DUF989 - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

DUF989 - Protein of unknown function (DUF989)

PFAM:	PF06181	Sequences: AYLLEWLNLLLRWLHVIAGIAWIGSSFYFVWLDNSLRPPDPEDLPKGVAGELWAVHGGGFYHVQKYLVAPAELPEHLHWFKWEAYTTWLSGFALLVVVYYLGAELYLIDPSVADLSPWQAIAISLGSLVVGWLVYDLLCRSPLGRNETLLAAVLFVLLVAAAWGLTQVFSGRAAFLHVGAMLGTIMAANVFFVIIPGQRKMVAALKAGREPDPALGKRAKQRSVHNNYLTLPVLFIMLSNHYPMTYGHPYNWLILALLMLAGALIRHFFNLRHAGKGSPWWLWAAAALLLALAVWLA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	297 (292)
Sequences:	4446 (2163)
Seq/√Len:	126.6
META:	0.892

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_L	90_S	3.856	1.00
204_A	209_R	3.739	1.00
227_N	270_N	3.604	1.00
195_I	199_R	3.169	1.00
161_A	181_M	3.116	1.00
100_Y	125_L	3.046	1.00
116_S	119_Q	2.981	1.00
84_A	187_A	2.912	1.00
159_V	256_A	2.911	1.00
127_S	165_L	2.874	1.00
11_L	97_V	2.732	1.00
124_S	177_H	2.558	1.00
131_G	181_M	2.547	1.00
100_Y	177_H	2.425	1.00
235_F	245_T	2.403	1.00
146_N	149_L	2.398	1.00
200_K	209_R	2.352	1.00
133_L	137_L	2.341	1.00
200_K	215_L	2.316	1.00
37_R	76_H	2.279	1.00
115_L	119_Q	2.234	1.00
166_T	251_N	2.220	1.00
214_A	218_R	2.206	1.00
132_W	136_D	2.177	1.00
89_L	93_A	2.163	1.00
86_T	89_L	2.124	1.00
109_D	112_V	2.101	1.00
16_V	234_L	2.029	1.00
110_P	114_D	2.012	1.00
142_P	145_R	2.007	1.00
134_V	157_L	2.005	1.00
18_A	86_T	1.989	1.00
11_L	93_A	1.963	1.00
92_F	125_L	1.951	1.00
33_D	220_K	1.929	1.00
203_A	207_A	1.905	1.00
155_F	159_V	1.894	1.00
118_W	122_A	1.841	1.00
141_S	144_G	1.837	1.00
197_G	215_L	1.828	1.00
137_L	140_R	1.733	1.00
107_L	169_F	1.720	1.00
133_L	192_F	1.717	1.00
236_I	255_L	1.713	1.00
31_W	80_F	1.668	1.00
214_A	217_K	1.662	1.00
100_Y	124_S	1.590	1.00
235_F	258_L	1.589	1.00
147_E	221_Q	1.579	1.00
156_V	160_A	1.578	1.00
158_L	182_L	1.551	1.00
164_G	168_V	1.528	1.00
107_L	173_A	1.527	1.00
30_V	224_V	1.512	1.00
54_A	63_V	1.511	1.00
127_S	168_V	1.509	1.00
128_L	180_A	1.499	1.00
16_V	19_G	1.499	1.00
250_Y	253_L	1.487	1.00
31_W	52_L	1.484	1.00
279_P	282_L	1.477	1.00
14_L	18_A	1.455	1.00
39_P	43_D	1.406	1.00
183_G	187_A	1.400	1.00
30_V	34_N	1.400	1.00
108_I	113_A	1.399	1.00
154_L	229_L	1.384	1.00
80_F	83_E	1.381	1.00
245_T	254_I	1.365	1.00
88_W	188_A	1.362	1.00
227_N	267_H	1.362	1.00
31_W	35_S	1.359	1.00
49_A	67_L	1.348	1.00
121_I	124_S	1.348	1.00
5_E	8_N	1.344	1.00
88_W	184_T	1.343	1.00
14_L	86_T	1.340	1.00
127_S	130_V	1.332	1.00
139_C	154_L	1.330	1.00
104_E	117_P	1.328	1.00
82_W	86_T	1.319	1.00
280_W	283_W	1.319	1.00
108_I	120_A	1.305	1.00
163_W	167_Q	1.302	1.00
267_H	270_N	1.299	1.00
166_T	174_A	1.295	1.00
112_V	171_G	1.294	1.00
9_L	245_T	1.288	1.00
96_V	101_L	1.274	1.00
160_A	163_W	1.265	1.00
85_Y	191_F	1.258	1.00
271_L	276_K	1.241	1.00
197_G	218_R	1.239	1.00
155_F	260_L	1.236	1.00
