GREMLIN Database
DUF1043 - Protein of unknown function (DUF1043)
PFAM: PF06295 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 122 (117)
Sequences: 1404 (1061)
Seq/√Len: 98.1
META: 0.691

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_Y47_V3.2661.00
32_E37_K2.9551.00
36_L40_L2.7521.00
13_A16_A2.7211.00
51_F76_A2.3761.00
5_L8_G2.3261.00
58_V72_L2.3121.00
57_L71_H2.2901.00
53_Q56_E2.2811.00
5_L11_I2.1461.00
58_V68_V2.1451.00
8_G12_G2.1051.00
69_Y73_A2.0811.00
60_N64_S2.0041.00
65_Y71_H1.8971.00
54_T58_V1.8761.00
66_R70_Q1.7711.00
61_L68_V1.6621.00
83_L86_Q1.6501.00
54_T65_Y1.5851.00
65_Y69_Y1.5811.00
84_P87_D1.5711.00
55_A73_A1.5461.00
62_T69_Y1.4801.00
71_H75_G1.4801.00
85_R88_L1.4461.00
34_D38_E1.4291.00
10_I14_L1.4000.99
108_E111_R1.3980.99
64_S69_Y1.3800.99
30_E34_D1.3790.99
86_Q90_A1.3780.99
33_L36_L1.3550.99
62_T68_V1.3430.99
60_N63_E1.3380.99
50_H71_H1.2970.99
9_L14_L1.2730.99
42_Q48_T1.2640.99
111_R114_A1.2140.99
73_A76_A1.2130.99
51_F65_Y1.1950.98
83_L87_D1.1720.98
82_E85_R1.1700.98
55_A69_Y1.1490.98
87_D90_A1.1440.98
14_L18_L1.1400.98
59_N69_Y1.1080.97
50_H57_L1.0960.97
9_L12_G1.0750.97
54_T72_L1.0530.96
82_E89_P1.0430.96
51_F75_G1.0420.96
31_Q34_D1.0370.96
82_E88_L1.0370.96
13_A19_L1.0340.96
84_P88_L1.0160.96
51_F69_Y1.0150.96
42_Q46_E1.0050.95
85_R89_P0.9860.95
38_E42_Q0.9830.95
82_E86_Q0.9800.95
6_L10_I0.9720.94
95_E98_E0.9670.94
40_L43_Y0.9650.94
64_S68_V0.9630.94
91_A95_E0.9490.94
29_L36_L0.9480.94
43_Y79_L0.9460.94
28_E32_E0.9270.93
42_Q49_E0.9260.93
58_V65_Y0.9220.93
31_Q35_E0.9190.93
47_V75_G0.9090.92
11_I17_R0.9060.92
44_Q76_A0.9010.92
72_L75_G0.8960.92
84_P89_P0.8830.91
51_F73_A0.8790.91
17_R33_L0.8750.91
36_L39_E0.8630.90
107_V114_A0.8610.90
94_L97_S0.8590.90
51_F55_A0.8550.90
57_L68_V0.8480.89
60_N67_D0.8450.89
69_Y72_L0.8440.89
55_A66_R0.8390.89
55_A71_H0.8340.88
83_L89_P0.8280.88
54_T71_H0.8260.88
55_A62_T0.8240.88
81_P84_P0.8200.88
100_E103_E0.8160.87
62_T75_G0.8100.87
38_E41_E0.8030.86
83_L90_A0.8020.86
35_E39_E0.7960.86
11_I14_L0.7960.86
98_E102_E0.7940.86
59_N62_T0.7870.85
49_E53_Q0.7810.85
35_E38_E0.7750.84
6_L9_L0.7610.83
40_L68_V0.7600.83
86_Q94_L0.7570.83
8_G16_A0.7530.83
90_A94_L0.7510.83
17_R20_S0.7500.82
66_R69_Y0.7460.82
9_L15_L0.7330.81
35_E41_E0.7320.81
43_Y48_T0.7240.80
99_A102_E0.7190.80
15_L82_E0.7160.79
82_E87_D0.7150.79
85_R91_A0.7140.79
99_A103_E0.7110.79
3_I7_V0.7080.79
57_L65_Y0.7040.78
10_I19_L0.7040.78
80_C88_L0.6930.77
16_A20_S0.6810.76
44_Q80_C0.6750.75
32_E35_E0.6710.75
86_Q92_S0.6670.75
61_L69_Y0.6540.73
97_S100_E0.6530.73
63_E70_Q0.6500.73
97_S101_A0.6430.72
113_Y118_S0.6400.71
100_E104_E0.6340.71
70_Q74_E0.6330.71
47_V50_H0.6300.70
29_L33_L0.6300.70
82_E90_A0.6260.70
50_H65_Y0.6250.70
74_E77_Q0.6250.70
16_A44_Q0.6200.69
53_Q57_L0.6180.69
91_A97_S0.6070.67
85_R90_A0.6010.67
65_Y68_V0.6000.67
36_L75_G0.5970.66
66_R111_R0.5950.66
4_G7_V0.5880.65
54_T62_T0.5850.65
114_A118_S0.5840.64
63_E83_L0.5840.64
86_Q89_P0.5820.64
26_Q32_E0.5770.64
7_V45_Q0.5750.63
46_E78_R0.5720.63
44_Q62_T0.5710.63
51_F62_T0.5700.63
58_V70_Q0.5650.62
62_T72_L0.5650.62
94_L102_E0.5650.62
55_A65_Y0.5620.62
48_T52_A0.5620.62
47_V68_V0.5580.61
65_Y76_A0.5530.60
85_R92_S0.5530.60
43_Y65_Y0.5420.59
47_V65_Y0.5400.58
50_H54_T0.5370.58
97_S106_D0.5360.58
82_E94_L0.5240.56
50_H75_G0.5200.56
58_V69_Y0.5200.56
85_R99_A0.5200.56
96_E99_A0.5190.56
14_L28_E0.5170.55
62_T65_Y0.5110.54
109_P115_P0.5050.54
93_K100_E0.5020.53
55_A80_C0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f95B 2 0.0984 82.8 0.838 Contact Map
4f23A 3 0.9672 82.5 0.839 Contact Map
4lvhA 3 0.1148 72.1 0.853 Contact Map
4mc5A 3 0.9672 69.4 0.856 Contact Map
4wsrA 5 0.9672 69.4 0.856 Contact Map
4cq4A 4 0.6148 68.4 0.857 Contact Map
2kluA 1 0.4672 66.8 0.858 Contact Map
2wr1A 3 0.9672 63.4 0.861 Contact Map
3qnqA 2 0.3197 63.3 0.861 Contact Map
2yp5A 3 0.9672 56.4 0.867 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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