GREMLIN Database
DUF992 - Protein of unknown function (DUF992)
PFAM: PF06186 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 142 (138)
Sequences: 4624 (2737)
Seq/√Len: 233.0
META: 0.936

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_E105_G2.9091.00
99_T127_Q2.8621.00
8_A11_Q2.6381.00
34_S57_R2.4381.00
29_F32_G2.4131.00
104_V118_A2.2391.00
33_S62_D2.2171.00
40_V49_P2.2141.00
20_T70_V2.2041.00
113_S116_S2.1841.00
108_V122_L2.1471.00
37_L139_L2.0521.00
23_V26_G2.0431.00
57_R138_S2.0161.00
18_V72_V1.9311.00
38_S51_R1.9281.00
90_T140_T1.9091.00
20_T42_T1.8591.00
104_V108_V1.8321.00
67_G128_T1.7891.00
82_L117_I1.7831.00
23_V35_K1.7711.00
43_P49_P1.7561.00
95_S137_A1.7291.00
26_G35_K1.7261.00
81_R115_R1.7091.00
35_K66_T1.7081.00
105_G125_E1.7021.00
34_S55_T1.6721.00
31_I59_F1.6391.00
100_V130_L1.6231.00
7_A10_A1.6201.00
16_V77_A1.6001.00
92_V138_S1.5981.00
6_P9_A1.5561.00
107_N123_S1.5531.00
14_V78_P1.4961.00
50_E85_G1.4531.00
58_K95_S1.4241.00
37_L54_G1.4161.00
57_R140_T1.4151.00
43_P47_G1.3891.00
58_K137_A1.3821.00
27_V65_Y1.3641.00
15_K44_S1.3571.00
9_A12_A1.3521.00
18_V74_A1.3431.00
22_D70_V1.2961.00
23_V71_L1.2921.00
40_V51_R1.2681.00
42_T49_P1.2611.00
23_V37_L1.2381.00
69_G125_E1.2311.00
7_A11_Q1.2211.00
32_G62_D1.2121.00
37_L56_I1.1891.00
32_G59_F1.1831.00
79_T116_S1.1381.00
55_T140_T1.1351.00
108_V118_A1.1241.00
64_G131_N1.1231.00
94_A110_V1.1221.00
85_G88_A1.1031.00
90_T142_R1.0971.00
90_T138_S1.0911.00
35_K58_K1.0801.00
43_P48_P1.0751.00
8_A12_A1.0601.00
49_P53_T1.0381.00
15_K74_A1.0361.00
72_V126_G1.0291.00
18_V44_S1.0191.00
22_D38_S1.0151.00
96_A134_A0.9881.00
36_D53_T0.9821.00
99_T130_L0.9801.00
35_K69_G0.9671.00
38_S53_T0.9631.00
106_A122_L0.9541.00
33_S58_K0.9511.00
23_V69_G0.9501.00
41_F76_F0.9491.00
30_I63_I0.9361.00
20_T72_V0.9251.00
31_I61_L0.9251.00
60_G93_G0.9181.00
17_G21_C0.9091.00
97_E127_Q0.9061.00
43_P50_E0.8910.99
95_S107_N0.8660.99
13_G76_F0.8620.99
50_E84_P0.8620.99
58_K133_A0.8620.99
28_G64_G0.8570.99
97_E107_N0.8500.99
45_G48_P0.8450.99
24_S36_D0.8400.99
6_P10_A0.8350.99
77_A86_A0.8340.99
96_A106_A0.8260.99
44_S47_G0.8260.99
22_D68_G0.8250.99
77_A116_S0.8160.99
5_A8_A0.8160.99
23_V54_G0.8150.99
81_R84_P0.8060.99
5_A10_A0.7930.99
24_S54_G0.7910.99
68_G128_T0.7870.99
54_G69_G0.7800.99
132_V135_G0.7800.99
21_C39_C0.7780.99
110_V118_A0.7570.98
56_I137_A0.7570.98
66_T99_T0.7550.98
29_F34_S0.7490.98
28_G66_T0.7470.98
74_A122_L0.7360.98
98_A102_V0.7320.98
22_D40_V0.7310.98
83_G114_N0.7300.98
13_G118_A0.7290.98
5_A11_Q0.7260.98
32_G57_R0.7160.97
113_S118_A0.7140.97
61_L132_V0.7120.97
66_T127_Q0.7010.97
100_V104_V0.7000.97
15_K45_G0.6920.97
95_S123_S0.6860.97
15_K18_V0.6830.97
99_T131_N0.6810.97
36_D55_T0.6780.96
29_F57_R0.6730.96
36_D67_G0.6600.96
59_F138_S0.6590.96
32_G64_G0.6570.96
28_G105_G0.6540.96
81_R86_A0.6490.96
94_A108_V0.6480.95
41_F45_G0.6450.95
133_A136_V0.6440.95
61_L65_Y0.6420.95
22_D25_G0.6400.95
5_A9_A0.6340.95
29_F59_F0.6300.95
131_N137_A0.6300.95
120_Q123_S0.6290.95
80_S114_N0.6260.95
50_E82_L0.6210.94
48_P84_P0.6110.94
46_G115_R0.6010.93
24_S69_G0.6000.93
79_T82_L0.6000.93
99_T129_G0.5970.93
97_E133_A0.5970.93
109_L139_L0.5930.93
30_I62_D0.5930.93
25_G65_Y0.5910.93
97_E125_E0.5890.93
58_K91_Y0.5860.92
96_A103_G0.5830.92
40_V70_V0.5820.92
38_S54_G0.5800.92
70_V74_A0.5760.92
88_A114_N0.5740.92
56_I73_W0.5690.91
7_A12_A0.5670.91
89_G112_G0.5630.91
42_T46_G0.5620.91
5_A12_A0.5620.91
25_G67_G0.5550.90
33_S129_G0.5550.90
29_F56_I0.5550.90
71_L136_V0.5540.90
93_G105_G0.5530.90
32_G58_K0.5510.90
71_L95_S0.5510.90
28_G131_N0.5500.90
42_T45_G0.5440.89
64_G107_N0.5430.89
24_S27_V0.5410.89
16_V41_F0.5410.89
72_V124_V0.5350.89
6_P12_A0.5320.88
13_G78_P0.5290.88
24_S38_S0.5270.88
45_G80_S0.5270.88
57_R90_T0.5260.88
88_A113_S0.5240.88
73_W123_S0.5220.87
40_V43_P0.5200.87
103_G123_S0.5190.87
49_P83_G0.5190.87
71_L133_A0.5180.87
33_S93_G0.5160.87
33_S63_I0.5150.87
77_A117_I0.5150.87
59_F136_V0.5140.87
13_G25_G0.5140.87
94_A98_A0.5110.86
25_G56_I0.5050.86
15_K84_P0.5020.85
35_K97_E0.5010.85
127_Q137_A0.5000.85
24_S37_L0.5000.85
36_D142_R0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jj0A 4 0.0141 4.8 0.942 Contact Map
3wguG 1 0.1972 3.4 0.946 Contact Map
2imhA 2 0.4085 1.8 0.954 Contact Map
2m0sA 1 0.1972 1.5 0.956 Contact Map
3pguA 1 0.3873 1.2 0.958 Contact Map
3u0rA 1 0.0493 1 0.96 Contact Map
4nbqA 3 0.9437 1 0.96 Contact Map
3dwoX 1 0.3873 0.9 0.961 Contact Map
4ui9U 1 0.169 0.8 0.962 Contact Map
2yd6A 2 0.2817 0.8 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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