GREMLIN Database
DUF1168 - Protein of unknown function (DUF1168)
PFAM: PF06658 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 135 (126)
Sequences: 564 (429)
Seq/√Len: 38.2
META: 0.204

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_E77_K4.2421.00
66_E70_K3.6641.00
84_A88_A3.3501.00
60_E64_E2.9811.00
88_A91_Q2.6991.00
74_E78_A2.6851.00
72_R76_K2.5941.00
63_K67_E2.5681.00
27_Q37_E2.3891.00
76_K80_E2.3851.00
67_E71_K2.3601.00
53_K57_E2.3141.00
52_L56_D2.1500.99
71_K75_R2.0350.99
77_K81_E1.9950.99
42_R86_N1.9430.98
44_S47_R1.9340.98
87_R91_Q1.9090.98
27_Q43_A1.9000.98
20_P23_V1.8240.98
73_E76_K1.8140.97
12_K15_T1.7030.96
72_R75_R1.5750.94
59_A63_K1.5690.94
96_K99_K1.5100.93
110_E117_S1.4550.91
2_D10_P1.4270.91
23_V26_V1.4120.90
16_P19_P1.4000.90
70_K74_E1.3410.88
99_K102_K1.3260.87
27_Q42_R1.3050.86
55_M80_E1.2840.85
122_E126_E1.2650.84
27_Q44_S1.2640.84
37_E43_A1.2210.82
84_A91_Q1.2150.82
50_E55_M1.2060.81
11_P15_T1.1790.80
82_K86_N1.1700.79
22_F27_Q1.1690.79
117_S120_S1.1550.79
33_A37_E1.1540.79
37_E40_V1.1520.78
84_A87_R1.1470.78
69_E72_R1.1420.78
84_A94_K1.1410.78
79_A83_T1.1390.78
36_G40_V1.1310.77
36_G46_R1.1200.76
31_A38_F1.0630.73
116_D122_E1.0630.73
32_G36_G1.0620.72
29_S39_H1.0580.72
35_S51_R1.0520.72
43_A47_R1.0520.72
40_V49_Y1.0290.70
27_Q36_G1.0250.70
68_F72_R1.0230.70
121_D125_D1.0150.69
119_D125_D1.0080.68
26_V55_M1.0060.68
36_G39_H1.0030.68
61_K65_D0.9940.67
20_P81_E0.9930.67
13_E61_K0.9900.67
105_K109_E0.9900.67
65_D69_E0.9820.66
46_R49_Y0.9790.66
121_D124_S0.9670.65
105_K108_E0.9370.63
95_Q100_K0.9200.61
95_Q101_K0.9190.61
14_K25_N0.9120.61
60_E65_D0.9110.60
32_G41_Y0.9100.60
23_V31_A0.9080.60
36_G43_A0.8920.59
52_L75_R0.8870.58
36_G41_Y0.8830.58
124_S127_E0.8820.58
20_P39_H0.8540.56
111_E114_E0.8520.55
99_K103_A0.8410.54
104_K108_E0.8380.54
22_F42_R0.8310.53
78_A82_K0.8290.53
111_E115_E0.8230.53
40_V53_K0.8160.52
30_S50_E0.8150.52
24_R42_R0.8130.52
37_E44_S0.7950.50
40_V57_E0.7930.50
10_P101_K0.7860.49
112_E115_E0.7780.49
20_P24_R0.7750.48
6_P9_E0.7740.48
118_S125_D0.7680.48
27_Q40_V0.7670.48
117_S121_D0.7610.47
120_S125_D0.7600.47
38_F46_R0.7550.47
83_T87_R0.7520.46
109_E114_E0.7490.46
23_V67_E0.7440.46
2_D93_K0.7440.46
26_V46_R0.7270.44
119_D123_D0.7270.44
15_T54_L0.7200.44
119_D122_E0.7200.44
64_E89_K0.7190.43
118_S121_D0.7190.43
75_R79_A0.7170.43
32_G40_V0.7130.43
11_P61_K0.7030.42
68_F71_K0.7020.42
74_E77_K0.6970.42
109_E124_S0.6970.42
25_N50_E0.6890.41
89_K93_K0.6810.40
39_H46_R0.6750.40
2_D7_I0.6720.39
113_E123_D0.6700.39
27_Q32_G0.6640.39
118_S122_E0.6630.39
55_M58_E0.6620.39
95_Q98_K0.6610.38
110_E113_E0.6480.37
116_D121_D0.6480.37
16_P54_L0.6460.37
9_E12_K0.6430.37
75_R94_K0.6390.37
15_T82_K0.6360.36
37_E42_R0.6350.36
106_G111_E0.6290.36
107_K112_E0.6280.36
3_K56_D0.6240.35
93_K96_K0.6230.35
22_F79_A0.6230.35
79_A94_K0.6160.35
120_S124_S0.6160.35
24_R44_S0.6150.35
114_E117_S0.6090.34
69_E73_E0.6090.34
57_E67_E0.6030.34
122_E125_D0.6030.34
36_G47_R0.6020.34
103_A106_G0.6000.33
8_P80_E0.5980.33
115_E126_E0.5910.33
117_S124_S0.5910.33
103_A111_E0.5900.33
22_F59_A0.5880.32
7_I13_E0.5750.31
95_Q105_K0.5700.31
31_A35_S0.5680.31
21_E33_A0.5680.31
107_K122_E0.5670.31
99_K108_E0.5650.31
41_Y51_R0.5640.31
100_K104_K0.5630.31
5_V59_A0.5600.30
113_E116_D0.5550.30
29_S40_V0.5520.30
108_E116_D0.5450.29
101_K116_D0.5410.29
27_Q46_R0.5410.29
63_K68_F0.5400.29
64_E104_K0.5380.29
40_V43_A0.5350.28
10_P13_E0.5350.28
28_G35_S0.5340.28
108_E115_E0.5320.28
81_E84_A0.5270.28
4_P59_A0.5190.27
123_D127_E0.5180.27
5_V91_Q0.5170.27
28_G51_R0.5130.27
6_P14_K0.5120.27
42_R50_E0.5120.27
50_E53_K0.5090.27
57_E61_K0.5070.26
102_K105_K0.5050.26
32_G35_S0.5040.26
30_S87_R0.5040.26
54_L68_F0.5040.26
11_P16_P0.5030.26
38_F47_R0.5010.26
30_S92_K0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kt5C 1 0.0519 8.2 0.938 Contact Map
4u7aA 1 0 6.1 0.941 Contact Map
4m9qA 1 0.5407 4.4 0.945 Contact Map
4mtlA 4 0.3556 4.1 0.946 Contact Map
2mpwA 1 0.3185 4.1 0.946 Contact Map
5a21C 2 0.3333 3.7 0.947 Contact Map
4whtA 2 0.0444 3.5 0.948 Contact Map
3ziaJ 1 0.237 3.1 0.949 Contact Map
4c2m3 1 0.2667 3 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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