GREMLIN Database
DUF1150 - Protein of unknown function (DUF1150)
PFAM: PF06620 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (75)
Sequences: 3473 (2010)
Seq/√Len: 232.0
META: 0.912

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_P40_T3.3041.00
58_R62_F2.3511.00
46_A50_T2.2211.00
44_L65_A2.1331.00
21_R40_T2.0351.00
21_R24_D2.0061.00
63_A67_Q1.9991.00
57_S60_A1.9431.00
66_R72_P1.9321.00
46_A52_L1.8521.00
18_R51_P1.8451.00
6_F9_L1.8011.00
55_T61_A1.7471.00
22_S38_G1.6321.00
5_A8_A1.5841.00
7_A10_G1.5471.00
62_F66_R1.5321.00
64_N68_N1.4031.00
23_E38_G1.4011.00
8_A11_G1.3841.00
4_E8_A1.3671.00
53_A64_N1.3491.00
17_V72_P1.3321.00
6_F10_G1.3241.00
26_P34_Q1.3181.00
22_S35_L1.3121.00
68_N72_P1.2341.00
13_R71_E1.1121.00
42_F61_A1.1001.00
20_V25_L1.0831.00
13_R70_L1.0681.00
17_V61_A1.0511.00
62_F71_E1.0501.00
29_F32_A1.0411.00
17_V42_F1.0331.00
64_N72_P1.0221.00
44_L64_N0.9931.00
55_T60_A0.9881.00
2_T5_A0.9791.00
8_A13_R0.9741.00
22_S39_L0.9561.00
9_L47_A0.9521.00
16_Y65_A0.9501.00
52_L65_A0.9371.00
44_L55_T0.9341.00
35_L41_L0.9271.00
10_G47_A0.9261.00
11_G14_I0.9030.99
3_P6_F0.9010.99
27_R32_A0.8750.99
15_A44_L0.8710.99
31_Q53_A0.8690.99
58_R74_S0.8650.99
21_R39_L0.8540.99
19_P74_S0.8530.99
53_A61_A0.8500.99
15_A70_L0.8250.99
26_P31_Q0.8160.99
16_Y45_H0.8150.99
12_G47_A0.8140.99
25_L33_P0.8120.99
66_R71_E0.8050.99
35_L38_G0.8020.99
41_L65_A0.8020.99
45_H51_P0.7960.99
25_L54_L0.7890.99
44_L70_L0.7830.99
17_V62_F0.7390.98
16_Y61_A0.7390.98
50_T56_D0.7360.98
62_F72_P0.7350.98
29_F54_L0.7340.98
63_A66_R0.7310.98
14_I51_P0.7190.97
43_A54_L0.7170.97
11_G48_D0.7150.97
32_A37_P0.7130.97
10_G46_A0.7120.97
20_V28_L0.7010.97
42_F45_H0.6880.97
20_V54_L0.6870.97
24_D27_R0.6860.97
42_F55_T0.6750.96
66_R69_D0.6640.96
55_T64_N0.6530.96
65_A73_V0.6480.95
11_G65_A0.6380.95
33_P36_P0.6380.95
32_A35_L0.6320.95
4_E53_A0.6280.95
67_Q72_P0.6250.94
19_P42_F0.6200.94
60_A64_N0.6170.94
20_V43_A0.6170.94
10_G59_E0.6100.94
43_A51_P0.6030.93
31_Q34_Q0.6000.93
59_E63_A0.5830.92
5_A27_R0.5810.92
3_P52_L0.5790.92
25_L31_Q0.5770.92
68_N73_V0.5640.91
15_A25_L0.5530.90
27_R33_P0.5400.89
46_A70_L0.5350.88
18_R71_E0.5300.88
11_G52_L0.5300.88
18_R38_G0.5180.87
25_L32_A0.5170.87
35_L73_V0.5060.86
36_P48_D0.5020.85
42_F53_A0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oi3A 2 0.8289 30.4 0.859 Contact Map
1vbiA 2 0.9605 22.7 0.868 Contact Map
1wtjA 2 0.9737 22.6 0.868 Contact Map
2x06A 2 0.9737 21.1 0.87 Contact Map
2g8yA 2 0.9737 19.1 0.872 Contact Map
1v9nA 2 0.9737 18.7 0.873 Contact Map
3i0pA 2 0.9737 17.4 0.874 Contact Map
1z2iA 2 0.9737 15.9 0.877 Contact Map
4h8aA 2 0.9737 15.8 0.877 Contact Map
3uoeA 2 0.9737 15.8 0.877 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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