ABC2_membrane_6 - PFAM28P - GREMLIN Contacts

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ABC2_membrane_6 - ABC-2 family transporter protein

PFAM:	PF06182	Sequences: LLWLAVQLFLWLAIFSRTGSIGGWTLAEMLLYYGLFLLVFGLAALFFAGNWDELAELIRTGTLDFYLLRPVDPLFQVLARRLGLRRLGDLLLGLVLLAYALFRLGLPWTPATLLLFLLSLLLGALIFFALFLLLALLAFWTVEVSGLVELFYGLLSGARYPLDIFPGWLRRILTFVLPFAFVAYFPAEILLGRLSPLWLLALQLLWAVVLLLLARLVWRRGLRRYSSAG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	229 (226)
Sequences:	21059 (15892)
Seq/√Len:	1057.1
META:	0.848

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
177_L	180_A	2.802	1.00
25_T	28_E	2.729	1.00
133_L	217_V	2.714	1.00
109_T	112_T	2.661	1.00
212_L	216_L	2.643	1.00
72_D	215_R	2.631	1.00
57_L	62_T	2.570	1.00
216_L	220_R	2.519	1.00
57_L	66_Y	2.429	1.00
220_R	223_R	2.411	1.00
140_W	221_G	2.408	1.00
170_R	174_T	2.334	1.00
215_R	219_R	2.145	1.00
12_L	26_L	2.130	1.00
167_G	171_R	2.109	1.00
136_L	217_V	2.108	1.00
129_A	214_A	2.105	1.00
184_Y	188_E	2.101	1.00
122_L	207_A	2.049	1.00
95_V	99_Y	2.003	1.00
185_F	199_L	1.989	1.00
167_G	170_R	1.974	1.00
98_A	102_F	1.965	1.00
168_W	171_R	1.920	1.00
137_L	141_T	1.908	1.00
28_E	193_R	1.900	1.00
72_D	75_F	1.899	1.00
129_A	211_L	1.833	1.00
188_E	193_R	1.830	1.00
92_L	95_V	1.823	1.00
125_L	207_A	1.822	1.00
59_R	143_E	1.817	1.00
129_A	207_A	1.811	1.00
122_L	204_L	1.729	1.00
27_A	103_R	1.707	1.00
220_R	224_R	1.680	1.00
35_L	116_F	1.667	1.00
163_D	188_E	1.663	1.00
133_L	214_A	1.661	1.00
98_A	101_L	1.629	1.00
64_D	227_S	1.620	1.00
95_V	98_A	1.573	1.00
174_T	180_A	1.569	1.00
198_W	202_L	1.557	1.00
100_A	103_R	1.517	1.00
149_E	152_Y	1.505	1.00
74_L	214_A	1.499	1.00
133_L	210_L	1.499	1.00
94_L	98_A	1.492	1.00
197_L	201_A	1.491	1.00
64_D	225_Y	1.473	1.00
56_E	60_T	1.472	1.00
205_L	209_V	1.470	1.00
226_S	229_G	1.461	1.00
171_R	174_T	1.459	1.00
160_Y	164_I	1.455	1.00
20_S	23_G	1.452	1.00
213_L	216_L	1.442	1.00
73_P	218_W	1.441	1.00
102_F	105_G	1.438	1.00
149_E	153_G	1.420	1.00
91_L	95_V	1.414	1.00
139_F	221_G	1.393	1.00
211_L	215_R	1.389	1.00
216_L	219_R	1.383	1.00
132_L	136_L	1.352	1.00
119_S	189_I	1.350	1.00
26_L	30_L	1.347	1.00
129_A	210_L	1.341	1.00
58_I	138_A	1.337	1.00
168_W	172_I	1.334	1.00
97_L	100_A	1.319	1.00
24_W	163_D	1.318	1.00
181_F	202_L	1.297	1.00
163_D	184_Y	1.296	1.00
212_L	215_R	1.293	1.00
114_L	118_L	1.280	1.00
78_L	128_F	1.272	1.00
119_S	203_Q	1.270	1.00
138_A	144_V	1.260	1.00
12_L	16_S	1.252	1.00
101_L	104_L	1.250	1.00
91_L	94_L	1.241	1.00
67_L	222_L	1.220	1.00
161_P	164_I	1.219	1.00
156_S	159_R	1.209	1.00
126_I	207_A	1.207	1.00
84_L	88_G	1.204	1.00
71_V	76_Q	1.202	1.00
171_R	175_F	1.198	1.00
74_L	132_L	1.195	1.00
65_F	69_R	1.194	1.00
217_V	220_R	1.176	1.00
37_L	40_F	1.158	1.00
200_L	203_Q	1.157	1.00
74_L	215_R	1.157	1.00
199_L	202_L	1.155	1.00
59_R	142_V	1.149	1.00
27_A	30_L	1.126	1.00
34_G	100_A	1.113	1.00
132_L	214_A	1.111	1.00
100_A	104_L	1.093	1.00
