GREMLIN Database
DUF997 - Protein of unknown function (DUF997)
PFAM: PF06196 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (75)
Sequences: 1402 (968)
Seq/√Len: 111.8
META: 0.71

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_F49_V2.6301.00
7_L11_G2.3491.00
32_P35_Y2.3321.00
61_L65_F2.3301.00
24_A47_S2.0771.00
19_W51_P2.0631.00
12_L58_L2.0481.00
13_W16_Y1.8921.00
1_Q4_R1.8221.00
37_I45_F1.7681.00
44_F48_C1.7591.00
42_D46_W1.6441.00
9_T16_Y1.6201.00
8_I66_F1.5491.00
23_F27_L1.5081.00
3_R7_L1.4581.00
24_A27_L1.4441.00
52_W56_I1.4361.00
64_K67_F1.4361.00
62_M67_F1.4231.00
24_A29_S1.4091.00
40_F45_F1.3621.00
22_G26_G1.3591.00
63_V67_F1.3571.00
11_G15_A1.3161.00
36_Y45_F1.2780.99
17_F21_Y1.2300.99
60_W64_K1.1970.99
44_F47_S1.1910.99
18_V22_G1.1870.99
59_V62_M1.1800.99
17_F20_W1.1380.99
24_A28_G1.1230.98
11_G18_V1.1110.98
1_Q68_K1.0840.98
61_L66_F1.0820.98
37_I42_D1.0760.98
53_I57_V1.0580.98
20_W48_C1.0350.97
16_Y20_W1.0040.97
16_Y21_Y0.9990.97
44_F51_P0.9930.97
13_W20_W0.9910.97
21_Y51_P0.9850.96
56_I60_W0.9670.96
26_G29_S0.9440.95
12_L17_F0.9430.95
31_P34_E0.9310.95
1_Q69_D0.9110.94
15_A22_G0.9110.94
14_L18_V0.8940.94
71_P75_E0.8860.94
13_W17_F0.8820.93
64_K68_K0.8760.93
2_A6_A0.8390.92
16_Y19_W0.8330.91
37_I46_W0.8330.91
1_Q70_I0.8240.91
62_M66_F0.8150.90
45_F50_V0.8140.90
57_V61_L0.8090.90
25_Y32_P0.7930.89
53_I56_I0.7830.89
15_A68_K0.7810.88
20_W23_F0.7640.87
13_W59_V0.7510.86
20_W24_A0.7320.85
15_A55_F0.7320.85
30_G34_E0.7230.84
45_F49_V0.7220.84
1_Q9_T0.7220.84
48_C51_P0.7160.84
6_A9_T0.7050.83
23_F54_V0.7030.83
19_W24_A0.7020.83
13_W48_C0.6910.82
58_L62_M0.6900.81
63_V66_F0.6860.81
16_Y55_F0.6820.81
27_L46_W0.6800.81
26_G31_P0.6790.80
46_W50_V0.6680.79
59_V63_V0.6670.79
30_G42_D0.6650.79
71_P74_D0.6620.79
2_A9_T0.6590.78
19_W23_F0.6510.78
31_P35_Y0.6340.76
50_V54_V0.6300.75
6_A72_L0.6260.75
36_Y50_V0.6200.74
44_F52_W0.6110.73
47_S63_V0.6070.73
23_F47_S0.6010.72
11_G14_L0.6010.72
38_L49_V0.5990.72
8_I11_G0.5980.71
52_W55_F0.5890.70
2_A52_W0.5890.70
42_D45_F0.5840.70
12_L20_W0.5760.69
13_W51_P0.5620.67
34_E65_F0.5570.66
65_F68_K0.5530.66
2_A44_F0.5530.66
54_V58_L0.5530.66
55_F62_M0.5290.62
21_Y25_Y0.5220.61
40_F51_P0.5220.61
2_A13_W0.5190.61
22_G27_L0.5090.59
68_K73_E0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o9gA 3 0.8816 11.3 0.89 Contact Map
2kncA 1 0.6053 9.4 0.894 Contact Map
4aw6A 2 0.9342 8.8 0.895 Contact Map
4lz6A 1 0.8553 7.8 0.897 Contact Map
3w4tA 1 0.8816 6.5 0.901 Contact Map
3cn5A 3 0.8947 6.1 0.903 Contact Map
3dl8G 1 0.8816 5.8 0.903 Contact Map
2l8sA 1 0.5263 5.5 0.904 Contact Map
4il3A 1 0.9342 5.1 0.906 Contact Map
4i0uA 4 0.7895 4.9 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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