GREMLIN Database
DUF1161 - Protein of unknown function (DUF1161)
PFAM: PF06649 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (50)
Sequences: 1998 (898)
Seq/√Len: 127.0
META: 0.868

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_A13_D4.4551.00
22_L48_I2.4651.00
27_K47_K2.3941.00
4_L7_E2.3531.00
8_I48_I2.3511.00
26_P29_A2.2551.00
28_D47_K1.9291.00
42_E46_K1.9131.00
37_V49_V1.8571.00
8_I38_V1.7901.00
12_L15_K1.7101.00
35_G49_V1.7001.00
7_E11_K1.4581.00
13_D20_Y1.4161.00
9_A22_L1.2060.99
12_L20_Y1.1880.99
29_A33_A1.1760.99
12_L17_V1.0560.98
40_S44_G1.0510.98
9_A20_Y1.0200.98
17_V50_Y1.0050.98
4_L40_S0.9960.98
10_A14_A0.9580.97
26_P46_K0.9380.97
30_V35_G0.9370.97
30_V34_D0.9230.96
6_A10_A0.9060.96
27_K40_S0.9030.96
2_E5_K0.8890.96
34_D51_K0.8620.95
43_G52_R0.8580.95
7_E14_A0.8520.94
25_V37_V0.8390.94
30_V33_A0.7890.92
26_P33_A0.7780.91
15_K36_K0.7770.91
13_D18_K0.7720.91
13_D19_G0.7660.91
4_L8_I0.7620.90
11_K17_V0.7610.90
27_K45_T0.7550.90
5_K24_I0.7480.90
16_G50_Y0.7460.89
3_E40_S0.6870.85
3_E34_D0.6800.85
3_E7_E0.6770.84
24_I48_I0.6720.84
23_E35_G0.6710.84
6_A46_K0.6660.83
9_A44_G0.6560.82
4_L39_G0.6550.82
38_V50_Y0.6420.81
42_E45_T0.6360.80
22_L38_V0.6190.79
30_V40_S0.5980.76
14_A42_E0.5810.74
12_L38_V0.5810.74
3_E24_I0.5780.74
27_K30_V0.5760.74
29_A47_K0.5650.72
25_V33_A0.5640.72
8_I15_K0.5640.72
29_A35_G0.5600.72
33_A49_V0.5560.71
25_V49_V0.5500.70
28_D34_D0.5460.70
14_A45_T0.5430.69
23_E51_K0.5390.69
19_G43_G0.5230.66
16_G29_A0.5200.66
21_T24_I0.5100.64
30_V38_V0.5090.64
25_V45_T0.5090.64
14_A20_Y0.5050.64
27_K38_V0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mx4A 1 0.75 9.1 0.869 Contact Map
5bxvB 1 0.1346 6.9 0.876 Contact Map
3wkrC 2 0 6 0.879 Contact Map
2hiqA 2 0.6538 5.2 0.882 Contact Map
3hxiC 1 0.1346 5.2 0.882 Contact Map
3g4nA 1 0.4615 5.1 0.883 Contact Map
3h90A 3 0.5769 4.8 0.884 Contact Map
4aukA 2 0.8654 3.9 0.889 Contact Map
3nqwA 2 0.3462 3.7 0.89 Contact Map
4lvcA 4 0.4615 3.6 0.891 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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