GREMLIN Database
Na_trans_assoc - Sodium ion transport-associated
PFAM: PF06512 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 184 (184)
Sequences: 785 (498)
Seq/√Len: 36.7
META: 0.004

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_E115_S3.3971.00
112_E116_K3.2111.00
121_S125_T2.9461.00
40_E45_D2.9341.00
78_F81_N2.7241.00
148_P151_C2.6411.00
106_S109_S2.6131.00
67_K70_D2.5771.00
119_S122_E2.3551.00
121_S127_D2.3521.00
111_D115_S2.1640.99
110_S115_S2.1540.99
121_S124_S2.1210.99
40_E47_L2.0990.99
104_D107_S2.0900.99
43_P46_E2.0530.99
111_D116_K2.0510.99
58_I61_H1.9410.98
89_P94_E1.9340.98
63_G66_I1.9260.98
38_L41_K1.9210.98
110_S116_K1.8830.98
78_F82_P1.8390.97
41_K44_L1.8280.97
77_S81_N1.8160.97
113_E116_K1.7950.97
156_C162_C1.7630.97
91_A94_E1.7530.96
74_D77_S1.7470.96
157_V176_W1.6860.96
102_D105_E1.6790.96
64_A68_D1.6630.95
39_K42_K1.6560.95
111_D114_K1.6360.95
38_L43_P1.6200.95
103_E106_S1.6150.94
57_C61_H1.6140.94
176_W180_K1.5810.94
28_F33_L1.5580.93
104_D109_S1.5550.93
40_E44_L1.5280.93
1_D5_N1.4850.91
73_S76_M1.4750.91
91_A96_D1.4330.90
124_S127_D1.4190.89
40_E43_P1.4080.89
41_K45_D1.3990.89
110_S117_Q1.3980.89
47_L51_D1.3950.89
54_K61_H1.3590.87
13_R148_P1.3560.87
72_E76_M1.3510.87
77_S80_T1.3420.87
40_E46_E1.3070.85
34_K37_K1.2850.84
76_M79_I1.2620.83
119_S123_G1.2570.83
123_G143_E1.2550.83
54_K60_N1.2310.81
7_L156_C1.2280.81
104_D108_E1.2240.81
62_T65_E1.2050.80
41_K48_K1.1960.80
89_P182_C1.1950.79
102_D106_S1.1910.79
111_D117_Q1.1830.79
39_K46_E1.1750.78
137_E140_E1.1530.77
54_K57_C1.1490.77
16_R166_D1.1470.77
176_W182_C1.1450.76
101_E106_S1.1260.75
6_N91_A1.1190.75
82_P85_T1.1100.74
37_K41_K1.1040.74
39_K45_D1.0950.73
39_K43_P1.0860.73
66_I69_L1.0850.72
12_A183_Y1.0830.72
6_N12_A1.0820.72
75_H78_F1.0650.71
103_E108_E1.0540.70
8_Q94_E1.0500.70
35_K38_L1.0440.70
91_A98_E1.0350.69
175_W179_R1.0270.68
55_E60_N1.0270.68
167_I170_G1.0250.68
94_E182_C1.0170.67
110_S114_K1.0170.67
157_V164_Q1.0150.67
120_S184_R1.0080.67
12_A126_V1.0050.67
21_V25_I1.0040.66
56_N61_H0.9910.65
81_N86_V0.9880.65
85_T97_L0.9870.65
42_K45_D0.9860.65
41_K47_L0.9840.65
78_F86_V0.9830.65
61_H66_I0.9820.65
163_C176_W0.9780.64
41_K46_E0.9680.64
149_E166_D0.9680.64
62_T67_K0.9590.63
20_F24_T0.9560.63
61_H64_A0.9520.62
64_A67_K0.9500.62
4_M183_Y0.9450.62
95_S98_E0.9430.62
35_K183_Y0.9370.61
6_N17_G0.9330.61
15_Q19_D0.9320.61
100_L103_E0.9270.60
161_P166_D0.9220.60
7_L13_R0.9170.59
122_E133_E0.9170.59
36_K41_K0.9160.59
107_S116_K0.9040.58
135_L138_I0.9040.58
39_K44_L0.8970.58
93_G103_E0.8940.57
89_P125_T0.8880.57
82_P152_F0.8860.57
17_G175_W0.8800.56
91_A124_S0.8710.55
173_K184_R0.8630.55
42_K47_L0.8620.55
165_V168_T0.8540.54
135_L139_E0.8480.53
94_E124_S0.8470.53
81_N84_L0.8420.53
157_V165_V0.8370.52
26_L30_C0.8360.52
82_P86_V0.8350.52
79_I82_P0.8300.52
171_P177_N0.8290.52
155_G163_C0.8260.51
175_W182_C0.8250.51
151_C179_R0.8200.51
44_L47_L0.8190.51
38_L48_K0.8160.51
24_T159_R0.8150.51
