GREMLIN Database
DUF975 - Protein of unknown function (DUF975)
PFAM: PF06161 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 244 (237)
Sequences: 1554 (1393)
Seq/√Len: 90.5
META: 0.743

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
196_N199_R4.4541.00
167_Y190_R3.7211.00
116_I120_P3.4951.00
193_M200_L3.2831.00
14_A235_E3.0321.00
180_L185_A2.9361.00
77_R238_L2.9331.00
4_R202_L2.8911.00
211_Y229_M2.8401.00
165_L204_D2.8071.00
8_K206_S2.7321.00
193_M236_F2.7211.00
203_L232_T2.5601.00
4_R8_K2.5271.00
198_W202_L2.5031.00
188_E191_R2.4451.00
169_L193_M2.4081.00
7_L232_T2.3941.00
170_A186_L2.3831.00
214_G225_V2.3481.00
207_F232_T2.3421.00
166_R190_R2.2931.00
206_S228_Y2.2211.00
193_M197_K2.2121.00
210_W228_Y2.2071.00
197_K201_F2.1971.00
207_F228_Y2.1481.00
200_L236_F2.0981.00
8_K12_R2.0271.00
158_I162_I1.9831.00
173_I185_A1.9501.00
77_R176_D1.9281.00
176_D237_Y1.9121.00
166_R197_K1.9061.00
192_L241_K1.8251.00
165_L200_L1.7601.00
214_G221_G1.7551.00
199_R239_D1.7491.00
109_I113_W1.7291.00
200_L204_D1.7281.00
222_L225_V1.7051.00
214_G217_T1.6671.00
165_L197_K1.6661.00
231_A234_A1.6491.00
172_Y234_A1.6471.00
170_A185_A1.6141.00
214_G222_L1.5861.00
217_T221_G1.5641.00
74_K86_D1.5341.00
67_G87_L1.5241.00
177_N180_L1.5121.00
155_I159_V1.5011.00
15_L19_Y1.4991.00
113_W167_Y1.4851.00
168_S204_D1.4771.00
204_D233_Y1.4681.00
172_Y230_N1.4611.00
207_F210_W1.4580.99
217_T220_I1.4440.99
165_L168_S1.4380.99
169_L192_L1.4320.99
202_L205_L1.4290.99
74_K80_E1.4250.99
221_G225_V1.4140.99
165_L201_F1.4130.99
159_V164_S1.4020.99
206_S210_W1.3970.99
198_W201_F1.3830.99
189_S193_M1.3810.99
199_R236_F1.3710.99
76_A235_E1.3620.99
117_A120_P1.3570.99
105_L109_I1.3230.99
102_L170_A1.3080.99
174_L185_A1.2850.99
199_R202_L1.2800.99
7_L235_E1.2740.99
159_V163_I1.2740.99
209_G213_L1.2630.99
217_T224_W1.2600.99
219_G227_P1.2450.98
8_K232_T1.2410.98
96_F100_L1.2350.98
231_A235_E1.2220.98
63_P90_G1.2200.98
73_L77_R1.2060.98
173_I192_L1.1860.98
196_N240_L1.1860.98
72_F231_A1.1770.98
183_K187_K1.1720.98
10_E14_A1.1710.98
221_G224_W1.1610.97
168_S200_L1.1330.97
18_N21_K1.1030.97
19_Y23_I1.0920.96
235_E238_L1.0800.96
29_I87_L1.0660.96
216_L221_G1.0590.96
150_I154_L1.0580.96
87_L91_F1.0520.95
20_G23_I1.0490.95
211_Y214_G1.0380.95
230_N234_A1.0360.95
98_K102_L1.0270.95
159_V162_I1.0210.95
84_V88_F1.0200.95
158_I164_S1.0030.94
49_S52_L0.9960.94
180_L188_E0.9910.94
22_A75_L0.9900.94
206_S209_G0.9840.93
58_S63_P0.9840.93
63_P67_G0.9830.93
9_A16_K0.9830.93
109_I167_Y0.9800.93
9_A12_R0.9790.93
238_L241_K0.9770.93
113_W116_I0.9760.93
