GREMLIN Database
PDR_CDR - CDR ABC transporter
PFAM: PF06422 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 97 (94)
Sequences: 2126 (1574)
Seq/√Len: 162.4
META: 0.238

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_E43_S3.9151.00
24_V34_A3.6621.00
31_S34_A3.6051.00
51_F55_I3.5661.00
44_Y47_L3.1701.00
24_V27_Q2.4061.00
33_D44_Y2.1301.00
13_G16_Q2.0611.00
56_A60_F2.0131.00
21_V39_S2.0041.00
17_V25_P1.9681.00
60_F64_L1.9381.00
63_A67_V1.8811.00
53_I60_F1.8691.00
5_G8_Y1.7731.00
87_G90_P1.7451.00
46_H49_R1.7011.00
21_V38_T1.6461.00
85_K88_H1.6261.00
67_V71_L1.6251.00
19_A23_A1.6221.00
58_W62_L1.5261.00
53_I56_A1.4831.00
43_S46_H1.4701.00
34_A37_E1.4031.00
90_P93_K1.3961.00
34_A38_T1.3651.00
11_V16_Q1.3491.00
35_Y40_Y1.3431.00
12_S15_N1.3381.00
47_L51_F1.3311.00
59_V63_A1.3131.00
49_R53_I1.2431.00
55_I59_V1.2191.00
48_W51_F1.1681.00
1_L16_Q1.0951.00
9_E16_Q1.0810.99
12_S16_Q1.0600.99
72_N75_A1.0300.99
6_P9_E1.0210.99
62_L66_L1.0070.99
55_I58_W1.0020.99
79_G82_L0.9940.99
11_V15_N0.9720.99
74_A78_G0.9530.99
4_S8_Y0.9310.98
40_Y84_F0.9270.98
54_L58_W0.9210.98
50_N53_I0.9070.98
9_E14_A0.8950.98
57_F61_F0.8950.98
64_L68_A0.8940.98
37_E41_G0.8640.98
10_N15_N0.8640.98
56_A61_F0.8590.97
10_N14_A0.8420.97
1_L28_T0.8370.97
27_Q34_A0.8270.97
42_Y49_R0.8260.97
9_E13_G0.8250.97
47_L76_K0.8190.97
9_E12_S0.8180.97
74_A80_E0.8110.96
66_L76_K0.8100.96
1_L5_G0.7900.96
68_A73_S0.7820.96
90_P94_K0.7740.95
56_A59_V0.7720.95
65_Y80_E0.7690.95
32_G48_W0.7570.95
72_N77_S0.7520.94
51_F62_L0.7500.94
16_Q20_V0.7420.94
82_L88_H0.7350.94
77_S80_E0.7030.92
16_Q28_T0.7020.92
42_Y65_Y0.6950.92
73_S83_V0.6880.91
69_T82_L0.6880.91
33_D37_E0.6810.91
48_W52_G0.6750.91
23_A39_S0.6680.90
17_V21_V0.6660.90
7_G11_V0.6650.90
49_R56_A0.6640.90
69_T72_N0.6630.90
58_W69_T0.6620.90
59_V62_L0.6590.90
65_Y73_S0.6590.90
89_K93_K0.6550.89
80_E84_F0.6510.89
83_V87_G0.6500.89
58_W76_K0.6480.89
22_G30_V0.6460.89
79_G83_V0.6420.88
64_L69_T0.6340.88
3_P7_G0.6230.87
66_L73_S0.6170.86
73_S77_S0.6140.86
91_K94_K0.6100.86
77_S82_L0.6040.85
82_L85_K0.6030.85
51_F54_L0.6030.85
49_R52_G0.6020.85
1_L4_S0.6000.85
37_E44_Y0.5980.85
17_V23_A0.5890.84
2_V19_A0.5890.84
68_A71_L0.5870.83
75_A78_G0.5870.83
86_R90_P0.5870.83
75_A79_G0.5840.83
80_E85_K0.5770.82
40_Y64_L0.5760.82
69_T75_A0.5690.82
38_T91_K0.5660.81
55_I70_E0.5650.81
45_S50_N0.5580.80
47_L66_L0.5570.80
4_S9_E0.5540.80
65_Y77_S0.5540.80
40_Y70_E0.5530.80
39_S69_T0.5500.79
65_Y72_N0.5470.79
43_S59_V0.5410.78
87_G92_K0.5380.78
74_A77_S0.5360.78
89_K94_K0.5350.77
12_S93_K0.5350.77
9_E15_N0.5310.77
77_S81_V0.5300.77
51_F61_F0.5300.77
42_Y52_G0.5290.77
21_V91_K0.5260.76
89_K92_K0.5240.76
50_N54_L0.5210.76
35_Y62_L0.5190.75
79_G86_R0.5190.75
58_W68_A0.5120.74
88_H93_K0.5070.74
5_G9_E0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qb3A 2 0.8557 14.7 0.918 Contact Map
4bw5A 2 0.5258 12 0.921 Contact Map
1cksA 5 0.7629 8.6 0.926 Contact Map
3qy2A 4 0.8454 7.2 0.929 Contact Map
4yc6B 1 0.7113 7.2 0.929 Contact Map
1pucA 2 0.7835 6.6 0.93 Contact Map
4e6zA 1 0 4.8 0.934 Contact Map
4reoA 1 0.7732 4.6 0.935 Contact Map
4h6qA 1 0.2062 3.5 0.938 Contact Map
2kncA 1 0.5361 3.5 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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