GREMLIN Database
DUF1002 - Protein of unknown function (DUF1002)
PFAM: PF06207 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 221 (219)
Sequences: 1193 (854)
Seq/√Len: 57.7
META: 0.538

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_T193_Q3.8081.00
159_I201_M3.2521.00
156_I197_L3.1771.00
34_E115_K3.1531.00
179_N194_I3.1111.00
1_L14_L2.7031.00
73_N103_P2.6581.00
74_I82_Y2.6411.00
171_E202_E2.6391.00
193_Q196_Q2.5631.00
52_A108_A2.5051.00
59_T95_D2.5051.00
175_R179_N2.5011.00
68_N95_D2.4221.00
210_D213_Q2.4211.00
86_L96_V2.4141.00
176_K180_E2.4051.00
162_E165_E2.3961.00
61_L95_D2.3861.00
11_A15_K2.3561.00
195_Q199_D2.2001.00
16_L99_A2.0611.00
10_K21_E2.0411.00
10_K29_T1.9941.00
197_L201_M1.9801.00
191_D195_Q1.9361.00
180_E183_K1.9361.00
36_H40_G1.8591.00
9_Q102_F1.8501.00
171_E175_R1.8401.00
170_T173_E1.8180.99
125_L129_A1.8170.99
17_F97_I1.8150.99
135_E203_K1.8050.99
136_E160_K1.8040.99
14_L27_V1.7520.99
74_I98_V1.7140.99
146_G193_Q1.7000.99
175_R195_Q1.6810.99
7_E11_A1.6730.99
75_T103_P1.6640.99
13_V99_A1.6330.99
100_A104_V1.6260.99
12_E15_K1.6250.99
32_N36_H1.6220.99
172_E176_K1.6050.99
118_E130_K1.6030.99
179_N183_K1.5910.99
80_E83_A1.5840.98
65_S93_D1.5800.98
64_G93_D1.5720.98
178_I198_V1.5710.98
62_E65_S1.5520.98
173_E176_K1.5380.98
72_N99_A1.5080.98
43_V47_Q1.5020.98
162_E166_G1.4900.98
132_V204_I1.4720.98
168_P177_I1.4520.97
180_E184_E1.4280.97
201_M204_I1.4220.97
56_A113_I1.4170.97
151_K154_E1.4060.97
178_I197_L1.4000.97
126_D129_A1.4000.97
33_A37_K1.3730.96
200_L204_I1.3600.96
63_K93_D1.3430.96
61_L65_S1.3390.96
44_S47_Q1.3160.95
82_Y98_V1.3100.95
80_E153_A1.3090.95
32_N52_A1.2880.95
35_E105_S1.2770.94
13_V17_F1.2760.94
76_W141_G1.2670.94
195_Q198_V1.2560.94
3_A31_T1.2340.93
212_D216_D1.2250.93
92_E213_Q1.2200.93
155_L185_L1.2120.93
140_T152_A1.2100.93
6_T9_Q1.2070.93
91_V94_A1.2010.92
158_E185_L1.1810.92
180_E186_N1.1620.91
36_H45_A1.1490.91
105_S108_A1.1400.90
156_I200_L1.1280.90
199_D202_E1.1260.90
70_E97_I1.1200.89
8_E11_A1.1170.89
53_I100_A1.1060.89
135_E139_T1.1050.89
1_L55_S1.1050.89
144_A149_S1.1000.89
168_P173_E1.0910.88
111_T130_K1.0690.87
56_A98_V1.0580.87
31_T52_A1.0460.86
35_E107_T1.0370.85
148_G152_A1.0300.85
216_D219_E1.0100.84
134_N137_L1.0050.84
13_V101_P1.0030.83
17_F57_Y0.9930.83
19_V25_V0.9870.82
127_E130_K0.9830.82
172_E175_R0.9810.82
35_E49_G0.9790.82
