GREMLIN Database
ABC_trans_CmpB - Putative ABC-transporter type IV
PFAM: PF06541 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 148 (146)
Sequences: 6773 (5474)
Seq/√Len: 453.1
META: 0.814

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_Y91_N3.7471.00
62_T99_S3.7021.00
86_K97_L3.6231.00
57_G106_G3.4351.00
73_E93_R3.0171.00
6_Y114_H2.9531.00
69_G93_R2.8061.00
36_F139_L2.2411.00
95_C98_F2.1071.00
58_A99_S2.0771.00
54_F103_G2.0261.00
98_F102_W1.9881.00
58_A103_G1.9321.00
66_Y90_I1.8991.00
71_L75_L1.8771.00
88_F96_L1.8711.00
108_L112_F1.8051.00
33_Y146_L1.7861.00
15_V19_S1.7061.00
72_L80_W1.6791.00
98_F101_F1.6741.00
36_F140_F1.6061.00
97_L101_F1.5511.00
66_Y93_R1.5471.00
8_F36_F1.5451.00
107_L111_Y1.5441.00
73_E79_R1.5021.00
13_L17_Y1.5011.00
13_L105_L1.4891.00
19_S25_F1.4781.00
70_W74_K1.4491.00
126_P130_K1.4411.00
47_I106_G1.4401.00
2_L121_I1.4241.00
6_Y44_A1.4201.00
125_P128_L1.4151.00
62_T94_I1.4011.00
4_F137_L1.3871.00
118_E122_E1.3681.00
128_L131_I1.3581.00
89_N92_G1.3511.00
127_K131_I1.3211.00
116_L120_L1.3021.00
90_I94_I1.2881.00
48_L114_H1.2871.00
54_F107_L1.2831.00
46_L64_L1.2821.00
129_G133_A1.2671.00
18_C22_E1.2611.00
17_Y21_K1.2561.00
11_W37_C1.2561.00
53_L111_Y1.2481.00
100_L104_L1.2371.00
7_S36_F1.2351.00
15_V28_N1.2211.00
13_L98_F1.2201.00
63_V67_I1.2091.00
134_I138_V1.2061.00
54_F58_A1.1891.00
39_I68_T1.1841.00
44_A109_L1.1811.00
70_W93_R1.1661.00
53_L57_G1.1651.00
130_K134_I1.1621.00
69_G91_N1.1381.00
18_C29_R1.1361.00
15_V25_F1.1311.00
13_L101_F1.1281.00
86_K95_C1.1211.00
43_G61_A1.1181.00
64_L68_T1.1131.00
2_L114_H1.0911.00
17_Y98_F1.0641.00
7_S41_G1.0531.00
1_L133_A1.0481.00
5_I121_I1.0481.00
19_S22_E1.0341.00
2_L118_E1.0301.00
58_A61_A1.0291.00
12_I16_I1.0241.00
140_F143_D1.0241.00
44_A107_L1.0021.00
30_G38_P0.9971.00
61_A106_G0.9941.00
140_F144_F0.9881.00
131_I135_I0.9861.00
68_T72_L0.9841.00
70_W91_N0.9701.00
116_L119_K0.9661.00
94_I99_S0.9531.00
7_S37_C0.9431.00
72_L78_A0.9381.00
4_F136_L0.9371.00
56_L60_L0.9301.00
62_T90_I0.8981.00
29_R37_C0.8981.00
42_F46_L0.8921.00
79_R82_D0.8871.00
133_A137_L0.8801.00
1_L129_G0.8751.00
22_E26_V0.8731.00
137_L141_L0.8721.00
42_F140_F0.8721.00
47_I61_A0.8661.00
55_L58_A0.8631.00
114_H118_E0.8421.00
130_K133_A0.8211.00
101_F105_L0.8151.00
4_F36_F0.7961.00
42_F144_F0.7921.00
9_L13_L0.7921.00
65_E83_Y0.7831.00
69_G74_K0.7711.00
2_L6_Y0.7681.00
67_I70_W0.7681.00
39_I64_L0.7661.00
55_L59_I0.7521.00