8_K207_F0.9740.93
156_L160_G0.9720.93
207_F225_V0.9710.93
173_I180_L0.9700.93
59_L97_G0.9690.93
11_A235_E0.9660.93
153_L157_L0.9630.93
185_A189_S0.9620.93
211_Y225_V0.9620.93
212_L216_L0.9590.93
99_A102_L0.9570.93
181_G184_E0.9560.92
169_L189_S0.9480.92
177_N188_E0.9360.92
209_G228_Y0.9290.91
4_R12_R0.9290.91
113_W190_R0.9260.91
4_R199_R0.9260.91
34_F38_F0.9130.91
166_R186_L0.9130.91
35_L39_L0.8910.90
76_A238_L0.8900.90
168_S233_Y0.8760.89
3_S6_E0.8730.89
229_M232_T0.8720.89
59_L96_F0.8600.88
86_D89_Y0.8580.88
20_G24_L0.8570.88
44_G47_G0.8550.88
102_L185_A0.8540.87
8_K202_L0.8490.87
105_L113_W0.8470.87
220_I224_W0.8420.87
236_F239_D0.8280.86
101_L104_L0.8260.86
119_I122_L0.8210.85
83_S154_L0.8190.85
104_L108_L0.8150.85
180_L184_E0.8140.85
6_E9_A0.8120.85
151_L155_I0.8110.85
162_I166_R0.8100.85
213_L217_T0.8100.85
22_A72_F0.7990.84
119_I127_S0.7950.83
73_L175_A0.7950.83
67_G90_G0.7930.83
20_G25_A0.7910.83
134_S137_I0.7900.83
132_L135_S0.7890.83
167_Y187_K0.7890.83
193_M203_L0.7890.83
211_Y222_L0.7870.83
67_G91_F0.7870.83
182_A186_L0.7840.83
214_G219_G0.7840.83
95_N99_A0.7830.83
70_Y74_K0.7830.83
157_L162_I0.7810.82
123_I127_S0.7770.82
115_L120_P0.7770.82
15_L221_G0.7740.82
106_I171_P0.7740.82
177_N209_G0.7730.82
189_S220_I0.7600.81
71_F82_V0.7570.80
66_V99_A0.7560.80
206_S232_T0.7550.80
35_L42_L0.7540.80
127_S142_L0.7500.80
151_L158_I0.7500.80
69_A172_Y0.7480.80
123_I128_L0.7460.79
40_I43_I0.7450.79
19_Y221_G0.7390.79
19_Y210_W0.7380.79
97_G101_L0.7380.79
18_N23_I0.7370.79
152_L156_L0.7320.78
88_F91_F0.7310.78
173_I178_P0.7270.78
156_L159_V0.7260.78
205_L208_I0.7240.77
167_Y183_K0.7230.77
183_K186_L0.7200.77
160_G164_S0.7180.77
101_L108_L0.7150.76
50_S53_S0.7100.76
18_N25_A0.7080.76
232_T236_F0.7080.76
225_V228_Y0.7070.76
176_D238_L0.7070.76
40_I47_G0.7050.75
68_L72_F0.6990.75
228_Y232_T0.6950.74
114_S119_I0.6890.74
16_K20_G0.6880.74
25_A71_F0.6870.74
175_A185_A0.6870.74
37_S41_S0.6840.73
34_F45_G0.6760.72
63_P66_V0.6740.72
161_I164_S0.6730.72
40_I45_G0.6730.72
169_L240_L0.6730.72
41_S44_G0.6710.72
169_L236_F0.6710.72
64_L67_G0.6690.72
210_W217_T0.6640.71
217_T222_L0.6630.71
11_A14_A0.6600.71
126_I129_G0.6550.70
22_A25_A0.6520.70
25_A82_V0.6470.69
40_I49_S0.6450.69
169_L200_L0.6450.69
66_V175_A0.6420.68
10_E235_E0.6420.68
162_I197_K0.6380.68
157_L160_G0.6350.68
196_N236_F0.6300.67
120_P127_S0.6300.67
138_S142_L0.6280.67
161_I201_F0.6250.66
27_L31_L0.6250.66
38_F118_L0.6190.66
101_L182_A0.6180.66
31_L36_L0.6170.65
165_L198_W0.6160.65
111_F115_L0.6130.65
13_E16_K0.6100.65
214_G220_I0.6090.64