202_E205_S0.9780.82
175_R198_V0.9740.82
175_R194_I0.9740.82
69_V141_G0.9710.81
32_N39_L0.9560.80
61_L69_V0.9550.80
142_E196_Q0.9550.80
158_E161_E0.9510.80
147_I152_A0.9500.80
124_K172_E0.9290.78
77_V134_N0.9160.77
179_N191_D0.9070.77
32_N35_E0.9030.76
158_E184_E0.9030.76
191_D194_I0.8970.76
38_Y111_T0.8930.76
67_I70_E0.8890.75
2_G5_L0.8890.75
65_S68_N0.8860.75
203_K206_K0.8780.74
43_V76_W0.8750.74
19_V57_Y0.8730.74
161_E165_E0.8730.74
8_E12_E0.8690.74
192_E199_D0.8670.73
148_G151_K0.8570.73
152_A155_L0.8560.72
35_E52_A0.8540.72
84_N136_E0.8530.72
10_K27_V0.8480.72
47_Q102_F0.8450.72
81_M152_A0.8420.71
162_E180_E0.8420.71
177_I180_E0.8410.71
9_Q12_E0.8380.71
7_E172_E0.8320.70
171_E198_V0.8300.70
159_I177_I0.8290.70
188_T191_D0.8280.70
35_E48_I0.8280.70
144_A152_A0.8210.69
42_Y131_E0.8200.69
77_V104_V0.8190.69
197_L214_V0.8160.69
174_I201_M0.8140.69
201_M214_V0.8040.68
1_L27_V0.8020.67
26_E119_E0.7990.67
186_N193_Q0.7950.67
32_N48_I0.7910.66
156_I174_I0.7880.66
174_I177_I0.7830.66
76_W107_T0.7830.66
168_P174_I0.7810.65
154_E158_E0.7800.65
88_T136_E0.7750.65
4_D49_G0.7740.65
178_I202_E0.7700.64
84_N87_I0.7630.64
201_M205_S0.7620.64
12_E16_L0.7610.63
10_K14_L0.7560.63
71_T99_A0.7540.63
214_V218_L0.7520.62
178_I193_Q0.7520.62
49_G107_T0.7490.62
58_I96_V0.7430.62
182_A185_L0.7410.61
204_I207_L0.7390.61
86_L203_K0.7360.61
190_T199_D0.7300.60
66_G93_D0.7300.60
57_Y97_I0.7260.60
77_V205_S0.7250.60
176_K179_N0.7190.59
209_I217_Q0.7130.58
199_D203_K0.7100.58
53_I102_F0.7050.58
79_E83_A0.6990.57
82_Y116_A0.6990.57
86_L113_I0.6980.57
84_N160_K0.6960.57
99_A141_G0.6950.56
163_I201_M0.6920.56
178_I182_A0.6920.56
211_W214_V0.6890.56
32_N49_G0.6870.56
139_T144_A0.6870.56
56_A108_A0.6830.55
61_L68_N0.6810.55
145_E216_D0.6810.55
27_V31_T0.6790.55
5_L9_Q0.6780.55
52_A107_T0.6760.54
78_T220_D0.6760.54
143_L152_A0.6740.54
48_I107_T0.6710.54
13_V16_L0.6710.54
174_I202_E0.6710.54
71_T74_I0.6640.53
3_A29_T0.6620.53
4_D51_R0.6610.53
125_L130_K0.6590.53
128_E187_I0.6570.52
56_A120_A0.6550.52
196_Q199_D0.6530.52
144_A147_I0.6470.51
8_E33_A0.6420.51
81_M86_L0.6420.51
114_Y219_E0.6400.50
35_E39_L0.6370.50
7_E10_K0.6360.50
165_E215_K0.6360.50
162_E177_I0.6350.50
189_L195_Q0.6350.50
129_A204_I0.6330.50
12_E72_N0.6310.49
87_I217_Q0.6310.49
114_Y211_W0.6300.49
127_E131_E0.6250.49
135_E172_E0.6220.48
98_V113_I0.6220.48
