GREMLIN Database
CreD - Inner membrane protein CreD
PFAM: PF06123 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 429 (427)
Sequences: 4893 (3732)
Seq/√Len: 180.6
META: 0.861

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_G198_F5.0161.00
93_G223_L4.5461.00
95_L284_L3.7331.00
225_S247_G3.5831.00
41_I107_V3.5341.00
20_L301_A3.5001.00
367_T384_G3.4051.00
99_E106_E3.2401.00
113_D203_D3.2211.00
116_L200_F3.1671.00
100_R241_R3.1321.00
87_E217_K3.1051.00
90_D220_T3.0751.00
93_G114_L3.0301.00
115_K201_D2.9581.00
97_P226_D2.8481.00
365_L417_A2.8251.00
61_T136_L2.8171.00
87_E121_D2.6991.00
136_L139_K2.6211.00
294_S343_L2.6091.00
222_T251_T2.5981.00
345_L349_I2.5821.00
92_D222_T2.5751.00
229_H401_E2.4351.00
102_R231_S2.3821.00
160_W196_L2.3671.00
57_V83_Y2.3661.00
240_E251_T2.3591.00
352_N395_Y2.2931.00
33_R36_E2.2701.00
62_E80_R2.2681.00
242_E249_T2.2391.00
304_F394_L2.2041.00
221_V280_F2.1921.00
94_D224_T2.1901.00
159_T164_P2.1441.00
40_E102_R2.1311.00
153_R205_N2.1301.00
101_K106_E2.1201.00
57_V81_Y2.0681.00
159_T162_G2.0191.00
95_L210_L1.9781.00
61_T77_T1.9741.00
371_R377_R1.9671.00
261_Y278_S1.9441.00
117_S199_S1.9151.00
349_I353_L1.9031.00
113_D201_D1.8871.00
295_E299_K1.8851.00
98_E111_T1.8771.00
159_T199_S1.8731.00
88_T119_R1.8651.00
363_V388_A1.8531.00
64_V78_V1.8511.00
154_E253_K1.8491.00
231_S285_I1.8451.00
66_E76_R1.8051.00
52_A213_V1.8021.00
37_A103_G1.7911.00
27_I298_V1.7891.00
161_N197_P1.7821.00
360_A364_G1.7821.00
57_V143_V1.7681.00
224_T249_T1.7601.00
368_L421_Y1.7441.00
222_T249_T1.7401.00
144_L200_F1.7261.00
325_P429_Y1.7251.00
161_N196_L1.7151.00
119_R197_P1.7151.00
90_D117_S1.7011.00
349_I357_I1.7001.00
101_K241_R1.6941.00
371_R380_A1.6821.00
220_T253_K1.6721.00
228_P247_G1.6711.00
220_T251_T1.6681.00
393_F411_G1.6661.00
65_T73_T1.6611.00
119_R195_P1.6411.00
337_L412_L1.6391.00
212_F221_V1.6361.00
92_D224_T1.5971.00
38_V208_E1.5811.00
25_G28_S1.5781.00
359_A363_V1.5621.00
229_H287_P1.5611.00
96_K226_D1.5491.00
361_A413_F1.5451.00
115_K199_S1.5441.00
68_D74_E1.5401.00
233_D283_S1.5261.00
223_L282_V1.5211.00
157_T164_P1.5071.00
353_L356_L1.5051.00
232_F243_V1.5021.00
344_S409_S1.5001.00
400_L407_I1.4811.00
350_G353_L1.4761.00
361_A410_I1.4731.00
345_L357_I1.4721.00
310_L419_V1.4711.00
27_I294_S1.4701.00
154_E203_D1.4551.00
7_L11_F1.4361.00
156_P181_I1.4201.00
33_R105_Y1.4191.00
117_S197_P1.4151.00
33_R37_A1.4051.00
146_I204_L1.4021.00
34_R289_D1.3951.00
61_T79_T1.3941.00
84_F123_P1.3501.00
307_L415_I1.3501.00
37_A40_E1.3451.00
161_N194_A1.3451.00
213_V279_A1.3411.00
56_L185_L1.3361.00
255_S258_N1.3321.00
34_R38_V1.3291.00
236_F254_V1.3271.00
53_G89_L1.3201.00
