GREMLIN Database
SHR-BD - SHR-binding domain of vacuolar-sorting associated protein 13
PFAM: PF06650 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 271 (266)
Sequences: 897 (670)
Seq/√Len: 41.1
META: 0.207

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_D144_P5.4651.00
130_E164_R5.0751.00
262_Y265_D3.5631.00
225_I254_L3.5451.00
11_I115_F3.3881.00
121_L213_F3.3551.00
47_L50_F3.2841.00
163_L213_F3.2021.00
235_F254_L3.1261.00
97_G118_R3.0161.00
198_I213_F2.9631.00
202_V225_I2.9211.00
174_G266_D2.8591.00
96_V115_F2.8101.00
10_W110_T2.7301.00
202_V219_G2.6411.00
143_K146_E2.5861.00
187_K265_D2.4601.00
224_R228_H2.4391.00
45_P48_F2.3371.00
255_P258_S2.2601.00
227_N237_Q2.2341.00
222_P265_D2.2211.00
14_K114_T2.1790.99
252_Y265_D2.1320.99
8_P109_L2.1150.99
78_G81_G2.0180.99
48_F59_A1.9850.99
209_I213_F1.9660.99
130_E141_T1.9430.99
126_S215_D1.9020.99
29_S33_Q1.8960.99
236_Y251_R1.8500.98
57_N75_D1.8210.98
50_F59_A1.7750.98
97_G207_A1.7390.97
201_E235_F1.7220.97
102_E111_K1.6960.97
121_L187_K1.6780.97
45_P49_S1.6780.97
22_R68_W1.6700.97
29_S32_G1.6590.97
77_V100_V1.6530.96
14_K22_R1.6070.96
128_D143_K1.6000.96
74_L115_F1.5950.96
197_L221_W1.5820.95
15_T256_P1.5530.95
235_F260_M1.5440.95
82_E95_H1.4950.94
118_R207_A1.4930.94
258_S261_P1.4840.94
173_S225_I1.4810.94
176_F186_L1.4710.93
131_V146_E1.4580.93
110_T198_I1.4580.93
12_I121_L1.4340.92
174_G186_L1.3810.91
182_G185_H1.3790.91
108_K148_V1.3660.90
10_W221_W1.3540.90
44_L47_L1.3530.90
13_N18_P1.3480.90
211_I219_G1.3400.90
90_G113_V1.3280.89
95_H106_K1.3280.89
110_T152_W1.3260.89
7_S19_L1.3180.89
46_L53_D1.3000.88
19_L50_F1.2910.88
7_S114_T1.2730.87
133_E174_G1.2710.87
74_L235_F1.2550.86
111_K210_F1.2510.86
239_N243_G1.2390.85
50_F57_N1.2350.85
11_I19_L1.2300.85
54_D61_L1.2290.85
171_Q188_L1.2290.85
102_E105_G1.2210.85
62_R68_W1.2170.84
8_P133_E1.2040.84
205_E210_F1.1980.83
90_G159_K1.1890.83
10_W16_G1.1880.83
65_D84_V1.1820.83
33_Q36_E1.1750.82
120_V175_P1.1720.82
185_H188_L1.1610.81
19_L115_F1.1510.81
176_F200_V1.1480.81
121_L131_V1.1470.81
11_I52_D1.1350.80
112_V126_S1.1300.80
118_R172_W1.1180.79
232_E256_P1.1150.79
94_Y200_V1.0990.78
98_V108_K1.0940.77
172_W178_I1.0930.77
230_D258_S1.0880.77
48_F262_Y1.0840.77
65_D129_I1.0840.77
118_R197_L1.0830.77
45_P59_A1.0800.77
32_G35_G1.0770.76
18_P130_E1.0730.76
172_W223_Y1.0670.76
70_K119_Y1.0650.75
172_W237_Q1.0500.74
243_G246_G1.0480.74
86_P150_L1.0390.74
31_A37_H1.0320.73
45_P262_Y1.0280.73
109_L133_E1.0270.73
27_S53_D1.0220.72
94_Y152_W1.0190.72
126_S198_I1.0110.72
32_G56_K1.0090.71
224_R259_S1.0090.71
78_G111_K1.0040.71
226_E259_S1.0030.71
74_L143_K1.0020.71
69_S78_G1.0000.71
178_I181_I0.9990.71
188_L229_S0.9980.71
170_N174_G0.9930.70
224_R237_Q0.9930.70
176_F229_S0.9850.70
41_R44_L0.9840.70
146_E158_E0.9810.69
80_S99_S0.9760.69
68_W99_S0.9740.69
