GREMLIN Database
ABC2_membrane_6 - ABC-2 family transporter protein
PFAM: PF06182 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 229 (226)
Sequences: 21059 (15892)
Seq/√Len: 1057.1
META: 0.848

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
177_L180_A2.8021.00
25_T28_E2.7291.00
133_L217_V2.7141.00
109_T112_T2.6611.00
212_L216_L2.6431.00
72_D215_R2.6311.00
57_L62_T2.5701.00
216_L220_R2.5191.00
57_L66_Y2.4291.00
220_R223_R2.4111.00
140_W221_G2.4081.00
170_R174_T2.3341.00
215_R219_R2.1451.00
12_L26_L2.1301.00
167_G171_R2.1091.00
136_L217_V2.1081.00
129_A214_A2.1051.00
184_Y188_E2.1011.00
122_L207_A2.0491.00
95_V99_Y2.0031.00
185_F199_L1.9891.00
167_G170_R1.9741.00
98_A102_F1.9651.00
168_W171_R1.9201.00
137_L141_T1.9081.00
28_E193_R1.9001.00
72_D75_F1.8991.00
129_A211_L1.8331.00
188_E193_R1.8301.00
92_L95_V1.8231.00
125_L207_A1.8221.00
59_R143_E1.8171.00
129_A207_A1.8111.00
122_L204_L1.7291.00
27_A103_R1.7071.00
220_R224_R1.6801.00
35_L116_F1.6671.00
163_D188_E1.6631.00
133_L214_A1.6611.00
98_A101_L1.6291.00
64_D227_S1.6201.00
95_V98_A1.5731.00
174_T180_A1.5691.00
198_W202_L1.5571.00
100_A103_R1.5171.00
149_E152_Y1.5051.00
74_L214_A1.4991.00
133_L210_L1.4991.00
94_L98_A1.4921.00
197_L201_A1.4911.00
64_D225_Y1.4731.00
56_E60_T1.4721.00
205_L209_V1.4701.00
226_S229_G1.4611.00
171_R174_T1.4591.00
160_Y164_I1.4551.00
20_S23_G1.4521.00
213_L216_L1.4421.00
73_P218_W1.4411.00
102_F105_G1.4381.00
149_E153_G1.4201.00
91_L95_V1.4141.00
139_F221_G1.3931.00
211_L215_R1.3891.00
216_L219_R1.3831.00
132_L136_L1.3521.00
119_S189_I1.3501.00
26_L30_L1.3471.00
129_A210_L1.3411.00
58_I138_A1.3371.00
168_W172_I1.3341.00
97_L100_A1.3191.00
24_W163_D1.3181.00
181_F202_L1.2971.00
163_D184_Y1.2961.00
212_L215_R1.2931.00
114_L118_L1.2801.00
78_L128_F1.2721.00
119_S203_Q1.2701.00
138_A144_V1.2601.00
12_L16_S1.2521.00
101_L104_L1.2501.00
91_L94_L1.2411.00
67_L222_L1.2201.00
161_P164_I1.2191.00
156_S159_R1.2091.00
126_I207_A1.2071.00
84_L88_G1.2041.00
71_V76_Q1.2021.00
171_R175_F1.1981.00
74_L132_L1.1951.00
65_F69_R1.1941.00
217_V220_R1.1761.00
37_L40_F1.1581.00
200_L203_Q1.1571.00
74_L215_R1.1571.00
199_L202_L1.1551.00
59_R142_V1.1491.00
27_A30_L1.1261.00
34_G100_A1.1131.00
132_L214_A1.1111.00
100_A104_L1.0931.00
54_L73_P1.0861.00
99_Y103_R1.0801.00
57_L77_V1.0651.00
180_A184_Y1.0651.00
181_F185_F1.0611.00
166_P169_L1.0611.00
96_L100_A1.0581.00
112_T192_G1.0481.00
206_W210_L1.0471.00