58_I84_F1.3171.00
142_L158_L1.3171.00
84_F125_L1.3161.00
35_D39_A1.3091.00
314_L423_T1.2991.00
209_S283_S1.2931.00
165_L183_A1.2901.00
29_E33_R1.2871.00
63_T77_T1.2781.00
368_L372_S1.2771.00
410_I414_A1.2711.00
292_Q295_E1.2631.00
21_A25_G1.2511.00
100_R109_V1.2271.00
48_A209_S1.2271.00
67_T73_T1.2221.00
79_T139_K1.2201.00
124_D127_A1.2191.00
362_T413_F1.2191.00
233_D281_G1.2171.00
63_T134_D1.2091.00
244_T249_T1.2001.00
40_E44_K1.1901.00
306_G310_L1.1891.00
211_S281_G1.1891.00
86_P216_G1.1871.00
369_Y373_V1.1861.00
288_V292_Q1.1851.00
121_D195_P1.1811.00
362_T365_L1.1711.00
367_T380_A1.1661.00
97_P108_P1.1641.00
160_W165_L1.1511.00
365_L413_F1.1501.00
57_V141_E1.1471.00
301_A339_Y1.1451.00
211_S233_D1.1431.00
396_V407_I1.1421.00
46_G150_R1.1401.00
48_A208_E1.1351.00
167_F200_F1.1331.00
365_L368_L1.1301.00
337_L416_L1.1301.00
217_K256_H1.1181.00
60_Y80_R1.1151.00
118_G197_P1.1131.00
239_D253_K1.1121.00
418_A422_L1.1101.00
416_L419_V1.0971.00
16_L332_G1.0831.00
374_L379_R1.0801.00
322_R429_Y1.0751.00
38_V42_A1.0721.00
59_P137_W1.0711.00
31_Q295_E1.0711.00
24_Q298_V1.0701.00
91_I212_F1.0691.00
21_A24_Q1.0631.00
158_L167_F1.0551.00
231_S283_S1.0541.00
17_L302_I1.0541.00
17_L21_A1.0531.00
145_G177_L1.0521.00
312_F370_S1.0491.00
381_L385_G1.0491.00
85_L261_Y1.0421.00
66_E70_E1.0411.00
11_F15_L1.0371.00
88_T218_T1.0351.00
92_D117_S1.0341.00
400_L403_Y1.0331.00
31_Q35_D1.0311.00
334_A365_L1.0271.00
313_F317_V1.0260.99
394_L398_L1.0250.99
87_E119_R1.0200.99
92_D115_K1.0060.99
370_S383_F1.0050.99
94_D113_D1.0040.99
153_R239_D1.0040.99
262_P265_W1.0030.99
228_P244_T1.0030.99
349_I354_A1.0020.99
376_S379_R0.9940.99
421_Y425_K0.9930.99
26_L29_E0.9920.99
336_V340_L0.9890.99
49_Q148_D0.9870.99
118_G160_W0.9860.99
381_L384_G0.9850.99
23_I336_V0.9810.99
50_T211_S0.9770.99
167_F181_I0.9770.99
366_I387_L0.9720.99
62_E78_V0.9700.99
40_E43_S0.9700.99
103_G285_I0.9690.99
68_D71_G0.9690.99
85_L263_Q0.9680.99
144_L181_I0.9670.99
24_Q295_E0.9670.99
35_D38_V0.9630.99
125_L128_L0.9630.99
151_G236_F0.9610.99
37_A107_V0.9580.99
79_T136_L0.9580.99
122_L195_P0.9500.99
169_P256_H0.9470.99
60_Y266_T0.9450.99
52_A215_L0.9400.99
370_S374_L0.9390.99
58_I137_W0.9380.99
3_T7_L0.9360.99
63_T75_T0.9320.99
14_L17_L0.9310.99
49_Q110_Y0.9270.99
212_F280_F0.9260.99
14_L19_P0.9260.99
123_P128_L0.9250.99
323_I327_Q0.9240.99
46_G151_G0.9230.99
116_L120_F0.9210.99
26_L343_L0.9170.99
341_L409_S0.9120.99
395_Y399_Q0.9120.99
165_L186_P0.9090.99
65_T75_T0.9050.99
388_A392_G0.9020.99
13_I305_I0.8990.99
19_P22_M0.8970.99
84_F264_Q0.8960.99
352_N356_L0.8960.99
16_L305_I0.8930.99
218_T253_K0.8930.99
341_L344_S0.8930.99
311_A386_L0.8900.99
82_L264_Q0.8890.99
