GREMLIN Database
DUF1152 - Protein of unknown function (DUF1152)
PFAM: PF06626 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 295 (294)
Sequences: 854 (669)
Seq/√Len: 39.0
META: 0.799

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_E224_R4.4251.00
184_L189_G4.1521.00
96_V105_L3.5291.00
189_G255_A3.3111.00
285_R293_E3.2931.00
123_G152_L3.2721.00
222_A245_S3.1971.00
280_H289_D3.1111.00
56_E92_E3.0981.00
276_N280_H2.8531.00
77_G80_P2.8201.00
181_L251_F2.7501.00
19_R22_R2.7371.00
130_V161_L2.6191.00
5_I130_V2.4781.00
6_G10_D2.4751.00
277_D280_H2.3821.00
133_R183_E2.3741.00
79_L82_E2.3671.00
7_G10_D2.3461.00
104_G269_T2.3011.00
52_I63_A2.2621.00
113_A121_V2.2100.99
77_G82_E2.1750.99
76_R79_L2.1300.99
17_T162_A2.1010.99
102_V106_A2.0670.99
54_G68_D2.0390.99
265_A282_L1.9940.99
79_L87_E1.9940.99
101_G104_G1.9840.99
74_G77_G1.9760.99
80_P83_A1.9460.99
273_E292_R1.9180.98
15_L207_A1.8980.98
33_L144_A1.8830.98
124_V162_A1.8790.98
206_E209_E1.8780.98
276_N289_D1.8490.98
130_V149_L1.8360.98
17_T248_T1.8290.98
202_E206_E1.8170.98
112_A116_L1.8140.98
106_A154_E1.8090.98
79_L83_A1.8050.98
76_R82_E1.7630.97
164_F248_T1.7330.97
48_S51_E1.7300.97
276_N292_R1.7300.97
76_R80_P1.7040.97
278_A281_A1.7000.97
175_D240_E1.6870.96
59_A111_E1.6540.96
96_V148_M1.6540.96
103_A270_E1.6520.96
231_E238_T1.6460.96
102_V269_T1.6370.96
198_P202_E1.6050.95
75_G79_L1.6030.95
75_G78_V1.6020.95
75_G82_E1.5890.95
173_T176_E1.5770.95
142_P169_D1.5670.94
154_E267_A1.5580.94
2_V17_T1.5570.94
107_E111_E1.5340.94
65_A95_L1.4940.93
53_E70_R1.4760.92
49_L63_A1.4570.92
56_E64_L1.4550.92
121_V152_L1.4350.91
166_P177_V1.4310.91
18_A30_L1.4270.91
221_R226_E1.4270.91
57_P60_P1.4210.91
6_G9_G1.4100.91
13_G126_V1.4100.91
208_L220_V1.3840.90
271_S274_E1.3820.90
84_R87_E1.3780.90
75_G80_P1.3490.89
15_L30_L1.3440.88
103_A154_E1.3310.88
288_L292_R1.3260.88
56_E115_E1.3170.87
261_R265_A1.3160.87
251_F256_V1.3090.87
78_V82_E1.3080.87
229_E238_T1.3030.87
11_V14_A1.2950.86
195_G247_L1.2950.86
193_A197_T1.2940.86
78_V81_A1.2930.86
87_E210_W1.2870.86
147_V275_A1.2650.85
193_A247_L1.2380.84
76_R83_A1.2370.84
20_A194_W1.2330.84
61_G108_G1.2280.83
78_V83_A1.2260.83
139_L142_P1.2250.83
277_D281_A1.2230.83
286_T289_D1.2180.83
204_L208_L1.2170.83
4_G10_D1.2150.83
31_G94_V1.2140.83
55_A63_A1.2110.83
75_G83_A1.2030.82
77_G83_A1.2000.82
37_R42_P1.1980.82
257_A260_S1.1810.81
55_A69_T1.1800.81
82_E86_A1.1510.79
61_G100_G1.1260.78
71_T75_G1.1220.77
4_G7_G1.1200.77
62_V112_A1.1200.77
140_R236_R1.1200.77
244_L247_L1.1150.77
22_R91_E1.1090.77
275_A287_E1.1080.76
227_F243_P1.1060.76
190_L193_A1.1010.76
244_L249_F1.0880.75
181_L243_P1.0880.75
266_V275_A1.0810.75
162_A248_T1.0780.74
270_E274_E1.0760.74
131_L149_L1.0710.74
221_R230_V1.0670.74
280_H286_T1.0660.74
182_A243_P1.0650.74
162_A250_F1.0630.73
66_N69_T1.0600.73
257_A263_A1.0510.73
25_G28_V1.0450.72
144_A172_L1.0440.72
110_E158_P1.0330.71
66_N92_E1.0140.70
47_R71_T1.0130.70
17_T250_F1.0090.69
29_V116_L1.0070.69
111_E115_E1.0060.69
2_V21_L0.9990.69
199_E242_T0.9970.68
110_E156_E0.9940.68
128_G169_D0.9930.68
177_V181_L0.9920.68
