PsiE - PFAM28P - GREMLIN Contacts

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PsiE - Phosphate-starvation-inducible E

PFAM:	PF06146	Sequences: GDILLVLIALELLETIKAYLREHRIPVRVVLLIAIIALARKVIILDLKGTDALELLGLAAAILALG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	66 (65)
Sequences:	7450 (3890)
Seq/√Len:	482.5
META:	0.883

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
56_L	60_A	3.615	1.00
51_D	54_E	2.945	1.00
34_A	39_A	2.700	1.00
53_L	56_L	2.397	1.00
57_G	61_A	2.058	1.00
17_K	21_R	1.974	1.00
42_V	61_A	1.860	1.00
31_L	65_L	1.725	1.00
30_V	36_I	1.694	1.00
53_L	57_G	1.614	1.00
40_R	44_I	1.576	1.00
50_T	54_E	1.530	1.00
41_K	44_I	1.515	1.00
61_A	64_A	1.491	1.00
22_E	26_P	1.484	1.00
15_T	33_I	1.456	1.00
35_I	62_I	1.359	1.00
55_L	61_A	1.327	1.00
59_A	64_A	1.302	1.00
54_E	57_G	1.290	1.00
27_V	32_L	1.280	1.00
14_E	17_K	1.236	1.00
52_A	56_L	1.225	1.00
17_K	20_L	1.219	1.00
37_A	41_K	1.161	1.00
48_K	54_E	1.148	1.00
49_G	54_E	1.141	1.00
60_A	64_A	1.125	1.00
3_I	7_L	1.121	1.00
31_L	39_A	1.112	1.00
29_V	33_I	1.112	1.00
52_A	55_L	1.097	1.00
12_L	33_I	1.095	1.00
28_R	32_L	1.072	1.00
18_A	21_R	0.959	1.00
7_L	14_E	0.948	1.00
49_G	53_L	0.942	1.00
8_I	33_I	0.938	1.00
50_T	53_L	0.934	1.00
48_K	53_L	0.921	1.00
52_A	57_G	0.914	1.00
37_A	43_I	0.872	1.00
8_I	11_E	0.867	1.00
18_A	26_P	0.864	1.00
27_V	35_I	0.862	1.00
57_G	60_A	0.859	1.00
18_A	24_R	0.858	1.00
21_R	24_R	0.834	1.00
18_A	29_V	0.834	1.00
37_A	44_I	0.822	1.00
31_L	35_I	0.806	1.00
13_L	17_K	0.793	1.00
34_A	43_I	0.790	1.00
19_Y	27_V	0.786	1.00
11_E	33_I	0.775	1.00
2_D	5_L	0.756	1.00
15_T	30_V	0.753	1.00
28_R	36_I	0.739	1.00
29_V	36_I	0.737	1.00
5_L	9_A	0.735	1.00
57_G	66_G	0.732	1.00
9_A	35_I	0.731	1.00
11_E	37_A	0.728	1.00
18_A	22_E	0.705	1.00
11_E	23_H	0.700	1.00
41_K	58_L	0.696	1.00
56_L	59_A	0.677	1.00
41_K	46_D	0.674	1.00
25_I	28_R	0.670	1.00
58_L	61_A	0.663	1.00
54_E	58_L	0.650	1.00
6_V	9_A	0.649	1.00
35_I	66_G	0.647	1.00
7_L	16_I	0.633	1.00
42_V	62_I	0.619	0.99
30_V	39_A	0.618	0.99
55_L	58_L	0.616	0.99
27_V	31_L	0.604	0.99
9_A	14_E	0.595	0.99
52_A	59_A	0.590	0.99
5_L	10_L	0.588	0.99
34_A	59_A	0.583	0.99
14_E	29_V	0.583	0.99
23_H	26_P	0.573	0.99
5_L	42_V	0.572	0.99
8_I	40_R	0.559	0.99
32_L	35_I	0.555	0.99
14_E	19_Y	0.554	0.99
48_K	51_D	0.553	0.99
51_D	55_L	0.538	0.99
12_L	15_T	0.536	0.99
31_L	66_G	0.535	0.99
4_L	36_I	0.530	0.98
4_L	16_I	0.527	0.98
53_L	60_A	0.526	0.98
7_L	10_L	0.525	0.98
20_L	26_P	0.514	0.98
38_L	61_A	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1oi4A	2	0.7424	2.8	0.858	Contact Map
3cedA	1	0.5	1.2	0.884	Contact Map
2qtsA	4	0.3182	1.1	0.887	Contact Map
2ww8A	1	0	1.1	0.889	Contact Map
3qv2A	1	0.3333	1	0.89	Contact Map
4u7tA	2	0.3485	1	0.891	Contact Map
4k0jA	3	0.3636	0.9	0.894	Contact Map
2qrvA	2	0.3485	0.9	0.894	Contact Map
2qswA	2	0.5	0.9	0.894	Contact Map
2qrrA	2	0.5152	0.8	0.896	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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