GREMLIN Database
DUF998 - Protein of unknown function (DUF998)
PFAM: PF06197 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 185 (181)
Sequences: 18164 (14789)
Seq/√Len: 1099.2
META: 0.874

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_L108_A4.2821.00
138_L142_A3.3851.00
135_L139_S3.0201.00
27_T30_E2.9741.00
42_F46_F2.8991.00
165_G169_R2.7411.00
100_L104_L2.6771.00
26_Q30_E2.6591.00
15_G23_P2.4381.00
92_D99_T2.3111.00
89_F104_L2.1891.00
137_L141_V2.1731.00
30_E91_M2.1731.00
27_T164_V2.1631.00
39_G43_N2.1421.00
32_G43_N2.1321.00
57_A77_A2.1151.00
10_A45_G1.9431.00
141_V145_L1.8611.00
42_F45_G1.8371.00
22_S25_R1.8271.00
43_N90_P1.8211.00
24_V166_L1.7981.00
91_M95_G1.7971.00
134_L138_L1.7141.00
72_G123_L1.6981.00
116_L175_I1.6791.00
47_I84_I1.6751.00
129_R132_W1.6431.00
125_A128_R1.6411.00
28_I172_V1.6361.00
92_D102_G1.6281.00
82_G108_A1.6121.00
136_S139_S1.5871.00
136_S140_G1.5341.00
128_R131_G1.5231.00
132_W136_S1.5171.00
11_V28_I1.5171.00
61_R73_A1.4961.00
116_L120_A1.4881.00
71_I74_A1.4881.00
140_G144_L1.4871.00
47_I87_G1.4571.00
54_L80_G1.4271.00
6_L10_A1.3861.00
132_W135_L1.3711.00
32_G42_F1.3481.00
56_F183_A1.3391.00
99_T102_G1.3261.00
109_A113_F1.3191.00
91_M94_G1.3171.00
54_L77_A1.2951.00
137_L140_G1.2821.00
11_V23_P1.2661.00
85_L89_F1.2511.00
53_L80_G1.2471.00
132_W137_L1.2251.00
126_R129_R1.2141.00
82_G111_L1.2011.00
125_A131_G1.1971.00
130_R133_R1.1911.00
78_L115_L1.1751.00
86_A109_A1.1741.00
50_G80_G1.1661.00
53_L79_A1.1651.00
135_L138_L1.1651.00
14_A18_R1.1481.00
76_L119_A1.1381.00
150_L153_F1.1361.00
90_P101_H1.1341.00
13_V16_L1.1211.00
131_G134_L1.1151.00
40_W44_A1.1021.00
18_R36_G1.0981.00
163_G167_A1.0941.00
36_G42_F1.0921.00
18_R21_Y1.0921.00
111_L115_L1.0861.00
143_L147_L1.0721.00
133_R137_L1.0711.00
44_A48_L1.0691.00
52_L56_F1.0671.00
140_G143_L1.0651.00
50_G87_G1.0521.00
70_R73_A1.0521.00
57_A73_A1.0521.00
104_L108_A1.0401.00
7_F10_A1.0301.00
49_L52_L1.0291.00
57_A80_G1.0281.00
139_S143_L1.0231.00
117_P120_A1.0121.00
173_L177_L0.9991.00
127_R131_G0.9961.00
125_A129_R0.9911.00
37_P42_F0.9901.00
8_V11_V0.9821.00
133_R136_S0.9771.00
153_F156_A0.9761.00
142_A146_L0.9731.00
139_S142_A0.9701.00
163_G166_L0.9641.00
29_S105_H0.9571.00
69_G72_G0.9521.00
146_L150_L0.9471.00
135_L142_A0.9441.00
151_A155_A0.9431.00
126_R132_W0.9411.00
70_R74_A0.9331.00
85_L104_L0.9301.00
13_V17_L0.9281.00
21_Y26_Q0.9251.00
130_R135_L0.9201.00
152_L156_A0.9181.00
21_Y31_L0.9171.00
125_A132_W0.9101.00
132_W140_G0.9071.00
34_I92_D0.9031.00
4_P8_V0.8991.00
5_L9_A0.8921.00
38_T41_L0.8851.00
72_G119_A0.8771.00
131_G135_L0.8751.00
12_L16_L0.8721.00
66_G69_G0.8571.00
178_W182_L0.8561.00
106_G110_L0.8561.00
100_L103_T0.8471.00
14_A41_L0.8461.00
7_F11_V0.8391.00
103_T107_V0.8341.00
145_L149_L0.8331.00
160_P163_G0.8271.00
14_A42_F0.8271.00
59_G62_R0.8261.00
38_T42_F0.8241.00
149_L152_L0.8141.00
57_A76_L0.8141.00
128_R134_L0.8111.00
118_L122_L0.8111.00
85_L88_L0.8101.00
140_G154_L0.8061.00
127_R130_R0.8051.00
