GREMLIN Database
DUF1071 - Protein of unknown function (DUF1071)
PFAM: PF06378 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 148 (133)
Sequences: 2933 (2052)
Seq/√Len: 177.9
META: 0.967

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_T22_T4.3841.00
92_T95_D3.2461.00
94_F98_T3.1631.00
32_E35_K3.0731.00
33_L69_I2.6951.00
66_T73_T2.6791.00
34_K74_H2.3831.00
76_M101_M2.2351.00
33_L108_I2.1691.00
82_D86_K2.0701.00
65_V107_A2.0561.00
2_V5_T2.0281.00
14_H28_W2.0281.00
43_E66_T1.9301.00
2_V37_Y1.9001.00
68_T73_T1.8461.00
30_W40_A1.7111.00
61_A91_P1.6881.00
28_W119_A1.6871.00
7_S31_A1.6751.00
32_E36_H1.6081.00
17_K22_T1.5521.00
3_F31_A1.4901.00
4_E8_K1.4841.00
5_T36_H1.4741.00
5_T37_Y1.4711.00
61_A80_V1.4691.00
42_Y104_L1.4641.00
94_F97_N1.4631.00
31_A115_L1.4601.00
66_T75_T1.4601.00
33_L40_A1.4551.00
7_S35_K1.4411.00
46_E64_K1.4371.00
67_V108_I1.4301.00
31_A35_K1.4241.00
42_Y110_M1.4131.00
107_A111_H1.4001.00
81_M98_T1.3881.00
78_L103_C1.3651.00
2_V72_I1.3301.00
37_Y70_E1.3151.00
79_P94_F1.3061.00
76_M110_M1.2971.00
65_V103_C1.2921.00
39_D70_E1.2841.00
87_A93_S1.2841.00
15_T117_I1.2761.00
20_G84_R1.2731.00
12_N15_T1.2681.00
12_N116_Y1.2621.00
62_M100_I1.2511.00
9_I36_H1.2221.00
10_D13_D1.2111.00
39_D71_G1.1791.00
81_M94_F1.1561.00
17_K20_G1.1551.00
30_W42_Y1.1541.00
44_V100_I1.1381.00
29_A108_I1.1281.00
65_V100_I1.1271.00
3_F115_L1.1071.00
64_K75_T1.0641.00
47_F50_T1.0451.00
63_V99_A1.0220.99
25_S122_D1.0050.99
76_M107_A1.0010.99
44_V65_V0.9930.99
95_D98_T0.9880.99
41_T68_T0.9860.99
3_F7_S0.9810.99
24_L29_A0.9790.99
5_T8_K0.9770.99
127_E130_K0.9700.99
56_T61_A0.9620.99
27_A119_A0.9530.99
79_P97_N0.9490.99
45_Y66_T0.9300.99
24_L117_I0.9290.99
86_K95_D0.9170.99
21_L81_M0.9050.99
2_V69_I0.9030.99
19_G83_N0.8960.99
14_H32_E0.8880.98
78_L81_M0.8880.98
82_D95_D0.8670.98
131_K134_K0.8650.98
88_I95_D0.8610.98
2_V70_E0.8340.98
53_P57_D0.8330.98
16_E25_S0.8330.98
129_P132_E0.8320.98
16_E120_G0.8300.98
34_K40_A0.8250.98
67_V107_A0.8220.97
43_E68_T0.8220.97
116_Y124_P0.8180.97
64_K77_W0.8070.97
44_V101_M0.8050.97
48_D51_G0.7970.97
56_T62_M0.7930.97
4_E35_K0.7890.97
46_E75_T0.7880.97
30_W104_L0.7860.97
86_K89_E0.7860.97
68_T71_G0.7850.97
128_E131_K0.7760.96
81_M87_A0.7660.96
60_T93_S0.7510.96
11_V32_E0.7490.96
48_D55_F0.7470.96
73_T111_H0.7370.95
30_W34_K0.7330.95
74_H111_H0.7290.95
87_A92_T0.7240.95
76_M104_L0.7230.95
86_K94_F0.7140.94
101_M110_M0.7120.94
77_W101_M0.7090.94
47_F64_K0.7050.94
74_H110_M0.7040.94
25_S28_W0.7030.94
78_L99_A0.6880.93
45_Y48_D0.6810.93
130_K133_P0.6800.93
83_N94_F0.6790.93
108_I111_H0.6760.93
28_W32_E0.6740.92
47_F51_G0.6720.92
52_L62_M0.6700.92
48_D52_L0.6690.92
41_T74_H0.6640.92
129_P134_K0.6620.92
21_L118_Y0.6620.92
35_K125_E0.6550.91
86_K90_N0.6540.91
42_Y76_M0.6530.91
51_G55_F0.6530.91
128_E133_P0.6520.91
128_E132_E0.6500.91
30_W110_M0.6440.91
46_E51_G0.6420.91
67_V111_H0.6380.90
16_E28_W0.6370.90
46_E50_T0.6370.90
45_Y50_T0.6360.90
82_D85_N0.6340.90
34_K72_I0.6310.90
28_W31_A0.6310.90
105_V113_L0.6220.89
11_V28_W0.6150.89
83_N88_I0.6130.88
80_V96_V0.6130.88
81_M85_N0.6090.88
54_Y61_A0.6050.88
24_L28_W0.6050.88
13_D116_Y0.6040.88
81_M92_T0.6020.88
79_P98_T0.5990.87
77_W100_I0.5950.87
40_A108_I0.5920.87
56_T59_G0.5910.87
21_L78_L0.5910.87
130_K134_K0.5880.86
33_L37_Y0.5860.86
98_T125_E0.5790.85
11_V24_L0.5750.85
83_N86_K0.5750.85
58_G92_T0.5730.85
91_P95_D0.5710.85
87_A91_P0.5590.83
18_K85_N0.5590.83
30_W74_H0.5570.83
44_V77_W0.5570.83
47_F52_L0.5550.83
57_D62_M0.5530.83
28_W116_Y0.5500.82
129_P133_P0.5490.82
28_W115_L0.5480.82
45_Y75_T0.5480.82
105_V109_A0.5470.82
54_Y57_D0.5440.82
12_N22_T0.5400.81
101_M107_A0.5350.81
61_A96_V0.5310.80
76_M103_C0.5270.80
53_P56_T0.5250.79
109_A118_Y0.5230.79
37_Y40_A0.5220.79
126_E129_P0.5220.79
27_A122_D0.5220.79
96_V100_I0.5180.79
57_D60_T0.5170.78
37_Y69_I0.5150.78
127_E132_E0.5130.78
83_N95_D0.5130.78
62_M96_V0.5110.78
25_S123_L0.5060.77
2_V7_S0.5060.77
40_A69_I0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h2iA 5 0.9527 70.6 0.915 Contact Map
4cvoA 2 0.277 22.9 0.938 Contact Map
1s3rA 3 0 6.6 0.951 Contact Map
2xb0X 1 0.3784 6.3 0.952 Contact Map
2ly1A 1 0.3378 4.1 0.956 Contact Map
1yvuA 1 0.4932 3.7 0.957 Contact Map
2lhuA 1 0.2297 3.6 0.957 Contact Map
3f42A 4 0.5878 3.6 0.957 Contact Map
4b4cA 2 0.3378 3.5 0.957 Contact Map
1hulA 2 0.3108 3.2 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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