GREMLIN Database
DUF1109 - Protein of unknown function (DUF1109)
PFAM: PF06532 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 203 (201)
Sequences: 7298 (5784)
Seq/√Len: 408.0
META: 0.899

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_S189_V3.4531.00
177_F182_H3.4181.00
151_G193_G3.0731.00
135_L154_A2.6221.00
152_A190_A2.4281.00
148_A198_R2.4001.00
139_L154_A2.3901.00
156_L190_A2.3401.00
148_A194_A2.3001.00
196_L200_L2.2401.00
11_L14_P2.2381.00
22_A26_A2.2251.00
72_A142_G2.2211.00
146_R149_L2.1081.00
197_G201_L2.1081.00
65_A157_A2.1061.00
90_L93_W2.1031.00
2_A5_L1.9661.00
57_T164_T1.9391.00
112_L180_V1.8631.00
22_A29_A1.8351.00
170_C177_F1.8351.00
65_A69_L1.7981.00
71_L150_A1.7801.00
135_L157_A1.7681.00
61_A161_L1.7641.00
125_L189_V1.7221.00
155_G159_G1.7031.00
159_G186_I1.6961.00
119_V169_H1.6281.00
73_R76_R1.6171.00
86_A90_L1.6001.00
55_A59_A1.5981.00
44_A47_T1.5601.00
8_V11_L1.5601.00
54_L57_T1.5551.00
12_A16_R1.5521.00
112_L116_S1.5431.00
88_P92_L1.5301.00
37_L41_L1.5021.00
104_P107_G1.4761.00
166_Y182_H1.4511.00
14_P17_R1.4191.00
53_K57_T1.4181.00
53_K182_H1.4041.00
71_L74_P1.3821.00
42_A45_L1.3651.00
130_P134_A1.3581.00
74_P77_S1.3421.00
54_L167_A1.3401.00
131_P162_G1.3391.00
40_D44_A1.3351.00
191_A194_A1.3341.00
124_I166_Y1.3301.00
80_R83_L1.3241.00
104_P108_W1.3181.00
72_A139_L1.3161.00
191_A195_L1.3131.00
20_L24_A1.3081.00
24_A27_A1.2971.00
71_L153_A1.2891.00
26_A29_A1.2811.00
62_V65_A1.2801.00
11_L17_R1.2781.00
108_W111_L1.2701.00
38_R41_L1.2671.00
13_P16_R1.2631.00
131_P165_A1.2581.00
132_L136_L1.2581.00
13_P17_R1.2431.00
28_L31_V1.2341.00
69_L73_R1.2321.00
106_A109_A1.2001.00
86_A93_W1.1811.00
109_A113_L1.1801.00
187_A191_A1.1741.00
152_A194_A1.1721.00
45_L48_P1.1711.00
166_Y169_H1.1681.00
12_A18_A1.1571.00
151_G155_G1.1501.00
93_W97_L1.1441.00
62_V66_A1.1351.00
129_L133_A1.1341.00
22_A25_L1.1321.00
21_L25_L1.1301.00
120_C170_C1.1301.00
75_G145_T1.1271.00
95_A99_E1.1221.00
108_W112_L1.1161.00
98_G102_A1.1151.00
158_A162_G1.1131.00
132_L189_V1.1121.00
177_F185_A1.1051.00
20_L27_A1.1021.00
43_A46_A1.0961.00
54_L164_T1.0941.00
121_L125_L1.0921.00
164_T168_L1.0901.00
26_A30_L1.0741.00
114_G117_W1.0731.00
137_W141_R1.0691.00
147_P198_R1.0671.00
15_R18_A1.0621.00
144_P150_A1.0491.00
58_L164_T1.0421.00
178_V181_W1.0281.00
16_R19_L1.0271.00
113_L116_S1.0231.00
166_Y177_F1.0201.00
172_E177_F1.0181.00
70_R76_R1.0171.00
91_L95_A1.0151.00
110_A114_G1.0111.00
130_P133_A1.0071.00
107_G111_L0.9891.00
19_L22_A0.9821.00
66_A70_R0.9811.00
111_L115_H0.9791.00
82_W86_A0.9771.00
68_A139_L0.9741.00
131_P161_L0.9671.00
137_W140_R0.9611.00
105_P108_W0.9561.00
194_A198_R0.9541.00
132_L193_G0.9531.00
198_R202_R0.9321.00
92_L96_A0.9301.00
5_L8_V0.9291.00
105_P109_A0.9181.00
113_L117_W0.9161.00
160_A164_T0.9151.00
57_T163_A0.9111.00
60_L63_A0.9101.00
56_L183_G0.9101.00
67_A153_A0.9051.00
107_G112_L0.8911.00
103_A107_G0.8871.00
22_A34_A0.8871.00
100_L108_W0.8841.00
9_R12_A0.8731.00
64_A160_A0.8721.00
10_P13_P0.8681.00
163_A167_A0.8611.00
132_L158_A0.8581.00
186_I189_V0.8571.00
124_I162_G0.8541.00
121_L188_L0.8501.00
53_K56_L0.8381.00
123_L169_H0.8381.00
12_A17_R0.8371.00
70_R75_G0.8341.00
38_R44_A0.8331.00
91_L94_L0.8281.00
192_L196_L0.8271.00
23_G26_A0.8261.00
