GREMLIN Database
DUF1059 - Protein of unknown function (DUF1059)
PFAM: PF06348 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (54)
Sequences: 11280 (6184)
Seq/√Len: 841.6
META: 0.961

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_E35_E3.0131.00
22_E51_R2.7791.00
2_K22_E2.4901.00
8_D55_K2.4871.00
3_S16_V1.8021.00
43_T46_L1.7021.00
49_K53_A1.7021.00
19_A28_A1.6351.00
27_E31_E1.5171.00
42_D47_R1.3541.00
49_K52_A1.3491.00
3_S18_R1.3441.00
28_A31_E1.3411.00
4_I29_A1.3301.00
5_D16_V1.3231.00
7_R10_G1.3171.00
23_E27_E1.2501.00
15_F28_A1.2241.00
25_V54_I1.2211.00
21_T24_E1.2121.00
5_D8_D1.2101.00
17_I25_V1.1891.00
25_V29_A1.1391.00
34_V40_H1.1201.00
30_A47_R1.1191.00
44_P48_E1.1061.00
3_S8_D1.0601.00
48_E52_A1.0571.00
39_M43_T1.0311.00
13_C32_H1.0261.00
47_R51_R1.0231.00
7_R14_T1.0021.00
9_V12_G0.9941.00
19_A24_E0.9791.00
48_E51_R0.9611.00
17_I28_A0.9561.00
22_E54_I0.9451.00
19_A25_V0.9341.00
24_E27_E0.9321.00
45_E49_K0.9121.00
3_S55_K0.9031.00
32_H37_H0.8841.00
4_I25_V0.8721.00
7_R12_G0.8631.00
26_L54_I0.8021.00
24_E28_A0.7891.00
39_M46_L0.7821.00
46_L49_K0.7801.00
30_A42_D0.7681.00
9_V53_A0.7661.00
30_A34_V0.7651.00
31_E36_V0.7581.00
27_E30_A0.7541.00
44_P47_R0.7261.00
46_L50_I0.7221.00
14_T24_E0.7111.00
11_P36_V0.6791.00
39_M42_D0.6741.00
23_E51_R0.6721.00
43_T47_R0.6701.00
4_I8_D0.6691.00
6_C32_H0.6651.00
26_L29_A0.6101.00
26_L30_A0.6051.00
45_E48_E0.5931.00
11_P14_T0.5871.00
13_C37_H0.5521.00
33_A38_G0.5461.00
7_R11_P0.5411.00
8_D53_A0.5411.00
42_D46_L0.5311.00
17_I31_E0.5261.00
41_E45_E0.5251.00
26_L50_I0.5211.00
31_E34_V0.5201.00
4_I54_I0.5181.00
41_E44_P0.5121.00
4_I26_L0.5071.00
26_L47_R0.5061.00
17_I24_E0.5001.00
16_V19_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1aipC 2 0.9107 18.7 0.816 Contact Map
1tfeA 2 0.9107 13 0.829 Contact Map
4b4uA 2 0.9821 11.1 0.834 Contact Map
4lmgA 1 0.9464 9.2 0.84 Contact Map
1edzA 2 0.9464 9.2 0.84 Contact Map
3l07A 2 0.9821 8.1 0.844 Contact Map
2c2xA 2 0.9821 8 0.845 Contact Map
1b0aA 2 0.9821 7.7 0.846 Contact Map
3avxA 1 0.875 6.8 0.85 Contact Map
4a5oA 2 0.9821 6.7 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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