GREMLIN Database
DUF1134 - Protein of unknown function (DUF1134)
PFAM: PF06577 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 160 (159)
Sequences: 2561 (1135)
Seq/√Len: 90.0
META: 0.906

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_P101_A4.1901.00
91_M131_L3.5411.00
50_F82_F3.4291.00
113_A142_L3.2771.00
30_A121_V3.1851.00
39_G61_L3.0451.00
124_L151_F2.8081.00
58_E70_K2.7971.00
100_D153_R2.7451.00
104_Q126_A2.6721.00
125_R130_V2.4901.00
19_T136_S2.4671.00
29_K33_D2.4571.00
12_G23_L2.2501.00
4_S7_E2.2441.00
152_T156_T2.1971.00
26_V119_F2.1711.00
150_K156_T2.0591.00
21_E25_S2.0571.00
39_G63_T2.0371.00
8_I31_F2.0201.00
6_D10_D1.9781.00
123_Y132_A1.9521.00
28_E36_R1.9391.00
140_L144_A1.9061.00
106_F129_V1.8641.00
131_L151_F1.7931.00
25_S28_E1.7591.00
155_P158_N1.6641.00
51_V82_F1.6551.00
51_V78_I1.6551.00
63_T66_A1.6401.00
69_R103_Y1.6291.00
11_A14_G1.6011.00
125_R128_D1.5911.00
115_F140_L1.5701.00
119_F134_I1.5641.00
8_I27_I1.5461.00
38_N63_T1.5431.00
26_V121_V1.5131.00
91_M149_L1.4691.00
27_I134_I1.4460.99
91_M151_F1.4370.99
44_E58_E1.4180.99
60_T68_D1.3310.99
60_T70_K1.3300.99
113_A140_L1.3070.99
29_K32_S1.3040.99
26_V30_A1.3000.99
109_V112_S1.2950.99
31_F36_R1.2870.99
4_S36_R1.2660.99
96_L129_V1.2370.98
36_R64_K1.1930.98
10_D14_G1.1900.98
95_N130_V1.1900.98
63_T99_T1.1860.98
42_L62_Y1.1770.98
20_S136_S1.1550.97
18_K22_G1.1490.97
74_Q152_T1.1460.97
69_R99_T1.1450.97
137_G143_G1.1390.97
101_A104_Q1.1330.97
85_N117_G1.1200.97
98_D101_A1.1020.96
152_T155_P1.1020.96
71_V102_I1.0630.96
104_Q129_V1.0420.95
66_A69_R1.0340.95
150_K158_N1.0300.95
16_F20_S1.0180.94
112_S120_G0.9960.94
9_V13_H0.9840.93
5_E12_G0.9810.93
85_N110_E0.9780.93
38_N97_P0.9770.93
13_H18_K0.9710.93
34_Q130_V0.9700.93
21_E34_Q0.9690.93
26_V29_K0.9610.93
2_T36_R0.9600.93
38_N96_L0.9500.92
40_Y62_Y0.9340.91
62_Y68_D0.9300.91
15_F42_L0.9230.91
109_V125_R0.9170.91
96_L101_A0.9090.90
71_V103_Y0.9060.90
63_T67_G0.8880.89
108_G122_T0.8850.89
5_E28_E0.8840.89
32_S154_K0.8600.88
126_A150_K0.8590.88
65_N68_D0.8480.87
30_A34_Q0.8430.87
18_K23_L0.8290.86
12_G27_I0.8260.86
25_S39_G0.8220.85
13_H22_G0.8120.85
58_E155_P0.8080.84
61_L64_K0.8020.84
42_L60_T0.7840.82
106_F126_A0.7830.82
16_F22_G0.7770.82
115_F142_L0.7660.81
86_G138_V0.7560.80
31_F34_Q0.7540.80
3_Y62_Y0.7530.80
107_P124_L0.7480.79
22_G25_S0.7430.79
61_L96_L0.7380.78
13_H88_R0.7360.78
86_G90_F0.7330.78
143_G148_Y0.7300.78
13_H21_E0.7300.78
19_T22_G0.7280.78
104_Q127_G0.7270.77
20_S24_A0.7240.77
3_Y6_D0.7240.77
73_W76_P0.7230.77
132_A137_G0.7220.77
58_E74_Q0.7220.77
34_Q123_Y0.7210.77
69_R100_D0.7200.77
