GREMLIN Database
ComK - ComK protein
PFAM: PF06338 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 152 (147)
Sequences: 1116 (956)
Seq/√Len: 78.8
META: 0.515

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_I25_T5.3881.00
114_T133_F3.9561.00
84_F99_S3.2051.00
71_K136_Q2.9211.00
45_D49_K2.3741.00
54_S60_E2.3611.00
57_G61_G2.3571.00
106_Y133_F2.3061.00
83_I140_A2.2961.00
116_I133_F2.2851.00
38_K46_E2.2791.00
100_L140_A2.2101.00
115_I123_S2.1681.00
56_E60_E2.1101.00
103_I137_I2.0041.00
53_S58_R1.9811.00
107_E115_I1.8051.00
12_A124_I1.7531.00
128_I133_F1.7291.00
113_K127_D1.7031.00
11_M102_H1.6871.00
87_T95_C1.6781.00
53_S57_G1.6701.00
38_K42_K1.6501.00
107_E117_T1.6321.00
104_K121_G1.6121.00
113_K125_E1.5550.99
26_K33_E1.5440.99
55_Y59_K1.5330.99
115_I125_E1.4900.99
27_V36_V1.4860.99
62_T66_L1.4770.99
29_E32_G1.4770.99
88_K94_D1.4400.99
117_T123_S1.4370.99
102_H119_K1.3820.99
68_I72_V1.3700.99
109_I115_I1.3590.99
62_T72_V1.3500.98
43_I47_S1.3460.98
48_C58_R1.3310.98
42_K45_D1.3220.98
99_S102_H1.3200.98
41_L55_Y1.3130.98
30_E102_H1.2920.98
16_I26_K1.2820.98
106_Y130_Y1.2650.98
59_K74_I1.2340.97
39_S42_K1.2150.97
49_K60_E1.1820.96
144_R148_R1.1790.96
11_M118_F1.1750.96
78_E83_I1.1500.96
75_I143_L1.1490.96
136_Q139_R1.1350.96
47_S50_Y1.1340.96
44_I76_I1.1260.95
98_I116_I1.1230.95
33_E122_K1.1230.95
10_T29_E1.1180.95
104_K119_K1.1160.95
128_I132_S1.1080.95
62_T143_L1.1050.95
90_P95_C1.1050.95
54_S61_G1.0760.94
15_P96_I1.0600.94
55_Y90_P1.0490.93
85_F140_A1.0480.93
145_Y148_R1.0470.93
8_P80_N1.0460.93
106_Y114_T1.0440.93
54_S57_G1.0420.93
71_K132_S1.0280.93
50_Y150_R1.0180.92
18_D22_K1.0140.92
135_N139_R1.0120.92
45_D56_E1.0060.92
22_K37_K0.9990.91
44_I55_Y0.9740.90
13_I40_P0.9730.90
56_E59_K0.9730.90
105_K117_T0.9680.90
76_I84_F0.9600.90
14_I28_I0.9430.89
40_P116_I0.9390.89
25_T40_P0.9270.88
36_V43_I0.9250.88
83_I100_L0.9160.87
12_A28_I0.9140.87
11_M120_N0.9090.87
141_A145_Y0.9030.87
60_E63_K0.8930.86
62_T68_I0.8890.86
59_K63_K0.8800.85
129_S136_Q0.8790.85
86_P95_C0.8710.85
9_E30_E0.8670.84
89_S136_Q0.8590.84
57_G95_C0.8570.84
98_I126_L0.8570.84
4_Y7_N0.8550.84
106_Y137_I0.8520.83
48_C71_K0.8500.83
100_L144_R0.8410.83
100_L141_A0.8400.82
55_Y134_E0.8360.82
68_I139_R0.8180.81
47_S51_F0.8180.81
38_K43_I0.8040.80
31_D120_N0.8030.80
146_K150_R0.8020.79
143_L146_K0.8000.79
48_C97_W0.7960.79
67_G72_V0.7860.78
103_I133_F0.7850.78
103_I116_I0.7790.77
142_R146_K0.7790.77
