GREMLIN Database
DUF1077 - Protein of unknown function (DUF1077)
PFAM: PF06417 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 117 (113)
Sequences: 515 (359)
Seq/√Len: 33.8
META: 0.369

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_K15_E4.2121.00
29_F33_M3.3241.00
81_L85_L3.2111.00
27_N49_L2.7911.00
96_Y99_N2.7211.00
106_T109_S2.4411.00
24_L90_A2.4140.99
82_V85_L2.3140.99
61_N80_K2.1990.99
34_S48_M2.1190.99
16_I67_F2.0650.98
49_L90_A2.0180.98
108_A115_E1.9980.98
14_W79_Q1.9910.98
59_S83_Y1.8980.97
63_A83_Y1.8310.97
14_W82_V1.7950.96
88_L92_A1.7170.95
36_N100_S1.6120.93
32_Y38_L1.6020.93
36_N45_M1.5400.91
32_Y40_I1.5380.91
93_L97_K1.5010.90
64_F80_K1.4890.90
104_L109_S1.4550.89
96_Y100_S1.4530.89
27_N90_A1.4530.89
57_L84_V1.4280.88
4_E7_A1.4250.88
85_L92_A1.4100.87
105_P110_D1.3910.86
52_N55_K1.3870.86
31_M41_F1.3840.86
39_Q87_N1.3640.85
30_M87_N1.3180.83
41_F104_L1.3120.83
69_G72_N1.2950.82
56_A87_N1.2880.82
25_P86_C1.2260.78
76_L80_K1.2180.78
86_C89_L1.2080.77
44_M48_M1.2070.77
95_L98_C1.1960.77
94_G97_K1.1870.76
18_L22_K1.1560.74
15_E77_L1.1550.74
57_L62_Q1.1280.72
42_S48_M1.1250.72
8_L102_G1.1190.72
106_T113_A1.1140.71
48_M53_P1.1020.70
87_N90_A1.1000.70
8_L11_K1.0720.68
48_M52_N1.0610.67
57_L60_V1.0440.66
107_T115_E1.0400.66
25_P49_L1.0140.64
38_L98_C1.0120.64
59_S62_Q0.9990.63
16_I19_A0.9950.62
3_E81_L0.9880.62
60_V84_V0.9830.61
39_Q45_M0.9820.61
72_N76_L0.9700.60
46_V55_K0.9550.59
17_A26_M0.9470.59
48_M94_G0.9460.58
62_Q71_G0.9390.58
66_R82_V0.9370.58
31_M57_L0.9260.57
38_L94_G0.8850.53
40_I62_Q0.8760.53
44_M94_G0.8710.52
32_Y63_A0.8630.52
47_F104_L0.8600.51
49_L53_P0.8570.51
43_I47_F0.8470.50
42_S65_A0.8450.50
54_I58_L0.8450.50
46_V91_L0.8210.48
10_L16_I0.8180.48
13_A79_Q0.8170.48
11_K15_E0.8160.48
17_A109_S0.7730.44
55_K62_Q0.7700.44
62_Q65_A0.7670.43
53_P94_G0.7630.43
17_A20_P0.7560.43
28_A93_L0.7510.42
12_K69_G0.7470.42
91_L104_L0.7450.42
54_I68_E0.7450.42
20_P48_M0.7280.40
10_L58_L0.7190.40
66_R86_C0.7160.39
72_N83_Y0.7160.39
23_Q102_G0.7140.39
77_L88_L0.7060.38
32_Y96_Y0.7030.38
14_W25_P0.7020.38
25_P48_M0.7020.38
102_G105_P0.6990.38
51_K54_I0.6960.38
5_M9_K0.6960.38
52_N56_A0.6930.37
8_L12_K0.6890.37
97_K111_W0.6860.37
51_K55_K0.6820.37
76_L79_Q0.6690.36
49_L56_A0.6680.35
16_I63_A0.6630.35
34_S39_Q0.6630.35
37_S95_L0.6560.35
14_W20_P0.6470.34
27_N52_N0.6440.34
36_N98_C0.6410.33
41_F106_T0.6340.33
24_L27_N0.6290.33
77_L85_L0.6180.32
19_A24_L0.6150.32
23_Q89_L0.6120.31
30_M42_S0.6040.31
27_N55_K0.6020.31
47_F65_A0.6000.30
9_K70_E0.5990.30
68_E73_R0.5940.30
39_Q46_V0.5930.30
38_L43_I0.5910.30
54_I73_R0.5910.30
24_L93_L0.5830.29
59_S113_A0.5760.29
59_S63_A0.5750.29
19_A22_K0.5730.29
3_E95_L0.5710.28
73_R88_L0.5650.28
67_F72_N0.5650.28
24_L89_L0.5630.28
33_M85_L0.5620.28
93_L98_C0.5590.28
13_A34_S0.5580.28
41_F98_C0.5560.27
101_M111_W0.5550.27
67_F84_V0.5540.27
101_M105_P0.5540.27
15_E22_K0.5520.27
25_P28_A0.5510.27
13_A84_V0.5480.27
20_P32_Y0.5380.26
39_Q49_L0.5330.26
41_F76_L0.5330.26
60_V80_K0.5320.26
23_Q76_L0.5310.26
55_K59_S0.5300.26
62_Q83_Y0.5270.25
27_N40_I0.5260.25
49_L93_L0.5220.25
45_M56_A0.5210.25
61_N84_V0.5180.25
18_L82_V0.5180.25
57_L80_K0.5150.25
40_I112_L0.5100.24
56_A63_A0.5100.24
28_A100_S0.5100.24
59_S96_Y0.5080.24
3_E24_L0.5070.24
22_K25_P0.5040.24
21_A36_N0.5020.24
54_I83_Y0.5010.24
25_P39_Q0.5010.24
81_L84_V0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j27B 2 0.4188 8.1 0.94 Contact Map
4b03D 5 0.4615 7.8 0.941 Contact Map
3w9iA 3 1 5.8 0.944 Contact Map
1ll2A 2 0 5.3 0.945 Contact Map
4cbfB 2 0.4359 5 0.946 Contact Map
4cctD 2 0.4359 5 0.946 Contact Map
3b8cA 1 0.9402 3.3 0.95 Contact Map
4mt1A 3 0.9573 3 0.952 Contact Map
4dx5A 3 1 3 0.952 Contact Map
2ixsA 1 0.7094 2.8 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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