GREMLIN Database
SPC12 - Microsomal signal peptidase 12 kDa subunit (SPC12)
PFAM: PF06645 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 71 (69)
Sequences: 778 (599)
Seq/√Len: 72.1
META: 0.411

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_F44_G3.7271.00
16_I48_T2.9801.00
31_T36_L2.9041.00
49_A53_V2.8031.00
4_E7_K2.5551.00
43_A47_L2.3681.00
9_A52_V2.0561.00
4_E62_H1.7011.00
34_F37_T1.6501.00
27_V36_L1.6411.00
55_P60_N1.6411.00
4_E8_L1.6050.99
12_L16_I1.5940.99
26_I30_I1.5800.99
1_M55_P1.5560.99
1_M34_F1.4890.99
5_G9_A1.4150.98
35_S39_Y1.4000.98
27_V40_I1.3680.98
15_I19_L1.3350.98
41_Y45_V1.3150.98
11_R15_I1.2770.97
16_I51_V1.2480.97
24_G40_I1.2190.96
23_I43_A1.2100.96
13_Y48_T1.2010.96
45_V49_A1.1620.95
56_W63_P1.1470.95
38_L41_Y1.1360.94
44_G55_P1.0740.92
56_W61_R1.0620.92
39_Y51_V1.0460.91
42_L49_A1.0440.91
3_F60_N1.0360.91
27_V31_T1.0160.90
28_G37_T1.0040.90
11_R43_A0.9830.89
13_Y52_V0.9620.88
24_G41_Y0.9520.87
44_G48_T0.9410.86
27_V67_L0.9310.86
37_T41_Y0.9260.85
34_F55_P0.9000.84
2_D5_G0.8790.82
13_Y17_L0.8540.81
14_Q24_G0.8530.80
10_E45_V0.8490.80
51_V58_F0.8450.80
26_I47_L0.8410.79
39_Y43_A0.8280.78
39_Y42_L0.8110.77
33_D41_Y0.8070.77
36_L39_Y0.7900.75
33_D36_L0.7780.74
3_F32_Q0.7750.74
5_G56_W0.7680.73
44_G47_L0.7570.72
14_Q22_V0.7540.72
35_S43_A0.7250.69
53_V58_F0.7170.68
18_V23_I0.7090.67
29_Y36_L0.7040.66
14_Q18_V0.6920.65
7_K69_P0.6870.64
4_E30_I0.6830.64
57_P61_R0.6810.64
19_L26_I0.6570.61
14_Q33_D0.6530.61
15_I20_F0.6530.61
30_I45_V0.6520.60
50_L56_W0.6480.60
26_I65_K0.6430.59
26_I43_A0.6390.59
35_S38_L0.6370.59
3_F55_P0.6330.58
3_F25_F0.6270.57
23_I40_I0.6230.57
29_Y37_T0.6210.57
20_F48_T0.6150.56
1_M37_T0.6070.55
21_G44_G0.5990.54
35_S61_R0.5990.54
33_D57_P0.5880.53
22_V59_Y0.5880.53
12_L59_Y0.5820.52
30_I35_S0.5780.52
23_I57_P0.5690.50
13_Y49_A0.5670.50
53_V69_P0.5660.50
1_M14_Q0.5590.49
10_E13_Y0.5580.49
60_N64_L0.5560.49
1_M4_E0.5490.48
50_L57_P0.5360.46
52_V59_Y0.5310.46
59_Y69_P0.5280.45
31_T39_Y0.5230.45
24_G67_L0.5190.44
16_I34_F0.5180.44
11_R19_L0.5140.44
45_V67_L0.5110.43
18_V69_P0.5060.43
7_K26_I0.5000.42
17_L48_T0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.9155 25.7 0.868 Contact Map
4i0uA 4 0.8873 21 0.873 Contact Map
4uvmA 1 1 15.2 0.881 Contact Map
2a3mA 1 0.169 12.8 0.885 Contact Map
2gfpA 2 1 8.3 0.894 Contact Map
4q65A 1 0.9859 8 0.895 Contact Map
4oh3A 2 0.9859 7.8 0.896 Contact Map
2xq2A 2 0.7887 7.4 0.896 Contact Map
4xnjA 1 0.8873 5.7 0.902 Contact Map
1pw4A 1 0.9014 5.7 0.902 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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