GREMLIN Database
DUF1036 - Protein of unknown function (DUF1036)
PFAM: PF06282 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 113 (110)
Sequences: 4608 (2977)
Seq/√Len: 283.8
META: 0.934

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_C40_C5.0901.00
74_V95_A3.0291.00
73_C87_C2.6451.00
18_A79_F2.4471.00
16_G34_R2.4251.00
28_V80_T2.3671.00
10_R111_Q2.3651.00
7_V55_V2.2751.00
40_C73_C2.1941.00
20_G72_F1.9881.00
71_P94_R1.9251.00
14_R34_R1.9101.00
71_P96_G1.8311.00
7_V17_V1.7831.00
30_R33_W1.7621.00
30_R80_T1.6921.00
8_C73_C1.6641.00
20_G29_T1.6631.00
19_I33_W1.5361.00
14_R36_D1.4991.00
52_Y99_E1.4731.00
86_D89_A1.4711.00
36_D39_Q1.4601.00
55_V110_V1.3761.00
13_Y59_D1.3691.00
15_V66_W1.3601.00
5_L110_V1.3511.00
4_G42_T1.3461.00
48_L53_Y1.3461.00
44_L48_L1.3431.00
59_D63_G1.3041.00
81_I92_Y1.2921.00
21_Y30_R1.2721.00
22_D27_W1.2681.00
29_T72_F1.2511.00
19_I44_L1.2481.00
56_Y95_A1.2371.00
58_E65_E1.2341.00
51_R101_D1.2311.00
27_W72_F1.2251.00
54_Y99_E1.2001.00
6_R42_T1.1851.00
33_W43_V1.1741.00
16_G58_E1.1711.00
52_Y101_D1.1391.00
44_L53_Y1.1251.00
31_G79_F1.1101.00
18_A97_F1.0961.00
26_G82_R1.0741.00
16_G60_V1.0641.00
4_G107_D1.0581.00
35_I39_Q1.0571.00
11_T73_C1.0551.00
70_A84_A1.0471.00
57_A66_W1.0241.00
40_C87_C1.0231.00
55_V98_F1.0061.00
29_T81_I0.9971.00
62_G65_E0.9891.00
71_P74_V0.9721.00
27_W52_Y0.9631.00
33_W41_A0.9421.00
108_W111_Q0.9311.00
12_S37_P0.9131.00
46_G49_T0.8961.00
11_T37_P0.8891.00
72_F84_A0.8801.00
76_D93_D0.8761.00
23_D26_G0.8671.00
103_G106_K0.8661.00
4_G46_G0.8601.00
74_V97_F0.8571.00
75_R81_I0.8571.00
11_T66_W0.8551.00
42_T45_K0.8521.00
74_V93_D0.8401.00
60_V64_G0.8311.00
66_W95_A0.8241.00
7_V43_V0.8201.00
33_W78_K0.8191.00
10_R38_G0.8171.00
15_V57_A0.8150.99
67_G96_G0.8150.99
20_G27_W0.8130.99
59_D66_W0.7970.99
11_T14_R0.7930.99
105_Q108_W0.7900.99
5_L100_V0.7870.99
11_T59_D0.7850.99
12_S38_G0.7840.99
90_R94_R0.7750.99
66_W96_G0.7680.99
55_V100_V0.7610.99
98_F104_E0.7600.99
75_R78_K0.7530.99
13_Y61_D0.7520.99
22_D26_G0.7490.99
47_P106_K0.7480.99
21_Y28_V0.7430.99
60_V65_E0.7420.99
14_R37_P0.7370.99
27_W99_E0.7330.99
35_I41_A0.7300.99
102_T108_W0.7210.99
7_V15_V0.7200.99
11_T20_G0.7190.99
58_E76_D0.7180.99
44_L54_Y0.7170.99
5_L53_Y0.7100.99
42_T107_D0.7080.99
29_T83_G0.6880.98
14_R60_V0.6870.98
59_D62_G0.6860.98
45_K53_Y0.6860.98
8_C87_C0.6810.98
23_D82_R0.6770.98
3_A107_D0.6710.98
43_V58_E0.6710.98
5_L19_I0.6700.98
13_Y62_G0.6640.98
61_D64_G0.6620.98
5_L48_L0.6550.98
19_I30_R0.6520.98
60_V67_G0.6480.97
105_Q111_Q0.6450.97
59_D64_G0.6350.97
81_I90_R0.6320.97
69_D98_F0.6290.97
86_D90_R0.6260.97
21_Y80_T0.6240.97
69_D96_G0.6220.97
88_A91_G0.6150.97
75_R92_Y0.6130.96
89_A93_D0.6100.96
15_V68_G0.6100.96
104_E107_D0.6020.96
45_K48_L0.6000.96
44_L47_P0.5980.96
74_V79_F0.5910.96
68_G96_G0.5910.96
29_T40_C0.5910.96
2_R15_V0.5890.96
70_A99_E0.5890.96
85_E88_A0.5810.95
54_Y72_F0.5690.95
48_L102_T0.5640.94
12_S36_D0.5620.94
58_E62_G0.5580.94
29_T84_A0.5510.94
60_V63_G0.5440.93
83_G90_R0.5410.93
19_I43_V0.5340.93
20_G53_Y0.5320.93
104_E108_W0.5260.92
22_D25_G0.5220.92
52_Y55_V0.5210.92
45_K82_R0.5180.92
78_K88_A0.5170.92
21_Y29_T0.5110.91
71_P77_K0.5100.91
43_V107_D0.5090.91
16_G59_D0.5070.91
57_A68_G0.5020.90
9_N20_G0.5010.90
13_Y68_G0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ahnA 1 0.9292 45.7 0.871 Contact Map
2vhkA 1 0.8938 35.1 0.879 Contact Map
4bctA 1 0.8496 25.9 0.887 Contact Map
1du5A 2 0.8584 24.2 0.888 Contact Map
3g7mA 2 0.9027 23.3 0.889 Contact Map
1aunA 1 0.8673 18.6 0.894 Contact Map
3qisA 1 0.8673 6.2 0.914 Contact Map
3qbtB 1 0.7965 5 0.918 Contact Map
4gioA 1 0.5133 2.7 0.928 Contact Map
2huhA 2 0.8673 2.7 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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