GREMLIN Database
DUF1013 - Protein of unknown function (DUF1013)
PFAM: PF06242 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 139 (138)
Sequences: 3306 (1172)
Seq/√Len: 99.8
META: 0.922

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_C40_A4.9191.00
32_E35_E4.5531.00
28_R32_E4.1281.00
33_R40_A3.9471.00
101_Q105_D3.8691.00
5_G11_V3.3151.00
32_E36_A3.0801.00
72_D117_R2.9391.00
34_C42_L2.7401.00
77_L84_L2.7181.00
98_P102_A2.5831.00
30_E33_R2.5541.00
18_L25_Q2.3061.00
110_N113_N2.2791.00
84_L133_A1.9871.00
75_A114_I1.9561.00
121_T127_Q1.8391.00
30_E40_A1.7381.00
6_I12_A1.7241.00
27_T45_A1.7091.00
25_Q44_L1.6281.00
19_D22_A1.6211.00
86_D104_R1.6081.00
127_Q131_D1.5881.00
4_Q8_D1.5741.00
95_T100_I1.5481.00
85_K88_Q1.5341.00
109_W113_N1.4971.00
31_I35_E1.4941.00
85_K90_S1.4841.00
50_P55_R1.4691.00
103_I111_S1.4201.00
91_K133_A1.3740.99
117_R121_T1.3280.99
118_D127_Q1.3090.99
131_D135_E1.3000.99
73_A93_V1.2810.99
72_D115_K1.2780.99
37_D40_A1.2540.99
85_K91_K1.2470.99
128_I131_D1.2440.99
111_S114_I1.2370.99
5_G118_D1.2290.99
84_L93_V1.2050.99
30_E43_K1.1800.98
128_I132_A1.1640.98
132_A135_E1.1620.98
72_D110_N1.1180.98
40_A43_K1.1150.98
90_S100_I1.0960.97
78_L90_S1.0950.97
9_G13_Q1.0880.97
70_R93_V1.0850.97
111_S117_R1.0780.97
108_H114_I1.0710.97
28_R35_E1.0560.97
106_R111_S1.0550.97
34_C41_R1.0340.96
83_E138_A1.0290.96
18_L23_N1.0210.96
120_V127_Q1.0070.96
30_E34_C1.0000.95
6_I9_G0.9980.95
11_V14_G0.9970.95
48_K52_P0.9830.95
19_D28_R0.9550.94
118_D131_D0.9480.94
70_R121_T0.9400.94
10_E15_I0.9330.93
69_D124_L0.9300.93
50_P58_G0.9260.93
86_D101_Q0.9190.93
131_D138_A0.9180.93
10_E14_G0.9000.92
55_R58_G0.8950.92
90_S95_T0.8850.91
29_E32_E0.8750.91
38_P41_R0.8530.90
107_T113_N0.8480.90
46_K50_P0.8430.89
77_L93_V0.8420.89
77_L103_I0.8390.89
26_L42_L0.8330.89
135_E138_A0.8310.89
118_D128_I0.8240.88
9_G14_G0.8240.88
31_I34_C0.8200.88
13_Q16_K0.8190.88
47_S51_V0.8150.88
66_K90_S0.8110.87
45_A48_K0.8100.87
64_V69_D0.8100.87
76_W80_N0.8050.87
118_D121_T0.7970.87
48_K56_K0.7920.86
84_L137_A0.7910.86
95_T99_T0.7900.86
98_P103_I0.7840.86
70_R94_G0.7810.85
86_D97_K0.7800.85
1_L4_Q0.7620.84
24_G45_A0.7610.84
132_A136_K0.7520.83
126_S129_D0.7450.83
79_R116_P0.7410.82
87_A90_S0.7290.81
75_A116_P0.7280.81
115_K121_T0.7260.81
28_R76_W0.7250.81
120_V131_D0.7170.80
76_W81_H0.7140.80
85_K115_K0.7110.80
33_R42_L0.7000.79
121_T128_I0.6990.78
72_D75_A0.6950.78
98_P101_Q0.6930.78
48_K51_V0.6870.77
64_V70_R0.6790.76
81_H134_V0.6790.76
66_K93_V0.6740.76
5_G12_A0.6690.75
26_L30_E0.6680.75
50_P56_K0.6600.74
23_N47_S0.6540.74
77_L92_L0.6500.73
83_E137_A0.6470.73
21_I30_E0.6410.72
75_A85_K0.6400.72
121_T131_D0.6400.72
31_I42_L0.6390.72
73_A97_K0.6380.72
75_A80_N0.6370.72
19_D76_W0.6350.72
48_K53_E0.6280.71
59_P136_K0.6260.70
3_V6_I0.6200.70
55_R64_V0.6160.69
10_E13_Q0.6150.69
49_V52_P0.6150.69
16_K64_V0.6120.69
109_W118_D0.6090.68
68_Q79_R0.6060.68
81_H84_L0.6050.68
46_K49_V0.6030.68
24_G27_T0.6010.67
74_I95_T0.6000.67
50_P54_K0.5980.67
18_L24_G0.5940.66
134_V138_A0.5940.66
109_W127_Q0.5900.66
78_L101_Q0.5890.66
62_T68_Q0.5850.65
117_R138_A0.5850.65
21_I26_L0.5840.65
85_K133_A0.5840.65
5_G127_Q0.5820.65
26_L31_I0.5810.65
92_L133_A0.5770.64
58_G62_T0.5770.64
10_E22_A0.5750.64
47_S52_P0.5690.63
75_A91_K0.5690.63
12_A16_K0.5660.63
128_I134_V0.5650.63
128_I135_E0.5650.63
22_A25_Q0.5640.62
50_P53_E0.5630.62
129_D132_A0.5630.62
61_Y64_V0.5590.62
57_K75_A0.5590.62
6_I11_V0.5560.61
5_G121_T0.5550.61
70_R76_W0.5540.61
66_K73_A0.5530.61
117_R135_E0.5490.60
9_G12_A0.5490.60
11_V15_I0.5480.60
33_R43_K0.5470.60
41_R54_K0.5460.60
5_G9_G0.5460.60
128_I138_A0.5440.60
75_A111_S0.5430.60
102_A114_I0.5430.60
6_I14_G0.5410.59
93_V98_P0.5390.59
3_V7_A0.5370.59
53_E56_K0.5360.59
80_N127_Q0.5350.58
121_T138_A0.5340.58
4_Q16_K0.5330.58
100_I108_H0.5310.58
93_V133_A0.5300.58
70_R115_K0.5290.58
70_R117_R0.5250.57
33_R45_A0.5200.56
6_I10_E0.5190.56
100_I113_N0.5180.56
69_D106_R0.5150.56
44_L47_S0.5130.55
15_I18_L0.5110.55
90_S93_V0.5100.55
70_R118_D0.5080.55
76_W130_L0.5070.54
86_D119_P0.5040.54
16_K28_R0.5040.54
60_R64_V0.5030.54
79_R131_D0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hoeA 2 0.4604 30.9 0.948 Contact Map
1z6rA 3 0.4604 28.2 0.949 Contact Map
3dn7A 2 0.4676 25.2 0.95 Contact Map
3dkwA 2 0.9281 23.7 0.951 Contact Map
2x48A 1 0.3885 21.4 0.952 Contact Map
1iufA 1 0.6187 21.4 0.952 Contact Map
4dyqA 5 0.482 20 0.953 Contact Map
1o5lA 2 0.4676 18.5 0.953 Contact Map
2i1qA 1 0.3669 17.7 0.954 Contact Map
1j9iA 2 0.3957 17.5 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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