190_A193_G0.8860.99
394_L423_T0.8840.98
37_A41_I0.8800.98
93_G112_A0.8790.98
290_H293_K0.8770.98
64_V76_R0.8760.98
91_I116_L0.8750.98
340_L409_S0.8740.98
94_D97_P0.8720.98
361_A365_L0.8710.98
4_L8_L0.8710.98
108_P286_E0.8670.98
22_M25_G0.8670.98
36_E39_A0.8630.98
376_S380_A0.8630.98
118_G122_L0.8620.98
290_H294_S0.8530.98
334_A366_I0.8530.98
96_K113_D0.8530.98
254_V259_R0.8510.98
45_W205_N0.8480.98
97_P110_Y0.8480.98
66_E69_G0.8450.98
91_I221_V0.8440.98
160_W198_F0.8440.98
409_S413_F0.8420.98
20_L336_V0.8420.98
148_D151_G0.8410.98
32_S35_D0.8400.98
61_T134_D0.8390.98
415_I419_V0.8380.98
24_Q28_S0.8380.98
301_A305_I0.8370.98
6_L9_I0.8370.98
144_L202_L0.8360.98
52_A145_G0.8360.98
111_T205_N0.8350.98
111_T203_D0.8350.98
167_F183_A0.8320.98
66_E74_E0.8310.98
36_E40_E0.8290.98
130_I134_D0.8270.98
216_G219_T0.8260.98
96_K111_T0.8250.98
312_F331_V0.8240.98
102_R237_L0.8240.98
219_T280_F0.8220.98
149_L152_I0.8200.98
143_V182_H0.8180.98
348_H403_Y0.8180.98
340_L423_T0.8180.98
60_Y82_L0.8170.97
368_L371_R0.8150.97
312_F315_F0.8090.97
150_R236_F0.8060.97
68_D72_K0.8030.97
7_L10_G0.7990.97
90_D222_T0.7970.97
33_R402_D0.7930.97
286_E292_Q0.7920.97
55_V83_Y0.7900.97
232_F241_R0.7900.97
383_F387_L0.7870.97
380_A384_G0.7870.97
29_E32_S0.7850.97
371_R375_K0.7830.97
160_W185_L0.7810.97
208_E283_S0.7790.97
83_Y143_V0.7790.97
58_I140_A0.7780.97
26_L33_R0.7770.97
191_A194_A0.7760.97
295_E298_V0.7730.96
51_I204_L0.7700.96
405_L409_S0.7670.96
106_E286_E0.7630.96
114_L212_F0.7630.96
168_E256_H0.7620.96
141_E182_H0.7610.96
237_L241_R0.7600.96
89_L216_G0.7580.96
308_T390_L0.7570.96
382_L385_G0.7550.96
58_I135_I0.7540.96
14_L22_M0.7530.96
171_T180_G0.7510.96
333_L416_L0.7490.96
288_V293_K0.7480.96
333_L336_V0.7480.96
91_I219_T0.7470.96
323_I331_V0.7460.96
314_L419_V0.7460.96
393_F407_I0.7450.96
359_A364_G0.7430.96
85_L265_W0.7430.96
334_A417_A0.7410.96
229_H285_I0.7370.95
304_F390_L0.7350.95
130_I133_E0.7330.95
102_R107_V0.7320.95
219_T259_R0.7310.95
170_G182_H0.7300.95
404_A408_G0.7290.95
319_S379_R0.7290.95
362_T394_L0.7280.95
294_S346_S0.7280.95
149_L258_N0.7240.95
84_F122_L0.7240.95
315_F379_R0.7230.95
105_Y293_K0.7210.95
230_P243_V0.7200.95
11_F21_A0.7190.95
124_D128_L0.7190.95
153_R203_D0.7180.95
312_F366_I0.7170.95
217_K263_Q0.7160.95
93_G212_F0.7130.95
345_L410_I0.7100.94
407_I411_G0.7090.94
363_V387_L0.7080.94
28_S32_S0.7030.94
395_Y423_T0.7020.94
97_P284_L0.7010.94
211_S283_S0.7000.94
114_L202_L0.6990.94
21_A28_S0.6960.94
98_E241_R0.6930.94
329_L394_L0.6910.94
352_N399_Q0.6910.94
364_G368_L0.6900.94
41_I106_E0.6890.93
225_S243_V0.6890.93
105_Y312_F0.6880.93
159_T201_D0.6880.93
405_L408_G0.6840.93