25_V186_N0.6210.48
169_A173_E0.6200.48
172_E198_V0.6180.48
46_S93_D0.6180.48
15_K190_T0.6170.48
143_L193_Q0.6140.48
67_I87_I0.6080.47
20_D24_D0.6030.46
154_E185_L0.6020.46
185_L209_I0.6010.46
63_K92_E0.5960.46
1_L5_L0.5950.45
132_V207_L0.5900.45
7_E37_K0.5900.45
53_I117_Y0.5860.44
163_I177_I0.5860.44
114_Y125_L0.5860.44
39_L140_T0.5830.44
135_E218_L0.5830.44
128_E189_L0.5810.44
16_L72_N0.5790.44
140_T197_L0.5760.43
202_E206_K0.5750.43
181_A184_E0.5740.43
178_I187_I0.5740.43
164_A204_I0.5740.43
149_S153_A0.5730.43
41_G45_A0.5730.43
4_D32_N0.5720.43
58_I139_T0.5690.43
190_T194_I0.5690.43
174_I178_I0.5680.43
158_E181_A0.5640.42
213_Q216_D0.5600.42
76_W108_A0.5590.42
30_V34_E0.5590.42
131_E135_E0.5590.42
147_I187_I0.5580.41
67_I113_I0.5570.41
44_S123_E0.5570.41
151_K171_E0.5570.41
150_E154_E0.5570.41
183_K188_T0.5570.41
91_V114_Y0.5530.41
167_K176_K0.5530.41
199_D204_I0.5510.41
205_S208_D0.5490.41
139_T158_E0.5480.40
20_D23_D0.5470.40
83_A213_Q0.5450.40
174_I188_T0.5440.40
9_Q14_L0.5430.40
5_L101_P0.5430.40
149_S190_T0.5400.40
187_I205_S0.5380.39
163_I167_K0.5370.39
84_N88_T0.5360.39
192_E196_Q0.5350.39
209_I214_V0.5350.39
77_V81_M0.5350.39
38_Y115_K0.5270.38
92_E124_K0.5270.38
41_G131_E0.5250.38
49_G52_A0.5240.38
25_V135_E0.5220.38
67_I94_A0.5210.38
14_L21_E0.5210.38
86_L100_A0.5190.37
48_I105_S0.5180.37
163_I209_I0.5180.37
15_K20_D0.5160.37
71_T189_L0.5140.37
6_T51_R0.5140.37
61_L129_A0.5130.37
62_E219_E0.5120.37
49_G105_S0.5120.37
40_G127_E0.5120.37
174_I195_Q0.5110.37
72_N100_A0.5100.36
159_I204_I0.5090.36
168_P171_E0.5080.36
69_V98_V0.5080.36
11_A18_G0.5070.36
184_E215_K0.5060.36
49_G76_W0.5060.36
187_I193_Q0.5060.36
204_I211_W0.5050.36
206_K214_V0.5050.36
54_S109_A0.5040.36
26_E58_I0.5040.36
67_I83_A0.5030.36
101_P108_A0.5030.36
127_E162_E0.5030.36
35_E108_A0.5020.36
74_I89_A0.5000.35
169_A174_I0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o36A 1 0.6471 49.3 0.947 Contact Map
2o3eA 1 0.7014 45.4 0.949 Contact Map
2i88A 1 0.3529 41.8 0.95 Contact Map
1m5yA 1 0.4434 39 0.951 Contact Map
4ka7A 1 0.6968 38.1 0.951 Contact Map
3kheA 1 0.6697 34.1 0.952 Contact Map
1ij5A 1 0.8371 23.7 0.956 Contact Map
3q5iA 1 0.6697 22.8 0.956 Contact Map
1colA 1 0.4118 22.6 0.956 Contact Map
3rgcA 2 0.3801 22.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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