101_E109_S0.8140.50
155_G158_R0.8120.50
133_E136_E0.8090.50
57_C60_N0.8020.49
8_Q182_C0.7960.49
56_N59_S0.7940.49
163_C183_Y0.7900.48
27_D33_L0.7900.48
78_F85_T0.7850.48
153_T184_R0.7820.48
157_V160_F0.7820.48
110_S113_E0.7800.47
170_G173_K0.7730.47
34_K41_K0.7670.46
25_I33_L0.7670.46
45_D48_K0.7650.46
49_D53_K0.7620.46
9_I181_T0.7610.46
120_S153_T0.7590.46
51_D62_T0.7560.45
35_K41_K0.7500.45
62_T66_I0.7490.45
53_K61_H0.7470.45
103_E109_S0.7400.44
163_C166_D0.7350.44
14_I17_G0.7230.42
91_A182_C0.7220.42
132_E135_L0.7210.42
102_D108_E0.7200.42
12_A16_R0.7200.42
21_V24_T0.7180.42
164_Q170_G0.7160.42
125_T182_C0.7110.41
43_P47_L0.7100.41
124_S182_C0.7100.41
113_E117_Q0.7100.41
89_P124_S0.7070.41
88_V95_S0.7050.41
15_Q163_C0.7030.41
29_C146_K0.7010.41
53_K59_S0.6960.40
125_T149_E0.6960.40
2_G144_E0.6920.40
43_P48_K0.6920.40
2_G75_H0.6910.40
24_T27_D0.6910.40
12_A17_G0.6820.39
8_Q11_I0.6810.39
57_C68_D0.6750.38
44_L86_V0.6740.38
62_T68_D0.6730.38
78_F97_L0.6720.38
150_D154_E0.6720.38
128_L131_P0.6640.38
167_I172_G0.6620.37
81_N85_T0.6580.37
45_D51_D0.6570.37
138_I141_E0.6450.36
57_C92_V0.6440.36
30_C144_E0.6410.36
73_S77_S0.6400.36
94_E180_K0.6400.36
126_V181_T0.6400.36
166_D169_K0.6390.35
39_K51_D0.6380.35
89_P96_D0.6360.35
56_N60_N0.6350.35
51_D54_K0.6300.35
22_K151_C0.6300.35
38_L46_E0.6290.35
53_K57_C0.6250.34
78_F84_L0.6240.34
52_S55_E0.6230.34
38_L45_D0.6190.34
91_A181_T0.6120.33
104_D112_E0.6110.33
33_L172_G0.6100.33
125_T181_T0.6080.33
6_N181_T0.6050.33
119_S163_C0.6040.33
5_N176_W0.6040.33
5_N86_V0.6010.32
48_K59_S0.5940.32
26_L33_L0.5920.32
74_D86_V0.5910.32
38_L44_L0.5900.32
177_N180_K0.5880.31
151_C156_C0.5790.31
36_K39_K0.5730.30
91_A125_T0.5710.30
39_K47_L0.5690.30
171_P174_I0.5640.30
16_R136_E0.5640.30
122_E131_P0.5630.30
36_K53_K0.5590.29
152_F158_R0.5590.29
140_E183_Y0.5580.29
100_L104_D0.5570.29
81_N101_E0.5570.29
10_A16_R0.5520.29
8_Q96_D0.5520.29
172_G175_W0.5520.29
165_V182_C0.5490.29
119_S128_L0.5440.28
169_K184_R0.5430.28
99_N128_L0.5420.28
46_E58_I0.5410.28
53_K60_N0.5380.28
42_K58_I0.5360.28
26_L172_G0.5360.28
8_Q89_P0.5340.28
44_L51_D0.5330.27
152_F165_V0.5320.27
6_N95_S0.5310.27
88_V101_E0.5310.27
129_K144_E0.5300.27
122_E127_D0.5290.27
131_P147_E0.5260.27
3_E7_L0.5260.27
22_K156_C0.5240.27
99_N102_D0.5220.27
105_E109_S0.5150.26
130_P145_S0.5140.26
7_L10_A0.5110.26
6_N10_A0.5100.26
128_L153_T0.5090.26
27_D30_C0.5080.26
9_I17_G0.5070.26
2_G15_Q0.5060.26
11_I48_K0.5050.26
53_K56_N0.5050.26
20_F155_G0.5020.25
4_M17_G0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lhrA 2 0.1957 11.2 0.95 Contact Map
2fi2A 2 0.2011 9.9 0.951 Contact Map
4bhxA 2 0.1957 9.3 0.952 Contact Map
4e6sA 2 0.1957 6.8 0.955 Contact Map
1y7qA 2 0.212 5.7 0.957 Contact Map
2msqA 1 0.125 5.6 0.957 Contact Map
2bezF 1 0.1196 3.8 0.96 Contact Map
3mwbA 3 0.3207 3.7 0.96 Contact Map
2k13X 1 0.2011 3.4 0.961 Contact Map
3j39U 1 0.3804 3 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0071 seconds.