302_I306_G0.6830.93
41_I109_V0.6830.93
384_G388_A0.6830.93
86_P215_L0.6810.93
236_F258_N0.6790.93
157_T201_D0.6780.93
82_L125_L0.6770.93
219_T254_V0.6750.93
170_G180_G0.6750.93
89_L219_T0.6740.93
404_A407_I0.6740.93
109_V294_S0.6740.93
308_T362_T0.6720.93
46_G290_H0.6710.93
105_Y416_L0.6690.92
27_I343_L0.6690.92
259_R263_Q0.6690.92
17_L24_Q0.6680.92
20_L24_Q0.6660.92
129_G132_P0.6660.92
32_S39_A0.6620.92
69_G72_K0.6620.92
308_T335_L0.6620.92
34_R290_H0.6590.92
193_G196_L0.6580.92
55_V143_V0.6580.92
84_F120_F0.6570.92
3_T6_L0.6560.92
308_T363_V0.6550.92
2_L24_Q0.6540.92
350_G354_A0.6540.92
89_L198_F0.6530.92
168_E217_K0.6530.92
26_L401_E0.6520.91
367_T371_R0.6500.91
6_L326_V0.6430.91
150_R235_A0.6420.91
348_H354_A0.6400.91
49_Q204_L0.6400.91
81_Y141_E0.6390.91
117_S224_T0.6380.91
327_Q369_Y0.6360.90
5_K316_E0.6340.90
314_L424_R0.6340.90
324_H428_W0.6330.90
33_R40_E0.6320.90
169_P180_G0.6310.90
421_Y424_R0.6310.90
99_E108_P0.6310.90
226_D247_G0.6310.90
125_L130_I0.6300.90
403_Y407_I0.6270.90
209_S233_D0.6260.90
139_K184_P0.6230.90
293_K352_N0.6220.89
391_Y394_L0.6210.89
335_L412_L0.6210.89
370_S373_V0.6200.89
225_S228_P0.6200.89
82_L128_L0.6200.89
59_P140_A0.6200.89
157_T166_A0.6190.89
258_N362_T0.6180.89
13_I302_I0.6180.89
396_V400_L0.6170.89
243_V285_I0.6170.89
373_V380_A0.6170.89
232_F303_L0.6160.89
323_I373_V0.6160.89
179_S260_N0.6150.89
6_L10_G0.6150.89
50_T279_A0.6150.89
200_F210_L0.6150.89
93_G210_L0.6140.89
383_F390_L0.6110.89
146_I181_I0.6110.89
230_P248_F0.6100.89
82_L122_L0.6100.89
364_G367_T0.6100.89
397_L411_G0.6090.88
110_Y210_L0.6070.88
67_T71_G0.6040.88
239_D251_T0.6040.88
91_I215_L0.6030.88
18_I22_M0.6030.88
273_Y276_S0.6020.88
259_R262_P0.6000.88
37_A44_K0.5990.88
375_K425_K0.5970.87
303_L374_L0.5960.87
413_F417_A0.5960.87
290_H346_S0.5960.87
265_W316_E0.5960.87
46_G205_N0.5960.87
150_R294_S0.5960.87
242_E246_D0.5950.87
363_V367_T0.5950.87
286_E326_V0.5940.87
417_A421_Y0.5940.87
94_D226_D0.5940.87
424_R429_Y0.5930.87
25_G29_E0.5890.87
393_F396_V0.5890.87
34_R60_Y0.5880.87
348_H404_A0.5870.87
51_I114_L0.5870.87
59_P138_D0.5860.87
318_L422_L0.5860.87
168_E182_H0.5820.86
393_F406_L0.5820.86
372_S421_Y0.5820.86
45_W207_S0.5820.86
326_V428_W0.5810.86
227_W312_F0.5810.86
256_H260_N0.5800.86
5_K151_G0.5790.86
64_V77_T0.5790.86
379_R383_F0.5770.86
327_Q429_Y0.5760.86
289_D292_Q0.5750.85
321_L379_R0.5730.85
4_L23_I0.5720.85
304_F391_Y0.5710.85
210_L221_V0.5700.85
375_K378_R0.5690.85
155_N218_T0.5680.85
290_H350_G0.5670.85
216_G263_Q0.5660.85
286_E289_D0.5660.85
100_R243_V0.5660.85
189_A193_G0.5650.84
137_W140_A0.5650.84
244_T247_G0.5650.84
48_A211_S0.5640.84
306_G333_L0.5640.84
