GREMLIN Database
DUF983 - Protein of unknown function (DUF983)
PFAM: PF06170 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 85 (84)
Sequences: 20330 (12558)
Seq/√Len: 1370.2
META: 0.935

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_L75_P2.3771.00
10_R15_G2.1861.00
45_L49_A2.1341.00
10_R17_D2.1121.00
2_R8_A2.0781.00
57_H61_W2.0661.00
53_P56_V1.9661.00
8_A12_P1.9541.00
55_W59_A1.8671.00
16_L20_R1.8241.00
9_D19_E1.6911.00
3_G6_K1.6861.00
46_V50_F1.6621.00
59_A63_P1.6451.00
54_L58_L1.6211.00
33_L37_H1.6171.00
2_R6_K1.5961.00
17_D20_R1.5561.00
56_V59_A1.5461.00
7_M81_I1.5061.00
32_I36_G1.4961.00
78_G82_A1.4161.00
29_Y33_L1.4041.00
79_L83_L1.3771.00
52_P56_V1.3431.00
37_H41_A1.3261.00
26_G30_F1.2981.00
4_F74_R1.2681.00
2_R9_D1.2581.00
47_E51_D1.2471.00
25_D28_A1.2341.00
26_G80_W1.2321.00
65_T69_S1.2281.00
56_V60_L1.2091.00
9_D17_D1.1991.00
33_L36_G1.1611.00
39_V65_T1.1441.00
35_V68_L1.1411.00
76_S79_L1.1231.00
7_M21_E1.0901.00
29_Y32_I1.0821.00
21_E24_D1.0711.00
45_L48_L1.0571.00
58_L62_L1.0341.00
68_L72_L1.0301.00
52_P57_H1.0261.00
31_V76_S0.9861.00
8_A18_F0.9721.00
26_G31_V0.9621.00
44_L48_L0.9581.00
30_F76_S0.9561.00
47_E50_F0.9201.00
21_E84_Q0.9181.00
29_Y37_H0.9151.00
80_W84_Q0.9131.00
57_H60_L0.9051.00
41_A45_L0.8921.00
60_L63_P0.8921.00
34_I37_H0.8781.00
62_L66_L0.8721.00
5_L73_L0.8541.00
42_L61_W0.8471.00
25_D29_Y0.8451.00
35_V72_L0.8421.00
49_A52_P0.8411.00
69_S73_L0.8351.00
69_S72_L0.8341.00
74_R77_K0.8291.00
30_F33_L0.8281.00
81_I84_Q0.8101.00
48_L51_D0.8081.00
47_E57_H0.8061.00
30_F34_I0.7931.00
47_E54_L0.7891.00
63_P67_L0.7831.00
46_V61_W0.7681.00
7_M18_F0.7641.00
46_V49_A0.7591.00
64_L68_L0.7581.00
44_L47_E0.7561.00
24_D84_Q0.7531.00
59_A62_L0.7521.00
28_A31_V0.7471.00
75_P78_G0.7441.00
54_L59_A0.7381.00
45_L50_F0.7371.00
38_I42_L0.7201.00
16_L81_I0.7201.00
30_F80_W0.7141.00
23_G27_P0.7071.00
73_L77_K0.7061.00
40_V43_A0.7051.00
23_G81_I0.7031.00
72_L76_S0.6841.00
35_V69_S0.6821.00
76_S80_W0.6771.00
79_L82_A0.6711.00
58_L61_W0.6661.00
39_V43_A0.6651.00
80_W83_L0.6621.00
24_D81_I0.6511.00
47_E52_P0.6391.00
21_E81_I0.6381.00
31_V35_V0.6301.00
32_I35_V0.6071.00
40_V44_L0.5981.00
19_E23_G0.5761.00
61_W64_L0.5751.00
46_V57_H0.5701.00
42_L46_V0.5661.00
39_V64_L0.5641.00
54_L57_H0.5581.00
57_H62_L0.5561.00
46_V52_P0.5471.00
42_L45_L0.5451.00
34_I76_S0.5411.00
19_E22_P0.5391.00
39_V61_W0.5351.00
70_L74_R0.5341.00
62_L65_T0.5271.00
28_A32_I0.5231.00
3_G8_A0.5181.00
50_F57_H0.5151.00
36_G40_V0.5141.00
3_G74_R0.5041.00
67_L70_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nw0A 1 0.3412 61.9 0.808 Contact Map
2gmgA 1 0.3412 39.9 0.832 Contact Map
1i7dA 1 0.0824 32.8 0.839 Contact Map
2ectA 1 0.4 23.1 0.851 Contact Map
2ct0A 1 0.3529 22.6 0.851 Contact Map
1k82A 1 0.4235 21.7 0.852 Contact Map
2ecmA 1 0.2353 21.3 0.853 Contact Map
2ecyA 1 0.2824 20.9 0.854 Contact Map
2kizA 1 0.3059 20.7 0.854 Contact Map
2ma6A 1 0.3176 19 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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