GREMLIN Database
DUF989 - Protein of unknown function (DUF989)
PFAM: PF06181 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 297 (292)
Sequences: 4446 (2163)
Seq/√Len: 126.6
META: 0.892

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_L90_S3.8561.00
204_A209_R3.7391.00
227_N270_N3.6041.00
195_I199_R3.1691.00
161_A181_M3.1161.00
100_Y125_L3.0461.00
116_S119_Q2.9811.00
84_A187_A2.9121.00
159_V256_A2.9111.00
127_S165_L2.8741.00
11_L97_V2.7321.00
124_S177_H2.5581.00
131_G181_M2.5471.00
100_Y177_H2.4251.00
235_F245_T2.4031.00
146_N149_L2.3981.00
200_K209_R2.3521.00
133_L137_L2.3411.00
200_K215_L2.3161.00
37_R76_H2.2791.00
115_L119_Q2.2341.00
166_T251_N2.2201.00
214_A218_R2.2061.00
132_W136_D2.1771.00
89_L93_A2.1631.00
86_T89_L2.1241.00
109_D112_V2.1011.00
16_V234_L2.0291.00
110_P114_D2.0121.00
142_P145_R2.0071.00
134_V157_L2.0051.00
18_A86_T1.9891.00
11_L93_A1.9631.00
92_F125_L1.9511.00
33_D220_K1.9291.00
203_A207_A1.9051.00
155_F159_V1.8941.00
118_W122_A1.8411.00
141_S144_G1.8371.00
197_G215_L1.8281.00
137_L140_R1.7331.00
107_L169_F1.7201.00
133_L192_F1.7171.00
236_I255_L1.7131.00
31_W80_F1.6681.00
214_A217_K1.6621.00
100_Y124_S1.5901.00
235_F258_L1.5891.00
147_E221_Q1.5791.00
156_V160_A1.5781.00
158_L182_L1.5511.00
164_G168_V1.5281.00
107_L173_A1.5271.00
30_V224_V1.5121.00
54_A63_V1.5111.00
127_S168_V1.5091.00
128_L180_A1.4991.00
16_V19_G1.4991.00
250_Y253_L1.4871.00
31_W52_L1.4841.00
279_P282_L1.4771.00
14_L18_A1.4551.00
39_P43_D1.4061.00
183_G187_A1.4001.00
30_V34_N1.4001.00
108_I113_A1.3991.00
154_L229_L1.3841.00
80_F83_E1.3811.00
245_T254_I1.3651.00
88_W188_A1.3621.00
227_N267_H1.3621.00
31_W35_S1.3591.00
49_A67_L1.3481.00
121_I124_S1.3481.00
5_E8_N1.3441.00
88_W184_T1.3431.00
14_L86_T1.3401.00
127_S130_V1.3321.00
139_C154_L1.3301.00
104_E117_P1.3281.00
82_W86_T1.3191.00
280_W283_W1.3191.00
108_I120_A1.3051.00
163_W167_Q1.3021.00
267_H270_N1.2991.00
166_T174_A1.2951.00
112_V171_G1.2941.00
9_L245_T1.2881.00
96_V101_L1.2741.00
160_A163_W1.2651.00
85_Y191_F1.2581.00
271_L276_K1.2411.00
197_G218_R1.2391.00
155_F260_L1.2361.00
137_L141_S1.2250.99
127_S161_A1.2250.99
112_V166_T1.2130.99
31_W54_A1.2080.99
155_F256_A1.2060.99
97_V101_L1.2040.99
248_H254_I1.2040.99
139_C150_L1.2000.99
133_L136_D1.1970.99
182_L229_L1.1920.99
62_H66_Y1.1790.99
112_V170_S1.1660.99
122_A126_G1.1600.99
118_W121_I1.1570.99
269_F273_H1.1510.99
16_V238_L1.1510.99
281_W284_A1.1500.99
268_F277_G1.1490.99
119_Q122_A1.1490.99
220_K224_V1.1460.99
123_I168_V1.1350.99
201_M204_A1.1320.99
108_I117_P1.1190.99
39_P44_L1.1020.99
200_K205_L1.1010.99
54_A78_H1.0960.99
46_K71_A1.0940.99
282_L286_A1.0910.99
143_L146_N1.0830.99
165_L181_M1.0830.99
21_A25_S1.0810.99
127_S181_M1.0810.99
149_L153_V1.0760.99
25_S28_Y1.0630.99
25_S54_A1.0590.98
201_M205_L1.0580.98
188_A192_F1.0560.98
138_L150_L1.0530.98
38_P44_L1.0480.98
203_A206_K1.0420.98
107_L120_A1.0340.98
215_L218_R1.0340.98
200_K203_A1.0330.98
28_Y54_A1.0290.98
173_A176_L1.0290.98
201_M215_L1.0280.98
51_E64_Q1.0250.98
39_P51_E1.0220.98
212_D215_L1.0220.98
267_H271_L1.0210.98
63_V80_F1.0080.98
265_I289_L1.0080.98
