GREMLIN Database
PTAC - Phosphate propanoyltransferase
PFAM: PF06130 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 82 (67)
Sequences: 13105 (5875)
Seq/√Len: 717.7
META: 0.892

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_D68_L3.4771.00
17_A64_P3.0441.00
44_T56_E2.9591.00
14_P18_E2.5021.00
14_P64_P2.3361.00
13_S16_D2.2961.00
53_L80_L2.1821.00
45_V70_V2.1731.00
63_P66_F1.9791.00
42_T57_N1.8491.00
42_T59_R1.8251.00
53_L56_E1.6941.00
44_T53_L1.6731.00
12_L60_V1.6071.00
38_A59_R1.5941.00
12_L68_L1.5581.00
10_I43_V1.3661.00
46_V53_L1.3131.00
13_S67_A1.2941.00
22_G41_E1.2851.00
7_A59_R1.2701.00
21_F60_V1.2371.00
7_A76_E1.2101.00
7_A42_T1.1771.00
16_D19_A1.1451.00
13_S68_L1.1361.00
74_T78_N1.1291.00
55_F80_L1.1071.00
8_R76_E1.0751.00
74_T77_A1.0481.00
16_D67_A1.0281.00
45_V58_V1.0251.00
52_G79_A1.0241.00
46_V54_V1.0211.00
5_V51_R1.0181.00
52_G56_E0.9931.00
39_D62_G0.9841.00
44_T54_V0.9831.00
46_V56_E0.9691.00
15_E18_E0.9541.00
12_L20_L0.9391.00
48_P52_G0.9291.00
52_G57_N0.9081.00
15_E19_A0.8991.00
62_G66_F0.8811.00
72_I77_A0.8601.00
17_A62_G0.8471.00
10_I70_V0.8381.00
58_V70_V0.7901.00
73_D77_A0.7521.00
49_G52_G0.7391.00
5_V81_G0.7271.00
72_I80_L0.7111.00
46_V52_G0.7081.00
47_G82_I0.7031.00
12_L21_F0.6961.00
21_F43_V0.6861.00
43_V60_V0.6771.00
8_R55_F0.6761.00
51_R81_G0.6561.00
14_P62_G0.6441.00
73_D79_A0.6401.00
7_A50_E0.6351.00
18_E22_G0.6321.00
7_A57_N0.6171.00
50_E57_N0.6131.00
16_D20_L0.6071.00
56_E79_A0.6031.00
47_G52_G0.5991.00
65_R69_Q0.5981.00
17_A37_F0.5971.00
74_T79_A0.5911.00
50_E81_G0.5881.00
12_L17_A0.5861.00
47_G80_L0.5831.00
53_L79_A0.5821.00
46_V49_G0.5781.00
4_I7_A0.5761.00
20_L68_L0.5761.00
40_G59_R0.5721.00
4_I38_A0.5711.00
55_F79_A0.5661.00
4_I74_T0.5601.00
12_L16_D0.5591.00
17_A39_D0.5561.00
8_R54_V0.5551.00
17_A41_E0.5551.00
47_G51_R0.5491.00
2_G61_R0.5461.00
10_I58_V0.5451.00
72_I78_N0.5411.00
13_S63_P0.5351.00
73_D78_N0.5341.00
11_H71_H0.5331.00
10_I60_V0.5311.00
51_R76_E0.5261.00
13_S66_F0.5251.00
59_R76_E0.5201.00
44_T57_N0.5171.00
14_P17_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ujsA 1 0.6341 31.4 0.876 Contact Map
2k6mS 1 0.561 27.1 0.88 Contact Map
1qzpA 1 0.561 26.1 0.881 Contact Map
1yu8X 1 0.561 26.1 0.881 Contact Map
2ff4A 2 0.7927 10.7 0.9 Contact Map
2iv2X 1 0.6585 9.8 0.902 Contact Map
3esmA 2 0.7073 7.5 0.907 Contact Map
3ounA 1 0.6951 6.5 0.91 Contact Map
2napA 1 0.7561 6.2 0.911 Contact Map
2e7zA 1 0.7561 5.8 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0041 seconds.