GREMLIN Database
DUF1097 - Protein of unknown function (DUF1097)
PFAM: PF06496 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 147 (145)
Sequences: 2472 (1684)
Seq/√Len: 139.8
META: 0.793

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_A111_A3.5421.00
39_G42_G3.0081.00
9_G81_G2.8731.00
52_F90_L2.8691.00
32_C46_T2.7541.00
83_V106_F2.6511.00
74_L77_V2.6111.00
85_F89_L2.6001.00
63_L79_A2.3781.00
57_A109_T2.3271.00
28_I108_A2.1781.00
51_L129_I2.1551.00
28_I104_Y2.1021.00
24_W111_A2.1001.00
58_W125_L2.0981.00
50_N132_L2.0411.00
137_V141_L2.0211.00
32_C50_N1.9771.00
35_A104_Y1.9591.00
73_L76_A1.9311.00
74_L78_W1.9091.00
36_A98_F1.9001.00
33_Y143_E1.7801.00
43_L136_A1.7661.00
72_G76_A1.6961.00
55_V59_L1.6951.00
35_A98_F1.6921.00
41_K45_K1.6651.00
6_V145_L1.6201.00
61_L113_L1.5971.00
30_W142_S1.5721.00
11_W26_A1.5281.00
47_I136_A1.5261.00
141_L145_L1.5201.00
41_K44_K1.5061.00
46_T136_A1.4841.00
31_A107_A1.4761.00
134_I138_F1.4381.00
15_A26_A1.4321.00
98_F101_A1.4091.00
11_W15_A1.3931.00
103_F110_F1.3911.00
32_C104_Y1.3901.00
27_F103_F1.3701.00
71_L76_A1.3611.00
52_F102_A1.3351.00
80_V110_F1.3201.00
39_G143_E1.3111.00
43_L137_V1.2961.00
47_I133_V1.2961.00
54_V109_T1.2921.00
89_L92_K1.2681.00
87_M102_A1.2501.00
45_K98_F1.2481.00
61_L110_F1.1981.00
71_L78_W1.1690.99
140_Y144_K1.1520.99
62_L66_A1.1490.99
54_V132_L1.1360.99
49_G101_A1.1210.99
71_L77_V1.1060.99
12_T15_A1.0950.99
84_V88_V1.0820.99
63_L66_A1.0690.99
27_F110_F1.0590.99
28_I107_A1.0360.99
60_A83_V1.0210.99
3_S145_L1.0180.99
70_G76_A0.9770.98
33_Y38_G0.9770.98
7_L34_F0.9730.98
125_L132_L0.9660.98
71_L74_L0.9640.98
132_L138_F0.9580.98
57_A106_F0.9560.98
13_W17_G0.9510.98
104_Y108_A0.9450.98
34_F142_S0.9380.98
73_L78_W0.9350.98
29_A46_T0.9270.97
121_L128_V0.9230.97
52_F56_W0.9170.97
14_L17_G0.9150.97
14_L138_F0.9110.97
116_T120_T0.9070.97
68_G78_W0.9030.97
67_L72_G0.8990.97
72_G77_V0.8950.97
86_V90_L0.8820.97
56_W90_L0.8800.96
32_C136_A0.8720.96
81_G88_V0.8720.96
75_A78_W0.8600.96
40_L44_K0.8600.96
83_V87_M0.8460.96
12_T80_V0.8320.95
33_Y139_G0.8300.95
73_L77_V0.8280.95
122_G126_L0.8280.95
90_L99_I0.8250.95
130_V133_V0.8130.95
115_L118_G0.8090.94
87_M91_A0.8060.94
29_A132_L0.8040.94
12_T19_G0.8040.94
70_G75_A0.7950.94
54_V128_V0.7910.94
87_M106_F0.7870.94
79_A83_V0.7870.94
69_G72_G0.7840.93
5_G85_F0.7810.93
8_A80_V0.7720.93
51_L133_V0.7680.93
34_F103_F0.7670.93
81_G84_V0.7670.93