54_L	73_P	1.086	1.00
99_Y	103_R	1.080	1.00
57_L	77_V	1.065	1.00
180_A	184_Y	1.065	1.00
181_F	185_F	1.061	1.00
166_P	169_L	1.061	1.00
96_L	100_A	1.058	1.00
112_T	192_G	1.048	1.00
206_W	210_L	1.047	1.00
15_F	19_G	1.041	1.00
140_W	220_R	1.033	1.00
86_R	89_D	1.029	1.00
122_L	203_Q	1.029	1.00
126_I	210_L	1.028	1.00
162_L	180_A	1.028	1.00
40_F	44_A	1.025	1.00
55_A	143_E	1.021	1.00
140_W	217_V	1.021	1.00
99_Y	102_F	1.020	1.00
128_F	132_L	1.020	1.00
118_L	122_L	1.019	1.00
40_F	43_A	1.017	1.00
111_A	114_L	1.003	1.00
125_L	129_A	1.002	1.00
15_F	29_M	0.997	1.00
113_L	117_L	0.991	1.00
174_T	185_F	0.991	1.00
93_G	97_L	0.986	1.00
198_W	201_A	0.986	1.00
92_L	102_F	0.982	1.00
119_S	122_L	0.972	1.00
142_V	228_A	0.971	1.00
213_L	217_V	0.966	1.00
24_W	188_E	0.966	1.00
75_F	79_A	0.963	1.00
225_Y	228_A	0.962	1.00
76_Q	80_R	0.952	1.00
111_A	115_L	0.944	1.00
74_L	129_A	0.937	1.00
93_G	96_L	0.936	1.00
53_E	81_R	0.934	1.00
62_T	65_F	0.932	1.00
67_L	73_P	0.928	1.00
104_L	107_P	0.921	1.00
85_R	89_D	0.910	1.00
57_L	73_P	0.908	1.00
115_L	189_I	0.908	1.00
69_R	76_Q	0.902	1.00
114_L	117_L	0.897	1.00
91_L	101_L	0.891	1.00
93_G	101_L	0.887	1.00
109_T	113_L	0.886	1.00
203_Q	207_A	0.876	1.00
110_P	114_L	0.874	1.00
117_L	121_L	0.866	1.00
127_F	182_V	0.860	1.00
108_W	112_T	0.860	1.00
115_L	119_S	0.855	1.00
43_A	46_F	0.853	1.00
41_G	46_F	0.853	1.00
116_F	190_L	0.852	1.00
201_A	205_L	0.848	1.00
110_P	113_L	0.844	1.00
208_V	212_L	0.838	1.00
66_Y	76_Q	0.835	1.00
93_G	100_A	0.834	1.00
92_L	99_Y	0.823	1.00
162_L	184_Y	0.823	1.00
77_V	81_R	0.819	1.00
54_L	135_A	0.819	1.00
209_V	212_L	0.818	1.00
126_I	181_F	0.817	1.00
169_L	173_L	0.816	1.00
29_M	32_Y	0.814	1.00
85_R	88_G	0.810	1.00
57_L	80_R	0.806	1.00
219_R	223_R	0.803	1.00
136_L	221_G	0.800	1.00
16_S	19_G	0.800	1.00
81_R	85_R	0.789	1.00
108_W	113_L	0.788	1.00
97_L	101_L	0.785	1.00
133_L	137_L	0.785	1.00
125_L	211_L	0.782	1.00
92_L	96_L	0.771	1.00
15_F	18_T	0.771	1.00
42_L	45_L	0.769	1.00
211_L	214_A	0.767	1.00
55_A	144_V	0.765	1.00
150_L	153_G	0.765	1.00
202_L	205_L	0.764	1.00
39_V	42_L	0.761	1.00
39_V	43_A	0.754	1.00
53_E	57_L	0.754	1.00
171_R	176_V	0.750	1.00
160_Y	165_F	0.750	1.00
73_P	77_V	0.747	1.00
57_L	60_T	0.745	1.00
81_R	84_L	0.743	1.00
40_F	47_F	0.739	1.00
95_V	102_F	0.738	1.00
66_Y	73_P	0.736	1.00
77_V	80_R	0.734	1.00
123_G	126_I	0.732	1.00
22_G	163_D	0.731	1.00
142_V	226_S	0.725	1.00
141_T	147_L	0.724	1.00
209_V	213_L	0.716	1.00
24_W	32_Y	0.716	1.00
185_F	188_E	0.711	1.00
5_A	9_F	0.708	1.00
41_G	45_L	0.707	1.00
78_L	125_L	0.707	1.00
201_A	204_L	0.703	1.00
33_Y	36_F	0.700	1.00
134_L	151_F	0.699	1.00
32_Y	35_L	0.697	1.00
53_E	56_E	0.691	1.00
79_A	83_G	0.688	1.00
31_L	190_L	0.684	1.00
192_G	195_S	0.683	1.00
199_L	203_Q	0.683	1.00
133_L	136_L	0.681	1.00
94_L	101_L	0.679	1.00
15_F	26_L	0.674	1.00
63_L	225_Y	0.673	1.00
96_L	99_Y	0.672	1.00
151_F	154_L	0.671	1.00
112_T	115_L	0.670	1.00
48_A	51_W	0.668	1.00
