GREMLIN Database
DUF962 - Protein of unknown function (DUF962)
PFAM: PF06127 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 95 (93)
Sequences: 16521 (8981)
Seq/√Len: 931.3
META: 0.905

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_P87_L3.1621.00
88_L92_T3.0861.00
17_N20_N2.7171.00
25_F90_M2.5791.00
60_V64_F2.3301.00
34_S53_V2.2451.00
85_R89_A1.9491.00
3_S6_E1.9471.00
20_N61_G1.8651.00
85_R88_L1.8491.00
8_Y89_A1.8171.00
18_P22_A1.8081.00
31_I50_L1.7691.00
25_F87_L1.7121.00
87_L91_L1.6401.00
19_T65_F1.6331.00
4_F82_G1.5241.00
45_W48_L1.5161.00
10_F14_E1.4981.00
30_L53_V1.4951.00
4_F85_R1.4671.00
37_A47_L1.4611.00
89_A94_R1.4201.00
19_T22_A1.4031.00
28_T84_P1.3851.00
14_E71_A1.3821.00
5_A9_P1.2911.00
72_T75_D1.2761.00
32_L84_P1.2451.00
59_W63_F1.2411.00
27_G57_F1.1721.00
37_A46_L1.1701.00
3_S7_F1.1601.00
23_L61_G1.1241.00
10_F13_S1.1081.00
22_A26_I1.1071.00
48_L51_F1.1061.00
59_W73_F1.0851.00
21_R90_M1.0841.00
77_L81_L1.0731.00
10_F71_A1.0651.00
19_T23_L1.0461.00
60_V65_F1.0441.00
21_R25_F1.0371.00
10_F74_K1.0321.00
4_F8_Y1.0271.00
14_E74_K1.0221.00
82_G85_R1.0221.00
37_A41_T1.0071.00
41_T44_W1.0041.00
53_V57_F0.9971.00
81_L84_P0.9941.00
35_L50_L0.9901.00
23_L57_F0.9841.00
31_I51_F0.9771.00
22_A90_M0.9701.00
34_S38_A0.9421.00
8_Y12_L0.9371.00
22_A25_F0.9261.00
4_F78_W0.9151.00
64_F67_G0.8991.00
45_W49_A0.8921.00
63_F69_K0.8911.00
27_G54_G0.8901.00
38_A47_L0.8861.00
80_L84_P0.8851.00
26_I29_P0.8691.00
2_R6_E0.8661.00
44_W48_L0.8621.00
31_I84_P0.8601.00
55_Y59_W0.8571.00
33_L37_A0.8561.00
34_S50_L0.8551.00
13_S16_R0.8491.00
56_G60_V0.8451.00
38_A44_W0.8391.00
38_A42_G0.8311.00
89_A92_T0.8191.00
84_P87_L0.8111.00
23_L60_V0.8111.00
16_R66_E0.8101.00
4_F7_F0.8071.00
49_A53_V0.7921.00
36_V40_A0.7841.00
20_N65_F0.7831.00
83_D86_M0.7781.00
75_D78_W0.7721.00
52_V56_G0.7721.00
28_T83_D0.7361.00
38_A46_L0.7361.00
26_I57_F0.7341.00
84_P88_L0.7201.00
42_G45_W0.7061.00
49_A52_V0.7001.00
46_L49_A0.6981.00
69_K74_K0.6921.00
17_N65_F0.6921.00
51_F55_Y0.6901.00
34_S46_L0.6851.00
43_P46_L0.6751.00
6_E9_P0.6721.00
86_M90_M0.6651.00
23_L65_F0.6571.00
32_L87_L0.6541.00
38_A41_T0.6531.00
25_F91_L0.6511.00
90_M94_R0.6461.00
15_H24_H0.6451.00
9_P13_S0.6391.00
38_A51_F0.6331.00
28_T32_L0.6291.00
61_G65_F0.6071.00
53_V56_G0.5961.00
7_F10_F0.5961.00
37_A40_A0.5891.00
78_W85_R0.5881.00
29_P91_L0.5861.00
80_L83_D0.5791.00
30_L34_S0.5761.00
20_N66_E0.5731.00
34_S49_A0.5671.00
14_E68_N0.5671.00
30_L50_L0.5651.00
33_L50_L0.5631.00
76_P79_S0.5561.00
63_F73_F0.5551.00
81_L85_R0.5541.00
32_L36_V0.5511.00
26_I30_L0.5501.00
30_L57_F0.5501.00
55_Y58_A0.5421.00
39_L42_G0.5321.00
12_L16_R0.5321.00
89_A93_G0.5311.00
30_L54_G0.5241.00
78_W81_L0.5221.00
2_R5_A0.5141.00
10_F75_D0.5121.00
10_F79_S0.5051.00
34_S37_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wxwA 1 0.9474 11.2 0.892 Contact Map
2y8nA 2 0.9895 3.7 0.914 Contact Map
2ls4A 1 0.2526 3.1 0.917 Contact Map
2nrgA 1 0.8632 2.7 0.92 Contact Map
4ltoA 3 0.5368 2.6 0.92 Contact Map
1kdlA 1 0.2105 2.6 0.92 Contact Map
1j6wA 2 0.9789 2.3 0.923 Contact Map
4nfuA 1 0.3053 2.1 0.925 Contact Map
3j9pD 4 0.7474 2 0.925 Contact Map
2wxfA 1 0.1579 1.7 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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