15_F19_G1.0411.00
140_W220_R1.0331.00
86_R89_D1.0291.00
122_L203_Q1.0291.00
126_I210_L1.0281.00
162_L180_A1.0281.00
40_F44_A1.0251.00
55_A143_E1.0211.00
140_W217_V1.0211.00
99_Y102_F1.0201.00
128_F132_L1.0201.00
118_L122_L1.0191.00
40_F43_A1.0171.00
111_A114_L1.0031.00
125_L129_A1.0021.00
15_F29_M0.9971.00
113_L117_L0.9911.00
174_T185_F0.9911.00
93_G97_L0.9861.00
198_W201_A0.9861.00
92_L102_F0.9821.00
119_S122_L0.9721.00
142_V228_A0.9711.00
213_L217_V0.9661.00
24_W188_E0.9661.00
75_F79_A0.9631.00
225_Y228_A0.9621.00
76_Q80_R0.9521.00
111_A115_L0.9441.00
74_L129_A0.9371.00
93_G96_L0.9361.00
53_E81_R0.9341.00
62_T65_F0.9321.00
67_L73_P0.9281.00
104_L107_P0.9211.00
85_R89_D0.9101.00
57_L73_P0.9081.00
115_L189_I0.9081.00
69_R76_Q0.9021.00
114_L117_L0.8971.00
91_L101_L0.8911.00
93_G101_L0.8871.00
109_T113_L0.8861.00
203_Q207_A0.8761.00
110_P114_L0.8741.00
117_L121_L0.8661.00
127_F182_V0.8601.00
108_W112_T0.8601.00
115_L119_S0.8551.00
43_A46_F0.8531.00
41_G46_F0.8531.00
116_F190_L0.8521.00
201_A205_L0.8481.00
110_P113_L0.8441.00
208_V212_L0.8381.00
66_Y76_Q0.8351.00
93_G100_A0.8341.00
92_L99_Y0.8231.00
162_L184_Y0.8231.00
77_V81_R0.8191.00
54_L135_A0.8191.00
209_V212_L0.8181.00
126_I181_F0.8171.00
169_L173_L0.8161.00
29_M32_Y0.8141.00
85_R88_G0.8101.00
57_L80_R0.8061.00
219_R223_R0.8031.00
136_L221_G0.8001.00
16_S19_G0.8001.00
81_R85_R0.7891.00
108_W113_L0.7881.00
97_L101_L0.7851.00
133_L137_L0.7851.00
125_L211_L0.7821.00
92_L96_L0.7711.00
15_F18_T0.7711.00
42_L45_L0.7691.00
211_L214_A0.7671.00
55_A144_V0.7651.00
150_L153_G0.7651.00
202_L205_L0.7641.00
39_V42_L0.7611.00
39_V43_A0.7541.00
53_E57_L0.7541.00
171_R176_V0.7501.00
160_Y165_F0.7501.00
73_P77_V0.7471.00
57_L60_T0.7451.00
81_R84_L0.7431.00
40_F47_F0.7391.00
95_V102_F0.7381.00
66_Y73_P0.7361.00
77_V80_R0.7341.00
123_G126_I0.7321.00
22_G163_D0.7311.00
142_V226_S0.7251.00
141_T147_L0.7241.00
209_V213_L0.7161.00
24_W32_Y0.7161.00
185_F188_E0.7111.00
5_A9_F0.7081.00
41_G45_L0.7071.00
78_L125_L0.7071.00
201_A204_L0.7031.00
33_Y36_F0.7001.00
134_L151_F0.6991.00
32_Y35_L0.6971.00
53_E56_E0.6911.00
79_A83_G0.6881.00
31_L190_L0.6841.00
192_G195_S0.6831.00
199_L203_Q0.6831.00
133_L136_L0.6811.00
94_L101_L0.6791.00
15_F26_L0.6741.00
63_L225_Y0.6731.00
96_L99_Y0.6721.00
151_F154_L0.6711.00
112_T115_L0.6701.00
48_A51_W0.6681.00
39_V123_G0.6671.00
35_L39_V0.6651.00
34_G97_L0.6641.00
63_L222_L0.6641.00
140_W224_R0.6641.00
96_L103_R0.6631.00
