GREMLIN Database
DUF1156 - Protein of unknown function (DUF1156)
PFAM: PF06634 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 72 (70)
Sequences: 4285 (1557)
Seq/√Len: 186.1
META: 0.954

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_E68_R3.4891.00
42_F46_V3.2991.00
2_L7_I2.5241.00
17_I23_S2.2731.00
52_H55_E2.0091.00
10_E13_R1.8271.00
16_S19_H1.8041.00
27_L31_R1.8041.00
14_E35_A1.7981.00
47_D51_S1.7581.00
63_E67_E1.7581.00
19_H24_T1.6951.00
18_R24_T1.6911.00
52_H56_F1.5851.00
18_R23_S1.5231.00
18_R21_H1.5161.00
53_P56_F1.5021.00
16_S24_T1.4791.00
21_H24_T1.4201.00
1_A4_L1.3741.00
20_G24_T1.3611.00
55_E58_T1.3061.00
57_P62_Q1.3021.00
58_T61_A1.2701.00
16_S27_L1.2471.00
15_K33_P1.1981.00
57_P60_E1.1861.00
11_S36_A1.1791.00
41_L45_L1.1741.00
21_H31_R1.1691.00
61_A64_K1.0981.00
19_H23_S1.0541.00
13_R17_I1.0361.00
15_K18_R1.0351.00
16_S20_G1.0110.99
54_E62_Q1.0100.99
14_E31_R1.0060.99
18_R27_L0.9900.99
54_E58_T0.9860.99
60_E63_E0.9830.99
53_P57_P0.9820.99
6_A9_A0.9630.99
62_Q65_E0.9620.99
58_T62_Q0.9020.99
12_A16_S0.8920.99
5_E9_A0.8770.99
2_L43_A0.8690.98
54_E57_P0.8630.98
56_F61_A0.8630.98
66_R69_L0.8590.98
55_E62_Q0.8530.98
15_K23_S0.8500.98
4_L8_N0.8410.98
14_E23_S0.8410.98
23_S27_L0.8260.98
59_E63_E0.8100.98
17_I24_T0.7900.97
16_S23_S0.7720.97
47_D50_S0.7570.96
60_E64_K0.7510.96
57_P61_A0.7490.96
13_R16_S0.7340.96
23_S31_R0.7240.95
14_E21_H0.6980.94
63_E66_R0.6960.94
15_K20_G0.6950.94
59_E62_Q0.6860.94
56_F60_E0.6810.94
14_E17_I0.6790.93
56_F65_E0.6690.93
51_S58_T0.6690.93
19_H27_L0.6680.93
67_E70_F0.6670.93
64_K67_E0.6570.92
7_I39_A0.6520.92
41_L44_Q0.6500.92
21_H25_L0.6470.92
13_R19_H0.6350.91
52_H58_T0.6230.90
61_A67_E0.6210.90
50_S56_F0.6000.88
41_L46_V0.5980.88
15_K21_H0.5970.88
1_A70_F0.5920.88
53_P58_T0.5910.88
28_W70_F0.5880.87
1_A48_D0.5770.87
56_F59_E0.5680.86
15_K27_L0.5610.85
34_L37_A0.5600.85
51_S57_P0.5400.83
5_E22_P0.5390.83
52_H57_P0.5350.82
56_F62_Q0.5340.82
51_S56_F0.5270.81
63_E70_F0.5250.81
40_V44_Q0.5210.80
55_E61_A0.5200.80
52_H61_A0.5190.80
42_F50_S0.5160.80
37_A44_Q0.5150.80
17_I21_H0.5130.79
17_I20_G0.5040.78
32_R36_A0.5040.78
60_E67_E0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q33A 1 0.5556 4.2 0.908 Contact Map
1yewA 3 0.8472 4.1 0.908 Contact Map
4phzA 3 0.8472 3.8 0.91 Contact Map
3o6zA 2 0.4861 3.4 0.912 Contact Map
3fdhA 1 0.4722 3.3 0.912 Contact Map
3o7iA 1 0.8889 2.6 0.917 Contact Map
3e57A 2 0.3889 2.2 0.92 Contact Map
3f4kA 2 0.4583 2 0.922 Contact Map
1q27A 1 0.4583 2 0.922 Contact Map
1sjyA 2 0.5417 1.8 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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