GREMLIN Database
DUF981 - Protein of unknown function (DUF981)
PFAM: PF06168 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 186 (180)
Sequences: 523 (405)
Seq/√Len: 30.2
META: 0.711

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_G88_A5.0121.00
76_P134_Y3.9741.00
73_F124_T3.4281.00
119_I131_G3.2251.00
69_Y124_T3.1091.00
10_M59_M2.8521.00
112_I138_G2.8111.00
56_G81_G2.5360.99
10_M55_T2.3470.99
140_G166_L2.2280.99
6_Y58_H2.1990.98
175_L179_M2.1460.98
59_M74_G2.1270.98
168_V172_I2.0340.97
176_F180_A1.9990.97
63_W70_N1.9840.97
132_L136_L1.9470.97
24_Y38_L1.8500.95
118_I130_S1.7300.93
65_L138_G1.7070.93
42_A99_P1.6890.93
75_E114_I1.6740.92
137_T169_A1.6620.92
164_V168_V1.6450.92
119_I135_I1.6440.92
79_L107_A1.6290.91
136_L169_A1.6040.90
71_I75_E1.6010.90
11_L177_G1.5940.90
18_L137_T1.5750.90
157_T161_L1.5710.90
168_V171_L1.5660.89
143_L161_L1.5660.89
47_A82_V1.5550.89
112_I115_G1.5410.89
162_A166_L1.5340.88
117_A182_W1.5100.88
4_I70_N1.4960.87
48_L52_L1.4950.87
47_A86_A1.4730.86
115_G172_I1.4370.85
124_T127_P1.4140.84
87_A100_V1.4090.84
167_L171_L1.4070.84
55_T58_H1.4030.83
63_W71_I1.3950.83
19_L167_L1.3930.83
119_I128_L1.3930.83
164_V171_L1.3870.83
121_L182_W1.3480.81
146_P150_K1.3430.81
17_G84_L1.3380.80
6_Y55_T1.3350.80
151_R158_L1.3180.79
7_L14_L1.3070.79
19_L93_R1.2940.78
17_G80_F1.2850.77
4_I8_T1.2820.77
18_L55_T1.2700.77
57_L68_S1.2640.76
73_F134_Y1.2560.76
76_P110_A1.2540.76
54_V142_V1.2300.74
42_A50_L1.2270.74
9_L78_L1.2250.74
112_I142_V1.2240.74
111_A141_G1.2130.73
60_T75_E1.2100.73
7_L11_L1.2080.73
59_M75_E1.2070.73
126_A180_A1.2070.73
11_L173_W1.1800.71
41_W148_L1.1790.71
5_D11_L1.1720.71
20_L44_A1.1640.70
142_V161_L1.1620.70
114_I185_L1.1520.69
104_A174_L1.1450.69
72_L114_I1.1370.68
46_G92_W1.1310.68
12_I17_G1.1300.68
44_A48_L1.1170.67
25_L52_L1.1110.66
125_A183_T1.1080.66
52_L77_S1.0960.65
169_A172_I1.0850.65
16_A106_F1.0760.64
124_T130_S1.0690.63
72_L84_L1.0680.63
45_F72_L1.0610.63
179_M183_T1.0550.62
80_F142_V1.0520.62
50_L85_L1.0260.60
42_A53_L1.0210.60
129_F172_I1.0150.59
72_L82_V1.0060.59
6_Y62_T0.9980.58
47_A100_V0.9970.58
166_L180_A0.9910.57
98_R102_I0.9870.57
55_T71_I0.9800.57
163_A167_L0.9790.56
177_G180_A0.9540.55
85_L112_I0.9520.54
22_A163_A0.9460.54
15_G19_L0.9440.54
164_V175_L0.9380.53
130_S134_Y0.9360.53
53_L82_V0.9320.53
5_D124_T0.9320.53
19_L102_I0.9290.53
4_I62_T0.9260.52
140_G144_A0.9260.52
69_Y123_L0.9180.52
4_I20_L0.9140.51
122_G126_A0.8940.50
42_A88_A0.8910.49
131_G135_I0.8910.49
40_G43_A0.8870.49
52_L56_G0.8830.49
22_A25_L0.8780.48
147_A158_L0.8760.48
6_Y10_M0.8710.48
117_A121_L0.8650.47
140_G165_V0.8580.47
17_G41_W0.8550.47
54_V69_Y0.8510.46
88_A92_W0.8510.46
19_L182_W0.8460.46
104_A107_A0.8350.45
36_E93_R0.8160.44
37_D174_L0.8140.43
58_H61_F0.8130.43
11_L180_A0.8090.43
70_N81_G0.8040.43
122_G134_Y0.7980.42
7_L65_L0.7960.42
111_A135_I0.7950.42
10_M51_I0.7900.42
149_L152_R0.7890.41
19_L170_G0.7880.41
11_L124_T0.7860.41