84_A183_G1.0040.98
185_I188_A1.0030.98
51_E62_H0.9950.98
25_S83_E0.9950.98
124_S169_F0.9940.98
103_A117_P0.9910.98
127_S177_H0.9860.98
31_W78_H0.9830.98
148_T152_A0.9820.98
162_A166_T0.9820.98
136_D140_R0.9810.97
72_E75_E0.9790.97
131_G185_I0.9770.97
175_F235_F0.9760.97
171_G251_N0.9730.97
5_E244_M0.9730.97
88_W92_F0.9700.97
291_A295_W0.9700.97
272_R278_S0.9690.97
104_E110_P0.9680.97
175_F245_T0.9660.97
161_A165_L0.9650.97
161_A164_G0.9650.97
266_R269_F0.9620.97
282_L285_A0.9590.97
150_L154_L0.9590.97
95_L124_S0.9570.97
200_K204_A0.9530.97
3_L7_L0.9490.97
95_L177_H0.9470.97
82_W85_Y0.9450.97
257_L292_L0.9450.97
126_G129_V0.9380.97
45_P64_Q0.9340.97
279_P283_W0.9320.97
115_L123_I0.9310.97
218_R221_Q0.9270.96
53_W59_G0.9260.96
169_F173_A0.9190.96
85_Y195_I0.9140.96
261_A292_L0.9130.96
129_V133_L0.9090.96
139_C193_V0.9030.96
113_A168_V0.9000.96
199_R203_A0.9000.96
125_L129_V0.8990.96
8_N242_Y0.8980.96
131_G161_A0.8980.96
272_R277_G0.8970.96
43_D62_H0.8940.96
112_V115_L0.8890.96
144_G221_Q0.8800.95
143_L149_L0.8800.95
116_S122_A0.8770.95
283_W287_A0.8750.95
19_G238_L0.8740.95
11_L14_L0.8710.95
264_L284_A0.8710.95
236_I259_M0.8680.95
148_T151_A0.8680.95
52_L78_H0.8680.95
257_L295_W0.8630.95
127_S164_G0.8620.95
284_A288_L0.8550.94
31_W63_V0.8520.94
162_A178_V0.8460.94
101_L121_I0.8460.94
98_V102_G0.8460.94
92_F128_L0.8450.94
201_M216_G0.8340.94
55_V60_F0.8320.94
176_L236_I0.8320.94
265_I285_A0.8290.94
271_L275_G0.8290.94
104_E108_I0.8220.93
268_F272_R0.8210.93
185_I229_L0.8210.93
145_R217_K0.8190.93
19_G23_I0.8180.93
108_I114_D0.8170.93
69_A205_L0.8070.93
17_I234_L0.8070.93
93_A96_V0.8050.93
261_A288_L0.8040.92
165_L177_H0.8040.92
132_W192_F0.8020.92
9_L13_W0.7940.92
20_I234_L0.7940.92
158_L259_M0.7910.92
283_W286_A0.7900.92
253_L257_L0.7900.92
165_L168_V0.7840.92
33_D224_V0.7760.91
258_L289_L0.7750.91
170_S173_A0.7730.91
197_G200_K0.7690.91
184_T188_A0.7660.91
261_A264_L0.7640.90
193_V197_G0.7620.90
279_P285_A0.7610.90
164_G167_Q0.7580.90
52_L63_V0.7570.90
4_L101_L0.7500.90
162_A256_A0.7490.90
271_L274_A0.7490.90
11_L98_V0.7460.89
109_D114_D0.7400.89
8_N97_V0.7370.89
205_L211_P0.7300.88
281_W285_A0.7300.88
201_M219_A0.7300.88
129_V192_F0.7290.88
278_S281_W0.7270.88
25_S80_F0.7230.88
137_L142_P0.7220.88
152_A156_V0.7200.88
285_A289_L0.7160.87
128_L181_M0.7160.87
96_V125_L0.7130.87
197_G201_M0.7130.87
19_G183_G0.7120.87
73_L205_L0.7120.87
278_S282_L0.7110.87
130_V134_V0.7080.87
42_E46_K0.7070.87
157_L161_A0.7070.87
92_F96_V0.7070.87
195_I202_V0.7010.86
108_I118_W0.7010.86
42_E45_P0.6980.86
108_I112_V0.6980.86
204_A207_A0.6970.86
284_A291_A0.6970.86
160_A164_G0.6950.86
175_F236_I0.6950.86
95_L176_L0.6940.86
8_N98_V0.6920.86
157_L164_G0.6900.85
277_G282_L0.6880.85
28_Y32_L0.6860.85
108_I169_F0.6840.85
271_L278_S0.6840.85
140_R193_V0.6830.85
268_F275_G0.6820.85
280_W287_A0.6820.85
261_A286_A0.6820.85
255_L259_M0.6810.85
151_A154_L0.6810.85
261_A265_I0.6810.85
287_A291_A0.6800.85
177_H181_M0.6790.84
55_V216_G0.6780.84
217_K221_Q0.6770.84
138_L153_V0.6770.84
96_V100_Y0.6740.84
175_F255_L0.6730.84
165_L178_V0.6730.84
261_A289_L0.6720.84
