GREMLIN Database
DUF1018 - Protein of unknown function (DUF1018)
PFAM: PF06252 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 118 (118)
Sequences: 4130 (3509)
Seq/√Len: 323.0
META: 0.805

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
2_D5_T3.6161.00
89_K95_D2.9751.00
11_E17_R2.9411.00
3_D7_R2.7481.00
110_E113_K2.6891.00
16_K26_Q2.5711.00
6_Y10_L2.3441.00
27_L31_L2.2781.00
33_H37_L2.2691.00
33_H36_R2.2561.00
63_K66_A2.0181.00
6_Y19_A1.9661.00
23_T26_Q1.9481.00
12_R33_H1.9101.00
14_T30_V1.8821.00
28_E32_D1.8121.00
17_R21_D1.8081.00
94_V104_Q1.7551.00
8_A17_R1.6801.00
85_D96_R1.6441.00
101_T104_Q1.6301.00
85_D97_L1.5851.00
1_L9_L1.5841.00
13_V33_H1.5121.00
14_T26_Q1.4431.00
5_T8_A1.4331.00
95_D99_W1.4221.00
24_D27_L1.3841.00
60_Q109_I1.3781.00
10_L22_L1.3341.00
9_L34_L1.3301.00
70_E116_A1.3121.00
96_R99_W1.3101.00
11_E15_G1.3031.00
68_W84_L1.3031.00
64_I108_V1.3021.00
88_V108_V1.3001.00
87_F111_A1.2911.00
32_D35_K1.2901.00
83_A86_A1.2821.00
10_L19_A1.2331.00
100_L105_A1.2181.00
9_L33_H1.2131.00
71_L116_A1.2111.00
83_A87_F1.1891.00
19_A22_L1.1731.00
22_L27_L1.1691.00
110_E114_A1.1611.00
24_D28_E1.1591.00
10_L30_V1.1461.00
34_L39_F1.1221.00
87_F91_Q1.1201.00
94_V99_W1.1151.00
19_A27_L1.0981.00
87_F108_V1.0891.00
68_W83_A1.0841.00
14_T22_L1.0631.00
71_L76_A1.0561.00
35_K41_P1.0561.00
59_A62_R1.0441.00
30_V34_L1.0341.00
14_T29_A1.0101.00
64_I105_A1.0061.00
16_K21_D1.0021.00
72_G77_V1.0021.00
71_L115_W0.9801.00
13_V29_A0.9771.00
8_A12_R0.9651.00
100_L108_V0.9621.00
67_L109_I0.9561.00
16_K22_L0.9541.00
62_R65_R0.9331.00
91_Q111_A0.9311.00
87_F115_W0.9301.00
61_L65_R0.9271.00
108_V111_A0.9231.00
67_L116_A0.8931.00
102_D106_S0.8861.00
60_Q106_S0.8741.00
65_R69_I0.8741.00
63_K67_L0.8711.00
88_V92_T0.8651.00
9_L13_V0.8631.00
6_Y34_L0.8481.00
70_E73_W0.8461.00
88_V91_Q0.8381.00
58_P61_L0.8341.00
69_I73_W0.8281.00
56_A61_L0.8261.00
22_L30_V0.8161.00
39_F42_K0.8111.00
72_G80_R0.8111.00
114_A117_K0.7951.00
66_A69_I0.7781.00
113_K116_A0.7651.00
66_A70_E0.7600.99
51_P54_A0.7590.99
92_T107_K0.7530.99
58_P62_R0.7430.99
26_Q29_A0.7360.99
86_A89_K0.7350.99
35_K38_G0.7270.99
10_L14_T0.7250.99
25_A28_E0.7110.99
47_K50_R0.7090.99
13_V30_V0.7020.99
63_K109_I0.6980.99
115_W118_R0.6960.99
31_L39_F0.6950.99
63_K70_E0.6920.99
12_R37_L0.6870.99
11_E14_T0.6850.99
84_L88_V0.6830.99
107_K114_A0.6810.99
34_L38_G0.6790.99
57_T60_Q0.6750.99
73_W80_R0.6730.99
104_Q107_K0.6730.99
50_R53_G0.6680.99
106_S110_E0.6680.99
60_Q105_A0.6660.99
92_T100_L0.6630.99
63_K113_K0.6590.99
60_Q67_L0.6590.99
97_L100_L0.6440.98
103_A107_K0.6420.98
90_R111_A0.6340.98
82_A86_A0.6320.98
46_K50_R0.6260.98
23_T27_L0.6260.98
1_L34_L0.6230.98
111_A114_A0.6230.98
48_R51_P0.6200.98
63_K116_A0.6170.98
113_K117_K0.5980.97
27_L35_K0.5950.97
92_T108_V0.5890.97
56_A60_Q0.5890.97
57_T102_D0.5870.97
8_A11_E0.5840.97
9_L30_V0.5810.97
7_R10_L0.5790.97
87_F92_T0.5780.97
62_R66_A0.5760.97
86_A90_R0.5710.96
68_W73_W0.5680.96
22_L26_Q0.5640.96
29_A32_D0.5630.96
110_E118_R0.5630.96
84_L87_F0.5610.96
47_K52_P0.5590.96
68_W72_G0.5540.96
105_A109_I0.5540.96
83_A115_W0.5510.96
76_A116_A0.5510.96
71_L74_L0.5450.95
85_D98_R0.5390.95
43_P46_K0.5390.95
31_L34_L0.5310.95
3_D6_Y0.5310.95
38_G42_K0.5280.94
113_K118_R0.5260.94
92_T111_A0.5260.94
107_K111_A0.5240.94
101_T105_A0.5240.94
68_W87_F0.5220.94
50_R54_A0.5200.94
77_V80_R0.5200.94
69_I72_G0.5190.94
9_L12_R0.5180.94
35_K40_K0.5160.94
9_L37_L0.5160.94
85_D92_T0.5140.94
60_Q63_K0.5040.93
1_L5_T0.5040.93
10_L16_K0.5010.93
72_G83_A0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3deuA 2 0.7797 25 0.875 Contact Map
3nqoA 2 0.8475 22.9 0.878 Contact Map
1z91A 2 0.8305 20.9 0.88 Contact Map
2rdpA 2 0.822 20.2 0.881 Contact Map
2nyxA 2 0.8475 19.1 0.882 Contact Map
2nnnA 2 0.8305 18.8 0.883 Contact Map
4trbA 2 0.4831 18.1 0.883 Contact Map
3boqA 2 0.7881 17.9 0.884 Contact Map
2a61A 2 0.8475 17.4 0.884 Contact Map
1s3jA 2 0.8475 17.3 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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