GREMLIN Database
TniQ - TniQ
PFAM: PF06527 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 137 (136)
Sequences: 9654 (8508)
Seq/√Len: 729.5
META: 0.773

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
108_A135_C4.9651.00
113_D119_R4.7211.00
20_A30_L2.6171.00
112_E132_K2.6061.00
10_E18_R2.5441.00
103_L118_W2.5101.00
106_C109_C2.2741.00
100_R104_R2.2591.00
64_E67_A2.2261.00
6_P15_Y2.2121.00
127_V131_P2.1751.00
108_A111_A2.0931.00
9_D121_L2.0401.00
6_P68_H2.0301.00
4_P19_L2.0251.00
11_S14_S1.9771.00
26_S29_E1.9691.00
119_R122_W1.9521.00
9_D120_R1.8971.00
105_Y110_L1.8761.00
105_Y118_W1.8661.00
121_L131_P1.8441.00
19_L23_N1.8041.00
110_L122_W1.7961.00
15_Y19_L1.7871.00
11_S123_Q1.7361.00
48_P51_L1.5961.00
9_D119_R1.5231.00
129_V136_L1.5171.00
61_S64_E1.5111.00
53_R57_L1.4601.00
4_P22_A1.4511.00
25_L30_L1.4021.00
19_L58_T1.3871.00
11_S103_L1.3871.00
107_P135_C1.3731.00
103_L123_Q1.3501.00
31_L35_G1.3481.00
54_L58_T1.3211.00
55_A62_P1.3141.00
3_R15_Y1.3021.00
40_R43_A1.2941.00
41_S44_D1.2871.00
121_L127_V1.2681.00
118_W123_Q1.2561.00
14_S118_W1.2521.00
30_L34_L1.2341.00
16_L31_L1.2271.00
60_L64_E1.1981.00
27_P30_L1.1881.00
53_R56_A1.1191.00
112_E133_H1.1041.00
128_T136_L1.0811.00
81_P85_L1.0781.00
55_A60_L1.0561.00
130_C133_H1.0521.00
30_L35_G1.0471.00
75_A78_L1.0341.00
11_S15_Y1.0331.00
25_L28_R1.0121.00
52_E56_A1.0121.00
110_L118_W1.0071.00
17_A21_A1.0051.00
11_S120_R1.0041.00
13_S103_L0.9951.00
13_S123_Q0.9871.00
77_M80_G0.9771.00
6_P9_D0.9721.00
15_Y68_H0.9691.00
104_R123_Q0.9651.00
112_E116_P0.9631.00
13_S17_A0.9611.00
55_A59_G0.9481.00
129_V134_G0.9461.00
86_R91_L0.9321.00
2_I22_A0.9281.00
55_A58_T0.9261.00
72_P120_R0.9261.00
15_Y65_L0.9201.00
40_R44_D0.9171.00
86_R89_L0.9031.00
70_L74_Y0.9021.00
70_L73_Y0.8961.00
69_T72_P0.8931.00
133_H137_L0.8711.00
91_L94_S0.8681.00
66_R71_L0.8661.00
118_W121_L0.8651.00
45_R48_P0.8621.00
2_I23_N0.8561.00
85_L93_L0.8511.00
43_A46_D0.8491.00
42_L45_R0.8361.00
8_P119_R0.8361.00
25_L29_E0.8351.00
80_G83_G0.8341.00
92_L95_R0.8291.00
12_L65_L0.8281.00
94_S97_G0.8281.00
17_A118_W0.8231.00
28_R33_D0.8141.00
113_D132_K0.8031.00
109_C133_H0.7971.00
88_L93_L0.7901.00
123_Q126_G0.7821.00
86_R94_S0.7821.00
62_P65_L0.7801.00
82_G87_L0.7761.00
71_L74_Y0.7761.00
114_G117_Y0.7731.00
27_P32_R0.7721.00
29_E33_D0.7721.00
11_S118_W0.7621.00
110_L113_D0.7571.00
4_P15_Y0.7341.00
19_L30_L0.7271.00
93_L96_R0.7221.00
17_A103_L0.7191.00
111_A115_E0.7141.00
63_E66_R0.7121.00
128_T131_P0.7111.00
52_E62_P0.7061.00
87_L92_L0.7051.00
55_A63_E0.7051.00
125_P128_T0.7011.00
45_R50_H0.6961.00
20_A23_N0.6951.00
68_H71_L0.6841.00
14_S123_Q0.6801.00
75_A79_L0.6791.00
27_P35_G0.6781.00
15_Y122_W0.6761.00
78_L82_G0.6691.00
47_L50_H0.6591.00
79_L87_L0.6571.00
122_W131_P0.6531.00
76_A81_P0.6531.00
69_T120_R0.6511.00
86_R95_R0.6461.00
3_R23_N0.6431.00
27_P31_L0.6411.00
43_A47_L0.6411.00
47_L51_L0.6401.00
119_R132_K0.6391.00
106_C133_H0.6381.00
67_A72_P0.6341.00
92_L97_G0.6341.00
84_R90_G0.6341.00
68_H73_Y0.6271.00
54_L65_L0.6251.00
76_A88_L0.6211.00
39_R43_A0.6191.00
3_R19_L0.6131.00
32_R38_R0.6131.00
79_L82_G0.6091.00
8_P117_Y0.5991.00
20_A27_P0.5961.00
87_L90_G0.5961.00
127_V137_L0.5921.00
92_L96_R0.5901.00
55_A65_L0.5751.00
114_G119_R0.5721.00
78_L85_L0.5691.00
60_L65_L0.5681.00
69_T73_Y0.5651.00
46_D49_L0.5641.00
75_A80_G0.5621.00
77_M81_P0.5571.00
69_T74_Y0.5561.00
55_A61_S0.5541.00
86_R90_G0.5521.00
113_D117_Y0.5491.00
65_L68_H0.5491.00
29_E32_R0.5481.00
116_P132_K0.5481.00
66_R69_T0.5471.00
11_S70_L0.5461.00
16_L118_W0.5401.00
120_R123_Q0.5391.00
78_L81_P0.5391.00
7_Y113_D0.5361.00
88_L91_L0.5341.00
12_L15_Y0.5341.00
31_L36_G0.5341.00
8_P132_K0.5331.00
14_S17_A0.5321.00
55_A64_E0.5311.00
99_R104_R0.5281.00
86_R97_G0.5241.00
82_G88_L0.5221.00
62_P66_R0.5211.00
87_L94_S0.5201.00
52_E55_A0.5191.00
39_R42_L0.5171.00
12_L69_T0.5111.00
25_L35_G0.5081.00
79_L85_L0.5081.00
46_D50_H0.5071.00
108_A112_E0.5061.00
44_D47_L0.5061.00
84_R88_L0.5010.99
80_G85_L0.5010.99
25_L32_R0.5000.99
91_L95_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ttcA 1 0.2774 8.1 0.899 Contact Map
4g9iA 1 0.9197 6.5 0.904 Contact Map
4pd2A 1 0.8978 5.6 0.907 Contact Map
5aj3p 1 0.5912 5 0.909 Contact Map
4kiyR 1 0.1679 4.2 0.912 Contact Map
1e5rA 2 0.6277 3.8 0.914 Contact Map
2kkeA 2 0.2847 3.7 0.915 Contact Map
3vthA 1 0.9489 3.2 0.917 Contact Map
3f2gA 1 0.8978 3.1 0.917 Contact Map
5c56A 1 0.5474 2.5 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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