52_L56_L0.8251.00
120_C182_H0.8201.00
57_T64_A0.8121.00
100_L103_A0.8111.00
154_A158_A0.8101.00
111_L116_S0.8091.00
136_L200_L0.8091.00
172_E185_A0.8031.00
103_A111_L0.8021.00
123_L126_L0.7961.00
68_A157_A0.7941.00
40_D43_A0.7941.00
14_P18_A0.7941.00
119_V123_L0.7931.00
24_A28_L0.7921.00
43_A47_T0.7891.00
167_A173_D0.7861.00
111_L114_G0.7851.00
60_L160_A0.7831.00
77_S80_R0.7821.00
41_L45_L0.7761.00
78_L82_W0.7741.00
127_L162_G0.7671.00
85_L95_A0.7511.00
29_A33_A0.7491.00
68_A72_A0.7491.00
48_P51_W0.7481.00
21_L24_A0.7461.00
124_I163_A0.7431.00
121_L124_I0.7411.00
88_P95_A0.7411.00
12_A15_R0.7381.00
177_F181_W0.7361.00
107_G110_A0.7351.00
84_L88_P0.7351.00
45_L49_R0.7311.00
32_L37_L0.7281.00
182_H185_A0.7281.00
190_A193_G0.7261.00
77_S81_R0.7251.00
184_L187_A0.7231.00
42_A46_A0.7221.00
155_G193_G0.7211.00
167_A178_V0.7211.00
72_A77_S0.7201.00
64_A68_A0.7171.00
167_A182_H0.7131.00
57_T60_L0.7121.00
31_V165_A0.7101.00
139_L150_A0.6981.00
180_V183_G0.6981.00
33_A37_L0.6971.00
11_L15_R0.6941.00
93_W99_E0.6931.00
85_L89_A0.6891.00
14_P19_L0.6881.00
53_K167_A0.6871.00
94_L98_G0.6831.00
23_G27_A0.6791.00
72_A76_R0.6770.99
109_A112_L0.6740.99
31_V34_A0.6700.99
114_G118_R0.6680.99
16_R141_R0.6670.99
164_T167_A0.6650.99
85_L92_L0.6630.99
186_I190_A0.6560.99
124_I185_A0.6560.99
124_I189_V0.6480.99
22_A27_A0.6450.99
70_R77_S0.6440.99
75_G78_L0.6410.99
94_L97_L0.6410.99
116_S172_E0.6390.99
99_E108_W0.6390.99
60_L186_I0.6390.99
53_K166_Y0.6380.99
31_V35_L0.6380.99
39_P44_A0.6360.99
151_G197_G0.6350.99
55_A58_L0.6240.99
169_H172_E0.6230.99
63_A66_A0.6200.99
159_G193_G0.6180.99
49_R52_L0.6180.99
88_P96_A0.6140.99
118_R122_L0.6060.99
41_L50_F0.6060.99
64_A156_L0.6050.99
108_W116_S0.6050.99
88_P91_L0.6020.99
35_L123_L0.5980.99
184_L188_L0.5960.99
71_L75_G0.5920.99
25_L28_L0.5920.99
122_L126_L0.5910.99
126_L130_P0.5900.99
184_L191_A0.5900.99
150_A154_A0.5900.99
174_S177_F0.5900.99
72_A75_G0.5890.99
59_A63_A0.5850.99
95_A98_G0.5850.99
110_A113_L0.5800.98
166_Y170_C0.5730.98
185_A189_V0.5720.98
143_A181_W0.5710.98
121_L181_W0.5700.98
52_L55_A0.5660.98
13_P18_A0.5620.98
48_P52_L0.5600.98
81_R88_P0.5590.98
104_P112_L0.5570.98
5_L10_P0.5570.98
21_L27_A0.5570.98
45_L50_F0.5550.98
2_A6_R0.5540.98
37_L42_A0.5540.98
99_E102_A0.5520.98
170_C182_H0.5470.98
21_L32_L0.5470.98
147_P150_A0.5460.98
170_C175_P0.5430.98
139_L142_G0.5390.98
91_L97_L0.5370.97
78_L81_R0.5360.97
133_A155_G0.5300.97
90_L94_L0.5280.97
37_L44_A0.5270.97
149_L152_A0.5260.97
90_L103_A0.5240.97
153_A157_A0.5240.97
71_L76_R0.5200.97
83_L87_L0.5190.97
50_F53_K0.5170.97
181_W184_L0.5140.97
98_G101_L0.5100.97
124_I128_S0.5100.97
129_L162_G0.5090.97
11_L19_L0.5060.96
10_P14_P0.5040.96
104_P116_S0.5020.96
50_F58_L0.5020.96
15_R19_L0.5010.96
112_L115_H0.5000.96
123_L127_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u7gA 3 0.9655 6 0.934 Contact Map
2b2hA 3 0.9606 3.9 0.94 Contact Map
4djkA 2 0.9606 2 0.948 Contact Map
4zw9A 1 0.8966 2 0.949 Contact Map
3orgA 2 0.3153 1.7 0.95 Contact Map
2wswA 3 0.3448 1.5 0.952 Contact Map
2ls4A 1 0.1084 1.5 0.952 Contact Map
1iijA 1 0.1724 1.4 0.953 Contact Map
4pypA 1 0.8818 1.4 0.953 Contact Map
3l1lA 2 0.931 1.3 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0079 seconds.