GREMLIN Database
GWT1 - GWT1
PFAM: PF06423 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 137 (136)
Sequences: 759 (586)
Seq/√Len: 50.3
META: 0.24

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_Y72_A3.5661.00
119_N122_G3.0201.00
54_W86_T2.8561.00
134_G137_N2.5491.00
72_A77_V2.4941.00
54_W82_A2.4361.00
19_G81_V2.3691.00
8_S72_A2.2601.00
14_A18_A2.2211.00
87_F91_F2.2151.00
130_N134_G2.0181.00
76_Y80_V1.9370.99
56_L78_L1.9280.99
13_L91_F1.8790.99
133_T137_N1.8250.99
3_R9_L1.8220.99
130_N133_T1.7980.99
52_V56_L1.7560.99
83_F87_F1.7510.99
130_N137_N1.7280.99
3_R7_F1.7100.99
39_W42_L1.6870.98
52_V55_L1.6850.98
2_N5_G1.6590.98
131_L135_L1.5940.98
4_E8_S1.5870.98
133_T136_V1.5800.98
92_L96_L1.5550.97
35_S55_L1.5380.97
12_Y70_R1.5290.97
126_F130_N1.5110.97
20_V23_G1.5080.97
101_E105_E1.4960.97
132_L135_L1.4480.96
9_L122_G1.4220.95
57_L71_L1.3820.95
19_G23_G1.3360.94
117_A121_N1.3260.93
91_F95_D1.3090.93
129_A133_T1.2970.93
8_S127_L1.2770.92
69_R130_N1.2740.92
53_L81_V1.2680.92
112_S119_N1.2660.92
12_Y68_S1.2590.91
118_I125_F1.2430.91
38_E46_L1.2380.91
8_S133_T1.2130.90
8_S12_Y1.2020.89
26_L76_Y1.2010.89
53_L85_L1.1870.89
26_L81_V1.1850.89
23_G117_A1.1580.88
41_K62_S1.1570.87
69_R73_N1.1530.87
67_V117_A1.1520.87
47_L89_L1.1370.87
44_I49_W1.1330.86
60_S78_L1.1170.86
73_N76_Y1.1090.85
1_A131_L1.1060.85
16_Y20_V1.0940.84
7_F10_L1.0860.84
125_F136_V1.0860.84
19_G93_L1.0840.84
60_S118_I1.0770.83
101_E104_K1.0750.83
36_V39_W1.0720.83
68_S71_L1.0540.82
35_S38_E1.0540.82
87_F118_I1.0510.82
22_T85_L1.0300.81
84_N122_G1.0230.80
46_L52_V1.0140.79
110_A136_V1.0090.79
82_A86_T1.0050.79
8_S76_Y0.9980.78
90_L118_I0.9930.78
100_K107_S0.9880.78
100_K109_L0.9820.77
3_R87_F0.9500.75
3_R8_S0.9430.74
72_A76_Y0.9420.74
23_G79_W0.9270.73
100_K103_E0.9130.72
89_L98_L0.8940.70
11_G133_T0.8940.70
51_L56_L0.8930.70
121_N124_A0.8920.70
117_A123_L0.8900.70
76_Y91_F0.8890.70
120_R135_L0.8870.70
100_K104_K0.8840.69
1_A90_L0.8770.69
94_I119_N0.8770.69
80_V125_F0.8600.67
23_G27_L0.8580.67
19_G88_L0.8580.67
8_S11_G0.8530.67
31_K43_L0.8310.65
47_L62_S0.8290.64
38_E60_S0.8060.62
74_L78_L0.8040.62
11_G119_N0.7920.61
84_N91_F0.7830.60
23_G95_D0.7800.60
60_S63_Y0.7720.59
15_I27_L0.7660.58
112_S122_G0.7610.58
16_Y80_V0.7600.58
6_I27_L0.7580.57
45_K52_V0.7550.57
101_E107_S0.7550.57
41_K88_L0.7540.57
12_Y122_G0.7500.57
30_S51_L0.7490.57
87_F90_L0.7420.56
123_L129_A0.7420.56
5_G8_S0.7420.56
7_F17_L0.7310.55
50_S89_L0.7290.55
30_S46_L0.7290.55
104_K108_K0.7220.54
100_K105_E0.7200.54
127_L130_N0.7180.53
50_S135_L0.7160.53
31_K51_L0.7150.53
19_G83_F0.7130.53
41_K44_I0.7120.53
33_R36_V0.7120.53
15_I80_V0.7090.53
5_G126_F0.7080.52
22_T93_L0.7020.52
7_F129_A0.6970.51
32_K40_I0.6970.51
25_Y33_R0.6940.51
1_A118_I0.6910.51
40_I51_L0.6900.51
6_I108_K0.6900.51
102_E108_K0.6890.50
20_V85_L0.6860.50
15_I72_A0.6800.50
65_E122_G0.6790.49
97_L103_E0.6790.49
9_L15_I0.6760.49
103_E107_S0.6750.49
57_L61_T0.6690.48
83_F128_L0.6690.48
19_G112_S0.6630.48
12_Y119_N0.6620.48
23_G26_L0.6580.47
25_Y95_D0.6580.47
38_E57_L0.6540.47
41_K51_L0.6540.47
21_Q95_D0.6440.46
6_I24_L0.6260.44
51_L82_A0.6240.44
58_Y63_Y0.6190.43
42_L45_K0.6190.43
63_Y66_P0.6170.43
102_E105_E0.6170.43
60_S98_L0.6150.43
85_L89_L0.6130.43
38_E92_L0.6000.41
67_V78_L0.6000.41
101_E108_K0.6000.41
3_R42_L0.5970.41
37_K40_I0.5930.41
46_L115_L0.5920.41
52_V106_R0.5890.40
32_K88_L0.5850.40
78_L111_T0.5850.40
72_A85_L0.5820.40
53_L120_R0.5770.39
79_W87_F0.5750.39
64_V80_V0.5720.39
111_T114_L0.5690.38
16_Y71_L0.5640.38
73_N130_N0.5620.38
68_S133_T0.5560.37
26_L61_T0.5530.37
69_R127_L0.5400.36
56_L118_I0.5350.35
48_L53_L0.5350.35
1_A77_V0.5320.35
128_L131_L0.5310.35
123_L137_N0.5300.35
12_Y84_N0.5230.34
21_Q25_Y0.5220.34
34_S102_E0.5200.34
123_L133_T0.5180.34
2_N130_N0.5150.33
25_Y125_F0.5140.33
27_L38_E0.5130.33
113_C128_L0.5130.33
110_A116_E0.5120.33
34_S106_R0.5120.33
105_E109_L0.5120.33
77_V119_N0.5100.33
75_P122_G0.5060.32
44_I48_L0.5040.32
77_V98_L0.5030.32
40_I45_K0.5010.32
116_E124_A0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x5mA 2 0.6861 1.9 0.95 Contact Map
2krtA 1 0.3212 1.8 0.95 Contact Map
3j8eG 3 0.9197 1.7 0.951 Contact Map
2gsmB 1 0.3212 1.5 0.953 Contact Map
2remA 1 0.3285 1.3 0.954 Contact Map
3pcvA 3 0.4964 1.3 0.954 Contact Map
4lz6A 1 0.9854 1.2 0.955 Contact Map
4aaiA 2 0.1825 1.2 0.955 Contact Map
3k2tA 1 0.2555 1.1 0.956 Contact Map
3j9pD 4 0.927 1 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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