39_R94_G0.7850.41
138_G142_V0.7850.41
53_L141_G0.7840.41
126_A183_T0.7760.40
159_R174_L0.7750.40
111_A121_L0.7720.40
11_L15_G0.7640.40
98_R101_S0.7560.39
43_A86_A0.7540.39
121_L185_L0.7520.39
7_L26_Y0.7430.38
10_M77_S0.7420.38
87_A168_V0.7400.38
84_L123_L0.7400.38
166_L176_F0.7390.38
89_L102_I0.7330.37
14_L76_P0.7290.37
150_K158_L0.7240.37
157_T165_V0.7220.36
54_V85_L0.7210.36
18_L177_G0.7190.36
115_G127_P0.7160.36
114_I181_Y0.7040.35
106_F109_L0.6990.35
67_G170_G0.6960.34
160_Y172_I0.6890.34
23_Y27_R0.6830.34
15_G174_L0.6820.33
126_A129_F0.6750.33
101_S171_L0.6750.33
10_M74_G0.6700.33
14_L173_W0.6690.33
55_T61_F0.6660.32
59_M65_L0.6630.32
146_P161_L0.6630.32
139_L167_L0.6610.32
146_P160_Y0.6590.32
52_L145_P0.6570.32
157_T160_Y0.6570.32
29_L113_V0.6560.32
86_A90_A0.6550.32
56_G88_A0.6530.31
69_Y126_A0.6530.31
24_Y45_F0.6510.31
22_A167_L0.6370.30
66_P69_Y0.6370.30
39_R144_A0.6370.30
76_P111_A0.6360.30
129_F179_M0.6340.30
8_T75_E0.6270.30
149_L161_L0.6260.30
80_F101_S0.6260.30
56_G97_L0.6220.29
167_L172_I0.6200.29
18_L169_A0.6170.29
4_I50_L0.6170.29
78_L86_A0.6160.29
70_N76_P0.6160.29
75_E173_W0.6100.29
39_R116_V0.6100.29
77_S123_L0.6090.29
62_T112_I0.6090.29
55_T60_T0.6020.28
112_I116_V0.6020.28
26_Y168_V0.5980.28
72_L124_T0.5960.28
37_D161_L0.5910.27
33_G172_I0.5910.27
105_F167_L0.5900.27
94_G125_A0.5890.27
82_V119_I0.5850.27
56_G74_G0.5840.27
43_A89_L0.5840.27
39_R80_F0.5760.26
35_R40_G0.5750.26
80_F177_G0.5740.26
22_A130_S0.5720.26
57_L158_L0.5700.26
16_A21_L0.5700.26
51_I71_I0.5680.26
21_L86_A0.5670.26
160_Y164_V0.5640.26
85_L91_L0.5620.26
136_L148_L0.5580.25
8_T13_A0.5530.25
54_V93_R0.5510.25
67_G118_I0.5510.25
7_L180_A0.5490.25
168_V178_A0.5480.25
103_F121_L0.5470.25
35_R142_V0.5460.25
27_R88_A0.5450.25
45_F91_L0.5430.24
110_A181_Y0.5430.24
6_Y59_M0.5420.24
6_Y60_T0.5420.24
44_A99_P0.5390.24
24_Y137_T0.5380.24
11_L103_F0.5380.24
173_W177_G0.5360.24
15_G64_P0.5350.24
145_P162_A0.5340.24
118_I124_T0.5340.24
83_L101_S0.5320.24
4_I121_L0.5320.24
23_Y112_I0.5310.24
12_I20_L0.5300.24
82_V143_L0.5290.24
58_H74_G0.5250.23
73_F125_A0.5240.23
13_A52_L0.5230.23
59_M114_I0.5230.23
34_D38_L0.5220.23
64_P70_N0.5220.23
5_D126_A0.5210.23
48_L80_F0.5160.23
159_R173_W0.5160.23
83_L100_V0.5160.23
107_A111_A0.5160.23
5_D125_A0.5150.23
153_N168_V0.5130.23
48_L65_L0.5100.23
20_L105_F0.5070.22
53_L89_L0.5030.22
110_A114_I0.5020.22
65_L151_R0.5020.22
176_F179_M0.5010.22
93_R97_L0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ux4A 3 0.8978 57.7 0.925 Contact Map
1xioA 2 0.3065 6 0.954 Contact Map
2gfpA 2 0.8548 5.6 0.955 Contact Map
4nv5A 1 0.7742 5.2 0.956 Contact Map
2i68A 2 0.4032 3.2 0.96 Contact Map
2g2qA 3 0.2097 3.2 0.96 Contact Map
3b5dA 2 0.5376 2.8 0.961 Contact Map
2looA 1 0.5323 2 0.964 Contact Map
4he8N 1 0.3763 2 0.964 Contact Map
3wajA 1 0.8226 2 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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