167_G170_N0.9740.69
133_E189_R0.9730.69
50_F119_Y0.9700.68
130_E166_P0.9660.68
18_P40_A0.9630.68
205_E212_T0.9620.68
39_E52_D0.9590.68
40_A44_L0.9550.67
40_A48_F0.9530.67
150_L154_R0.9520.67
72_F96_V0.9410.66
115_F196_G0.9380.66
103_G107_Y0.9380.66
38_E47_L0.9340.65
121_L124_K0.9330.65
27_S33_Q0.9250.65
200_V213_F0.9180.64
67_E77_V0.9140.64
72_F219_G0.9100.63
163_L173_S0.9060.63
255_P259_S0.9030.63
135_G229_S0.9000.63
41_R48_F0.8990.62
239_N242_V0.8910.62
105_G199_R0.8910.62
98_V203_L0.8890.62
182_G223_Y0.8820.61
8_P48_F0.8810.61
223_Y252_Y0.8790.61
21_Y129_I0.8780.61
59_A176_F0.8780.61
133_E152_W0.8780.61
150_L175_P0.8720.60
110_T255_P0.8710.60
113_V137_S0.8710.60
73_S77_V0.8650.59
73_S111_K0.8610.59
37_H40_A0.8600.59
61_L136_S0.8570.59
208_T220_A0.8540.58
232_E255_P0.8500.58
125_L215_D0.8500.58
30_A33_Q0.8460.58
11_I60_Q0.8390.57
129_I213_F0.8390.57
38_E52_D0.8370.57
147_L226_E0.8360.57
240_P255_P0.8350.57
199_R216_E0.8340.57
3_V178_I0.8330.57
122_K212_T0.8310.56
121_L200_V0.8260.56
100_V103_G0.8230.56
129_I189_R0.8200.55
14_K119_Y0.8180.55
19_L98_V0.8140.55
118_R181_I0.8110.55
77_V80_S0.8040.54
237_Q265_D0.8000.54
53_D59_A0.7980.53
5_I96_V0.7980.53
28_G33_Q0.7960.53
92_S96_V0.7910.53
225_I235_F0.7870.52
44_L49_S0.7840.52
42_K51_S0.7820.52
150_L153_L0.7800.52
77_V111_K0.7790.52
102_E109_L0.7770.51
234_T251_R0.7770.51
28_G34_A0.7740.51
5_I252_Y0.7730.51
38_E44_L0.7720.51
19_L32_G0.7700.51
124_K165_F0.7690.51
257_R263_A0.7640.50
133_E151_H0.7640.50
96_V172_W0.7630.50
5_I38_E0.7610.50
249_P269_A0.7610.50
4_S16_G0.7600.50
82_E235_F0.7570.50
200_V211_I0.7570.50
40_A47_L0.7530.49
85_L133_E0.7530.49
125_L198_I0.7530.49
45_P50_F0.7510.49
97_G104_E0.7500.49
78_G252_Y0.7480.49
75_D262_Y0.7460.48
12_I45_P0.7460.48
72_F81_G0.7460.48
121_L128_D0.7440.48
5_I10_W0.7420.48
181_I209_I0.7410.48
124_K145_G0.7400.48
68_W84_V0.7350.47
148_V192_G0.7340.47
20_Q179_D0.7330.47
5_I80_S0.7330.47
113_V163_L0.7320.47
259_S266_D0.7320.47
200_V261_P0.7310.47
140_I150_L0.7300.47
216_E219_G0.7290.47
114_T222_P0.7260.47
253_R256_P0.7240.46
38_E41_R0.7200.46
77_V81_G0.7190.46
116_T208_T0.7180.46
15_T70_K0.7170.46
9_Y73_S0.7160.46
209_I220_A0.7110.45
22_R29_S0.7110.45
173_S183_S0.7100.45
243_G269_A0.7090.45
40_A51_S0.7060.45
78_G83_V0.7060.45
91_D176_F0.7050.45
132_R161_L0.7050.45
198_I214_S0.7050.45
11_I129_I0.7040.45
253_R261_P0.7030.45
88_S130_E0.7020.44
104_E107_Y0.7010.44
89_N243_G0.7010.44
182_G187_K0.6980.44
103_G106_K0.6930.44
31_A235_F0.6880.43
221_W261_P0.6840.43
164_R224_R0.6830.43
97_G107_Y0.6810.43
120_V210_F0.6760.42
24_K29_S0.6730.42
126_S211_I0.6710.42
6_Y145_G0.6700.42
10_W152_W0.6700.42
130_E258_S0.6600.41
38_E50_F0.6600.41
107_Y257_R0.6570.40
89_N213_F0.6540.40
5_I142_L0.6530.40
74_L78_G0.6520.40
41_R46_L0.6510.40
198_I202_V0.6480.40
40_A50_F0.6470.39
145_G214_S0.6470.39