24_V163_G0.8001.00
83_L86_A0.7921.00
86_A108_A0.7911.00
135_L141_V0.7901.00
15_G21_Y0.7831.00
143_L150_L0.7771.00
67_R71_I0.7761.00
79_A116_L0.7731.00
147_L151_A0.7641.00
27_T91_M0.7631.00
146_L149_L0.7591.00
10_A46_F0.7511.00
152_L155_A0.7481.00
22_S26_Q0.7471.00
15_G18_R0.7441.00
104_L107_V0.7431.00
126_R131_G0.7431.00
171_A174_A0.7431.00
136_S146_L0.7371.00
131_G139_S0.7361.00
50_G84_I0.7301.00
128_R132_W0.7261.00
39_G42_F0.7251.00
106_G109_A0.7221.00
68_A72_G0.7211.00
58_V62_R0.7211.00
132_W138_L0.7191.00
129_R133_R0.7171.00
172_V176_L0.7161.00
75_L115_L0.7111.00
35_G39_G0.7071.00
79_A112_A0.7061.00
125_A133_R0.7061.00
36_G39_G0.7061.00
138_L141_V0.7041.00
140_G147_L0.7041.00
168_E172_V0.7031.00
14_A38_T0.6991.00
158_N161_G0.6981.00
53_L83_L0.6981.00
127_R132_W0.6971.00
129_R135_L0.6941.00
134_L139_S0.6911.00
150_L156_A0.6881.00
135_L140_G0.6811.00
134_L137_L0.6781.00
45_G49_L0.6781.00
28_I169_R0.6711.00
133_R140_G0.6701.00
167_A170_I0.6691.00
128_R135_L0.6691.00
126_R139_S0.6691.00
130_R134_L0.6681.00
168_E176_L0.6651.00
90_P93_P0.6641.00
132_W139_S0.6621.00
129_R134_L0.6621.00
14_A17_L0.6601.00
113_F116_L0.6531.00
83_L112_A0.6501.00
82_G115_L0.6491.00
43_N47_I0.6451.00
74_A78_L0.6341.00
24_V27_T0.6321.00
136_S142_A0.6321.00
10_A14_A0.6291.00
128_R136_S0.6261.00
149_L153_F0.6191.00
18_R38_T0.6161.00
167_A171_A0.6151.00
144_L148_A0.6121.00
139_S146_L0.6121.00
79_A115_L0.6091.00
33_A36_G0.6081.00
7_F49_L0.6031.00
17_L38_T0.6011.00
30_E33_A0.5981.00
127_R134_L0.5961.00
14_A31_L0.5941.00
126_R133_R0.5931.00
78_L82_G0.5871.00
130_R136_S0.5831.00
25_R163_G0.5791.00
147_L150_L0.5791.00
33_A91_M0.5761.00
138_L152_L0.5751.00
176_L180_A0.5731.00
159_L163_G0.5731.00
89_F108_A0.5711.00
49_L53_L0.5671.00
136_S143_L0.5671.00
69_G73_A0.5641.00
127_R133_R0.5621.00
108_A111_L0.5621.00
132_W149_L0.5611.00
53_L179_L0.5601.00
58_V61_R0.5551.00
112_A117_P0.5521.00
9_A13_V0.5501.00
6_L45_G0.5501.00
11_V15_G0.5481.00
126_R134_L0.5461.00
45_G48_L0.5451.00
23_P169_R0.5441.00
126_R130_R0.5441.00
13_V18_R0.5431.00
170_I174_A0.5411.00
165_G168_E0.5331.00
113_F117_P0.5311.00
47_I51_L0.5301.00
159_L162_P0.5301.00
51_L55_A0.5251.00
61_R74_A0.5241.00
148_A152_L0.5241.00
32_G87_G0.5241.00
136_S147_L0.5231.00
174_A177_L0.5221.00
11_V14_A0.5221.00
21_Y169_R0.5221.00
132_W150_L0.5211.00
142_A149_L0.5171.00
108_A112_A0.5141.00
173_L176_L0.5101.00
138_L153_F0.5071.00
113_F172_V0.5051.00
32_G91_M0.5051.00
148_A155_A0.5031.00
115_L119_A0.5021.00
95_G98_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ks1B 1 0.2378 6.7 0.914 Contact Map
4o6yA 2 0.9459 4.9 0.919 Contact Map
2o9gA 3 0.3459 3.7 0.924 Contact Map
3m73A 3 0.5784 3.2 0.926 Contact Map
4nv5A 1 0.9405 3.1 0.926 Contact Map
4k5yA 1 0.4757 2.9 0.928 Contact Map
3llqA 3 0.3459 2.7 0.929 Contact Map
2f2bA 4 0.3351 2.7 0.929 Contact Map
4wfeA 2 0.6757 2.6 0.93 Contact Map
4nefA 4 0.4216 2.5 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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