129_D145_D0.9830.67
52_I69_T0.9830.67
128_G170_G0.9760.67
155_L159_V0.9750.67
151_A253_P0.9700.66
280_H284_I0.9590.65
9_G35_W0.9550.65
80_P84_R0.9550.65
221_R241_L0.9540.65
21_L26_V0.9530.65
184_L255_A0.9500.65
269_T278_A0.9500.65
3_I148_M0.9460.64
19_R203_E0.9420.64
140_R245_S0.9370.64
103_A268_D0.9370.64
149_L260_S0.9350.63
229_E240_E0.9320.63
236_R290_L0.9280.63
257_A264_R0.9280.63
262_L284_I0.9170.62
48_S99_T0.9080.61
94_V112_A0.9070.61
143_L171_E0.9050.61
184_L251_F0.9040.61
143_L275_A0.9040.61
211_V215_A0.9000.60
60_P107_E0.8950.60
121_V155_L0.8950.60
101_G269_T0.8830.59
274_E277_D0.8800.59
140_R222_A0.8780.59
284_I290_L0.8770.58
82_E85_M0.8730.58
189_G253_P0.8710.58
283_G287_E0.8630.57
25_G243_P0.8630.57
218_I241_L0.8580.57
184_L261_R0.8560.57
201_A224_R0.8480.56
149_L161_L0.8450.56
218_I239_V0.8390.55
52_I55_A0.8360.55
208_L217_A0.8350.55
38_L294_L0.8320.54
106_A113_A0.8320.54
82_E93_V0.8280.54
128_G141_S0.8280.54
175_D179_E0.8280.54
285_R289_D0.8230.54
140_R290_L0.8220.54
54_G70_R0.8210.53
215_A233_R0.8100.52
290_L293_E0.8100.52
109_L186_R0.8080.52
283_G286_T0.8040.52
266_V278_A0.8010.52
43_V51_E0.7990.51
161_L251_F0.7980.51
139_L169_D0.7970.51
161_L256_V0.7910.51
15_L85_M0.7880.50
18_A32_G0.7860.50
118_I124_V0.7860.50
194_W250_F0.7840.50
187_A258_E0.7820.50
71_T123_G0.7810.50
62_V115_E0.7770.49
203_E207_A0.7740.49
80_P85_M0.7710.49
108_G112_A0.7700.49
16_A21_L0.7690.49
64_L92_E0.7680.49
278_A282_L0.7680.49
1_L6_G0.7640.48
168_C218_I0.7600.48
21_L28_V0.7590.48
285_R290_L0.7560.48
41_D46_P0.7560.48
1_L167_G0.7540.47
105_L148_M0.7530.47
128_G171_E0.7520.47
131_L163_V0.7520.47
13_G17_T0.7500.47
31_G112_A0.7470.47
169_D233_R0.7470.47
165_G246_A0.7460.47
126_V215_A0.7400.46
76_R85_M0.7350.46
264_R267_A0.7340.46
50_E60_P0.7310.45
40_I212_P0.7310.45
138_G173_T0.7290.45
46_P170_G0.7280.45
290_L294_L0.7270.45
111_E114_E0.7270.45
17_T27_E0.7270.45
32_G47_R0.7240.45
272_L288_L0.7240.45
183_E259_R0.7240.45
40_I106_A0.7210.44
164_F242_T0.7190.44
130_V180_R0.7150.44
109_L155_L0.7100.43
180_R183_E0.7070.43
24_L28_V0.7020.43
232_I235_G0.7020.43
114_E135_D0.7010.43
19_R200_D0.7000.43
201_A223_A0.6990.42
77_G86_A0.6970.42
49_L52_I0.6970.42
11_V266_V0.6970.42
196_L248_T0.6940.42
34_S99_T0.6920.42
226_E251_F0.6920.42
132_A216_S0.6910.42
192_G197_T0.6900.42
4_G8_G0.6890.42
155_L173_T0.6860.41
265_A278_A0.6840.41
97_D169_D0.6820.41
272_L276_N0.6790.41
274_E278_A0.6770.41
213_T216_S0.6770.41
169_D215_A0.6760.40
215_A218_I0.6750.40
81_A84_R0.6750.40
204_L207_A0.6740.40
123_G161_L0.6730.40
12_V85_M0.6700.40
187_A259_R0.6700.40
268_D278_A0.6700.40
47_R140_R0.6700.40
110_E114_E0.6690.40
146_A266_V0.6680.40
86_A89_L0.6680.40
71_T76_R0.6660.40
47_R173_T0.6640.39
287_E291_E0.6630.39
159_V253_P0.6620.39
102_V147_V0.6620.39
76_R81_A0.6610.39
194_W197_T0.6610.39
189_G251_F0.6610.39
5_I123_G0.6580.39
89_L92_E0.6570.39
1_L4_G0.6570.39
30_L207_A0.6570.39
126_V144_A0.6560.39
147_V182_A0.6530.38
19_R191_L0.6520.38
37_R128_G0.6480.38
105_L108_G0.6470.38
138_G168_C0.6450.38
65_A69_T0.6430.38
126_V139_L0.6420.38
161_L253_P0.6390.37
95_L148_M0.6380.37
190_L195_G0.6360.37