137_L	141_S	1.225	0.99
127_S	161_A	1.225	0.99
112_V	166_T	1.213	0.99
31_W	54_A	1.208	0.99
155_F	256_A	1.206	0.99
97_V	101_L	1.204	0.99
248_H	254_I	1.204	0.99
139_C	150_L	1.200	0.99
133_L	136_D	1.197	0.99
182_L	229_L	1.192	0.99
62_H	66_Y	1.179	0.99
112_V	170_S	1.166	0.99
122_A	126_G	1.160	0.99
118_W	121_I	1.157	0.99
269_F	273_H	1.151	0.99
16_V	238_L	1.151	0.99
281_W	284_A	1.150	0.99
268_F	277_G	1.149	0.99
119_Q	122_A	1.149	0.99
220_K	224_V	1.146	0.99
123_I	168_V	1.135	0.99
201_M	204_A	1.132	0.99
108_I	117_P	1.119	0.99
39_P	44_L	1.102	0.99
200_K	205_L	1.101	0.99
54_A	78_H	1.096	0.99
46_K	71_A	1.094	0.99
282_L	286_A	1.091	0.99
143_L	146_N	1.083	0.99
165_L	181_M	1.083	0.99
21_A	25_S	1.081	0.99
127_S	181_M	1.081	0.99
149_L	153_V	1.076	0.99
25_S	28_Y	1.063	0.99
25_S	54_A	1.059	0.98
201_M	205_L	1.058	0.98
188_A	192_F	1.056	0.98
138_L	150_L	1.053	0.98
38_P	44_L	1.048	0.98
203_A	206_K	1.042	0.98
107_L	120_A	1.034	0.98
215_L	218_R	1.034	0.98
200_K	203_A	1.033	0.98
28_Y	54_A	1.029	0.98
173_A	176_L	1.029	0.98
201_M	215_L	1.028	0.98
51_E	64_Q	1.025	0.98
39_P	51_E	1.022	0.98
212_D	215_L	1.022	0.98
267_H	271_L	1.021	0.98
63_V	80_F	1.008	0.98
265_I	289_L	1.008	0.98
84_A	183_G	1.004	0.98
185_I	188_A	1.003	0.98
51_E	62_H	0.995	0.98
25_S	83_E	0.995	0.98
124_S	169_F	0.994	0.98
103_A	117_P	0.991	0.98
127_S	177_H	0.986	0.98
31_W	78_H	0.983	0.98
148_T	152_A	0.982	0.98
162_A	166_T	0.982	0.98
136_D	140_R	0.981	0.97
72_E	75_E	0.979	0.97
131_G	185_I	0.977	0.97
175_F	235_F	0.976	0.97
171_G	251_N	0.973	0.97
5_E	244_M	0.973	0.97
88_W	92_F	0.970	0.97
291_A	295_W	0.970	0.97
272_R	278_S	0.969	0.97
104_E	110_P	0.968	0.97
175_F	245_T	0.966	0.97
161_A	165_L	0.965	0.97
161_A	164_G	0.965	0.97
266_R	269_F	0.962	0.97
282_L	285_A	0.959	0.97
150_L	154_L	0.959	0.97
95_L	124_S	0.957	0.97
200_K	204_A	0.953	0.97
3_L	7_L	0.949	0.97
95_L	177_H	0.947	0.97
82_W	85_Y	0.945	0.97
257_L	292_L	0.945	0.97
126_G	129_V	0.938	0.97
45_P	64_Q	0.934	0.97
279_P	283_W	0.932	0.97
115_L	123_I	0.931	0.97
218_R	221_Q	0.927	0.96
53_W	59_G	0.926	0.96
169_F	173_A	0.919	0.96
85_Y	195_I	0.914	0.96
261_A	292_L	0.913	0.96
129_V	133_L	0.909	0.96
139_C	193_V	0.903	0.96
113_A	168_V	0.900	0.96
199_R	203_A	0.900	0.96
125_L	129_V	0.899	0.96
8_N	242_Y	0.898	0.96
131_G	161_A	0.898	0.96
272_R	277_G	0.897	0.96
43_D	62_H	0.894	0.96
112_V	115_L	0.889	0.96
144_G	221_Q	0.880	0.95
143_L	149_L	0.880	0.95
116_S	122_A	0.877	0.95
283_W	287_A	0.875	0.95
19_G	238_L	0.874	0.95
11_L	14_L	0.871	0.95
264_L	284_A	0.871	0.95
236_I	259_M	0.868	0.95
148_T	151_A	0.868	0.95
52_L	78_H	0.868	0.95
257_L	295_W	0.863	0.95
127_S	164_G	0.862	0.95
284_A	288_L	0.855	0.94
31_W	63_V	0.852	0.94
162_A	178_V	0.846	0.94
101_L	121_I	0.846	0.94
98_V	102_G	0.846	0.94
92_F	128_L	0.845	0.94