236_Y254_L0.6470.39
224_R255_P0.6450.39
121_L201_E0.6450.39
43_A47_L0.6450.39
27_S31_A0.6420.39
174_G181_I0.6410.39
181_I187_K0.6410.39
11_I98_V0.6400.39
233_I257_R0.6380.39
47_L58_R0.6370.39
22_R41_R0.6370.39
40_A163_L0.6360.38
52_D219_G0.6330.38
65_D116_T0.6320.38
38_E46_L0.6320.38
115_F173_S0.6320.38
107_Y137_S0.6300.38
12_I120_V0.6280.38
73_S79_S0.6270.38
107_Y236_Y0.6270.38
29_S37_H0.6250.38
125_L192_G0.6220.37
88_S225_I0.6220.37
151_H216_E0.6220.37
58_R72_F0.6210.37
103_G108_K0.6200.37
163_L166_P0.6190.37
33_Q63_V0.6190.37
63_V204_L0.6180.37
97_G116_T0.6180.37
17_L42_K0.6180.37
38_E42_K0.6170.37
97_G161_L0.6110.36
121_L151_H0.6070.36
208_T256_P0.6070.36
100_V169_N0.6050.36
123_N227_N0.6020.36
11_I116_T0.6010.35
26_S191_E0.5990.35
58_R71_P0.5950.35
47_L53_D0.5950.35
27_S30_A0.5940.35
83_V134_P0.5940.35
10_W81_G0.5920.35
174_G189_R0.5910.35
199_R207_A0.5880.34
135_G138_K0.5830.34
129_I165_F0.5830.34
195_Q234_T0.5830.34
126_S144_P0.5830.34
254_L257_R0.5790.34
118_R182_G0.5790.34
98_V226_E0.5760.33
72_F145_G0.5760.33
50_F73_S0.5750.33
43_A50_F0.5710.33
98_V163_L0.5700.33
65_D119_Y0.5700.33
7_S128_D0.5670.33
33_Q202_V0.5670.33
66_S149_P0.5660.33
211_I214_S0.5660.33
17_L68_W0.5640.32
97_G220_A0.5620.32
43_A48_F0.5590.32
27_S32_G0.5590.32
202_V249_P0.5580.32
186_L189_R0.5580.32
81_G87_S0.5550.32
29_S35_G0.5550.32
146_E151_H0.5530.31
21_Y168_V0.5500.31
62_R100_V0.5480.31
165_F212_T0.5470.31
75_D92_S0.5470.31
34_A37_H0.5460.31
204_L265_D0.5450.31
236_Y260_M0.5440.31
82_E97_G0.5440.31
237_Q264_W0.5420.31
5_I51_S0.5410.31
113_V256_P0.5400.30
34_A200_V0.5390.30
89_N233_I0.5390.30
133_E154_R0.5380.30
182_G221_W0.5370.30
129_I156_S0.5360.30
218_K238_K0.5350.30
251_R258_S0.5340.30
52_D88_S0.5330.30
4_S164_R0.5330.30
129_I246_G0.5310.30
131_V234_T0.5300.30
64_G229_S0.5270.29
23_S97_G0.5240.29
86_P115_F0.5240.29
6_Y111_K0.5240.29
130_E136_S0.5230.29
208_T237_Q0.5220.29
13_N21_Y0.5210.29
97_G210_F0.5210.29
72_F195_Q0.5200.29
10_W17_L0.5200.29
54_D60_Q0.5170.29
174_G180_D0.5160.29
104_E207_A0.5160.29
77_V102_E0.5150.29
64_G238_K0.5130.28
258_S262_Y0.5100.28
175_P178_I0.5090.28
129_I138_K0.5090.28
121_L186_L0.5090.28
54_D58_R0.5070.28
140_I146_E0.5060.28
226_E261_P0.5040.28
212_T235_F0.5040.28
241_N244_E0.5040.28
39_E232_E0.5040.28
264_W268_A0.5000.27
201_E206_G0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gioA 1 0.3506 4.4 0.965 Contact Map
4joxA 1 0.2952 3.8 0.966 Contact Map
3fsaA 1 0.3801 2.3 0.97 Contact Map
4jdeB 1 0.214 2.2 0.97 Contact Map
1g0yI 1 0.048 2 0.971 Contact Map
4h25C 1 0.0812 1.9 0.971 Contact Map
3isyA 1 0.2952 1.9 0.971 Contact Map
4jdeA 1 0.214 1.7 0.972 Contact Map
2ccwA 1 0.3985 1.6 0.972 Contact Map
1ncgA 2 0.3173 1.6 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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