90_L96_L0.7620.92
117_G120_T0.7550.92
49_G98_F0.7550.92
112_Y115_L0.7550.92
88_V91_A0.7530.92
56_W96_L0.7470.92
36_A42_G0.7410.91
91_A99_I0.7400.91
42_G46_T0.7350.91
60_A106_F0.7260.90
53_G57_A0.7250.90
57_A128_V0.7250.90
8_A12_T0.7210.90
67_L70_G0.7210.90
54_V129_I0.7080.89
51_L55_V0.7070.89
59_L83_V0.7000.89
22_L115_L0.6980.89
62_L121_L0.6940.88
56_W83_V0.6930.88
86_V89_L0.6910.88
27_F34_F0.6910.88
80_V84_V0.6900.88
22_L127_V0.6880.88
34_F143_E0.6870.88
127_V131_S0.6860.88
116_T119_A0.6830.88
57_A87_M0.6800.87
7_L142_S0.6790.87
105_G133_V0.6750.87
64_A67_L0.6720.87
33_Y40_L0.6630.86
81_G85_F0.6590.86
45_K48_A0.6540.85
33_Y39_G0.6520.85
3_S7_L0.6470.85
11_W16_L0.6470.85
31_A146_A0.6400.84
64_A75_A0.6340.83
124_P135_G0.6250.83
4_I7_L0.6240.82
123_N129_I0.6220.82
28_I111_A0.6150.82
5_G11_W0.6140.81
128_V132_L0.6130.81
44_K48_A0.6070.81
84_V103_F0.6060.81
114_L117_G0.6050.81
29_A32_C0.5970.80
40_L43_L0.5960.80
50_N136_A0.5950.79
14_L18_L0.5880.79
22_L131_S0.5840.78
48_A52_F0.5770.77
9_G12_T0.5760.77
35_A101_A0.5750.77
45_K49_G0.5750.77
67_L71_L0.5750.77
133_V137_V0.5700.76
100_P107_A0.5700.76
128_V131_S0.5690.76
48_A95_L0.5670.76
24_W105_G0.5670.76
40_L144_K0.5660.76
125_L129_I0.5640.76
56_W86_V0.5600.75
15_A23_V0.5600.75
42_G143_E0.5520.74
49_G102_A0.5500.74
60_A110_F0.5490.74
41_K92_K0.5470.74
21_L131_S0.5470.74
134_I141_L0.5470.74
45_K93_I0.5460.73
48_A140_Y0.5440.73
85_F88_V0.5440.73
124_P131_S0.5440.73
15_A18_L0.5440.73
118_G123_N0.5440.73
125_L128_V0.5430.73
90_L102_A0.5430.73
121_L124_P0.5420.73
64_A79_A0.5390.72
27_F30_W0.5370.72
21_L25_A0.5360.72
84_V87_M0.5340.72
38_G143_E0.5330.72
36_A104_Y0.5310.71
40_L140_Y0.5290.71
8_A11_W0.5250.70
65_G72_G0.5240.70
4_I8_A0.5230.70
138_F142_S0.5230.70
8_A107_A0.5230.70
45_K97_S0.5220.70
70_G73_L0.5220.70
29_A142_S0.5210.70
12_T16_L0.5190.70
47_I51_L0.5130.69
5_G13_W0.5080.68
84_V91_A0.5050.68
11_W49_G0.5030.67
8_A15_A0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4b19A 1 0.1769 2.1 0.93 Contact Map
2kv5A 1 0.1837 1.9 0.932 Contact Map
2ksfA 1 0.6735 1.3 0.938 Contact Map
4ogqG 1 0.1361 1.2 0.94 Contact Map
1q90G 1 0.1361 1.2 0.94 Contact Map
4f35D 2 0.6667 1.1 0.94 Contact Map
1q90M 1 0.2109 0.9 0.943 Contact Map
1rzhL 1 0.3333 0.9 0.944 Contact Map
3iyzA 3 0.9796 0.8 0.945 Contact Map
3oufA 4 0.5374 0.8 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0061 seconds.