109_V122_T0.7160.76
104_Q110_E0.7050.75
20_S25_S0.7040.75
20_S23_L0.7040.75
5_E9_V0.7000.75
101_A129_V0.6990.75
61_L71_V0.6920.74
38_N58_E0.6920.74
137_G141_R0.6910.74
133_P137_G0.6900.74
11_A42_L0.6860.73
10_D13_H0.6800.73
65_N69_R0.6770.72
74_Q158_N0.6710.72
48_G84_G0.6670.71
61_L102_I0.6650.71
26_V41_I0.6640.71
63_T102_I0.6620.71
110_E122_T0.6620.71
96_L130_V0.6590.70
14_G18_K0.6590.70
47_S52_V0.6580.70
69_R153_R0.6540.70
85_N112_S0.6530.70
45_E73_W0.6470.69
7_E11_A0.6460.69
5_E10_D0.6450.69
43_G73_W0.6430.68
6_D9_V0.6400.68
31_F119_F0.6390.68
107_P125_R0.6390.68
87_S114_Y0.6360.68
55_R78_I0.6360.68
149_L160_F0.6340.67
128_D154_K0.6250.66
122_T151_F0.6210.66
74_Q156_T0.6210.66
2_T6_D0.6200.66
152_T158_N0.6100.64
110_E135_R0.6090.64
40_Y46_G0.6060.64
6_D89_T0.6060.64
41_I71_V0.6050.64
11_A26_V0.6030.63
13_H19_T0.6020.63
65_N99_T0.6020.63
71_V96_L0.6000.63
38_N66_A0.5980.63
55_R117_G0.5920.62
108_G146_V0.5910.62
43_G92_L0.5890.62
102_I151_F0.5890.62
18_K21_E0.5880.62
80_F144_A0.5880.62
10_D18_K0.5850.61
74_Q108_G0.5850.61
26_V31_F0.5840.61
53_G57_G0.5770.60
4_S10_D0.5760.60
7_E64_K0.5760.60
74_Q150_K0.5740.60
63_T113_A0.5730.60
136_S139_G0.5720.59
42_L58_E0.5700.59
90_F123_Y0.5700.59
8_I12_G0.5670.59
45_E110_E0.5650.58
39_G96_L0.5630.58
129_V133_P0.5620.58
101_A128_D0.5620.58
58_E72_Y0.5620.58
12_G90_F0.5570.57
157_W160_F0.5540.57
6_D13_H0.5500.56
6_D11_A0.5480.56
35_G76_P0.5450.56
78_I82_F0.5450.56
23_L119_F0.5450.56
146_V154_K0.5430.56
8_I14_G0.5420.55
73_W92_L0.5390.55
4_S14_G0.5380.55
85_N124_L0.5360.55
113_A117_G0.5350.54
17_G28_E0.5350.54
31_F87_S0.5330.54
12_G150_K0.5320.54
9_V14_G0.5320.54
84_G140_L0.5310.54
153_R157_W0.5300.54
47_S84_G0.5290.54
135_R141_R0.5290.54
56_Y81_D0.5280.53
114_Y120_G0.5250.53
46_G74_Q0.5190.52
116_V140_L0.5180.52
63_T69_R0.5170.52
150_K155_P0.5160.52
123_Y126_A0.5160.52
41_I74_Q0.5150.52
85_N114_Y0.5110.51
154_K158_N0.5110.51
80_F84_G0.5080.51
62_Y89_T0.5070.51
46_G62_Y0.5050.50
137_G148_Y0.5040.50
38_N67_G0.5020.50
98_D153_R0.5010.50
12_G19_T0.5010.50
7_E10_D0.5010.50
102_I124_L0.5000.50
106_F130_V0.5000.50
8_I157_W0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v7yA 1 0.525 8 0.957 Contact Map
4jneA 2 0.5 7.8 0.957 Contact Map
3d00A 2 0.6375 6 0.959 Contact Map
4m7xA 2 0.4562 5.8 0.959 Contact Map
1jcuA 1 0.3438 5.6 0.96 Contact Map
4opeA 2 0.8438 4.8 0.961 Contact Map
1k7jA 1 0.35 4.4 0.962 Contact Map
2i3sB 1 0.1187 4.3 0.962 Contact Map
2itmA 2 0.5062 4.1 0.962 Contact Map
2c1xA 1 0.35 3.8 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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