39_V	123_G	0.667	1.00
35_L	39_V	0.665	1.00
34_G	97_L	0.664	1.00
63_L	222_L	0.664	1.00
140_W	224_R	0.664	1.00
96_L	103_R	0.663	1.00
95_V	100_A	0.659	1.00
93_G	102_F	0.658	1.00
185_F	194_L	0.656	1.00
207_A	211_L	0.656	1.00
141_T	144_V	0.653	1.00
55_A	145_S	0.650	1.00
26_L	29_M	0.648	1.00
157_G	160_Y	0.646	1.00
94_L	97_L	0.645	1.00
41_G	90_L	0.643	1.00
7_Q	10_L	0.643	1.00
40_F	45_L	0.641	1.00
95_V	101_L	0.641	1.00
37_L	41_G	0.640	1.00
133_L	213_L	0.640	1.00
41_G	44_A	0.636	1.00
31_L	187_A	0.631	1.00
136_L	214_A	0.631	1.00
93_G	103_R	0.626	1.00
81_R	88_G	0.626	1.00
31_L	100_A	0.623	1.00
92_L	100_A	0.623	1.00
36_F	40_F	0.621	1.00
173_L	180_A	0.620	1.00
7_Q	11_W	0.619	1.00
107_P	110_P	0.618	1.00
225_Y	229_G	0.617	1.00
71_V	75_F	0.616	1.00
157_G	161_P	0.614	1.00
20_S	25_T	0.613	1.00
92_L	103_R	0.611	1.00
56_E	62_T	0.609	1.00
96_L	101_L	0.602	1.00
119_S	200_L	0.601	1.00
112_T	189_I	0.601	1.00
93_G	98_A	0.599	1.00
95_V	104_L	0.593	1.00
95_V	103_R	0.584	1.00
45_L	48_A	0.581	1.00
31_L	35_L	0.580	1.00
115_L	118_L	0.580	1.00
11_W	15_F	0.580	1.00
150_L	154_L	0.580	1.00
138_A	142_V	0.577	1.00
157_G	166_P	0.571	1.00
33_Y	37_L	0.569	1.00
155_L	173_L	0.565	1.00
105_G	108_W	0.563	1.00
10_L	14_I	0.563	1.00
160_Y	163_D	0.562	1.00
34_G	37_L	0.555	1.00
103_R	107_P	0.555	1.00
18_T	21_I	0.552	1.00
130_L	182_V	0.552	1.00
162_L	170_R	0.552	1.00
218_W	222_L	0.552	1.00
197_L	200_L	0.550	1.00
204_L	207_A	0.548	1.00
168_W	173_L	0.547	1.00
116_F	119_S	0.547	1.00
28_E	191_L	0.545	1.00
161_P	169_L	0.545	1.00
63_L	73_P	0.543	1.00
47_F	50_N	0.543	1.00
131_F	151_F	0.542	1.00
42_L	124_A	0.541	1.00
84_L	87_L	0.540	1.00
52_D	148_V	0.539	1.00
188_E	194_L	0.539	1.00
9_F	12_L	0.538	1.00
145_S	148_V	0.535	1.00
10_L	13_A	0.535	1.00
194_L	199_L	0.535	1.00
78_L	82_L	0.534	1.00
101_L	105_G	0.533	1.00
162_L	188_E	0.531	1.00
8_L	30_L	0.529	1.00
165_F	169_L	0.528	1.00
93_G	99_Y	0.528	1.00
129_A	133_L	0.526	1.00
165_F	168_W	0.524	1.00
107_P	112_T	0.524	1.00
92_L	101_L	0.524	1.00
146_G	149_E	0.523	1.00
106_L	112_T	0.522	1.00
8_L	12_L	0.518	1.00
12_L	17_R	0.518	1.00
12_L	15_F	0.518	1.00
214_A	218_W	0.518	1.00
166_P	170_R	0.518	1.00
158_A	183_A	0.518	1.00
172_I	176_V	0.517	1.00
56_E	59_R	0.516	1.00
113_L	190_L	0.513	1.00
121_L	125_L	0.513	1.00
37_L	43_A	0.510	1.00
203_Q	206_W	0.509	1.00
161_P	167_G	0.507	1.00
132_L	218_W	0.502	1.00
188_E	192_G	0.501	1.00
51_W	148_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4xk8K	1	0.0917	5.4	0.943	Contact Map
2lx0A	1	0.1397	2.5	0.952	Contact Map
2mfrA	1	0.2096	1.3	0.959	Contact Map
1hgvA	8	0.2009	1.2	0.96	Contact Map
1b9uA	1	0.1485	1	0.962	Contact Map
2i68A	2	0.1659	1	0.962	Contact Map
1jb0K	1	0.0873	0.8	0.964	Contact Map
2vpbB	1	0.1528	0.8	0.965	Contact Map
2ygvE	1	0.0873	0.8	0.965	Contact Map
2mmmA	1	0.0611	0.7	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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