GREMLIN Database
PsiE - Phosphate-starvation-inducible E
PFAM: PF06146 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 66 (65)
Sequences: 7450 (3890)
Seq/√Len: 482.5
META: 0.883

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_L60_A3.6151.00
51_D54_E2.9451.00
34_A39_A2.7001.00
53_L56_L2.3971.00
57_G61_A2.0581.00
17_K21_R1.9741.00
42_V61_A1.8601.00
31_L65_L1.7251.00
30_V36_I1.6941.00
53_L57_G1.6141.00
40_R44_I1.5761.00
50_T54_E1.5301.00
41_K44_I1.5151.00
61_A64_A1.4911.00
22_E26_P1.4841.00
15_T33_I1.4561.00
35_I62_I1.3591.00
55_L61_A1.3271.00
59_A64_A1.3021.00
54_E57_G1.2901.00
27_V32_L1.2801.00
14_E17_K1.2361.00
52_A56_L1.2251.00
17_K20_L1.2191.00
37_A41_K1.1611.00
48_K54_E1.1481.00
49_G54_E1.1411.00
60_A64_A1.1251.00
3_I7_L1.1211.00
31_L39_A1.1121.00
29_V33_I1.1121.00
52_A55_L1.0971.00
12_L33_I1.0951.00
28_R32_L1.0721.00
18_A21_R0.9591.00
7_L14_E0.9481.00
49_G53_L0.9421.00
8_I33_I0.9381.00
50_T53_L0.9341.00
48_K53_L0.9211.00
52_A57_G0.9141.00
37_A43_I0.8721.00
8_I11_E0.8671.00
18_A26_P0.8641.00
27_V35_I0.8621.00
57_G60_A0.8591.00
18_A24_R0.8581.00
21_R24_R0.8341.00
18_A29_V0.8341.00
37_A44_I0.8221.00
31_L35_I0.8061.00
13_L17_K0.7931.00
34_A43_I0.7901.00
19_Y27_V0.7861.00
11_E33_I0.7751.00
2_D5_L0.7561.00
15_T30_V0.7531.00
28_R36_I0.7391.00
29_V36_I0.7371.00
5_L9_A0.7351.00
57_G66_G0.7321.00
9_A35_I0.7311.00
11_E37_A0.7281.00
18_A22_E0.7051.00
11_E23_H0.7001.00
41_K58_L0.6961.00
56_L59_A0.6771.00
41_K46_D0.6741.00
25_I28_R0.6701.00
58_L61_A0.6631.00
54_E58_L0.6501.00
6_V9_A0.6491.00
35_I66_G0.6471.00
7_L16_I0.6331.00
42_V62_I0.6190.99
30_V39_A0.6180.99
55_L58_L0.6160.99
27_V31_L0.6040.99
9_A14_E0.5950.99
52_A59_A0.5900.99
5_L10_L0.5880.99
34_A59_A0.5830.99
14_E29_V0.5830.99
23_H26_P0.5730.99
5_L42_V0.5720.99
8_I40_R0.5590.99
32_L35_I0.5550.99
14_E19_Y0.5540.99
48_K51_D0.5530.99
51_D55_L0.5380.99
12_L15_T0.5360.99
31_L66_G0.5350.99
4_L36_I0.5300.98
4_L16_I0.5270.98
53_L60_A0.5260.98
7_L10_L0.5250.98
20_L26_P0.5140.98
38_L61_A0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1oi4A 2 0.7424 2.8 0.858 Contact Map
3cedA 1 0.5 1.2 0.884 Contact Map
2qtsA 4 0.3182 1.1 0.887 Contact Map
2ww8A 1 0 1.1 0.889 Contact Map
3qv2A 1 0.3333 1 0.89 Contact Map
4u7tA 2 0.3485 1 0.891 Contact Map
4k0jA 3 0.3636 0.9 0.894 Contact Map
2qrvA 2 0.3485 0.9 0.894 Contact Map
2qswA 2 0.5 0.9 0.894 Contact Map
2qrrA 2 0.5152 0.8 0.896 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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