GREMLIN Database
DUF1007 - Protein of unknown function (DUF1007)
PFAM: PF06226 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 211 (203)
Sequences: 3198 (2225)
Seq/√Len: 156.1
META: 0.792

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_D34_R5.0421.00
74_K78_E5.0301.00
27_V35_V3.8381.00
37_G119_T2.8011.00
70_A74_K2.7071.00
25_S38_V2.6431.00
26_E39_R2.5261.00
57_D68_E2.4961.00
43_T115_T2.4301.00
57_D61_D2.4031.00
189_Q193_P2.3351.00
53_L64_L2.2791.00
59_N68_E2.2771.00
66_R70_A2.2501.00
89_A133_L2.2461.00
66_R106_W2.2391.00
41_A117_H2.2061.00
97_K123_K2.1871.00
104_D119_T2.1081.00
76_N116_L2.1011.00
22_D113_R1.9981.00
28_V39_R1.9891.00
60_G63_K1.9701.00
59_N65_T1.9621.00
43_T113_R1.9531.00
193_P197_S1.9431.00
91_A96_V1.9391.00
61_D65_T1.9301.00
200_G203_F1.8751.00
28_V37_G1.8591.00
53_L109_Y1.7931.00
26_E157_V1.7511.00
35_V133_L1.7341.00
51_F55_G1.7261.00
99_G123_K1.6751.00
23_A148_F1.6151.00
35_V122_L1.6121.00
193_P196_G1.5741.00
88_F138_Y1.5721.00
28_V119_T1.5281.00
73_A77_V1.5191.00
173_D177_A1.5191.00
39_R117_H1.5021.00
77_V116_L1.4991.00
24_R155_K1.4941.00
26_E155_K1.4281.00
156_L159_A1.4251.00
73_A105_Y1.4211.00
34_R127_K1.4111.00
89_A98_F1.4031.00
99_G121_P1.3631.00
110_K115_T1.3411.00
61_D68_E1.3381.00
194_P198_N1.3321.00
174_A177_A1.3261.00
87_T120_L1.3211.00
106_W117_H1.3211.00
39_R119_T1.3201.00
22_D149_A1.3171.00
24_R43_T1.3151.00
122_L125_P1.2821.00
40_H137_V1.2791.00
23_A137_V1.2631.00
98_F120_L1.2381.00
64_L68_E1.2331.00
188_D193_P1.2291.00
108_E117_H1.2141.00
57_D60_G1.2091.00
73_A116_L1.1991.00
107_L114_L1.1951.00
23_A146_F1.1901.00
189_Q194_P1.1721.00
84_D88_F1.1701.00
176_A181_S1.1671.00
192_L195_P1.1591.00
192_L196_G1.1541.00
122_L126_V1.1521.00
52_A114_L1.1511.00
184_E189_Q1.1441.00
189_Q192_L1.1371.00
179_A183_S1.1331.00
84_D95_K1.1261.00
177_A180_Q1.1121.00
20_W145_D1.1111.00
9_A12_P1.0950.99
30_D36_T1.0940.99
39_R157_V1.0910.99
199_L202_Q1.0900.99
180_Q184_E1.0790.99
70_A73_A1.0770.99
148_F167_V1.0660.99
6_L9_A1.0630.99
170_P205_N1.0570.99
173_D203_F1.0550.99
191_F194_P1.0500.99
91_A126_V1.0470.99
65_T68_E1.0450.99
27_V209_V1.0450.99
188_D192_L1.0330.99
52_A72_L1.0330.99
188_D191_F1.0250.99
40_H87_T1.0170.99
25_S40_H1.0150.99
193_P198_N1.0140.99
180_Q183_S1.0020.99
5_L9_A1.0000.99
173_D176_A0.9970.99
30_D33_G0.9970.99
86_F121_P0.9960.99
196_G199_L0.9940.99
86_F146_F0.9880.99
49_S109_Y0.9880.99
52_A76_N0.9860.99
24_R41_A0.9840.99
172_P183_S0.9740.99
168_V208_T0.9670.99
46_E113_R0.9420.98
127_K130_G0.9380.98
57_D65_T0.9290.98
179_A199_L0.9230.98
35_V128_A0.9160.98
200_G204_A0.9140.98
29_F128_A0.9060.98
4_A10_A0.9020.98
39_R104_D0.9010.98
41_A115_T0.8980.98
181_S184_E0.8910.98
166_T210_T0.8860.98
40_H120_L0.8800.97
24_R115_T0.8760.97
154_V165_L0.8710.97
34_R124_T0.8650.97
29_F160_P0.8570.97
134_T206_K0.8470.97
199_L206_K0.8460.97
37_G121_P0.8400.97
195_P199_L0.8370.97
152_D155_K0.8330.96
28_V157_V0.8260.96
48_F76_N0.8250.96
194_P197_S0.8180.96
4_A11_A0.8130.96
109_Y115_T0.8130.96
67_E70_A0.8100.96
150_E153_P0.8100.96
125_P128_A0.8100.96
197_S203_F0.8070.96
188_D195_P0.8010.96
75_V79_S0.7990.96
108_E115_T0.7970.95
183_S188_D0.7900.95
77_V105_Y0.7870.95
26_E41_A0.7830.95
89_A122_L0.7760.95
197_S202_Q0.7740.95
38_V135_L0.7740.95
198_N201_A0.7730.95
90_K95_K0.7710.95
37_G122_L0.7710.95