201_M	216_G	0.834	0.94
55_V	60_F	0.832	0.94
176_L	236_I	0.832	0.94
265_I	285_A	0.829	0.94
271_L	275_G	0.829	0.94
104_E	108_I	0.822	0.93
268_F	272_R	0.821	0.93
185_I	229_L	0.821	0.93
145_R	217_K	0.819	0.93
19_G	23_I	0.818	0.93
108_I	114_D	0.817	0.93
69_A	205_L	0.807	0.93
17_I	234_L	0.807	0.93
93_A	96_V	0.805	0.93
261_A	288_L	0.804	0.92
165_L	177_H	0.804	0.92
132_W	192_F	0.802	0.92
9_L	13_W	0.794	0.92
20_I	234_L	0.794	0.92
158_L	259_M	0.791	0.92
283_W	286_A	0.790	0.92
253_L	257_L	0.790	0.92
165_L	168_V	0.784	0.92
33_D	224_V	0.776	0.91
258_L	289_L	0.775	0.91
170_S	173_A	0.773	0.91
197_G	200_K	0.769	0.91
184_T	188_A	0.766	0.91
261_A	264_L	0.764	0.90
193_V	197_G	0.762	0.90
279_P	285_A	0.761	0.90
164_G	167_Q	0.758	0.90
52_L	63_V	0.757	0.90
4_L	101_L	0.750	0.90
162_A	256_A	0.749	0.90
271_L	274_A	0.749	0.90
11_L	98_V	0.746	0.89
109_D	114_D	0.740	0.89
8_N	97_V	0.737	0.89
205_L	211_P	0.730	0.88
281_W	285_A	0.730	0.88
201_M	219_A	0.730	0.88
129_V	192_F	0.729	0.88
278_S	281_W	0.727	0.88
25_S	80_F	0.723	0.88
137_L	142_P	0.722	0.88
152_A	156_V	0.720	0.88
285_A	289_L	0.716	0.87
128_L	181_M	0.716	0.87
96_V	125_L	0.713	0.87
197_G	201_M	0.713	0.87
19_G	183_G	0.712	0.87
73_L	205_L	0.712	0.87
278_S	282_L	0.711	0.87
130_V	134_V	0.708	0.87
42_E	46_K	0.707	0.87
157_L	161_A	0.707	0.87
92_F	96_V	0.707	0.87
195_I	202_V	0.701	0.86
108_I	118_W	0.701	0.86
42_E	45_P	0.698	0.86
108_I	112_V	0.698	0.86
204_A	207_A	0.697	0.86
284_A	291_A	0.697	0.86
160_A	164_G	0.695	0.86
175_F	236_I	0.695	0.86
95_L	176_L	0.694	0.86
8_N	98_V	0.692	0.86
157_L	164_G	0.690	0.85
277_G	282_L	0.688	0.85
28_Y	32_L	0.686	0.85
108_I	169_F	0.684	0.85
271_L	278_S	0.684	0.85
140_R	193_V	0.683	0.85
268_F	275_G	0.682	0.85
280_W	287_A	0.682	0.85
261_A	286_A	0.682	0.85
255_L	259_M	0.681	0.85
151_A	154_L	0.681	0.85
261_A	265_I	0.681	0.85
287_A	291_A	0.680	0.85
177_H	181_M	0.679	0.84
55_V	216_G	0.678	0.84
217_K	221_Q	0.677	0.84
138_L	153_V	0.677	0.84
96_V	100_Y	0.674	0.84
175_F	255_L	0.673	0.84
165_L	178_V	0.673	0.84
261_A	289_L	0.672	0.84
39_P	42_E	0.672	0.84
136_D	222_R	0.666	0.83
148_T	155_F	0.666	0.83
110_P	113_A	0.661	0.83
157_L	185_I	0.655	0.82
36_L	59_G	0.651	0.82
143_L	147_E	0.651	0.82
279_P	284_A	0.649	0.82
7_L	97_V	0.649	0.82
291_A	294_V	0.649	0.82
44_L	47_G	0.647	0.82
171_G	240_N	0.644	0.81
183_G	236_I	0.644	0.81
86_T	191_F	0.643	0.81
17_I	30_V	0.641	0.81
57_G	66_Y	0.641	0.81
23_I	230_T	0.641	0.81
81_K	199_R	0.639	0.81
144_G	150_L	0.639	0.81
124_S	176_L	0.639	0.81
117_P	121_I	0.638	0.81
27_F	231_L	0.636	0.80
202_V	205_L	0.633	0.80
136_D	193_V	0.632	0.80
10_L	14_L	0.631	0.80
92_F	100_Y	0.631	0.80
286_A	290_L	0.629	0.80
290_L	294_V	0.628	0.80
287_A	294_V	0.624	0.79
82_W	199_R	0.623	0.79
290_L	293_A	0.623	0.79
239_S	245_T	0.618	0.78
