GREMLIN Database
DUF1145 - Protein of unknown function (DUF1145)
PFAM: PF06611 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 58 (56)
Sequences: 713 (401)
Seq/√Len: 53.6
META: 0.628

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_V37_G4.7651.00
20_N24_P4.0411.00
11_L15_L2.6571.00
20_N23_H1.9271.00
16_V33_L1.8700.99
37_G41_L1.8380.99
13_F37_G1.7670.99
20_N34_N1.6510.99
6_G10_T1.4630.97
43_M47_E1.4580.97
27_G30_A1.4550.97
25_F30_A1.4380.96
34_N38_A1.3900.96
20_N25_F1.3860.96
2_L7_K1.3500.95
45_L49_L1.3410.95
28_P36_A1.3380.95
46_L50_L1.3320.95
25_F33_L1.2330.92
28_P39_F1.2060.91
51_F57_G1.1190.87
11_L22_F1.1030.87
9_L15_L1.0650.85
33_L51_F1.0460.84
12_L49_L1.0380.83
17_V40_L1.0190.82
52_K56_K1.0160.82
13_F17_V0.9710.79
42_L50_L0.9590.78
32_L39_F0.9450.77
10_T40_L0.9410.77
5_L8_L0.9400.77
31_L34_N0.9330.76
33_L37_G0.8880.72
13_F41_L0.8840.72
37_G47_E0.8740.71
3_I39_F0.8730.71
35_L40_L0.8710.71
8_L25_F0.8700.71
22_F27_G0.8490.69
32_L36_A0.8360.68
13_F40_L0.8060.65
31_L39_F0.8030.65
8_L12_L0.7500.59
6_G16_V0.7490.59
21_L31_L0.7480.59
13_F47_E0.7390.58
47_E54_K0.7290.57
4_G39_F0.7250.57
38_A42_L0.7120.55
3_I53_G0.7050.55
26_P35_L0.6960.54
11_L26_P0.6860.53
5_L18_L0.6850.52
18_L21_L0.6800.52
49_L53_G0.6770.52
13_F33_L0.6730.51
7_K40_L0.6640.50
29_L48_L0.6610.50
5_L16_V0.6440.48
46_L53_G0.6440.48
15_L35_L0.6330.47
11_L23_H0.6180.45
10_T13_F0.6120.45
19_L26_P0.6110.45
34_N45_L0.6020.44
48_L56_K0.6000.43
54_K57_G0.5960.43
3_I38_A0.5930.43
36_A55_L0.5770.41
12_L19_L0.5620.40
31_L35_L0.5550.39
12_L16_V0.5540.39
2_L12_L0.5520.39
3_I11_L0.5470.38
35_L47_E0.5340.37
26_P41_L0.5310.36
17_V48_L0.5300.36
17_V47_E0.5280.36
11_L55_L0.5170.35
23_H27_G0.5150.35
2_L53_G0.5090.34
2_L46_L0.5020.34
7_K44_H0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lidA 3 0.2414 1.4 0.889 Contact Map
4mndA 2 0.931 1.4 0.89 Contact Map
4e6zA 1 0 1.2 0.893 Contact Map
4gbaF 1 0.1379 0.8 0.906 Contact Map
4u0cA 3 0.6552 0.7 0.91 Contact Map
2b2hA 3 0.5862 0.7 0.91 Contact Map
2kncA 1 0.7241 0.7 0.91 Contact Map
4p6vB 1 0.931 0.7 0.911 Contact Map
2xdeA 1 0.6552 0.7 0.912 Contact Map
1jb0K 1 0.2931 0.6 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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