GREMLIN Database
DUF965 - Bacterial protein of unknown function (DUF965)
PFAM: PF06135 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 78 (78)
Sequences: 3427 (1785)
Seq/√Len: 202.1
META: 0.834

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E59_L3.8001.00
29_E54_N3.2261.00
55_N58_S3.0091.00
26_A54_N2.3541.00
29_E53_H2.1881.00
19_I63_L2.0481.00
17_K21_K1.9881.00
28_K34_P1.9841.00
19_I23_V1.8541.00
14_N18_E1.8311.00
39_V69_L1.7411.00
17_K75_S1.7211.00
18_E22_E1.7161.00
45_G70_E1.7001.00
15_E18_E1.6221.00
19_I59_L1.5141.00
48_T51_T1.4801.00
38_I42_L1.4441.00
35_I74_K1.4331.00
25_E28_K1.4211.00
2_E5_K1.4111.00
33_N36_N1.4041.00
16_V68_L1.3631.00
75_S78_E1.3601.00
23_V27_L1.3211.00
26_A30_K1.2771.00
39_V73_V1.2691.00
42_L69_L1.2551.00
38_I73_V1.2521.00
2_E10_K1.2401.00
72_L75_S1.1971.00
71_E75_S1.1891.00
41_Y44_S1.0981.00
18_E21_K1.0811.00
20_L38_I1.0751.00
20_L72_L1.0631.00
25_E54_N1.0341.00
40_G46_D1.0311.00
42_L48_T1.0151.00
45_G64_E1.0101.00
42_L61_R0.9450.99
55_N59_L0.9440.99
13_E71_E0.9410.99
64_E70_E0.9240.99
7_S11_E0.9230.99
52_S70_E0.9220.99
22_E26_A0.9180.99
15_E62_K0.9160.99
16_V19_I0.9110.99
69_L73_V0.9040.99
23_V60_I0.8460.99
5_K10_K0.8450.99
27_L50_I0.8430.99
22_E25_E0.8400.99
32_Y36_N0.8350.99
48_T66_D0.8240.98
11_E14_N0.8230.98
21_K25_E0.8230.98
63_L68_L0.8210.98
68_L72_L0.8200.98
30_K53_H0.8190.98
1_D42_L0.8190.98
24_Y34_P0.8080.98
25_E29_E0.7820.98
18_E62_K0.7650.97
27_L58_S0.7400.97
71_E76_Y0.7150.96
53_H56_A0.7060.96
36_N39_V0.7020.96
15_E33_N0.6890.95
43_L61_R0.6830.95
42_L68_L0.6810.95
69_L72_L0.6780.95
7_S10_K0.6740.95
32_Y46_D0.6690.94
47_P61_R0.6660.94
20_L24_Y0.6490.93
22_E54_N0.6410.93
38_I60_I0.6400.93
60_I68_L0.6400.93
43_L48_T0.6350.93
58_S62_K0.6340.93
24_Y77_L0.6330.93
12_K18_E0.6260.92
45_G52_S0.6210.92
48_T58_S0.6210.92
14_N17_K0.6140.91
24_Y38_I0.6090.91
5_K9_E0.6090.91
23_V56_A0.6070.91
8_V15_E0.6070.91
35_I39_V0.6060.91
21_K75_S0.6040.91
10_K14_N0.6000.90
16_V63_L0.5990.90
51_T56_A0.5980.90
2_E12_K0.5950.90
9_E12_K0.5770.89
9_E14_N0.5770.89
71_E74_K0.5770.89
9_E13_E0.5650.88
4_M9_E0.5620.87
14_N21_K0.5540.87
15_E19_I0.5530.87
41_Y60_I0.5520.86
67_E76_Y0.5470.86
8_V11_E0.5430.86
1_D4_M0.5410.85
26_A56_A0.5360.85
20_L42_L0.5340.85
74_K78_E0.5310.84
24_Y28_K0.5280.84
49_Y67_E0.5200.83
33_N67_E0.5160.83
39_V66_D0.5090.82
13_E17_K0.5090.82
40_G49_Y0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3va9A 2 0.7949 70.8 0.863 Contact Map
3lhqA 2 0.859 17.2 0.905 Contact Map
1ujpA 1 0.6923 16.5 0.906 Contact Map
2iaiA 2 0.8333 13.3 0.91 Contact Map
4pjwA 1 0.8846 12.8 0.91 Contact Map
4bejA 2 0.7821 11.6 0.912 Contact Map
3ccyA 2 0.7436 10.9 0.913 Contact Map
3ih6A 5 0.9487 10.9 0.913 Contact Map
2fd5A 2 0.7949 10 0.915 Contact Map
3qkxA 2 0.7821 9.2 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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