43_T110_K0.7690.95
57_D63_K0.7670.94
183_S191_F0.7600.94
154_V207_I0.7590.94
27_V135_L0.7550.94
72_L76_N0.7530.94
57_D62_G0.7520.94
21_V144_V0.7470.94
179_A184_E0.7460.94
73_A107_L0.7450.94
11_A14_Q0.7420.93
48_F80_L0.7410.93
191_F195_P0.7400.93
10_A13_A0.7230.93
19_V48_F0.7220.92
80_L139_D0.7200.92
76_N107_L0.7110.92
60_G68_E0.7050.92
4_A167_V0.7050.92
200_G205_N0.6960.91
96_V126_V0.6940.91
24_R149_A0.6870.91
80_L137_V0.6860.90
89_A135_L0.6850.90
2_A8_L0.6840.90
79_S82_E0.6820.90
21_V146_F0.6810.90
184_E188_D0.6810.90
88_F95_K0.6790.90
196_G202_Q0.6780.90
55_G116_L0.6760.90
195_P198_N0.6760.90
148_F170_P0.6750.90
52_A55_G0.6740.90
48_F136_E0.6720.90
77_V107_L0.6660.89
176_A180_Q0.6620.89
6_L11_A0.6600.89
51_F54_Q0.6550.88
50_A53_L0.6540.88
101_P120_L0.6500.88
142_Y145_D0.6480.88
20_W47_M0.6470.88
58_K65_T0.6440.87
183_S193_P0.6440.87
38_V41_A0.6430.87
66_R108_E0.6420.87
171_D177_A0.6410.87
6_L94_K0.6350.87
176_A195_P0.6330.87
165_L207_I0.6330.87
100_E103_V0.6300.86
103_V121_P0.6290.86
189_Q196_G0.6280.86
189_Q195_P0.6280.86
29_F156_L0.6280.86
173_D183_S0.6260.86
75_V107_L0.6250.86
199_L203_F0.6170.85
183_S196_G0.6160.85
18_H143_F0.6140.85
175_A196_G0.6120.85
6_L10_A0.6110.85
30_D125_P0.6100.85
115_T144_V0.6060.84
193_P202_Q0.6040.84
86_F116_L0.6030.84
191_F196_G0.6030.84
140_P143_F0.6020.84
201_A206_K0.6020.84
48_F83_F0.6020.84
55_G144_V0.6000.84
203_F206_K0.5980.83
49_S114_L0.5960.83
91_A128_A0.5960.83
135_L148_F0.5950.83
10_A14_Q0.5940.83
136_E206_K0.5920.83
189_Q199_L0.5920.83
5_L11_A0.5910.83
71_P75_V0.5880.82
189_Q197_S0.5860.82
29_F33_G0.5850.82
138_Y204_A0.5850.82
168_V171_D0.5840.82
3_A6_L0.5800.81
96_V99_G0.5800.81
52_A75_V0.5790.81
86_F118_F0.5770.81
57_D64_L0.5770.81
44_F137_V0.5760.81
92_D127_K0.5740.81
8_L11_A0.5740.81
156_L160_P0.5670.80
183_S189_Q0.5660.80
59_N67_E0.5650.80
101_P105_Y0.5650.80
44_F48_F0.5630.80
134_T208_T0.5620.79
194_P203_F0.5610.79
196_G203_F0.5590.79
196_G200_G0.5570.79
180_Q189_Q0.5570.79
90_K136_E0.5550.79
136_E146_F0.5540.78
52_A64_L0.5540.78
167_V207_I0.5520.78
188_D194_P0.5510.78
171_D174_A0.5510.78
156_L165_L0.5500.78
177_A182_L0.5480.78
81_K100_E0.5460.77
136_E205_N0.5420.77
3_A9_A0.5400.77
22_D43_T0.5400.77
184_E199_L0.5390.77
3_A7_L0.5380.76
166_T208_T0.5360.76
98_F101_P0.5350.76
142_Y192_L0.5350.76
36_T125_P0.5300.75
149_A153_P0.5300.75
163_C211_C0.5300.75
28_V35_V0.5290.75
189_Q202_Q0.5270.75
191_F199_L0.5260.75
193_P199_L0.5260.75
44_F50_A0.5260.75
173_D196_G0.5260.75
192_L203_F0.5230.74
6_L12_P0.5220.74
80_L86_F0.5200.74
192_L199_L0.5180.74
20_W120_L0.5160.73
200_G211_C0.5160.73
141_T144_V0.5130.73
147_S150_E0.5120.73
8_L12_P0.5110.73
45_D49_S0.5080.72
189_Q198_N0.5070.72
203_F208_T0.5040.72
154_V157_V0.5020.71
61_D145_D0.5010.71
188_D198_N0.5010.71
61_D64_L0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2julA 1 0.564 29 0.944 Contact Map
1nubA 1 0.4929 28.9 0.944 Contact Map
2l2eA 1 0.564 24.3 0.946 Contact Map
3nyvA 1 0.4976 24.2 0.946 Contact Map
1fpwA 1 0.5592 21.9 0.947 Contact Map
2kz2A 1 0.4408 20.8 0.948 Contact Map
2ma2A 1 0.3697 18.6 0.949 Contact Map
1yx7A 1 0.3318 18.3 0.949 Contact Map
2be4A 1 0.3744 18.1 0.949 Contact Map
4qoxA 1 0.5118 17.6 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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