39_P42_E0.6720.84
136_D222_R0.6660.83
148_T155_F0.6660.83
110_P113_A0.6610.83
157_L185_I0.6550.82
36_L59_G0.6510.82
143_L147_E0.6510.82
279_P284_A0.6490.82
7_L97_V0.6490.82
291_A294_V0.6490.82
44_L47_G0.6470.82
171_G240_N0.6440.81
183_G236_I0.6440.81
86_T191_F0.6430.81
17_I30_V0.6410.81
57_G66_Y0.6410.81
23_I230_T0.6410.81
81_K199_R0.6390.81
144_G150_L0.6390.81
124_S176_L0.6390.81
117_P121_I0.6380.81
27_F231_L0.6360.80
202_V205_L0.6330.80
136_D193_V0.6320.80
10_L14_L0.6310.80
92_F100_Y0.6310.80
286_A290_L0.6290.80
290_L294_V0.6280.80
287_A294_V0.6240.79
82_W199_R0.6230.79
290_L293_A0.6230.79
239_S245_T0.6180.78
55_V195_I0.6170.78
46_K66_Y0.6170.78
7_L10_L0.6120.78
221_Q224_V0.6080.77
16_V20_I0.6080.77
280_W286_A0.6050.77
99_Y240_N0.6040.77
280_W284_A0.6030.77
48_V64_Q0.6010.77
30_V33_D0.6000.76
281_W288_L0.5990.76
123_I169_F0.5960.76
95_L165_L0.5960.76
256_A259_M0.5950.76
28_Y83_E0.5930.76
130_V161_A0.5930.76
166_T171_G0.5920.75
33_D57_G0.5920.75
213_P216_G0.5880.75
52_L76_H0.5870.75
6_W9_L0.5870.75
269_F272_R0.5870.75
98_V101_L0.5870.75
92_F187_A0.5850.75
12_R15_H0.5840.75
138_L149_L0.5840.75
113_A123_I0.5810.74
13_W262_G0.5810.74
178_V182_L0.5780.74
26_S230_T0.5750.73
39_P48_V0.5730.73
182_L259_M0.5730.73
115_L120_A0.5720.73
251_N254_I0.5710.73
134_V161_A0.5680.72
197_G219_A0.5680.72
88_W187_A0.5660.72
108_I121_I0.5660.72
167_Q252_W0.5640.72
280_W291_A0.5620.72
175_F251_N0.5610.72
178_V236_I0.5600.71
93_A101_L0.5590.71
264_L288_L0.5560.71
45_P48_V0.5540.71
33_D36_L0.5540.71
115_L168_V0.5530.70
157_L181_M0.5510.70
277_G284_A0.5510.70
289_L293_A0.5490.70
276_K280_W0.5490.70
66_Y69_A0.5480.70
264_L281_W0.5470.70
38_P49_A0.5470.70
68_V201_M0.5430.69
33_D61_Y0.5410.69
31_W34_N0.5410.69
123_I127_S0.5410.69
144_G147_E0.5400.69
127_S169_F0.5360.68
193_V218_R0.5350.68
260_L264_L0.5350.68
264_L277_G0.5340.68
78_H175_F0.5330.68
283_W289_L0.5320.68
257_L261_A0.5300.67
44_L48_V0.5290.67
275_G278_S0.5290.67
68_V211_P0.5280.67
251_N256_A0.5280.67
280_W292_L0.5270.67
25_S63_V0.5240.66
98_V106_Y0.5230.66
96_V124_S0.5210.66
23_I26_S0.5210.66
259_M263_A0.5210.66
4_L7_L0.5200.66
50_G74_P0.5200.66
13_W17_I0.5190.66
18_A21_A0.5180.66
39_P47_G0.5170.65
271_L277_G0.5170.65
130_V165_L0.5160.65
154_L158_L0.5150.65
39_P46_K0.5140.65
118_W123_I0.5120.65
219_A224_V0.5110.64
264_L286_A0.5110.64
39_P49_A0.5100.64
247_G251_N0.5090.64
248_H275_G0.5080.64
158_L178_V0.5080.64
38_P46_K0.5070.64
35_S52_L0.5060.64
128_L184_T0.5060.64
256_A260_L0.5030.63
274_A278_S0.5020.63
102_G106_Y0.5020.63
248_H253_L0.5020.63
267_H278_S0.5010.63
280_W288_L0.5010.63
124_S127_S0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xnjA 1 0.8114 7.1 0.98 Contact Map
3pcvA 3 0.4074 5 0.982 Contact Map
2q7rA 3 0.4074 4.3 0.982 Contact Map
3j08A 2 0.266 3.9 0.983 Contact Map
4n7wA 2 0.6566 3.7 0.983 Contact Map
4qndA 2 0.3131 3.7 0.983 Contact Map
3wajA 1 0.771 3 0.984 Contact Map
2h8aA 3 0.3939 2.9 0.984 Contact Map
2yggA 1 0.1347 2.7 0.984 Contact Map
3tuiA 2 0.4512 2.6 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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