95_V100_A0.6591.00
93_G102_F0.6581.00
185_F194_L0.6561.00
207_A211_L0.6561.00
141_T144_V0.6531.00
55_A145_S0.6501.00
26_L29_M0.6481.00
157_G160_Y0.6461.00
94_L97_L0.6451.00
41_G90_L0.6431.00
7_Q10_L0.6431.00
40_F45_L0.6411.00
95_V101_L0.6411.00
37_L41_G0.6401.00
133_L213_L0.6401.00
41_G44_A0.6361.00
31_L187_A0.6311.00
136_L214_A0.6311.00
93_G103_R0.6261.00
81_R88_G0.6261.00
31_L100_A0.6231.00
92_L100_A0.6231.00
36_F40_F0.6211.00
173_L180_A0.6201.00
7_Q11_W0.6191.00
107_P110_P0.6181.00
225_Y229_G0.6171.00
71_V75_F0.6161.00
157_G161_P0.6141.00
20_S25_T0.6131.00
92_L103_R0.6111.00
56_E62_T0.6091.00
96_L101_L0.6021.00
119_S200_L0.6011.00
112_T189_I0.6011.00
93_G98_A0.5991.00
95_V104_L0.5931.00
95_V103_R0.5841.00
45_L48_A0.5811.00
31_L35_L0.5801.00
115_L118_L0.5801.00
11_W15_F0.5801.00
150_L154_L0.5801.00
138_A142_V0.5771.00
157_G166_P0.5711.00
33_Y37_L0.5691.00
155_L173_L0.5651.00
105_G108_W0.5631.00
10_L14_I0.5631.00
160_Y163_D0.5621.00
34_G37_L0.5551.00
103_R107_P0.5551.00
18_T21_I0.5521.00
130_L182_V0.5521.00
162_L170_R0.5521.00
218_W222_L0.5521.00
197_L200_L0.5501.00
204_L207_A0.5481.00
168_W173_L0.5471.00
116_F119_S0.5471.00
28_E191_L0.5451.00
161_P169_L0.5451.00
63_L73_P0.5431.00
47_F50_N0.5431.00
131_F151_F0.5421.00
42_L124_A0.5411.00
84_L87_L0.5401.00
52_D148_V0.5391.00
188_E194_L0.5391.00
9_F12_L0.5381.00
145_S148_V0.5351.00
10_L13_A0.5351.00
194_L199_L0.5351.00
78_L82_L0.5341.00
101_L105_G0.5331.00
162_L188_E0.5311.00
8_L30_L0.5291.00
165_F169_L0.5281.00
93_G99_Y0.5281.00
129_A133_L0.5261.00
165_F168_W0.5241.00
107_P112_T0.5241.00
92_L101_L0.5241.00
146_G149_E0.5231.00
106_L112_T0.5221.00
8_L12_L0.5181.00
12_L17_R0.5181.00
12_L15_F0.5181.00
214_A218_W0.5181.00
166_P170_R0.5181.00
158_A183_A0.5181.00
172_I176_V0.5171.00
56_E59_R0.5161.00
113_L190_L0.5131.00
121_L125_L0.5131.00
37_L43_A0.5101.00
203_Q206_W0.5091.00
161_P167_G0.5071.00
132_L218_W0.5021.00
188_E192_G0.5011.00
51_W148_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xk8K 1 0.0917 5.4 0.943 Contact Map
2lx0A 1 0.1397 2.5 0.952 Contact Map
2mfrA 1 0.2096 1.3 0.959 Contact Map
1hgvA 8 0.2009 1.2 0.96 Contact Map
1b9uA 1 0.1485 1 0.962 Contact Map
2i68A 2 0.1659 1 0.962 Contact Map
1jb0K 1 0.0873 0.8 0.964 Contact Map
2vpbB 1 0.1528 0.8 0.965 Contact Map
2ygvE 1 0.0873 0.8 0.965 Contact Map
2mmmA 1 0.0611 0.7 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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