_L161_K0.8330.40
195_I240_L0.8260.39
5_G8_F0.8260.39
340_D355_V0.8250.39
363_Y370_K0.8240.39
179_D249_E0.8210.39
339_A354_E0.8200.39
234_K248_D0.8190.39
197_A247_L0.8160.39
119_D275_V0.8140.38
28_R52_K0.8120.38
356_V382_V0.8110.38
216_L223_V0.8100.38
98_L297_L0.8040.38
173_K316_A0.8030.38
82_G302_W0.7990.37
74_L230_R0.7970.37
18_A116_A0.7960.37
136_Y182_Y0.7950.37
278_A290_V0.7940.37
120_S174_G0.7940.37
81_L85_I0.7940.37
116_A171_T0.7920.37
194_A219_L0.7900.37
87_E143_L0.7900.37
227_E275_V0.7870.37
357_P374_Y0.7840.36
76_G330_Y0.7820.36
66_P325_V0.7810.36
123_A172_V0.7800.36
367_A371_L0.7790.36
208_P215_R0.7790.36
229_A234_K0.7770.36
354_E367_A0.7720.36
53_R185_E0.7720.36
281_G291_E0.7720.36
341_A356_V0.7710.35
360_A368_L0.7710.35
101_S287_V0.7710.35
29_P38_V0.7710.35
3_I7_V0.7650.35
164_L220_I0.7640.35
71_P331_N0.7620.35
278_A300_E0.7590.35
160_R186_P0.7550.34
74_L96_L0.7550.34
69_E76_G0.7540.34
357_P370_K0.7530.34
127_K331_N0.7510.34
327_P340_D0.7510.34
29_P67_S0.7500.34
148_P160_R0.7500.34
280_F288_A0.7460.34
142_G150_M0.7450.34
18_A21_R0.7450.34
348_P372_I0.7430.34
376_S380_A0.7410.33
176_P192_K0.7390.33
6_Q9_E0.7380.33
130_L353_L0.7360.33
379_G384_R0.7350.33
215_R220_I0.7350.33
222_E273_H0.7350.33
172_V208_P0.7320.33
259_F266_W0.7320.33
273_H292_E0.7310.33
76_G135_H0.7290.33
214_R301_N0.7270.33
21_R25_T0.7260.32
136_Y233_H0.7220.32
10_E24_A0.7210.32
132_G303_I0.7190.32
40_M51_L0.7190.32
24_A35_P0.7160.32
17_A39_E0.7140.32
46_G305_V0.7140.32
143_L158_V0.7130.32
3_I18_A0.7110.32
144_N186_P0.7100.31
333_P336_A0.7090.31
376_S379_G0.7080.31
81_L84_A0.7070.31
51_L56_D0.7060.31
9_E21_R0.7050.31
196_A298_V0.7020.31
141_A161_K0.7010.31
339_A358_A0.6970.31
3_I51_L0.6960.31
139_E188_S0.6940.30
62_A203_L0.6920.30
96_L212_G0.6920.30
226_I351_V0.6920.30
267_G275_V0.6900.30
332_L352_A0.6870.30
10_E307_S0.6870.30
207_Q264_A0.6870.30
320_E345_D0.6860.30
195_I220_I0.6850.30
4_G51_L0.6850.30
96_L224_K0.6850.30
151_A354_E0.6830.30
367_A372_I0.6820.30
67_S262_E0.6810.30
159_V286_G0.6810.30
307_S357_P0.6790.30
53_R136_Y0.6790.30
187_F236_V0.6790.30
229_A267_G0.6770.29
216_L302_W0.6760.29
43_A50_V0.6710.29
29_P69_E0.6710.29
77_L330_Y0.6700.29
28_R279_T0.6700.29
159_V162_H0.6680.29
132_G283_S0.6670.29
303_I381_W0.6620.28
20_A180_R0.6620.28
195_I198_R0.6580.28
358_A367_A0.6570.28
77_L302_W0.6550.28
133_L165_E0.6540.28
248_D255_L0.6510.28
313_L381_W0.6510.28
299_T303_I0.6500.28
337_P352_A0.6490.28
310_E315_D0.6460.28
134_L220_I0.6450.27
349_A355_V0.6450.27
23_Y28_R0.6420.27
226_I330_Y0.6420.27
218_L259_F0.6410.27
155_N161_K0.6400.27
136_Y160_R0.6390.27
226_I231_Y0.6380.27
97_K206_L0.6370.27
137_L239_H0.6370.27
66_P269_D0.6370.27
180_R257_R0.6360.27
141_A200_A0.6330.27
299_T351_V0.6300.27
197_A225_E0.6300.27
176_P183_V0.6300.27
266_W295_L0.6290.27
327_P354_E0.6280.26
363_Y374_Y0.6280.26
43_A67_S0.6260.26
294_A297_L0.6250.26
6_Q321_G0.6250.26
221_G270_E0.6230.26
208_P212_G0.6220.26
283_S287_V0.6210.26
82_G96_L0.6190.26
282_V285_A0.6180.26
142_G164_L0.6180.26
129_S342_V0.6160.26
87_E161_K0.6140.26
272_V305_V0.6130.26
129_S170_K0.6120.26
145_R338_L0.6120.26
234_K244_P0.6110.26
42_I49_Y0.6090.25
80_L331_N0.6080.25
43_A54_M0.6080.25
356_V376_S0.6070.25
145_R242_D0.6070.25
49_Y335_D0.6050.25