55_V	195_I	0.617	0.78
46_K	66_Y	0.617	0.78
7_L	10_L	0.612	0.78
221_Q	224_V	0.608	0.77
16_V	20_I	0.608	0.77
280_W	286_A	0.605	0.77
99_Y	240_N	0.604	0.77
280_W	284_A	0.603	0.77
48_V	64_Q	0.601	0.77
30_V	33_D	0.600	0.76
281_W	288_L	0.599	0.76
123_I	169_F	0.596	0.76
95_L	165_L	0.596	0.76
256_A	259_M	0.595	0.76
28_Y	83_E	0.593	0.76
130_V	161_A	0.593	0.76
166_T	171_G	0.592	0.75
33_D	57_G	0.592	0.75
213_P	216_G	0.588	0.75
52_L	76_H	0.587	0.75
6_W	9_L	0.587	0.75
269_F	272_R	0.587	0.75
98_V	101_L	0.587	0.75
92_F	187_A	0.585	0.75
12_R	15_H	0.584	0.75
138_L	149_L	0.584	0.75
113_A	123_I	0.581	0.74
13_W	262_G	0.581	0.74
178_V	182_L	0.578	0.74
26_S	230_T	0.575	0.73
39_P	48_V	0.573	0.73
182_L	259_M	0.573	0.73
115_L	120_A	0.572	0.73
251_N	254_I	0.571	0.73
134_V	161_A	0.568	0.72
197_G	219_A	0.568	0.72
88_W	187_A	0.566	0.72
108_I	121_I	0.566	0.72
167_Q	252_W	0.564	0.72
280_W	291_A	0.562	0.72
175_F	251_N	0.561	0.72
178_V	236_I	0.560	0.71
93_A	101_L	0.559	0.71
264_L	288_L	0.556	0.71
45_P	48_V	0.554	0.71
33_D	36_L	0.554	0.71
115_L	168_V	0.553	0.70
157_L	181_M	0.551	0.70
277_G	284_A	0.551	0.70
289_L	293_A	0.549	0.70
276_K	280_W	0.549	0.70
66_Y	69_A	0.548	0.70
264_L	281_W	0.547	0.70
38_P	49_A	0.547	0.70
68_V	201_M	0.543	0.69
33_D	61_Y	0.541	0.69
31_W	34_N	0.541	0.69
123_I	127_S	0.541	0.69
144_G	147_E	0.540	0.69
127_S	169_F	0.536	0.68
193_V	218_R	0.535	0.68
260_L	264_L	0.535	0.68
264_L	277_G	0.534	0.68
78_H	175_F	0.533	0.68
283_W	289_L	0.532	0.68
257_L	261_A	0.530	0.67
44_L	48_V	0.529	0.67
275_G	278_S	0.529	0.67
68_V	211_P	0.528	0.67
251_N	256_A	0.528	0.67
280_W	292_L	0.527	0.67
25_S	63_V	0.524	0.66
98_V	106_Y	0.523	0.66
96_V	124_S	0.521	0.66
23_I	26_S	0.521	0.66
259_M	263_A	0.521	0.66
4_L	7_L	0.520	0.66
50_G	74_P	0.520	0.66
13_W	17_I	0.519	0.66
18_A	21_A	0.518	0.66
39_P	47_G	0.517	0.65
271_L	277_G	0.517	0.65
130_V	165_L	0.516	0.65
154_L	158_L	0.515	0.65
39_P	46_K	0.514	0.65
118_W	123_I	0.512	0.65
219_A	224_V	0.511	0.64
264_L	286_A	0.511	0.64
39_P	49_A	0.510	0.64
247_G	251_N	0.509	0.64
248_H	275_G	0.508	0.64
158_L	178_V	0.508	0.64
38_P	46_K	0.507	0.64
35_S	52_L	0.506	0.64
128_L	184_T	0.506	0.64
256_A	260_L	0.503	0.63
274_A	278_S	0.502	0.63
102_G	106_Y	0.502	0.63
248_H	253_L	0.502	0.63
267_H	278_S	0.501	0.63
280_W	288_L	0.501	0.63
124_S	127_S	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4xnjA	1	0.8114	7.1	0.98	Contact Map
3pcvA	3	0.4074	5	0.982	Contact Map
2q7rA	3	0.4074	4.3	0.982	Contact Map
3j08A	2	0.266	3.9	0.983	Contact Map
4n7wA	2	0.6566	3.7	0.983	Contact Map
4qndA	2	0.3131	3.7	0.983	Contact Map
3wajA	1	0.771	3	0.984	Contact Map
2h8aA	3	0.3939	2.9	0.984	Contact Map
2yggA	1	0.1347	2.7	0.984	Contact Map
3tuiA	2	0.4512	2.6	0.984	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.