GREMLIN Database
DUF1049 - Protein of unknown function (DUF1049)
PFAM: PF06305 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 64 (61)
Sequences: 25166 (16190)
Seq/√Len: 2072.9
META: 0.915

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_A34_G2.1141.00
23_L26_A1.9941.00
52_L56_L1.9381.00
45_L49_A1.9181.00
17_L22_V1.8821.00
7_T16_E1.8211.00
55_E60_E1.7951.00
27_F33_L1.6931.00
6_V19_L1.6831.00
49_A52_L1.6491.00
27_F30_G1.6111.00
35_L38_G1.6011.00
56_L59_L1.5711.00
48_E52_L1.5551.00
43_L47_R1.5121.00
56_L60_E1.5041.00
5_P16_E1.4981.00
47_R51_R1.4841.00
26_A30_G1.4501.00
9_N12_F1.4001.00
18_P21_L1.3731.00
22_V26_A1.3441.00
48_E53_R1.3401.00
38_G42_R1.2841.00
42_R45_L1.2781.00
31_A37_A1.2301.00
8_V22_V1.2241.00
4_Q7_T1.1921.00
10_F13_W1.1801.00
35_L39_L1.1471.00
55_E58_R1.1441.00
7_T14_Q1.1341.00
9_N14_Q1.1131.00
55_E59_L1.0471.00
58_R62_E1.0301.00
53_R57_R1.0251.00
38_G41_R0.9831.00
57_R61_K0.9731.00
49_A53_R0.9631.00
4_Q19_L0.9471.00
39_L43_L0.9461.00
51_R55_E0.9421.00
47_R50_R0.9111.00
30_G34_G0.8831.00
10_F15_F0.8731.00
27_F31_A0.8661.00
54_R58_R0.8641.00
3_T20_A0.8611.00
42_R46_R0.8251.00
50_R54_R0.8101.00
41_R45_L0.8071.00
52_L55_E0.8051.00
40_L43_L0.7981.00
5_P18_P0.7911.00
19_L23_L0.7671.00
50_R57_R0.7511.00
54_R57_R0.7411.00
57_R60_E0.7361.00
46_R50_R0.7311.00
9_N13_W0.7181.00
36_L40_L0.7031.00
46_R49_A0.6821.00
11_L14_Q0.6781.00
8_V19_L0.6781.00
16_E20_A0.6741.00
48_E51_R0.6741.00
3_T6_V0.6591.00
34_G38_G0.6441.00
40_L44_R0.6221.00
6_V22_V0.6201.00
45_L48_E0.6161.00
4_Q9_N0.6121.00
7_T11_L0.6051.00
7_T22_V0.5991.00
12_F15_F0.5941.00
34_G37_A0.5941.00
39_L42_R0.5931.00
28_L31_A0.5931.00
17_L25_L0.5761.00
44_R48_E0.5581.00
58_R61_K0.5581.00
20_A23_L0.5571.00
41_R44_R0.5561.00
51_R54_R0.5521.00
53_R60_E0.5461.00
17_L20_A0.5331.00
3_T21_L0.5281.00
31_A35_L0.5181.00
45_L62_E0.5181.00
19_L22_V0.5111.00
22_V27_F0.5041.00
31_A38_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hi2A 1 0.7344 47.5 0.744 Contact Map
3sokA 1 0.75 43.4 0.749 Contact Map
4tllA 1 0.3281 41.7 0.752 Contact Map
1scfA 4 0 34.4 0.763 Contact Map
1oqwA 1 0.75 34 0.764 Contact Map
4bgnA 3 0.7188 28.9 0.772 Contact Map
2m7gA 1 0.75 28.1 0.774 Contact Map
4um9B 2 0 23.6 0.782 Contact Map
4uqqA 3 0.1719 23.2 0.783 Contact Map
5a2fA 1 0 18.3 0.793 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0044 seconds.