365_E371_L0.6030.25
67_S216_L0.6010.25
355_V363_Y0.6010.25
6_Q179_D0.6010.25
9_E12_D0.6010.25
150_M323_R0.6000.25
237_L290_V0.6000.25
293_L323_R0.5990.25
219_L245_L0.5990.25
366_A370_K0.5970.25
49_Y247_L0.5950.25
104_K127_K0.5930.25
34_R62_A0.5910.24
129_S270_E0.5900.24
255_L295_L0.5890.24
223_V280_F0.5880.24
90_A247_L0.5880.24
238_K279_T0.5870.24
23_Y29_P0.5870.24
216_L281_G0.5860.24
310_E358_A0.5850.24
57_T94_T0.5840.24
29_P43_A0.5840.24
102_L195_I0.5830.24
94_T148_P0.5810.24
98_L133_L0.5810.24
146_W150_M0.5800.24
26_K182_Y0.5790.24
124_D339_A0.5780.24
146_W296_M0.5780.24
321_G325_V0.5780.24
159_V267_G0.5770.24
55_P238_K0.5770.24
87_E113_P0.5770.24
49_Y105_R0.5760.24
121_V182_Y0.5730.23
75_S328_L0.5730.23
86_V321_G0.5720.23
42_I290_V0.5720.23
371_L376_S0.5720.23
51_L356_V0.5710.23
133_L267_G0.5700.23
218_L291_E0.5670.23
118_S258_R0.5630.23
145_R158_V0.5630.23
153_K300_E0.5630.23
34_R47_D0.5620.23
214_R229_A0.5610.23
6_Q11_D0.5610.23
82_G173_K0.5600.23
234_K270_E0.5590.23
104_K170_K0.5580.23
114_S120_S0.5580.23
6_Q18_A0.5570.23
268_A321_G0.5560.23
22_A39_E0.5560.23
162_H165_E0.5550.23
43_A184_P0.5540.22
155_N237_L0.5540.22
260_E300_E0.5530.22
57_T248_D0.5530.22
17_A276_A0.5530.22
221_G237_L0.5520.22
282_V295_L0.5520.22
30_L36_P0.5510.22
144_N159_V0.5500.22
297_L305_V0.5490.22
93_T299_T0.5480.22
247_L328_L0.5480.22
156_W224_K0.5460.22
325_V344_T0.5440.22
378_Y384_R0.5440.22
4_G22_A0.5440.22
183_V207_Q0.5440.22
39_E85_I0.5420.22
71_P97_K0.5420.22
233_H249_E0.5420.22
240_L245_L0.5410.22
77_L216_L0.5410.22
122_K289_T0.5410.22
168_E247_L0.5410.22
101_S179_D0.5400.22
3_I6_Q0.5400.22
47_D60_Q0.5400.22
130_L294_A0.5400.22
370_K379_G0.5390.22
38_V102_L0.5390.22
100_F163_L0.5390.22
12_D16_Q0.5390.22
256_E295_L0.5350.22
98_L242_D0.5350.22
28_R41_Y0.5350.22
17_A366_A0.5340.21
372_I380_A0.5330.21
285_A288_A0.5320.21
324_F365_E0.5290.21
32_L293_L0.5290.21
13_P17_A0.5290.21
356_V363_Y0.5280.21
152_G185_E0.5280.21
84_A121_V0.5280.21
140_E158_V0.5260.21
41_Y69_E0.5250.21
138_W292_E0.5250.21
6_Q17_A0.5250.21
10_E23_Y0.5240.21
159_V190_E0.5240.21
27_E49_Y0.5230.21
218_L277_I0.5230.21
141_A159_V0.5220.21
137_L167_A0.5220.21
29_P39_E0.5210.21
163_L200_A0.5210.21
205_R321_G0.5200.21
298_V301_N0.5190.21
123_A141_A0.5180.21
22_A26_K0.5180.21
95_T145_R0.5170.21
36_P348_P0.5160.21
238_K354_E0.5160.21
288_A315_D0.5150.21
42_I72_A0.5150.21
195_I234_K0.5150.21
231_Y234_K0.5140.20
85_I102_L0.5130.20
91_D355_V0.5130.20
132_G341_A0.5120.20
235_L369_E0.5110.20
225_E236_V0.5090.20
132_G329_R0.5080.20
313_L340_D0.5070.20
130_L381_W0.5060.20
367_A374_Y0.5060.20
194_A270_E0.5050.20
20_A44_R0.5050.20
218_L257_R0.5040.20
150_M203_L0.5030.20
110_A220_I0.5030.20
4_G27_E0.5030.20
76_G92_G0.5000.20
4_G21_R0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1m0dA 2 0.1844 89.1 0.956 Contact Map
1vsrA 1 0.1844 29.2 0.972 Contact Map
1t0fA 2 0.3429 10.5 0.977 Contact Map
3krtA 4 0.1429 8.2 0.978 Contact Map
3ltoA 2 0.1455 7.7 0.979 Contact Map
2ixsA 1 0.6545 6.5 0.979 Contact Map
3r3pA 3 0.1818 5.6 0.98 Contact Map
3s1sA 1 0.2312 5.3 0.98 Contact Map
3h49A 2 0.1273 4.9 0.98 Contact Map
4qbnA 2 0.2078 4.8 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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