7_N29_E0.7770.77
12_A98_I0.7590.76
108_K130_Y0.7580.76
52_G66_L0.7500.75
77_E80_N0.7410.74
138_L142_R0.7390.74
16_I35_I0.7370.73
44_I84_F0.7350.73
130_Y134_E0.7350.73
24_Y37_K0.7340.73
4_Y29_E0.7330.73
61_G139_R0.7310.73
11_M30_E0.7290.73
109_I125_E0.7280.73
98_I103_I0.7280.73
118_F124_I0.7270.72
114_T125_E0.7260.72
5_E47_S0.7230.72
6_I147_L0.7200.72
134_E138_L0.7160.71
14_I26_K0.7160.71
29_E47_S0.7150.71
58_R76_I0.7090.71
62_T75_I0.7030.70
5_E51_F0.6990.69
47_S143_L0.6910.69
84_F143_L0.6850.68
88_K92_N0.6820.68
49_K64_K0.6770.67
48_C136_Q0.6750.67
86_P136_Q0.6610.65
107_E132_S0.6570.65
95_C136_Q0.6550.64
7_N116_I0.6550.64
24_Y27_V0.6540.64
70_H134_E0.6530.64
13_I93_P0.6530.64
95_C139_R0.6410.63
52_G85_F0.6400.63
66_L143_L0.6360.62
144_R149_K0.6310.62
62_T83_I0.6290.61
5_E79_S0.6240.61
52_G75_I0.6230.61
51_F77_E0.6200.60
118_F122_K0.6150.60
59_K72_V0.6130.59
35_I122_K0.6110.59
106_Y134_E0.6060.58
70_H95_C0.6060.58
109_I113_K0.6050.58
32_G46_E0.6040.58
98_I118_F0.6030.58
138_L145_Y0.6010.58
32_G92_N0.5990.58
16_I103_I0.5940.57
49_K61_G0.5930.57
43_I146_K0.5890.56
86_P89_S0.5860.56
5_E50_Y0.5860.56
92_N113_K0.5830.56
66_L146_K0.5820.55
13_I44_I0.5790.55
123_S126_L0.5750.55
68_I135_N0.5700.54
132_S135_N0.5680.54
6_I10_T0.5670.54
8_P39_S0.5670.54
61_G120_N0.5670.54
81_N101_N0.5650.53
10_T47_S0.5650.53
87_T136_Q0.5610.53
145_Y149_K0.5580.52
30_E55_Y0.5570.52
71_K89_S0.5570.52
48_C87_T0.5570.52
28_I108_K0.5550.52
74_I84_F0.5520.52
75_I78_E0.5490.51
73_P143_L0.5490.51
15_P41_L0.5480.51
41_L131_G0.5440.51
86_P97_W0.5420.50
9_E31_D0.5400.50
130_Y137_I0.5360.50
4_Y52_G0.5350.49
63_K69_T0.5330.49
127_D130_Y0.5330.49
85_F97_W0.5330.49
50_Y61_G0.5320.49
27_V67_G0.5260.48
85_F98_I0.5250.48
58_R118_F0.5220.48
99_S139_R0.5160.47
41_L45_D0.5150.47
77_E132_S0.5110.46
53_S147_L0.5100.46
129_S132_S0.5060.46
135_N138_L0.5050.46
31_D109_I0.5040.45
52_G97_W0.5020.45
55_Y124_I0.5000.45
27_V128_I0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3d6wA 3 0.6579 24.4 0.918 Contact Map
3er9B 1 0.5987 8.4 0.933 Contact Map
1k8kD 1 0.8816 5.3 0.939 Contact Map
4atoA 1 0.7368 3.9 0.943 Contact Map
2auwA 2 0.3816 3.8 0.943 Contact Map
2k0qA 1 0.3092 3.5 0.944 Contact Map
2xdbA 1 0.7303 3 0.946 Contact Map
1mbyA 4 0.3487 2.5 0.948 Contact Map
4eo2A 3 0.5132 2 0.951 Contact Map
4parB 3 0.8289 1.9 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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