192_L196_N0.6090.64
15_L22_A0.6050.64
173_I188_E0.6050.64
143_L155_I0.6030.64
203_L236_F0.6030.64
224_W231_A0.6010.63
66_V90_G0.6000.63
173_I241_K0.6000.63
158_I163_I0.5990.63
165_L176_D0.5970.63
62_G171_P0.5960.63
77_R209_G0.5960.63
163_I166_R0.5940.63
154_L157_L0.5910.62
143_L147_L0.5900.62
114_S120_P0.5890.62
144_A216_L0.5880.62
175_A188_E0.5870.62
166_R169_L0.5870.62
77_R177_N0.5870.62
140_S143_L0.5860.61
64_L96_F0.5860.61
21_K25_A0.5830.61
211_Y215_I0.5800.61
182_A185_A0.5760.60
36_L44_G0.5730.60
36_L39_L0.5730.60
18_N75_L0.5720.60
133_L137_I0.5720.60
177_N241_K0.5710.59
157_L163_I0.5690.59
61_S65_S0.5690.59
66_V76_A0.5680.59
219_G224_W0.5680.59
169_L237_Y0.5660.59
22_A71_F0.5630.58
113_W186_L0.5620.58
98_K101_L0.5590.58
152_L155_I0.5570.58
168_S240_L0.5540.57
104_L107_G0.5530.57
193_M201_F0.5520.57
97_G100_L0.5510.57
203_L207_F0.5510.57
51_I57_S0.5500.57
188_E192_L0.5490.57
7_L239_D0.5490.57
12_R16_K0.5480.56
73_L86_D0.5470.56
126_I130_L0.5470.56
18_N22_A0.5470.56
49_S53_S0.5450.56
45_G50_S0.5450.56
34_F48_L0.5450.56
109_I112_L0.5450.56
217_T227_P0.5440.56
30_L226_I0.5440.56
141_L147_L0.5430.56
151_L154_L0.5420.56
97_G174_L0.5400.55
21_K71_F0.5400.55
47_G51_I0.5390.55
171_P234_A0.5380.55
138_S145_L0.5380.55
209_G241_K0.5370.55
106_I120_P0.5350.55
105_L193_M0.5340.54
107_G111_F0.5330.54
149_L156_L0.5310.54
26_T41_S0.5290.54
3_S14_A0.5280.54
102_L174_L0.5270.54
23_I224_W0.5260.53
80_E196_N0.5260.53
55_L58_S0.5230.53
125_L135_S0.5230.53
222_L229_M0.5220.53
229_M233_Y0.5190.52
201_F209_G0.5190.52
113_W117_A0.5170.52
189_S197_K0.5170.52
14_A19_Y0.5150.52
73_L234_A0.5150.52
124_L240_L0.5140.52
12_R209_G0.5140.52
225_V234_A0.5140.52
149_L153_L0.5140.52
203_L229_M0.5140.52
4_R206_S0.5130.52
75_L208_I0.5100.51
136_S139_S0.5090.51
21_K74_K0.5090.51
73_L237_Y0.5060.51
178_P185_A0.5050.51
70_Y90_G0.5050.51
102_L105_L0.5040.50
190_R193_M0.5040.50
20_G91_F0.5040.50
54_L181_G0.5030.50
169_L172_Y0.5030.50
67_G106_I0.5020.50
66_V102_L0.5020.50
132_L136_S0.5020.50
203_L237_Y0.5010.50
167_Y170_A0.5010.50
165_L190_R0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kogA 1 0.168 15.9 0.938 Contact Map
1n7lA 1 0.1557 12.1 0.941 Contact Map
4y3uB 1 0.1148 9.8 0.944 Contact Map
4kytB 2 0.1107 8.8 0.945 Contact Map
2m8rA 1 0.1803 5.3 0.95 Contact Map
3tx3A 2 0.2623 5.3 0.95 Contact Map
3hd7A 1 0.168 5.2 0.951 Contact Map
2xq2A 2 0.3607 3.9 0.954 Contact Map
2wswA 3 0.2869 3 0.956 Contact Map
3dl8C 1 0.1434 2.5 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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