341_L361_A0.5630.84
34_R37_A0.5610.84
28_S295_E0.5600.84
380_A396_V0.5600.84
142_L160_W0.5580.84
263_Q275_L0.5580.84
82_L135_I0.5570.84
13_I306_G0.5570.84
37_A108_P0.5560.84
180_G183_A0.5550.83
218_T255_S0.5550.83
12_L16_L0.5550.83
414_A418_A0.5510.83
65_T69_G0.5480.83
314_L394_L0.5480.83
95_L112_A0.5460.82
44_K344_S0.5460.82
361_A364_G0.5450.82
401_E405_L0.5450.82
29_E37_A0.5450.82
86_P89_L0.5440.82
331_V366_I0.5440.82
66_E71_G0.5430.82
363_V372_S0.5430.82
67_T72_K0.5410.82
19_P333_L0.5400.82
398_L423_T0.5400.82
85_L216_G0.5400.82
232_F238_P0.5400.82
115_K159_T0.5390.82
337_L361_A0.5380.82
337_L362_T0.5380.82
282_V384_G0.5380.82
46_G207_S0.5370.81
229_H286_E0.5370.81
12_L19_P0.5370.81
285_I289_D0.5370.81
213_V261_Y0.5360.81
23_I340_L0.5360.81
84_F140_A0.5350.81
408_G413_F0.5350.81
171_T182_H0.5350.81
128_L133_E0.5350.81
315_F321_L0.5340.81
356_L360_A0.5340.81
16_L374_L0.5310.81
23_I314_L0.5290.80
82_L137_W0.5290.80
22_M302_I0.5280.80
379_R423_T0.5270.80
5_K328_Y0.5270.80
16_L19_P0.5270.80
97_P227_W0.5270.80
42_A207_S0.5250.80
260_N263_Q0.5250.80
154_E255_S0.5230.80
314_L326_V0.5230.80
84_F124_D0.5220.80
27_I295_E0.5220.80
29_E299_K0.5210.79
389_L414_A0.5210.79
162_G165_L0.5210.79
104_I263_Q0.5210.79
65_T71_G0.5210.79
326_V426_I0.5200.79
182_H260_N0.5190.79
377_R381_L0.5180.79
111_T153_R0.5180.79
351_F398_L0.5170.79
115_K194_A0.5160.79
410_I413_F0.5160.79
385_G389_L0.5160.79
51_I146_I0.5160.79
94_D117_S0.5150.79
108_P400_L0.5150.79
289_D398_L0.5140.79
51_I116_L0.5140.79
119_R163_Q0.5140.79
341_L413_F0.5140.79
390_L415_I0.5130.78
186_P189_A0.5130.78
112_A210_L0.5130.78
297_A304_F0.5120.78
308_T397_L0.5120.78
287_P401_E0.5120.78
366_I383_F0.5110.78
259_R265_W0.5110.78
207_S308_T0.5100.78
236_F280_F0.5090.78
94_D245_D0.5090.78
216_G334_A0.5090.78
343_L350_G0.5090.78
189_A192_A0.5080.78
42_A107_V0.5080.78
228_P241_R0.5080.78
121_D124_D0.5070.78
130_I135_I0.5070.78
228_P243_V0.5060.77
293_K399_Q0.5060.77
297_A351_F0.5060.77
39_A47_G0.5040.77
146_I149_L0.5040.77
342_L397_L0.5030.77
112_A204_L0.5030.77
317_V422_L0.5030.77
8_L19_P0.5020.77
254_V258_N0.5010.77
329_L333_L0.5010.77
232_F237_L0.5000.77
51_I202_L0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b5dA 2 0.2308 19.7 0.978 Contact Map
4aw7A 1 0.4079 15.2 0.979 Contact Map
4m64A 1 0.0956 11.4 0.98 Contact Map
4o9uB 2 0.1818 8.9 0.981 Contact Map
4bwzA 2 0.31 7 0.982 Contact Map
4pgrA 1 0.3753 6.7 0.982 Contact Map
4j05A 3 0.303 6.1 0.982 Contact Map
2i68A 2 0.1772 6 0.982 Contact Map
4zw9A 1 0.3217 5.8 0.982 Contact Map
3wajA 1 0.3403 5.4 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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