GREMLIN Database
Usg - Usg-like family
PFAM: PF06233 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (79)
Sequences: 4522 (2057)
Seq/√Len: 231.4
META: 0.935

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_E59_R3.4931.00
11_E25_S3.3541.00
63_A67_K3.0721.00
45_D49_R2.5431.00
39_E42_K2.5391.00
26_F30_D2.4221.00
13_L25_S2.3131.00
16_M21_S2.2581.00
15_R56_H2.1341.00
6_G62_H2.0601.00
30_D39_E1.9841.00
20_P54_P1.9631.00
5_Y33_L1.9221.00
45_D48_Q1.8941.00
48_Q54_P1.8131.00
40_L60_V1.6011.00
74_V77_E1.5721.00
30_D40_L1.5671.00
12_I44_L1.5631.00
67_K70_E1.5371.00
48_Q55_L1.5191.00
15_R21_S1.4221.00
36_D41_R1.3651.00
26_F51_L1.2901.00
37_F62_H1.2751.00
73_A76_G1.2221.00
30_D55_L1.2101.00
23_L56_H1.1931.00
64_R67_K1.1861.00
44_L58_V1.1781.00
42_K45_D1.1601.00
46_F50_E1.1081.00
41_R45_D1.1051.00
5_Y39_E1.0971.00
16_M22_L1.0711.00
10_A40_L1.0501.00
15_R53_G1.0501.00
6_G11_E1.0301.00
9_T27_V0.9981.00
15_R54_P0.9831.00
15_R23_L0.9591.00
65_L68_P0.9451.00
70_E73_A0.9421.00
8_T62_H0.9000.99
2_L63_A0.8780.99
30_D62_H0.8680.99
65_L70_E0.8390.99
13_L23_L0.8350.99
72_R76_G0.8330.99
41_R48_Q0.8150.99
73_A77_E0.8120.99
16_M20_P0.7880.99
75_D79_R0.7850.99
10_A28_W0.7790.98
33_L39_E0.7620.98
70_E77_E0.7430.98
71_W76_G0.7400.98
34_A37_F0.7280.98
4_G62_H0.7180.97
66_I70_E0.7160.97
1_Q66_I0.7110.97
24_Q37_F0.7030.97
33_L36_D0.6940.97
5_Y8_T0.6920.97
44_L47_W0.6910.97
14_Y17_P0.6800.96
41_R60_V0.6780.96
63_A73_A0.6770.96
26_F46_F0.6760.96
8_T40_L0.6760.96
64_R70_E0.6620.96
15_R20_P0.6490.95
15_R57_S0.6470.95
6_G34_A0.6430.95
43_F47_W0.6390.95
19_H22_L0.6360.95
3_K11_E0.6320.95
67_K71_W0.6320.95
28_W53_G0.6280.95
8_T37_F0.6210.94
33_L42_K0.6210.94
13_L19_H0.6200.94
62_H65_L0.6150.94
13_L57_S0.6140.94
34_A64_R0.6100.94
46_F53_G0.6040.93
32_D35_P0.5970.93
13_L59_R0.5950.93
73_A78_F0.5940.93
12_I55_L0.5910.93
41_R71_W0.5820.92
37_F60_V0.5820.92
61_A76_G0.5800.92
14_Y18_D0.5790.92
12_I27_V0.5760.92
10_A58_V0.5710.91
72_R75_D0.5630.91
1_Q12_I0.5630.91
40_L53_G0.5580.90
12_I28_W0.5580.90
9_T13_L0.5520.90
1_Q75_D0.5510.90
12_I24_Q0.5470.89
59_R63_A0.5420.89
69_A73_A0.5390.89
43_F46_F0.5350.88
28_W43_F0.5300.88
8_T30_D0.5280.88
36_D39_E0.5240.87
10_A53_G0.5200.87
74_V78_F0.5190.87
31_Y46_F0.5160.87
48_Q53_G0.5150.86
71_W78_F0.5130.86
21_S73_A0.5110.86
1_Q4_G0.5090.86
53_G58_V0.5040.85
64_R69_A0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u6pA 1 0.575 19.7 0.913 Contact Map
4pd2A 1 0.5625 17.8 0.914 Contact Map
1ee8A 2 0.55 16 0.916 Contact Map
1k82A 1 0.575 13.2 0.919 Contact Map
3vk8A 1 0.5625 11.7 0.921 Contact Map
1k3xA 1 0.5375 10.2 0.923 Contact Map
2je8A 1 0.925 7.7 0.927 Contact Map
4mb1A 1 0.9875 7.1 0.929 Contact Map
1tdhA 1 0.575 6.7 0.929 Contact Map
2ze0A 2 0.9375 6.5 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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