128_G132_A0.6330.37
13_G216_S0.6290.36
4_G192_G0.6270.36
143_L214_E0.6270.36
179_E221_R0.6250.36
36_E41_D0.6250.36
32_G71_T0.6250.36
29_V56_E0.6230.36
101_G151_A0.6220.36
17_T164_F0.6220.36
141_S214_E0.6220.36
142_P215_A0.6220.36
178_L244_L0.6220.36
208_L213_T0.6210.36
143_L216_S0.6210.36
215_A219_P0.6200.36
69_T83_A0.6190.36
43_V189_G0.6180.35
166_P174_P0.6170.35
1_L10_D0.6150.35
214_E233_R0.6140.35
110_E118_I0.6130.35
138_G176_E0.6120.35
101_G271_S0.6090.35
115_E124_V0.6080.35
91_E95_L0.6080.35
166_P245_S0.6060.35
105_L121_V0.6060.35
128_G163_V0.6050.34
207_A210_W0.6050.34
63_A71_T0.6040.34
233_R236_R0.6040.34
209_E256_V0.6000.34
15_L165_G0.5980.34
139_L180_R0.5970.34
166_P180_R0.5970.34
233_R237_R0.5970.34
128_G214_E0.5960.34
177_V180_R0.5930.33
160_L191_L0.5920.33
195_G248_T0.5900.33
164_F219_P0.5890.33
105_L147_V0.5870.33
103_A274_E0.5860.33
141_S213_T0.5850.33
117_G186_R0.5850.33
32_G213_T0.5830.33
182_A227_F0.5830.33
147_V227_F0.5820.33
153_A186_R0.5810.32
136_E139_L0.5800.32
166_P178_L0.5800.32
257_A267_A0.5800.32
36_E39_V0.5790.32
133_R261_R0.5790.32
17_T20_A0.5780.32
4_G16_A0.5770.32
200_D204_L0.5770.32
121_V269_T0.5760.32
11_V16_A0.5740.32
193_A250_F0.5730.32
255_A258_E0.5720.32
199_E206_E0.5720.32
16_A196_L0.5710.32
9_G14_A0.5710.32
17_T124_V0.5690.32
22_R189_G0.5690.32
211_V219_P0.5690.32
178_L240_E0.5680.31
222_A227_F0.5650.31
146_A262_L0.5630.31
109_L113_A0.5590.31
197_T200_D0.5580.31
71_T223_A0.5570.31
133_R180_R0.5560.31
15_L19_R0.5560.31
222_A228_G0.5540.30
193_A248_T0.5530.30
180_R259_R0.5530.30
38_L290_L0.5530.30
170_G239_V0.5510.30
88_V220_V0.5510.30
115_E282_L0.5500.30
5_I148_M0.5490.30
216_S275_A0.5480.30
5_I12_V0.5470.30
62_V116_L0.5460.30
162_A261_R0.5430.30
189_G208_L0.5390.29
172_L214_E0.5380.29
72_I77_G0.5380.29
87_E186_R0.5370.29
57_P63_A0.5370.29
171_E214_E0.5370.29
20_A24_L0.5360.29
172_L176_E0.5340.29
71_T78_V0.5340.29
197_T248_T0.5330.29
43_V48_S0.5330.29
50_E56_E0.5320.29
1_L7_G0.5320.29
11_V15_L0.5310.29
275_A279_L0.5270.28
95_L108_G0.5260.28
37_R46_P0.5260.28
76_R184_L0.5260.28
36_E141_S0.5250.28
40_I250_F0.5240.28
42_P47_R0.5240.28
27_E60_P0.5230.28
19_R23_R0.5230.28
87_E267_A0.5230.28
278_A292_R0.5220.28
146_A173_T0.5200.28
132_A139_L0.5180.28
83_A90_G0.5170.28
103_A209_E0.5100.27
96_V102_V0.5090.27
85_M89_L0.5070.27
140_R144_A0.5060.27
78_V85_M0.5060.27
143_L215_A0.5060.27
193_A249_F0.5060.27
37_R45_G0.5050.27
9_G141_S0.5040.27
89_L121_V0.5040.27
51_E258_E0.5030.27
137_P188_G0.5020.27
217_A221_R0.5010.26
117_G268_D0.5010.26
21_L40_I0.5010.26
176_E180_R0.5000.26
280_H292_R0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zzgA 2 0.8746 51.3 0.959 Contact Map
2o3iA 3 0.7695 42.9 0.961 Contact Map
4c7oA 1 0.5831 39.6 0.962 Contact Map
3qxcA 2 0.7051 28.6 0.965 Contact Map
1pixA 4 0.9119 28.4 0.965 Contact Map
2o2cA 2 0.8814 24.8 0.966 Contact Map
2ozeA 2 0.8102 24.4 0.966 Contact Map
3a5fA 3 0.7119 24.1 0.966 Contact Map
3of5A 2 0.7017 22.8 0.966 Contact Map
3ic5A 1 0.3695 22.3 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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