79_R84_S0.7451.00
69_G73_E0.7441.00
57_G61_A0.7411.00
128_L132_L0.7401.00
53_L110_V0.7321.00
11_W28_N0.7291.00
67_I71_L0.7281.00
37_C40_Y0.7181.00
8_F12_I0.7141.00
51_L56_L0.7131.00
86_K98_F0.7081.00
79_R92_G0.7061.00
19_S23_G0.7001.00
43_G64_L0.6941.00
45_V49_L0.6911.00
6_Y48_L0.6911.00
97_L100_L0.6881.00
51_L57_G0.6871.00
15_V29_R0.6821.00
125_P129_G0.6821.00
50_L60_L0.6771.00
5_I117_L0.6741.00
61_A102_W0.6711.00
131_I134_I0.6681.00
87_P96_L0.6671.00
32_L144_F0.6671.00
57_G110_V0.6651.00
138_V142_I0.6641.00
88_F97_L0.6641.00
142_I146_L0.6591.00
52_L56_L0.6591.00
4_F133_A0.6591.00
135_I139_L0.6551.00
108_L113_I0.6491.00
57_G107_L0.6481.00
14_E65_E0.6370.99
124_I129_G0.6370.99
13_L16_I0.6370.99
3_F38_P0.6230.99
66_Y70_W0.6180.99
141_L145_I0.6130.99
4_F140_F0.6130.99
85_D89_N0.6080.99
119_K122_E0.6040.99
134_I137_L0.6030.99
139_L143_D0.6030.99
70_W75_L0.6010.99
48_L109_L0.6010.99
18_C21_K0.5940.99
70_W73_E0.5930.99
44_A105_L0.5930.99
121_I129_G0.5910.99
28_N37_C0.5910.99
122_E129_G0.5870.99
18_C26_V0.5810.99
87_P97_L0.5800.99
11_W15_V0.5790.99
120_L123_K0.5790.99
124_I128_L0.5740.99
48_L118_E0.5710.99
101_F104_L0.5680.99
132_L136_L0.5660.99
89_N95_C0.5640.99
39_I42_F0.5620.99
102_W129_G0.5620.99
54_F61_A0.5590.99
42_F49_L0.5570.99
28_N31_F0.5560.99
62_T102_W0.5550.99
83_Y102_W0.5480.98
132_L135_I0.5460.98
34_G143_D0.5450.98
15_V37_C0.5360.98
16_I20_I0.5360.98
118_E121_I0.5350.98
36_F136_L0.5340.98
105_L109_L0.5340.98
71_L74_K0.5310.98
139_L142_I0.5290.98
120_L124_I0.5260.98
57_G103_G0.5250.98
15_V18_C0.5200.98
103_G107_L0.5170.98
130_K137_L0.5170.98
90_I93_R0.5170.98
113_I116_L0.5150.98
37_C80_W0.5150.98
12_I15_V0.5140.98
12_I37_C0.5140.98
31_F72_L0.5130.98
104_L108_L0.5100.97
127_K130_K0.5090.97
39_I65_E0.5080.97
126_P131_I0.5040.97
109_L114_H0.5040.97
112_F116_L0.5040.97
82_D92_G0.5030.97
21_K98_F0.5010.97
58_A94_I0.5010.97
19_S26_V0.5010.97
120_L126_P0.5000.97
18_C98_F0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b9uA 1 0.2297 4.4 0.936 Contact Map
1orqC 4 0.4054 1.1 0.954 Contact Map
4ymuD 2 0.4392 0.9 0.956 Contact Map
3mp7B 1 0.1554 0.9 0.956 Contact Map
3b5xA 2 0.473 0.9 0.957 Contact Map
1dtcA 1 0.0608 0.9 0.957 Contact Map
4tkrA 2 0.6622 0.8 0.957 Contact Map
4tzcC 1 0.2432 0.8 0.957 Contact Map
4a82A 2 0.473 0.8 0.958 Contact Map
3b60A 2 0.4865 0.8 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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